Genetic dissection of pyrimidine biosynthesis and salvage in Leishmania donovani

Journal of Biological Chemistry

Volumn 287, Issue 16, 2012, Pages 12759-12770

  Wilson, Zachary N ^a   Gilroy, Caslin A ^a   Boitz, Jan M ^a   Ullman, Buddy ^a   Yates, Phillip A ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUXOTROPHY; CARBAMOYL PHOSPHATES; COMPLEMENTATION; GENETIC DISSECTION; LEISHMANIA; LIFE CYCLE STAGES; MAMMALIAN HOSTS; MUTANT LINES; NUCLEOBASES; NULL MUTANT; PARASITE-; PROMASTIGOTES; PROTOZOAN PARASITES; PYRIMIDINE BIOSYNTHESIS; PYRIMIDINE NUCLEOSIDES; RELATIVE CONTRIBUTION; SALVAGE ENZYMES; SALVAGE PATHWAY; SYNTHETASES; URACIL PHOSPHORIBOSYLTRANSFERASE; VISCERAL LEISHMANIASIS;

BIOCHEMISTRY; BIOMOLECULES; BIOSYNTHESIS; ENZYMES; MACHINERY; MAMMALS;

AROMATIC COMPOUNDS;

CARBAMOYL PHOSPHATE SYNTHASE; DIHYDROOROTIC ACID; NUCLEIC ACID BASE; OROTIC ACID; PYRIMIDINE; PYRIMIDINE NUCLEOSIDE; UNCLASSIFIED DRUG; URACIL; URACIL PHOSPHORIBOSYLTRANSFERASE;

AMASTIGOTE; ARTICLE; AUXOTROPHY; CONTROLLED STUDY; GENE SILENCING; GENETIC ANALYSIS; LEISHMANIA DONOVANI; LIFE CYCLE STAGE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMASTIGOTE; PROTOZOAL INFECTION; PYRIMIDINE METABOLISM; PYRIMIDINE SYNTHESIS;

ANIMALS; CARBAMOYL-PHOSPHATE SYNTHASE (AMMONIA); FEMALE; HOMEOSTASIS; LEISHMANIA DONOVANI; LEISHMANIASIS VACCINES; LEISHMANIASIS, VISCERAL; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PENTOSYLTRANSFERASES; PHOSPHORYLATION; PYRIMIDINES; URACIL; URIDINE;

LEISHMANIA DONOVANI; MAMMALIA; MUS; PROTOZOA;

EID: 84859765845     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.346502     Document Type: Article

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