Functional genome mining for metabolites encoded by large gene clusters through heterologous expression of a whole-genome bacterial artificial chromosome library in Streptomyces spp.

Applied and Environmental Microbiology

Volumn 82, Issue 19, 2016, Pages 5795-5805

  Xu, Min ^a   Wang, Yemin ^a   Zhao, Zhilong ^b   Gao, Guixi ^a   Huang, Sheng Xiong ^c   Kang, Qianjin ^a   He, Xinyi ^a   Lin, Shuangjun ^a   Pang, Xiuhua ^b   Deng, Zixin ^a   Tao, Meifeng ^a  

^a Shanghai Jiao Tong University   (China)

^b SHANDONG UNIVERSITY   (China)

^c KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; BACTERIOLOGY; BIOMOLECULES; BIOSYNTHESIS; CHROMOSOMES; DNA SEQUENCES; GENE EXPRESSION; LIBRARIES; METABOLITES; MICROORGANISMS;

ANTI-MICROBIAL ACTIVITY; BACTERIAL ARTIFICIAL CHROMOSOME LIBRARIES; BIOSYNTHETIC GENE CLUSTER; GENOME SEQUENCING PROJECTS; HETEROLOGOUS EXPRESSION; MICROBIAL METABOLITES; SECONDARY METABOLITES; STREPTOMYCES LIVIDANS;

GENES;

ANTIBIOTIC RESISTANCE; BACTERIUM; BIOACTIVITY; CHROMOSOME; GENE; GENE EXPRESSION; GENOME; GENOMICS; METABOLITE;

BACTERIA (MICROORGANISMS); STREPTOMYCES; STREPTOMYCES LIVIDANS; STREPTOMYCES ROCHEI; STREPTOMYCINEAE;

ANTIINFECTIVE AGENT;

BACTERIAL ARTIFICIAL CHROMOSOME; BACTERIAL GENOME; CHEMISTRY; GENE EXPRESSION; GENE LIBRARY; GENETICS; HIGH THROUGHPUT SEQUENCING; ISOLATION AND PURIFICATION; MULTIGENE FAMILY; STREPTOMYCES;

ANTI-BACTERIAL AGENTS; CHROMOSOMES, ARTIFICIAL, BACTERIAL; GENE EXPRESSION; GENOME, BACTERIAL; GENOMIC LIBRARY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; MULTIGENE FAMILY; STREPTOMYCES;

EID: 84987864192     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.01383-16     Document Type: Article

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