-
1
-
-
0026563253
-
Semisynthetic combinatorial antibody libraries: A chemical solution to the diversity problem
-
Barbas III C.F., Bain J.D., Hoekstra D.M., Lerner R.A. Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem. Proc. Natl. Acad. Sci. USA. 89:1992;4457.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 4457
-
-
Barbas C.F. III1
Bain, J.D.2
Hoekstra, D.M.3
Lerner, R.A.4
-
2
-
-
0029111580
-
Synthetic human antibodies
-
Barbas III C.F. Synthetic human antibodies. Nat. Med. 1:1995;837.
-
(1995)
Nat. Med.
, vol.1
, pp. 837
-
-
Barbas C.F. III1
-
4
-
-
0024537949
-
Comparison of variable region primary structures within an anti-fluorescein idiotype family
-
Bedzyk W.D., Johnson L.S., Riordan G.S., Voss E.W. Jr. Comparison of variable region primary structures within an anti-fluorescein idiotype family. J. Biol. Chem. 264:1989;1565.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 1565
-
-
Bedzyk, W.D.1
Johnson, L.S.2
Riordan, G.S.3
Voss, E.W.4
-
5
-
-
0022386943
-
Molecular events during maturation of the immune response to oxazolone
-
Berek C., Griffiths G.M., Milstein C. Molecular events during maturation of the immune response to oxazolone. Nature. 316:1985;412.
-
(1985)
Nature
, vol.316
, pp. 412
-
-
Berek, C.1
Griffiths, G.M.2
Milstein, C.3
-
6
-
-
0026502047
-
High level Escherichia coli expression and production of a bivalent humanized antibody fragment
-
Carter P., Kelley R.F., Rodrigues M.L., Snedecor B., Covarrubias M., Velligan M.D., Wong W.L., Rowland A.M., Kotts C.E., Carver M.E., Yang M., Bourell J.H., Shepard H.M., Henner D. High level Escherichia coli expression and production of a bivalent humanized antibody fragment. Biotechnology. 10:1992;163.
-
(1992)
Biotechnology
, vol.10
, pp. 163
-
-
Carter, P.1
Kelley, R.F.2
Rodrigues, M.L.3
Snedecor, B.4
Covarrubias, M.5
Velligan, M.D.6
Wong, W.L.7
Rowland, A.M.8
Kotts, C.E.9
Carver, M.E.10
Yang, M.11
Bourell, J.H.12
Shepard, H.M.13
Henner, D.14
-
7
-
-
0032523202
-
Genetic and immunological properties of phage-displayed human anti-Rh(D) antibodies: Implications for Rh(D) epitope topology
-
Chang T.Y., Siegel D.L. Genetic and immunological properties of phage-displayed human anti-Rh(D) antibodies: implications for Rh(D) epitope topology. Blood. 91:1998;3066.
-
(1998)
Blood
, vol.91
, pp. 3066
-
-
Chang, T.Y.1
Siegel, D.L.2
-
9
-
-
0032080665
-
Only selected light chains combine with a given heavy chain to confer specificity for a model glycopeptide antigen
-
Czerwinski M., Siemaszko D., Siegel D.L., Spitalnik S.L. Only selected light chains combine with a given heavy chain to confer specificity for a model glycopeptide antigen. J. Immunol. 160:1998;4406.
-
(1998)
J. Immunol.
, vol.160
, pp. 4406
-
-
Czerwinski, M.1
Siemaszko, D.2
Siegel, D.L.3
Spitalnik, S.L.4
-
11
-
-
0028825910
-
Selection of specific phage-display antibodies using libraries derived from chicken immunoglobulin genes
-
Davies E.L., Smith J.S., Birkett C.R., Manser J.M., Anderson-Dear D.V., Young J.R. Selection of specific phage-display antibodies using libraries derived from chicken immunoglobulin genes. J. Immunol. Methods. 186:1995;125.
-
(1995)
J. Immunol. Methods
, vol.186
, pp. 125
-
-
Davies, E.L.1
Smith, J.S.2
Birkett, C.R.3
Manser, J.M.4
Anderson-Dear, D.V.5
Young, J.R.6
-
12
-
-
0033603596
-
A large non-immunized human Fab fragment phage library that permits rapid isolation and kinetic analysis of high affinity antibodies
-
de Haard H.J., van Neer N., Reurs A., Hufton S.E., Roovers R.C., Henderikx P., de Bruine A.P., Arends J.W., Hoogenboom H.R. A large non-immunized human Fab fragment phage library that permits rapid isolation and kinetic analysis of high affinity antibodies. J. Biol. Chem. 274:1999;18218.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18218
-
-
De Haard, H.J.1
Van Neer, N.2
Reurs, A.3
Hufton, S.E.4
Roovers, R.C.5
Henderikx, P.6
De Bruine, A.P.7
Arends, J.W.8
Hoogenboom, H.R.9
-
13
-
-
0024551567
-
Variable region primary structures of high affinity anti-fluorescein immunoglobulin M cryoglobulin exhibiting oxazolone cross-reactivity
-
Dombrink-Kurtzman M.A., Johnson L.S., Riordan G.S., Bedzyk W.D., Voss E.W. Jr. Variable region primary structures of high affinity anti-fluorescein immunoglobulin M cryoglobulin exhibiting oxazolone cross-reactivity. J. Biol. Chem. 264:1989;4513.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 4513
-
-
Dombrink-Kurtzman, M.A.1
Johnson, L.S.2
Riordan, G.S.3
Bedzyk, W.D.4
Voss, E.W.5
-
14
-
-
0025981495
-
Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response
-
Fish S., Fleming M., Sharon J., Manser T. Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response. J. Exp. Med. 173:1991;665.
-
(1991)
J. Exp. Med.
, vol.173
, pp. 665
-
-
Fish, S.1
Fleming, M.2
Sharon, J.3
Manser, T.4
-
15
-
-
0025061455
-
Polyclonal antibodies against rat liver cytosolic casein kinase II (CK-2) cross-react with CD-2 from other tissues and nuclear for (PK-N2) of the enzyme
-
Goueli S.A., Hanten J., Davis A., Ahmed K. Polyclonal antibodies against rat liver cytosolic casein kinase II (CK-2) cross-react with CD-2 from other tissues and nuclear for (PK-N2) of the enzyme. Biochem. Int. 21:1990;685.
-
(1990)
Biochem. Int.
, vol.21
, pp. 685
-
-
Goueli, S.A.1
Hanten, J.2
Davis, A.3
Ahmed, K.4
-
16
-
-
0021711720
-
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone
-
Griffiths G.M., Berek C., Kaartinen M., Milstein C. Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature. 312:1984;217.
-
(1984)
Nature
, vol.312
, pp. 217
-
-
Griffiths, G.M.1
Berek, C.2
Kaartinen, M.3
Milstein, C.4
-
17
-
-
0028243456
-
Conversion of an anti-single-stranded DNA active site to an anti-fluorescein active site through heavy chain complementarity determining region transplantation
-
Gulliver G.A., Bedzyk W.D., Smith R.G., Bode S.L., Tetin S.Y., Voss E.W. Jr. Conversion of an anti-single-stranded DNA active site to an anti-fluorescein active site through heavy chain complementarity determining region transplantation. J. Biol. Chem. 269:1994;7934.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 7934
-
-
Gulliver, G.A.1
Bedzyk, W.D.2
Smith, R.G.3
Bode, S.L.4
Tetin, S.Y.5
Voss, E.W.6
-
20
-
-
0031812594
-
Antibody phage display technology and its applications
-
Hoogenboom H.R., de Bruine A.P., Hufton S.E., Hoet R.M., Arends J.W., Roovers R.C. Antibody phage display technology and its applications. Immunotechnology. 4:1998;1.
-
(1998)
Immunotechnology
, vol.4
, pp. 1
-
-
Hoogenboom, H.R.1
De Bruine, A.P.2
Hufton, S.E.3
Hoet, R.M.4
Arends, J.W.5
Roovers, R.C.6
-
21
-
-
0024556150
-
Engineering hybrid genes without the use of restriction enzymes: Gene splicing by overlap extension
-
Horton R.M., Hunt H.D., Ho S.N., Pullen J.K., Pease L.R. Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene. 77:1989;61.
-
(1989)
Gene
, vol.77
, pp. 61
-
-
Horton, R.M.1
Hunt, H.D.2
Ho, S.N.3
Pullen, J.K.4
Pease, L.R.5
-
22
-
-
0020666053
-
Anti-oxazolone hybridomas and the structure of the oxazolone idiotype
-
Kaartinen M., Griffiths G.M., Hamlyn P.H., Markham A.F., Karjalainen K., Pelkonen J.L.T., Makela O., Milstein C. Anti-oxazolone hybridomas and the structure of the oxazolone idiotype. J. Immunol. 130:1983;937.
-
(1983)
J. Immunol.
, vol.130
, pp. 937
-
-
Kaartinen, M.1
Griffiths, G.M.2
Hamlyn, P.H.3
Markham, A.F.4
Karjalainen, K.5
Pelkonen, J.L.T.6
Makela, O.7
Milstein, C.8
-
23
-
-
0020534350
-
MRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification
-
Kaartinen M., Griffiths G.M., Markham A.F., Milstein C. mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification. Nature. 304:1983;320.
-
(1983)
Nature
, vol.304
, pp. 320
-
-
Kaartinen, M.1
Griffiths, G.M.2
Markham, A.F.3
Milstein, C.4
-
24
-
-
0016756272
-
Continuous culture of fused cells secreting antibody of predefined specificity
-
Kohler G., Milstein C. Continuous culture of fused cells secreting antibody of predefined specificity. Nature. 256:1975;495.
-
(1975)
Nature
, vol.256
, pp. 495
-
-
Kohler, G.1
Milstein, C.2
-
25
-
-
0026031446
-
Epitope tagging and protein surveillance
-
Kolodziej P.A., Young R.A. Epitope tagging and protein surveillance. Methods Enzymol. 194:1991;508.
-
(1991)
Methods Enzymol.
, vol.194
, pp. 508
-
-
Kolodziej, P.A.1
Young, R.A.2
-
26
-
-
0019816557
-
Restricted reassociation of heavy and light chains from hapten-specific monoclonal antibodies
-
Kranz D.M., Voss E.W. Jr. Restricted reassociation of heavy and light chains from hapten-specific monoclonal antibodies. Proc. Natl. Acad. Sci. USA. 78:1981;5807.
-
(1981)
Proc. Natl. Acad. Sci. USA
, vol.78
, pp. 5807
-
-
Kranz, D.M.1
Voss, E.W.2
-
29
-
-
0025284779
-
Structural characterization of H chain-associated idiotopes of anti-p-azophenylarsonate monoclonal antibodies
-
Parhami-Seren B., Sharon J., Margolies M.N. Structural characterization of H chain-associated idiotopes of anti-p-azophenylarsonate monoclonal antibodies. J. Immunol. 144:1990;4426.
-
(1990)
J. Immunol.
, vol.144
, pp. 4426
-
-
Parhami-Seren, B.1
Sharon, J.2
Margolies, M.N.3
-
30
-
-
0024850698
-
The amino acid residues at the VH-D-JH junctions affect the affinity of anti-p-azophenylarsonate antibodies
-
Parhami-Seren B., Wysocki L., Margolies M.N. The amino acid residues at the VH-D-JH junctions affect the affinity of anti-p-azophenylarsonate antibodies. J. Immunol. 143:1989;4090.
-
(1989)
J. Immunol.
, vol.143
, pp. 4090
-
-
Parhami-Seren, B.1
Wysocki, L.2
Margolies, M.N.3
-
31
-
-
0025119989
-
Clustered H chain somatic mutations shared by anti-p-azophenylarsonate antibodies confer enhanced affinity and ablate the cross-reactive idiotypes
-
Parhami-Seren B., Wysocki L.J., Margolies M.N., Sharon J. Clustered H chain somatic mutations shared by anti-p-azophenylarsonate antibodies confer enhanced affinity and ablate the cross-reactive idiotypes. J. Immunol. 145:1990;2340.
-
(1990)
J. Immunol.
, vol.145
, pp. 2340
-
-
Parhami-Seren, B.1
Wysocki, L.J.2
Margolies, M.N.3
Sharon, J.4
-
32
-
-
0023969216
-
Chicken immunologlobulin g-heavy chains: Limited VH gene repertoire. Combinatorial diversification by D gene segments, and evolution of the heavy chain locus
-
Parvari R., Avivi A., Lentner F., Ziv E., Tel-Or S., Burstein Y., Schechter I. Chicken immunologlobulin g-heavy chains: limited VH gene repertoire. Combinatorial diversification by D gene segments, and evolution of the heavy chain locus. EMBO J. 7:1988;739.
-
(1988)
EMBO J.
, vol.7
, pp. 739
-
-
Parvari, R.1
Avivi, A.2
Lentner, F.3
Ziv, E.4
Tel-Or, S.5
Burstein, Y.6
Schechter, I.7
-
33
-
-
0030752337
-
Phage display of combinatorial antibody libraries
-
Rader C., Barbas III C.F. Phage display of combinatorial antibody libraries. Curr. Opin. Biotechnol. 8:1997;503.
-
(1997)
Curr. Opin. Biotechnol.
, vol.8
, pp. 503
-
-
Rader, C.1
Barbas C.F. III2
-
34
-
-
0032555214
-
A phage display approach for rapid antibody humanization: Designed combinatorial V gene libraries
-
Rader C., Cheresh D.A., Barbas III C.F. A phage display approach for rapid antibody humanization: designed combinatorial V gene libraries. Proc. Natl. Acad. Sci. USA. 95:1998;8910.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 8910
-
-
Rader, C.1
Cheresh, D.A.2
Barbas C.F. III3
-
35
-
-
0034607856
-
The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies
-
Rader C., Ritter G., Nathan S., Elia M., Gout I., Jungbluth A.A., Cohen L.S., Welt S., Old L.J., Barbas III C.F. The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies. J. Biol. Chem. 275:2000;13669.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 13669
-
-
Rader, C.1
Ritter, G.2
Nathan, S.3
Elia, M.4
Gout, I.5
Jungbluth, A.A.6
Cohen, L.S.7
Welt, S.8
Old, L.J.9
Barbas C.F. III10
-
36
-
-
0023892327
-
Anti-fluorescein antibody 3-13 VH gene rearrangement in idiotypically cross-reactive hybridomas
-
Reinitz D.M., Strich R., Scott J.F., Voss E.W. Jr. Anti-fluorescein antibody 3-13 VH gene rearrangement in idiotypically cross-reactive hybridomas. Mol. Immunol. 25:1988;621.
-
(1988)
Mol. Immunol.
, vol.25
, pp. 621
-
-
Reinitz, D.M.1
Strich, R.2
Scott, J.F.3
Voss, E.W.4
-
37
-
-
0023652339
-
A hyperconversion mechanism generates the chicken light chain preimmune repertoire
-
Reynaud C.-A., Anquez V., Grimal H., Weill J.-C. A hyperconversion mechanism generates the chicken light chain preimmune repertoire. Cell. 48:1987;379.
-
(1987)
Cell
, vol.48
, pp. 379
-
-
Reynaud, C.-A.1
Anquez, V.2
Grimal, H.3
Weill, J.-C.4
-
38
-
-
0026002863
-
The chicken D locus and its contribution to the immunoglobulin heavy chain repertoire
-
Reynaud C.-A., Anquez V., Weill J.-C. The chicken D locus and its contribution to the immunoglobulin heavy chain repertoire. Eur. J. Immunol. 21:1991;2661.
-
(1991)
Eur. J. Immunol.
, vol.21
, pp. 2661
-
-
Reynaud, C.-A.1
Anquez, V.2
Weill, J.-C.3
-
40
-
-
0023123378
-
k gene segments of A/J Ars-A antibodies: Somatic recombination generates the essential arginine at the junction of the variable and joining regions
-
k gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions. Proc. Natl. Acad. Sci. USA. 84:1987;1085.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 1085
-
-
Sanz, I.1
Capra, J.D.2
-
41
-
-
0024496737
-
Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten
-
Sharon J., Gefter M.L., Wysocki L.J., Margolies M.N. Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten. J. Immunol. 142:1989;596.
-
(1989)
J. Immunol.
, vol.142
, pp. 596
-
-
Sharon, J.1
Gefter, M.L.2
Wysocki, L.J.3
Margolies, M.N.4
-
42
-
-
14744267241
-
The functional expression of antibody Fv fragments in Escherichia coli: Improved vectors and a generally applicable purification technique
-
Skerra A., Pfitzinger I., Pluckthun A. The functional expression of antibody Fv fragments in Escherichia coli: improved vectors and a generally applicable purification technique. Bio/Technology. 9:1991;273.
-
(1991)
Bio/Technology
, vol.9
, pp. 273
-
-
Skerra, A.1
Pfitzinger, I.2
Pluckthun, A.3
-
43
-
-
0022226358
-
Antibodies to the alpha-subunit of insulin receptor from the eggs of immunized hens
-
Song C.S., Yu J.H., Bai D.H., Hester P.Y., Kim K.H. Antibodies to the alpha-subunit of insulin receptor from the eggs of immunized hens. J. Immunol. 135:1985;3354.
-
(1985)
J. Immunol.
, vol.135
, pp. 3354
-
-
Song, C.S.1
Yu, J.H.2
Bai, D.H.3
Hester, P.Y.4
Kim, K.H.5
-
44
-
-
0029955258
-
Selection of linkers for a catalytic single-chain antibody using phage display technology
-
Tang Y., Jiang N., Parakh C., Hilvert D. Selection of linkers for a catalytic single-chain antibody using phage display technology. J. Biol. Chem. 271:1996;15682.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 15682
-
-
Tang, Y.1
Jiang, N.2
Parakh, C.3
Hilvert, D.4
-
45
-
-
0023652303
-
Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment
-
Thompson C.B., Neiman P.E. Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment. Cell. 48:1987;369.
-
(1987)
Cell
, vol.48
, pp. 369
-
-
Thompson, C.B.1
Neiman, P.E.2
-
46
-
-
0020534965
-
Somatic generation of antibody diversity
-
Tonegawa S. Somatic generation of antibody diversity. Nature. 302:1983;575.
-
(1983)
Nature
, vol.302
, pp. 575
-
-
Tonegawa, S.1
-
47
-
-
0031584314
-
Importance of the linker in expression of single-chain Fv antibody fragments: Optimisation of peptide sequence using phage display technology
-
Turner D.J., Ritter M.A., George A.J.T. Importance of the linker in expression of single-chain Fv antibody fragments: optimisation of peptide sequence using phage display technology. J. Immunol. Methods. 205:1997;43.
-
(1997)
J. Immunol. Methods
, vol.205
, pp. 43
-
-
Turner, D.J.1
Ritter, M.A.2
George, A.J.T.3
-
48
-
-
0029608746
-
Expression studies of catalytic antibodies
-
Ulrich H.D., Patten P.A., Yang P.L., Romsberg F.E., Schultz P.G. Expression studies of catalytic antibodies. Proc. Natl. Acad. Sci. USA. 92:1995;11907.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 11907
-
-
Ulrich, H.D.1
Patten, P.A.2
Yang, P.L.3
Romsberg, F.E.4
Schultz, P.G.5
-
49
-
-
0021455017
-
The structure of an antigenic determinant in a protein
-
Wilson I.A., Niman H.L., Houghten R.A., Cherenson A.R., Connolly M.L., Lerner R.A. The structure of an antigenic determinant in a protein. Cell. 37:1984;767.
-
(1984)
Cell
, vol.37
, pp. 767
-
-
Wilson, I.A.1
Niman, H.L.2
Houghten, R.A.3
Cherenson, A.R.4
Connolly, M.L.5
Lerner, R.A.6
-
51
-
-
0022503258
-
Somatic evolution of variable region structures during an immune response
-
Wysocki L., Manser T., Gefter M. Somatic evolution of variable region structures during an immune response. Proc. Natl. Acad. Sci. USA. 83:1986;1847.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 1847
-
-
Wysocki, L.1
Manser, T.2
Gefter, M.3
-
52
-
-
0029564921
-
CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range
-
Yang W.-P., Green K., Pinz-Sweeney S., Briones A.T., Burton D.R., Barbas III C.F. CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range. J. Mol. Biol. 254:1995;392.
-
(1995)
J. Mol. Biol.
, vol.254
, pp. 392
-
-
Yang, W.-P.1
Green, K.2
Pinz-Sweeney, S.3
Briones, A.T.4
Burton, D.R.5
Barbas C.F. III6
-
53
-
-
0030210311
-
Chicken monoclonal antibody isolated by a phage display system
-
Yamanaka H.I., Inoue T., Ikeda-Tanaka O. Chicken monoclonal antibody isolated by a phage display system. J. Immunol. 157:1996;1156.
-
(1996)
J. Immunol.
, vol.157
, pp. 1156
-
-
Yamanaka, H.I.1
Inoue, T.2
Ikeda-Tanaka, O.3
-
54
-
-
0030039532
-
High level secretion of a humanized bispecific diabody from Escherichia coli
-
Zhu Z., Zapata G., Shalaby R., Snedecor B., Chen H., Carter P. High level secretion of a humanized bispecific diabody from Escherichia coli. Biotechnology. 14:1996;192.
-
(1996)
Biotechnology
, vol.14
, pp. 192
-
-
Zhu, Z.1
Zapata, G.2
Shalaby, R.3
Snedecor, B.4
Chen, H.5
Carter, P.6
|