Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

Autophagy

Volumn 12, Issue 11, 2016, Pages 2213-2229

  Hernández Tiedra, Sonia ^a,b   Fabriàs, Gemma ^c   Dávila, David ^a,b   Salanueva, Íñigo J ^a   Casas, Josefina ^c   Montes, L Ruth ^d   Antón, Zuriñe ^d   García Taboada, Elena ^a   Salazar Roa, María ^a   Lorente, Mar ^a,b   Nylandsted, Jesper ^e   Armstrong, Jane ^f,g   López Valero, Israel ^a,b   McKee, Christopher S ^f   Serrano Puebla, Ana ^a,h   García López, Roberto ^a   González Martínez, José ^a,b   Abad, José L ^c   Hanada, Kentaro ⁱ   Boya, Patricia ^h   Goñi, Félix ^d   Guzmán, Manuel ^a,j   Lovat, Penny ^f   Jäättelä, Marja ^e   Alonso, Alicia ^d   Velasco, Guillermo ^a,b   more..

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^c INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^d UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^e DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^f NEWCASTLE UNIVERSITY   (United Kingdom)

^g UNIVERSITY OF SUNDERLAND   (United Kingdom)

^h CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

ⁱ NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^j INSTITUTO RAMÓN Y CAJAL DE INVESTIGACIÓN SANITARIA IRYCIS   (Spain)

more..

Author keywords

autophagy; cancer; cannabinoids; cell death; sphingolipids

Indexed keywords

ALOXISTATIN; CANNABINOID; CATHEPSIN; CATHEPSIN B; CATHEPSIN L; CERAMIDE DERIVATIVE; DIHYDROCERAMIDE; MESSENGER RNA; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; TETRAHYDROCANNABINOL; UNCLASSIFIED DRUG; CERAMIDE; DRONABINOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CALORIMETRY; CANCER CELL; CANCER INHIBITION; CELL DEATH; CELL FRACTIONATION; CELL PERMEABILIZATION; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ELECTRON MICROSCOPY; EMBRYO; ENDOPLASMIC RETICULUM; ENZYME RELEASE; GLIOMA CELL; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIPID COMPOSITION; LIPOGENESIS; LYSOSOME MEMBRANE; MICROSOME; MOUSE; NONHUMAN; PHASE TRANSITION; SPHINGOLIPID METABOLISM; TEMPERATURE SENSITIVITY; TUMOR XENOGRAFT; TUNEL ASSAY; UPREGULATION; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL PROLIFERATION; DRUG EFFECT; INTRACELLULAR MEMBRANE; LYSOSOME; METABOLISM; NEOPLASM; PATHOLOGY; PERMEABILITY; PHAGOSOME; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE; ULTRASTRUCTURE;

APOPTOSIS; AUTOPHAGY; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CELL PROLIFERATION; CERAMIDES; DRONABINOL; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; HUMANS; INTRACELLULAR MEMBRANES; LYSOSOMES; MODELS, BIOLOGICAL; NEOPLASMS; PERMEABILITY; PHAGOSOMES; SPHINGOLIPIDS;

EID: 84987922569     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2016.1213927     Document Type: Article

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