Biochemical characterization of dihydroorotase of Leishmania donovani: Understanding pyrimidine metabolism through its inhibition

Biochimie

Volumn 131, Issue , 2016, Pages 45-53

  Tiwari, Kartikeya ^a   Kumar, Ritesh ^a   Dubey, Vikash Kumar ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY GUWAHATI   (India)

Author keywords

Anti leishmanial; LdDHOase; Leishmania donovani; Pyrimidine biosynthesis

Indexed keywords

4,5-DIHYDROOROTIC ACID; BIOTIN; BIOTIN SULFONE; CYTIDINE DEAMINASE; DIHYDROOROTASE; KAEMPFEROL; KAEMPFEROL DERIVATIVE; OROTIC ACID; PROTOZOAL PROTEIN; PYRIMIDINE; PYRIMIDINE DERIVATIVE; RECOMBINANT PROTEIN; SULFONE;

ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENETICS; KINETICS; LEISHMANIA DONOVANI; METABOLISM; MOLECULAR DOCKING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DOMAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BIOTIN; CYTIDINE DEAMINASE; DIHYDROOROTASE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, ENZYMOLOGIC; KAEMPFEROLS; KINETICS; LEISHMANIA DONOVANI; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; OROTIC ACID; PROTEIN DOMAINS; PROTOZOAN PROTEINS; PYRIMIDINES; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBSTRATE SPECIFICITY; SULFONES;

EID: 84988498653     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2016.09.009     Document Type: Article

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