Small-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouse

Diabetologia

Volumn 56, Issue 2, 2013, Pages 330-339

  Zertal Zidani, S ^a   Busiah, K ^a   Edelman, A ^a   Polak, M ^a   Scharfmann, R ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Beta cells; CFTR; Development; Glibenclamide; Pancreatic; Small molecules

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; GLIBENCLAMIDE; GLYCINE HYDRAZIDE; HYDRAZIDE DERIVATIVE; NEUROGENIN 3; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DRUG DERIVATIVE; GLYCINE; HYDRAZINE DERIVATIVE; N (2 NAPHTHALENYL) ((3,5 DIBROMO 2,4 DIHYDROXYPHENYL)METHYLENE)GLYCINE HYDRAZIDE; N-(2-NAPHTHALENYL)-((3,5-DIBROMO-2,4-DIHYDROXYPHENYL)METHYLENE)GLYCINE HYDRAZIDE; NERVE PROTEIN; NEUROG3 PROTEIN, MOUSE; NEUROG3 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; CELL ACTIVATION; CELL COUNT; CELL MATURATION; CELL SIZE; CELL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMBRYO; EXOCRINE CELL; EXPLANT; FEMALE; FETUS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; ORGANOGENESIS; PANCREAS DEVELOPMENT; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; ANIMAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOCHEMISTRY; METABOLISM; ORGAN CULTURE TECHNIQUE; PANCREAS; PREGNANCY; REAL TIME POLYMERASE CHAIN REACTION; WISTAR RAT;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; FEMALE; GLYBURIDE; GLYCINE; HYDRAZINES; IMMUNOCHEMISTRY; MICE; NERVE TISSUE PROTEINS; ORGAN CULTURE TECHNIQUES; PANCREAS; PREGNANCY; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION;

MLCS; MLOWN;

EID: 84878812399     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2778-8     Document Type: Article

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