Perpetuating the homing endonuclease life cycle: Identification of mutations that modulate and change I-TevI cleavage preference

Nucleic Acids Research

Volumn 44, Issue 15, 2016, Pages 7350-7359

  Roy, Alexander C ^a   Wilson, Geoffrey G ^b   Edgell, David R ^a  

^a WESTERN UNIVERSITY   (Canada)

^b NEW ENGLAND BIOLABS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE; HOMING ENDONUCLEASE I TEVI; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG; I-BMOI ENDONUCLEASE; I-TEVI ENDONUCLEASE; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; DIRECTED MOLECULAR EVOLUTION; DNA CLEAVAGE; DNA STRUCTURE; ENTEROBACTERIA PHAGE T4; ENZYME SUBSTRATE; GENE IDENTIFICATION; GENE MUTATION; GENETIC VARIABILITY; HOMING ENDONUCLEASE GENE; ISOSCHIZOMER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE ALIGNMENT; THYMIDYLATE SYNTHASE GENE; WILD TYPE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; INTRON; METABOLISM; MUTATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; DIRECTED MOLECULAR EVOLUTION; DNA CLEAVAGE; ENDODEOXYRIBONUCLEASES; INTRONS; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; MUTATION; PROTEIN DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84988421084     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkw614     Document Type: Article

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