-
1
-
-
84908216113
-
The biography of the immune system and the control of cancer: from St Peregrine to contemporary vaccination strategies
-
25128300
-
B.Krone, K.F.Kolmel, J.M.Grange. The biography of the immune system and the control of cancer:from St Peregrine to contemporary vaccination strategies. BMC Cancer 2014; 14:595; PMID:25128300; http://dx.doi.org/10.1186/1471-2407-14-595
-
(2014)
BMC Cancer
, vol.14
, pp. 595
-
-
Krone, B.1
Kolmel, K.F.2
Grange, J.M.3
-
2
-
-
0037383526
-
Cancer immunotherapy: the past, the present and the future
-
12631233
-
C.R.Parish. Cancer immunotherapy:the past, the present and the future. Immunol Cell Biol 2003; 81:106-13; PMID:12631233; http://dx.doi.org/10.1046/j.0818-9641.2003.01151.x
-
(2003)
Immunol Cell Biol
, vol.81
, pp. 106-113
-
-
Parish, C.R.1
-
3
-
-
84940379860
-
Cancer Immunotherapy: Past Progress and Future Directions
-
26320057
-
M.B.Atkins, M.Sznol. Cancer Immunotherapy:Past Progress and Future Directions. Semin Oncol 2015; 42:518-22; PMID:26320057; http://dx.doi.org/10.1053/j.seminoncol.2015.05.001
-
(2015)
Semin Oncol
, vol.42
, pp. 518-522
-
-
Atkins, M.B.1
Sznol, M.2
-
4
-
-
84880706152
-
Oncology meets immunology: the cancer-immunity cycle
-
23890059
-
D.S.Chen, I.Mellman. Oncology meets immunology:the cancer-immunity cycle. Immunity 2013; 39:1-10; PMID:23890059; http://dx.doi.org/10.1016/j.immuni.2013.07.012
-
(2013)
Immunity
, vol.39
, pp. 1-10
-
-
Chen, D.S.1
Mellman, I.2
-
5
-
-
84555218419
-
Cancer immunotherapy comes of age
-
22042955
-
S.L.Topalian, G.J.Weiner, D.M.Pardoll. Cancer immunotherapy comes of age. J Clin Oncol 2011; 29:4828-36; PMID:22042955; http://dx.doi.org/10.1200/JCO.2011.38.0899
-
(2011)
J Clin Oncol
, vol.29
, pp. 4828-4836
-
-
Topalian, S.L.1
Weiner, G.J.2
Pardoll, D.M.3
-
6
-
-
84940379785
-
Cancer and the Immune System: Basic Concepts and Targets for Intervention
-
26320058
-
D.Pardoll. Cancer and the Immune System:Basic Concepts and Targets for Intervention. Semin Oncol 2015; 42:523-38; PMID:26320058; http://dx.doi.org/10.1053/j.seminoncol.2015.05.003
-
(2015)
Semin Oncol
, vol.42
, pp. 523-538
-
-
Pardoll, D.1
-
7
-
-
84944472689
-
Releasing the Brakes on Cancer Immunotherapy
-
26348216
-
A.Ribas. Releasing the Brakes on Cancer Immunotherapy. N Engl J Med 2015; 373:1490-2; PMID:26348216; http://dx.doi.org/10.1056/NEJMp1510079
-
(2015)
N Engl J Med
, vol.373
, pp. 1490-1492
-
-
Ribas, A.1
-
8
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
22437870
-
D.M.Pardoll. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12:252-64; PMID:22437870; http://dx.doi.org/10.1038/nrc3239
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
9
-
-
84943143291
-
Current status and future directions of the immune checkpoint inhibitors ipilimumab, pembrolizumab, and nivolumab in oncology
-
25991832
-
M.S.Barbee, A.Ogunniyi, T.Z.Horvat, T.O.Dang. Current status and future directions of the immune checkpoint inhibitors ipilimumab, pembrolizumab, and nivolumab in oncology. Ann Pharmacother 2015; 49:907-37; PMID:25991832; http://dx.doi.org/10.1177/1060028015586218
-
(2015)
Ann Pharmacother
, vol.49
, pp. 907-937
-
-
Barbee, M.S.1
Ogunniyi, A.2
Horvat, T.Z.3
Dang, T.O.4
-
10
-
-
84929148767
-
PD-L1 inhibition with MPDL3280A for solid tumors
-
25965367
-
E.Cha, J.Wallin, M.Kowanetz. PD-L1 inhibition with MPDL3280A for solid tumors. Semin Oncol 2015; 42:484-7; PMID:25965367; http://dx.doi.org/10.1053/j.seminoncol.2015.02.002
-
(2015)
Semin Oncol
, vol.42
, pp. 484-487
-
-
Cha, E.1
Wallin, J.2
Kowanetz, M.3
-
11
-
-
84907501302
-
Immune checkpoint inhibitors in clinical trials
-
25189716
-
E.Sharon, H.Streicher, P.Goncalves, H.X.Chen. Immune checkpoint inhibitors in clinical trials. Chin J Cancer 2014; 33:434-44; PMID:25189716; http://dx.doi.org/10.5732/cjc.014.10122
-
(2014)
Chin J Cancer
, vol.33
, pp. 434-444
-
-
Sharon, E.1
Streicher, H.2
Goncalves, P.3
Chen, H.X.4
-
12
-
-
84987781321
-
-
FDA product label for nivolmab. http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/125554s012lbl.pdf
-
-
-
-
13
-
-
84945194223
-
Systemic Therapy for Stage IV Non-Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update
-
26324367
-
G.A.Masters, S.Temin, C.G.Azzoli, G.Giaccone, S.Baker, Jr, J.R.Brahmer, P.M.Ellis, A.Gajra, N.Rackear, J.H.Schiller, et al. Systemic Therapy for Stage IV Non-Small-Cell Lung Cancer:American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol 2015; 33:3488-515; PMID:26324367; http://dx.doi.org/10.1200/JCO.2015.62.1342
-
(2015)
J Clin Oncol
, vol.33
, pp. 3488-3515
-
-
Masters, G.A.1
Temin, S.2
Azzoli, C.G.3
Giaccone, G.4
Baker, S.5
Brahmer, J.R.6
Ellis, P.M.7
Gajra, A.8
Rackear, N.9
Schiller, J.H.10
-
14
-
-
0037214171
-
A retrospective analysis of the outcome of patients who have received two prior chemotherapy regimens including platinum and docetaxel for recurrent non-small-cell lung cancer
-
12499095
-
E.Massarelli, F.Andre, D.D.Liu, J.J.Lee, M.Wolf, A.Fandi, J.Ochs, T.Le Chevalier, F.Fossella, R.S.Herbst. A retrospective analysis of the outcome of patients who have received two prior chemotherapy regimens including platinum and docetaxel for recurrent non-small-cell lung cancer. Lung Cancer 2003; 39:55-61; PMID:12499095; http://dx.doi.org/10.1016/S0169-5002(02)00308-2
-
(2003)
Lung Cancer
, vol.39
, pp. 55-61
-
-
Massarelli, E.1
Andre, F.2
Liu, D.D.3
Lee, J.J.4
Wolf, M.5
Fandi, A.6
Ochs, J.7
Le Chevalier, T.8
Fossella, F.9
Herbst, R.S.10
-
15
-
-
84931571151
-
Precision Therapy for Lung Cancer: Tyrosine Kinase Inhibitors and Beyond
-
26074108
-
A.Rajan, D.S.Schrump. Precision Therapy for Lung Cancer:Tyrosine Kinase Inhibitors and Beyond. Semin Thorac Cardiovasc Surg 2015; 27:36-48; PMID:26074108; http://dx.doi.org/10.1053/j.semtcvs.2015.04.002
-
(2015)
Semin Thorac Cardiovasc Surg
, vol.27
, pp. 36-48
-
-
Rajan, A.1
Schrump, D.S.2
-
16
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
-
22285168
-
R.Rosell, E.Carcereny, R.Gervais, A.Vergnenegre, B.Massuti, E.Felip, R.Palmero, R.Garcia-Gomez, C.Pallares, J.M.Sanchez, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC):a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012; 13:239-46; PMID:22285168; http://dx.doi.org/10.1016/S1470-2045(11)70393-X
-
(2012)
Lancet Oncol
, vol.13
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
Vergnenegre, A.4
Massuti, B.5
Felip, E.6
Palmero, R.7
Garcia-Gomez, R.8
Pallares, C.9
Sanchez, J.M.10
-
17
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
20573926
-
M.Maemondo, A.Inoue, K.Kobayashi, S.Sugawara, S.Oizumi, H.Isobe, A.Gemma, M.Harada, H.Yoshizawa, I.Kinoshita, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010; 362:2380-8; PMID:20573926; http://dx.doi.org/10.1056/NEJMoa0909530
-
(2010)
N Engl J Med
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
Sugawara, S.4
Oizumi, S.5
Isobe, H.6
Gemma, A.7
Harada, M.8
Yoshizawa, H.9
Kinoshita, I.10
-
18
-
-
84884736973
-
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
-
23816960
-
L.V.Sequist, J.C.Yang, N.Yamamoto, K.O'Byrne, V.Hirsh, T.Mok, S.L.Geater, S.Orlov, C.M.Tsai, M.Boyer, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol 2013; 31:3327-34; PMID:23816960; http://dx.doi.org/10.1200/JCO.2012.44.2806
-
(2013)
J Clin Oncol
, vol.31
, pp. 3327-3334
-
-
Sequist, L.V.1
Yang, J.C.2
Yamamoto, N.3
O'Byrne, K.4
Hirsh, V.5
Mok, T.6
Geater, S.L.7
Orlov, S.8
Tsai, C.M.9
Boyer, M.10
-
19
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
23724913
-
A.T.Shaw, D.W.Kim, K.Nakagawa, T.Seto, L.Crinó, M.J.Ahn, T.De Pas, B.Besse, B.J.Solomon, F.Blackhall, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 2013; 368:2385-94; PMID:23724913; http://dx.doi.org/10.1056/NEJMoa1214886
-
(2013)
N Engl J Med
, vol.368
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
Seto, T.4
Crinó, L.5
Ahn, M.J.6
De Pas, T.7
Besse, B.8
Solomon, B.J.9
Blackhall, F.10
-
20
-
-
84896957081
-
Ceritinib in ALK-rearranged non-small-cell lung cancer
-
24670165
-
A.T.Shaw, D.W.Kim, R.Mehra, D.S.Tan, E.Felip, L.Q.Chow, D.R.Camidge, J.Vansteenkiste, S.Sharma, T.De Pas, et al. Ceritinib in ALK-rearranged non-small-cell lung cancer. N Engl J Med 2014; 370:1189-97; PMID:24670165; http://dx.doi.org/10.1056/NEJMoa1311107
-
(2014)
N Engl J Med
, vol.370
, pp. 1189-1197
-
-
Shaw, A.T.1
Kim, D.W.2
Mehra, R.3
Tan, D.S.4
Felip, E.5
Chow, L.Q.6
Camidge, D.R.7
Vansteenkiste, J.8
Sharma, S.9
De Pas, T.10
-
21
-
-
0033989205
-
Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma
-
10623706
-
M.R.Middleton, J.J.Grob, N.Aaronson, G.Fierlbeck, W.Tilgen, S.Seiter, M.Gore, S.Aamdal, J.Cebon, A.Coates, et al. Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. J Clin Oncol 2000; 18:158-66; PMID:10623706
-
(2000)
J Clin Oncol
, vol.18
, pp. 158-166
-
-
Middleton, M.R.1
Grob, J.J.2
Aaronson, N.3
Fierlbeck, G.4
Tilgen, W.5
Seiter, S.6
Gore, M.7
Aamdal, S.8
Cebon, J.9
Coates, A.10
-
22
-
-
0033024863
-
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993
-
10561265
-
M.B.Atkins, M.T.Lotze, J.P.Dutcher, R.I.Fisher, G.Weiss, K.Margolin, J.Abrams, M.Sznol, D.Parkinson, M.Hawkins, et al. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma:analysis of 270 patients treated between 1985 and 1993. J Clin Oncol 1999; 17:2105-16; PMID:10561265
-
(1999)
J Clin Oncol
, vol.17
, pp. 2105-2116
-
-
Atkins, M.B.1
Lotze, M.T.2
Dutcher, J.P.3
Fisher, R.I.4
Weiss, G.5
Margolin, K.6
Abrams, J.7
Sznol, M.8
Parkinson, D.9
Hawkins, M.10
-
23
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
12068308
-
H.Davies, G.R.Bignell, C.Cox, P.Stephens, S.Edkins, S.Clegg, J.Teague, H.Woffendin, M.J.Garnett, W.Bottomley, et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417:949-54; PMID:12068308; http://dx.doi.org/10.1038/nature00766
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
-
24
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
21639808
-
P.B.Chapman, A.Hauschild, C.Robert, J.B.Haanen, P.Ascierto, J.Larkin, R.Dummer, C.Garbe, A.Testori, M.Maio, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011; 364:2507-16; PMID:21639808; http://dx.doi.org/10.1056/NEJMoa1103782
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Haanen, J.B.4
Ascierto, P.5
Larkin, J.6
Dummer, R.7
Garbe, C.8
Testori, A.9
Maio, M.10
-
25
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
-
22735384
-
A.Hauschild, J.J.Grob, L.V.Demidov, T.Jouary, R.Gutzmer, M.Millward, P.Rutkowski, C.U.Blank, W.H.Miller, Jr, E.Kaempgen, et al. Dabrafenib in BRAF-mutated metastatic melanoma:a multicentre, open-label, phase 3 randomised controlled trial. Lancet 2012; 380:358-65; PMID:22735384; http://dx.doi.org/10.1016/S0140-6736(12)60868-X
-
(2012)
Lancet
, vol.380
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.J.2
Demidov, L.V.3
Jouary, T.4
Gutzmer, R.5
Millward, M.6
Rutkowski, P.7
Blank, C.U.8
Miller, W.H.9
Kaempgen, E.10
-
26
-
-
84863673204
-
Improved survival with MEK inhibition in BRAF-mutated melanoma
-
22663011
-
K.T.Flaherty, C.Robert, P.Hersey, et al. Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med 2012; 367:107-14; PMID:22663011; http://dx.doi.org/10.1056/NEJMoa1203421
-
(2012)
N Engl J Med
, vol.367
, pp. 107-114
-
-
Flaherty, K.T.1
Robert, C.2
Hersey, P.3
-
27
-
-
84920394727
-
Improved overall survival in melanoma with combined dabrafenib and trametinib
-
25399551
-
C.Robert, B.Karaszewska, J.Schachter, P.Rutkowski, A.Mackiewicz, D.Stroiakovski, M.Lichinitser, R.Dummer, F.Grange, L.Mortier, et al. Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med 2015; 372:30-9; PMID:25399551; http://dx.doi.org/10.1056/NEJMoa1412690
-
(2015)
N Engl J Med
, vol.372
, pp. 30-39
-
-
Robert, C.1
Karaszewska, B.2
Schachter, J.3
Rutkowski, P.4
Mackiewicz, A.5
Stroiakovski, D.6
Lichinitser, M.7
Dummer, R.8
Grange, F.9
Mortier, L.10
-
28
-
-
84908257665
-
Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma
-
25265492
-
G.V.Long, D.Stroyakovskiy, H.Gogas, E.Levchenko, F.de Braud, J.Larkin, C.Garbe, T.Jouary, A.Hauschild, J.J.Grob, et al. Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma. N Engl J Med 2014; 371:1877-88; PMID:25265492; http://dx.doi.org/10.1056/NEJMoa1406037
-
(2014)
N Engl J Med
, vol.371
, pp. 1877-1888
-
-
Long, G.V.1
Stroyakovskiy, D.2
Gogas, H.3
Levchenko, E.4
de Braud, F.5
Larkin, J.6
Garbe, C.7
Jouary, T.8
Hauschild, A.9
Grob, J.J.10
-
29
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
20525992
-
F.S.Hodi, S.J.O'Day, D.F.McDermott, R.W.Weber, J.A.Sosman, J.B.Haanen, R.Gonzalez, C.Robert, D.Schadendorf, J.C.Hassel, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010; 363:711-23; PMID:20525992; http://dx.doi.org/10.1056/NEJMoa1003466
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
Gonzalez, R.7
Robert, C.8
Schadendorf, D.9
Hassel, J.C.10
-
30
-
-
84928917822
-
Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma
-
25667295
-
D.Schadendorf, F.S.Hodi, C.Robert, et al. Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma. J Clin Oncol 2015; 33:1889-94; PMID:25667295; http://dx.doi.org/10.1200/JCO.2014.56.2736
-
(2015)
J Clin Oncol
, vol.33
, pp. 1889-1894
-
-
Schadendorf, D.1
Hodi, F.S.2
Robert, C.3
-
31
-
-
84987781170
-
-
FDA product label for ipilimumab. http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/125377s074lbl.pdf
-
-
-
-
32
-
-
84908354848
-
Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial
-
25034862
-
C.Robert, A.Ribas, J.D.Wolchok, F.S.Hodi, O.Hamid, R.Kefford, J.S.Weber, A.M.Joshua, W.J.Hwu, T.C.Gangadhar, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma:a randomised dose-comparison cohort of a phase 1 trial. Lancet 2014; 384:1109-17; PMID:25034862; http://dx.doi.org/10.1016/S0140-6736(14)60958-2
-
(2014)
Lancet
, vol.384
, pp. 1109-1117
-
-
Robert, C.1
Ribas, A.2
Wolchok, J.D.3
Hodi, F.S.4
Hamid, O.5
Kefford, R.6
Weber, J.S.7
Joshua, A.M.8
Hwu, W.J.9
Gangadhar, T.C.10
-
33
-
-
84987781309
-
-
FDA product label for pembrolizumab. http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/125514s004s006lbl.pdf
-
-
-
-
34
-
-
16644401873
-
Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma
-
15625368
-
D.F.McDermott, M.M.Regan, J.I.Clark, L.E.Flaherty, G.R.Weiss, T.F.Logan, J.M.Kirkwood, M.S.Gordon, J.A.Sosman, M.S.Ernstoff, et al. Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J Clin Oncol 2005; 23:133-41; PMID:15625368; http://dx.doi.org/10.1200/JCO.2005.03.206
-
(2005)
J Clin Oncol
, vol.23
, pp. 133-141
-
-
McDermott, D.F.1
Regan, M.M.2
Clark, J.I.3
Flaherty, L.E.4
Weiss, G.R.5
Logan, T.F.6
Kirkwood, J.M.7
Gordon, M.S.8
Sosman, J.A.9
Ernstoff, M.S.10
-
35
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
17215530
-
B.Escudier, T.Eisen, W.M.Stadler, C.Szczylik, S.Oudard, M.Staehler, S.Negrier, C.Chevreau, A.A.Desai, F.Rolland, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356:125-34; PMID:17215530; http://dx.doi.org/10.1056/NEJMoa060655
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Staehler, M.6
Negrier, S.7
Chevreau, C.8
Desai, A.A.9
Rolland, F.10
-
36
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
17215529
-
R.J.Motzer, T.E.Hutson, P.Tomczak, M.D.Michaelson, R.M.Bukowski, O.Rixe, S.Oudard, S.Negrier, C.Szczylik, S.T.Kim, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007; 356:115-24; PMID:17215529; http://dx.doi.org/10.1056/NEJMoa065044
-
(2007)
N Engl J Med
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, M.D.4
Bukowski, R.M.5
Rixe, O.6
Oudard, S.7
Negrier, S.8
Szczylik, C.9
Kim, S.T.10
-
37
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial
-
20100962
-
C.N.Sternberg, I.D.Davis, J.Mardiak, C.Szczylik, E.Lee, J.Wagstaff, C.H.Barrios, P.Salman, O.A.Gladkov, A.Kavina, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma:results of a randomized phase III trial. J Clin Oncol 2010; 28:1061-8; PMID:20100962; http://dx.doi.org/10.1200/JCO.2009.23.9764
-
(2010)
J Clin Oncol
, vol.28
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
Szczylik, C.4
Lee, E.5
Wagstaff, J.6
Barrios, C.H.7
Salman, P.8
Gladkov, O.A.9
Kavina, A.10
-
38
-
-
82755183572
-
Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial
-
22056247
-
B.I.Rini, B.Escudier, P.Tomczak, A.Kaprin, C.Szczylik, T.E.Hutson, M.D.Michaelson, V.A.Gorbunova, M.E.Gore, I.G.Rusakov, et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS):a randomised phase 3 trial. Lancet 2011; 378:1931-9; PMID:22056247; http://dx.doi.org/10.1016/S0140-6736(11)61613-9
-
(2011)
Lancet
, vol.378
, pp. 1931-1939
-
-
Rini, B.I.1
Escudier, B.2
Tomczak, P.3
Kaprin, A.4
Szczylik, C.5
Hutson, T.E.6
Michaelson, M.D.7
Gorbunova, V.A.8
Gore, M.E.9
Rusakov, I.G.10
-
39
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
17538086
-
G.Hudes, M.Carducci, P.Tomczak, J.Dutcher, R.Figlin, A.Kapoor, E.Staroslawska, J.Sosman, D.McDermott, I.Bodrogi, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007; 356:2271-81; PMID:17538086; http://dx.doi.org/10.1056/NEJMoa066838
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
Staroslawska, E.7
Sosman, J.8
McDermott, D.9
Bodrogi, I.10
-
40
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
-
18653228
-
R.J.Motzer, B.Escudier, S.Oudard, T.E.Hutson, C.Porta, S.Bracarda, V.Grünwald, J.A.Thompson, R.A.Figlin, N.Hollaender, et al. Efficacy of everolimus in advanced renal cell carcinoma:a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008; 372:449-56; PMID:18653228; http://dx.doi.org/10.1016/S0140-6736(08)61039-9
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
Hutson, T.E.4
Porta, C.5
Bracarda, S.6
Grünwald, V.7
Thompson, J.A.8
Figlin, R.A.9
Hollaender, N.10
-
41
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial
-
18156031
-
B.Escudier, A.Pluzanska, P.I.Koralewski. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma:a randomised, double-blind phase III trial. Lancet 2007; 370:2103-11; PMID:18156031; http://dx.doi.org/10.1016/S0140-6736(07)61904-7
-
(2007)
Lancet
, vol.370
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.I.3
-
42
-
-
84923305354
-
A systematic review of sequencing and combinations of systemic therapy in metastatic renal cancer
-
24841777
-
L.Albiges, T.Choueiri, B.Escudier, M.Galsky, D.George, F.Hofmann, T.Lam, R.Motzer, P.Mulders, C.Porta, et al. A systematic review of sequencing and combinations of systemic therapy in metastatic renal cancer. Eur Urol 2015; 67:100-10; PMID:24841777; http://dx.doi.org/10.1016/j.eururo.2014.04.006
-
(2015)
Eur Urol
, vol.67
, pp. 100-110
-
-
Albiges, L.1
Choueiri, T.2
Escudier, B.3
Galsky, M.4
George, D.5
Hofmann, F.6
Lam, T.7
Motzer, R.8
Mulders, P.9
Porta, C.10
-
43
-
-
84887862839
-
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
-
24240160
-
T.Okazaki, S.Chikuma, Y.Iwai, S.Fagarasan, T.Honjo. A rheostat for immune responses:the unique properties of PD-1 and their advantages for clinical application. Nat Immunol 2013; 14:1212-8; PMID:24240160; http://dx.doi.org/10.1038/ni.2762
-
(2013)
Nat Immunol
, vol.14
, pp. 1212-1218
-
-
Okazaki, T.1
Chikuma, S.2
Iwai, Y.3
Fagarasan, S.4
Honjo, T.5
-
44
-
-
17644425689
-
The B7 family revisited
-
15771580
-
R.J.Greenwald, G.J.Freeman, A.H.Sharpe. The B7 family revisited. Annu Rev Immunol 2005; 23:515-48; PMID:15771580; http://dx.doi.org/10.1146/annurev.immunol.23.021704.115611
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 515-548
-
-
Greenwald, R.J.1
Freeman, G.J.2
Sharpe, A.H.3
-
45
-
-
18544380239
-
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
-
12091876
-
H.Dong, S.E.Strome, D.R.Salomao, H.Tamura, F.Hirano, D.B.Flies, P.C.Roche, J.Lu, G.Zhu, K.Tamada, et al. Tumor-associated B7-H1 promotes T-cell apoptosis:a potential mechanism of immune evasion. Nat Med 2002; 8:793-800; PMID:12091876; http://dx.doi.org/10.1038/nm0902-1039c
-
(2002)
Nat Med
, vol.8
, pp. 793-800
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
Tamura, H.4
Hirano, F.5
Flies, D.B.6
Roche, P.C.7
Lu, J.8
Zhu, G.9
Tamada, K.10
-
46
-
-
84958759492
-
Predictive biomarkers in PD-1/PD-L1 checkpoint blockade immunotherapy
-
26589760
-
X.Meng, Z.Huang, F.Teng, L.Xing, J.Yu. Predictive biomarkers in PD-1/PD-L1 checkpoint blockade immunotherapy. Cancer Treat Rev 2015; 41:868-76; PMID:26589760; http://dx.doi.org/10.1016/j.ctrv.2015.11.001
-
(2015)
Cancer Treat Rev
, vol.41
, pp. 868-876
-
-
Meng, X.1
Huang, Z.2
Teng, F.3
Xing, L.4
Yu, J.5
-
47
-
-
84928774156
-
The future of immune checkpoint therapy
-
25838373
-
P.Sharma, J.P.Allison. The future of immune checkpoint therapy. Science 2015; 348:56-61; PMID:25838373; http://dx.doi.org/10.1126/science.aaa8172
-
(2015)
Science
, vol.348
, pp. 56-61
-
-
Sharma, P.1
Allison, J.P.2
-
48
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
21639810
-
C.Robert, L.Thomas, I.Bondarenko, S.O'Day, J.Weber, C.Garbe, C.Lebbe, J.F.Baurain, A.Testori, J.J.Grob, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011; 364:2517-26; PMID:21639810; http://dx.doi.org/10.1056/NEJMoa1104621
-
(2011)
N Engl J Med
, vol.364
, pp. 2517-2526
-
-
Robert, C.1
Thomas, L.2
Bondarenko, I.3
O'Day, S.4
Weber, J.5
Garbe, C.6
Lebbe, C.7
Baurain, J.F.8
Testori, A.9
Grob, J.J.10
-
49
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
11015443
-
G.J.Freeman, A.J.Long, Y.Iwai, K.Bourque, T.Chernova, H.Nishimura, L.J.Fitz, N.Malenkovich, T.Okazaki, M.C.Byrne, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000; 192:1027-34; PMID:11015443; http://dx.doi.org/10.1084/jem.192.7.1027
-
(2000)
J Exp Med
, vol.192
, pp. 1027-1034
-
-
Freeman, G.J.1
Long, A.J.2
Iwai, Y.3
Bourque, K.4
Chernova, T.5
Nishimura, H.6
Fitz, L.J.7
Malenkovich, N.8
Okazaki, T.9
Byrne, M.C.10
-
50
-
-
84929251102
-
Nivolumab: targeting PD-1 to bolster antitumor immunity
-
25798726
-
J.R.Brahmer, H.Hammers, E.J.Lipson. Nivolumab:targeting PD-1 to bolster antitumor immunity. Future Oncol 2015; 11:1307-26; PMID:25798726; http://dx.doi.org/10.2217/fon.15.52
-
(2015)
Future Oncol
, vol.11
, pp. 1307-1326
-
-
Brahmer, J.R.1
Hammers, H.2
Lipson, E.J.3
-
51
-
-
84920031180
-
In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates
-
24872026
-
C.Wang, K.B.Thudium, M.Han, X.T.Wang, H.Huang, D.Feingersh, C.Garcia, Y.Wu, M.Kuhne, M.Srinivasan, et al. In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates. Cancer Immunol Res 2014; 2:846-56; PMID:24872026; http://dx.doi.org/10.1158/2326-6066.CIR-14-0040
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 846-856
-
-
Wang, C.1
Thudium, K.B.2
Han, M.3
Wang, X.T.4
Huang, H.5
Feingersh, D.6
Garcia, C.7
Wu, Y.8
Kuhne, M.9
Srinivasan, M.10
-
52
-
-
77954899030
-
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates
-
20516446
-
J.R.Brahmer, C.G.Drake, I.Wollner, J.D.Powderly, J.Picus, W.H.Sharfman, E.Stankevich, A.Pons, T.M.Salay, T.L.McMiller, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors:safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 2010; 28:3167-75; PMID:20516446; http://dx.doi.org/10.1200/JCO.2009.26.7609
-
(2010)
J Clin Oncol
, vol.28
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
Powderly, J.D.4
Picus, J.5
Sharfman, W.H.6
Stankevich, E.7
Pons, A.8
Salay, T.M.9
McMiller, T.L.10
-
53
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
22658127
-
S.L.Topalian, F.S.Hodi, J.R.Brahmer, S.N.Gettinger, D.C.Smith, D.F.McDermott, J.D.Powderly, R.D.Carvajal, J.A.Sosman, M.B.Atkins, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012; 366:2443-54; PMID:22658127; http://dx.doi.org/10.1056/NEJMoa1200690
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
Powderly, J.D.7
Carvajal, R.D.8
Sosman, J.A.9
Atkins, M.B.10
-
54
-
-
84973314514
-
Model-based analysis of nivolumab to support clinical pharmacology profiling in subjects with solid tumors
-
Y.Feng, G.Bajaj, X.Wang, et al. Model-based analysis of nivolumab to support clinical pharmacology profiling in subjects with solid tumors. Clin Pharmacol Ther 2015; 97(Suppl 1):S41-2
-
(2015)
Clin Pharmacol Ther
, vol.97
, pp. S41-S42
-
-
Feng, Y.1
Bajaj, G.2
Wang, X.3
-
55
-
-
84961607617
-
Assessment of drug interaction potential by nivolumab using cytokine modulation data
-
C.Passey, J.Simon, Q.Hong, et al. Assessment of drug interaction potential by nivolumab using cytokine modulation data. Clin Pharmacol Ther 2015; 97(Suppl 1):S96.
-
(2015)
Clin Pharmacol Ther
, vol.97
-
-
Passey, C.1
Simon, J.2
Hong, Q.3
-
56
-
-
85026792141
-
Absence of QT prolongation (QTP) effect by nivolumab (nivo) or ipilimumab (ipi) in subjects with solid tumors
-
S.Agrawal, D.Williams, I.Waxman, et al. Absence of QT prolongation (QTP) effect by nivolumab (nivo) or ipilimumab (ipi) in subjects with solid tumors. Clin Pharmacol Ther 2015; 97(Suppl 1):S95-6
-
(2015)
Clin Pharmacol Ther
, vol.97
, pp. S95-S96
-
-
Agrawal, S.1
Williams, D.2
Waxman, I.3
-
57
-
-
84936791837
-
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer
-
26028407
-
J.Brahmer, K.L.Reckamp, P.Baas, L.Crin∫, W.E.Eberhardt, E.Poddubskaya, S.Antonia, A.Pluzanski, E.E.Vokes, E.Holgado, et al. Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer. N Engl J Med 2015; 373:123-35; PMID:26028407; http://dx.doi.org/10.1056/NEJMoa1504627
-
(2015)
N Engl J Med
, vol.373
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
Crin, L.4
Eberhardt, W.E.5
Poddubskaya, E.6
Antonia, S.7
Pluzanski, A.8
Vokes, E.E.9
Holgado, E.10
-
58
-
-
84944937210
-
Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer
-
26412456
-
H.Borghaei, L.Paz-Ares, L.Horn, D.R.Spigel, M.Steins, N.E.Ready, L.Q.Chow, E.E.Vokes, E.Felip, E.Holgado, et al. Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. N Engl J Med 2015; 373:1627-39; PMID:26412456; http://dx.doi.org/10.1056/NEJMoa1507643
-
(2015)
N Engl J Med
, vol.373
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
Spigel, D.R.4
Steins, M.5
Ready, N.E.6
Chow, L.Q.7
Vokes, E.E.8
Felip, E.9
Holgado, E.10
-
59
-
-
84907651086
-
First-line nivolumab (anti-PD-1; BMS-936558, ONO-4538) monotherapy in advanced NSCLC: Safety, efficacy, and correlation of outcomes with PD-L1 status
-
S.N.Gettinger, F.A.Shepherd, S.J.Antonia, et al. First-line nivolumab (anti-PD-1; BMS-936558, ONO-4538) monotherapy in advanced NSCLC:Safety, efficacy, and correlation of outcomes with PD-L1 status. ASCO Meeting Abstracts 2014; 32:8024
-
(2014)
ASCO Meeting Abstracts
, vol.32
, pp. 8024
-
-
Gettinger, S.N.1
Shepherd, F.A.2
Antonia, S.J.3
-
60
-
-
84908269560
-
Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC)
-
S.J.Antonia, J.R.Brahmer, S.N.Gettinger, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 2014; 32:8113
-
(2014)
ASCO Meeting Abstracts
, vol.32
, pp. 8113
-
-
Antonia, S.J.1
Brahmer, J.R.2
Gettinger, S.N.3
-
61
-
-
84908269560
-
Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: Interim phase I results
-
S.J.Antonia, S.N.Gettinger, L.Q.M.Chow, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC:Interim phase I results. ASCO Meeting Abstracts 2014; 32:8023
-
(2014)
ASCO Meeting Abstracts
, vol.32
, pp. 8023
-
-
Antonia, S.J.1
Gettinger, S.N.2
Chow, L.Q.M.3
-
62
-
-
84907651085
-
Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC
-
N.A.Rizvi, L.Q.M.Chow, H.Borghaei, et al. Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC. ASCO Meeting Abstracts 2014; 32:8022
-
(2014)
ASCO Meeting Abstracts
, vol.32
, pp. 8022
-
-
Rizvi, N.A.1
Chow, L.Q.M.2
Borghaei, H.3
-
63
-
-
84931083080
-
Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial
-
25795410
-
J.S.Weber, S.P.D'Angelo, D.Minor, F.S.Hodi, R.Gutzmer, B.Neyns, C.Hoeller, N.I.Khushalani, W.H.Miller, Jr, C.D.Lao, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037):a randomised, controlled, open-label, phase 3 trial. Lancet Oncol 2015; 16:375-84; PMID:25795410; http://dx.doi.org/10.1016/S1470-2045(15)70076-8
-
(2015)
Lancet Oncol
, vol.16
, pp. 375-384
-
-
Weber, J.S.1
D'Angelo, S.P.2
Minor, D.3
Hodi, F.S.4
Gutzmer, R.5
Neyns, B.6
Hoeller, C.7
Khushalani, N.I.8
Miller, W.H.9
Lao, C.D.10
-
64
-
-
84925222119
-
Nivolumab in previously untreated melanoma without BRAF mutation
-
25399552
-
C.Robert, G.V.Long, B.Brady, C.Dutriaux, M.Maio, L.Mortier, J.C.Hassel, P.Rutkowski, C.McNeil, E.Kalinka-Warzocha, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 2015; 372:320-30; PMID:25399552; http://dx.doi.org/10.1056/NEJMoa1412082
-
(2015)
N Engl J Med
, vol.372
, pp. 320-330
-
-
Robert, C.1
Long, G.V.2
Brady, B.3
Dutriaux, C.4
Maio, M.5
Mortier, L.6
Hassel, J.C.7
Rutkowski, P.8
McNeil, C.9
Kalinka-Warzocha, E.10
-
65
-
-
84936147067
-
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
-
26027431
-
J.Larkin, V.Chiarion-Sileni, R.Gonzalez, J.J.Grob, C.L.Cowey, C.D.Lao, D.Schadendorf, R.Dummer, M.Smylie, P.Rutkowski, et al. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. N Engl J Med 2015; 373:23-34; PMID:26027431; http://dx.doi.org/10.1056/NEJMoa1504030
-
(2015)
N Engl J Med
, vol.373
, pp. 23-34
-
-
Larkin, J.1
Chiarion-Sileni, V.2
Gonzalez, R.3
Grob, J.J.4
Cowey, C.L.5
Lao, C.D.6
Schadendorf, D.7
Dummer, R.8
Smylie, M.9
Rutkowski, P.10
-
66
-
-
84929481482
-
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
-
25891304
-
M.A.Postow, J.Chesney, A.C.Pavlick, C.Robert, K.Grossmann, D.McDermott, G.P.Linette, N.Meyer, J.K.Giguere, S.S.Agarwala, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med 2015; 372:2006-17; PMID:25891304; http://dx.doi.org/10.1056/NEJMoa1414428
-
(2015)
N Engl J Med
, vol.372
, pp. 2006-2017
-
-
Postow, M.A.1
Chesney, J.2
Pavlick, A.C.3
Robert, C.4
Grossmann, K.5
McDermott, D.6
Linette, G.P.7
Meyer, N.8
Giguere, J.K.9
Agarwala, S.S.10
-
67
-
-
84929572937
-
Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial
-
25452452
-
R.J.Motzer, B.I.Rini, D.F.McDermott, B.G.Redman, T.M.Kuzel, M.R.Harrison, U.N.Vaishampayan, H.A.Drabkin, S.George, T.F.Logan, et al. Nivolumab for Metastatic Renal Cell Carcinoma:Results of a Randomized Phase II Trial. J Clin Oncol 2015; 33:1430-7; PMID:25452452; http://dx.doi.org/10.1200/JCO.2014.59.0703
-
(2015)
J Clin Oncol
, vol.33
, pp. 1430-1437
-
-
Motzer, R.J.1
Rini, B.I.2
McDermott, D.F.3
Redman, B.G.4
Kuzel, T.M.5
Harrison, M.R.6
Vaishampayan, U.N.7
Drabkin, H.A.8
George, S.9
Logan, T.F.10
-
68
-
-
84946607195
-
Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
-
26406148
-
R.J.Motzer, B.Escudier, D.F.McDermott, S.George, H.J.Hammers, S.Srinivas, S.S.Tykodi, J.A.Sosman, G.Procopio, E.R.Plimack, et al. Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. N Engl J Med 2015; 373:1803-13; PMID:26406148; http://dx.doi.org/10.1056/NEJMoa1510665
-
(2015)
N Engl J Med
, vol.373
, pp. 1803-1813
-
-
Motzer, R.J.1
Escudier, B.2
McDermott, D.F.3
George, S.4
Hammers, H.J.5
Srinivas, S.6
Tykodi, S.S.7
Sosman, J.A.8
Procopio, G.9
Plimack, E.R.10
-
69
-
-
84914148032
-
Phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC)
-
H.J.Hammers, E.R.Plimack, J.R.Infante, et al. Phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC). ASCO Meeting Abstracts 2014; 32:4504
-
(2014)
ASCO Meeting Abstracts
, vol.32
, pp. 4504
-
-
Hammers, H.J.1
Plimack, E.R.2
Infante, J.R.3
-
70
-
-
84939150439
-
Expanded cohort results from CheckMate 016: A phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC)
-
H.J.Hammers, E.R.Plimack, J.R.Infante, et al. Expanded cohort results from CheckMate 016:A phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC). ASCO Meeting Abstracts 2015; 33:4516
-
(2015)
ASCO Meeting Abstracts
, vol.33
, pp. 4516
-
-
Hammers, H.J.1
Plimack, E.R.2
Infante, J.R.3
-
71
-
-
84914176528
-
Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC)
-
A.Amin, E.R.Plimack, J.R.Infante, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC). ASCO Meeting Abstracts 2014; 32:5010
-
(2014)
ASCO Meeting Abstracts
, vol.32
, pp. 5010
-
-
Amin, A.1
Plimack, E.R.2
Infante, J.R.3
-
72
-
-
84939518267
-
Phase I/II study of nivolumab with or without ipilimumab for treatment of recurrent small cell lung cancer (SCLC): CA209-032
-
S.J.Antonia, J.C.Bendell, M.H.Taylor, et al. Phase I/II study of nivolumab with or without ipilimumab for treatment of recurrent small cell lung cancer (SCLC):CA209-032. ASCO Meeting Abstracts 2015; 33:7503
-
(2015)
ASCO Meeting Abstracts
, vol.33
, pp. 7503
-
-
Antonia, S.J.1
Bendell, J.C.2
Taylor, M.H.3
-
73
-
-
84973527924
-
Safety and activity of nivolumab monotherapy in advanced and metastatic (A/M) gastric or gastroesophageal junction cancer (GC/GEC): Results from the CheckMate-032 study
-
26578608
-
D.Le, J.Bendell, E.Calvo, et al. Safety and activity of nivolumab monotherapy in advanced and metastatic (A/M) gastric or gastroesophageal junction cancer (GC/GEC):Results from the CheckMate-032 study. J Clin Oncol 2016; 34:6; PMID:26578608; http://dx.doi.org/10.1200/JCO.2015.62.2860
-
(2016)
J Clin Oncol
, vol.34
, pp. 6
-
-
Le, D.1
Bendell, J.2
Calvo, E.3
-
74
-
-
84925221855
-
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
-
25482239
-
S.M.Ansell, A.M.Lesokhin, I.Borrello, A.Halwani, E.C.Scott, M.Gutierrez, S.J.Schuster, M.M.Millenson, D.Cattry, G.J.Freeman, et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N Engl J Med 2015; 372:311-9; PMID:25482239; http://dx.doi.org/10.1056/NEJMoa1411087
-
(2015)
N Engl J Med
, vol.372
, pp. 311-319
-
-
Ansell, S.M.1
Lesokhin, A.M.2
Borrello, I.3
Halwani, A.4
Scott, E.C.5
Gutierrez, M.6
Schuster, S.J.7
Millenson, M.M.8
Cattry, D.9
Freeman, G.J.10
-
75
-
-
84951126341
-
Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer
-
26351349
-
J.Hamanishi, M.Mandai, T.Ikeda, M.Minami, A.Kawaguchi, T.Murayama, M.Kanai, Y.Mori, S.Matsumoto, S.Chikuma, et al. Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer. J Clin Oncol 2015; 33:4015-22; PMID:26351349; http://dx.doi.org/10.1200/JCO.2015.62.3397
-
(2015)
J Clin Oncol
, vol.33
, pp. 4015-4022
-
-
Hamanishi, J.1
Mandai, M.2
Ikeda, T.3
Minami, M.4
Kawaguchi, A.5
Murayama, T.6
Kanai, M.7
Mori, Y.8
Matsumoto, S.9
Chikuma, S.10
-
76
-
-
84987784391
-
Phase II study of nivolumab (ONO-4538/BMS-936558) in patients with esophageal cancer: Preliminary report of overall survival
-
T.Kojima, H.Hara, K.Yamaguchi, et al. Phase II study of nivolumab (ONO-4538/BMS-936558) in patients with esophageal cancer:Preliminary report of overall survival. J Clin Oncol 2016; 34:TPS175
-
(2016)
J Clin Oncol
, vol.34
, pp. TPS175
-
-
Kojima, T.1
Hara, H.2
Yamaguchi, K.3
-
77
-
-
84898973055
-
Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
-
24590637
-
S.L.Topalian, M.Sznol, D.F.McDermott, H.M.Kluger, R.D.Carvajal, W.H.Sharfman, J.R.Brahmer, D.P.Lawrence, M.B.Atkins, J.D.Powderly, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol 2014; 32:1020-30; PMID:24590637; http://dx.doi.org/10.1200/JCO.2013.53.0105
-
(2014)
J Clin Oncol
, vol.32
, pp. 1020-1030
-
-
Topalian, S.L.1
Sznol, M.2
McDermott, D.F.3
Kluger, H.M.4
Carvajal, R.D.5
Sharfman, W.H.6
Brahmer, J.R.7
Lawrence, D.P.8
Atkins, M.B.9
Powderly, J.D.10
-
78
-
-
84939227614
-
Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers
-
26086854
-
L.Carbognin, S.Pilotto, M.Milella, V.Vaccaro, M.Brunelli, A.Cali∫, F.Cuppone, I.Sperduti, D.Giannarelli, M.Chilosi, et al. Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1):Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers. PLoS One 2015; 10:e0130142; PMID:26086854; http://dx.doi.org/10.1371/journal.pone.0130142
-
(2015)
PLoS One
, vol.10
, pp. e0130142
-
-
Carbognin, L.1
Pilotto, S.2
Milella, M.3
Vaccaro, V.4
Brunelli, M.5
Cali, A.6
Cuppone, F.7
Sperduti, I.8
Giannarelli, D.9
Chilosi, M.10
-
79
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
25765070
-
N.A.Rizvi, M.D.Hellmann, A.Snyder, P.Kvistborg, V.Makarov, J.J.Havel, W.Lee, J.Yuan, P.Wong, T.S.Ho, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 2015; 348:124-8; PMID:25765070; http://dx.doi.org/10.1126/science.aaa1348
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
Kvistborg, P.4
Makarov, V.5
Havel, J.J.6
Lee, W.7
Yuan, J.8
Wong, P.9
Ho, T.S.10
-
80
-
-
84904024273
-
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
-
24714771
-
J.M.Taube, A.Klein, J.R.Brahmer, H.Xu, X.Pan, J.H.Kim, L.Chen, D.M.Pardoll, S.L.Topalian, R.A.Anders. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res 2014; 20:5064-74; PMID:24714771; http://dx.doi.org/10.1158/1078-0432.CCR-13-3271
-
(2014)
Clin Cancer Res
, vol.20
, pp. 5064-5074
-
-
Taube, J.M.1
Klein, A.2
Brahmer, J.R.3
Xu, H.4
Pan, X.5
Kim, J.H.6
Chen, L.7
Pardoll, D.M.8
Topalian, S.L.9
Anders, R.A.10
-
81
-
-
84932628341
-
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
-
26028255
-
D.T.Le, J.N.Uram, H.Wang, B.R.Bartlett, H.Kemberling, A.D.Eyring, A.D.Skora, B.S.Luber, N.S.Azad, D.Laheru, et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med 2015; 372:2509-20; PMID:26028255; http://dx.doi.org/10.1056/NEJMoa1500596
-
(2015)
N Engl J Med
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
Bartlett, B.R.4
Kemberling, H.5
Eyring, A.D.6
Skora, A.D.7
Luber, B.S.8
Azad, N.S.9
Laheru, D.10
-
82
-
-
84937846973
-
Evolving synergistic combinations of targeted immunotherapies to combat cancer
-
26205340
-
I.Melero, D.M.Berman, M.A.Aznar, A.J.Korman, J.L.Pérez Gracia, J.Haanen. Evolving synergistic combinations of targeted immunotherapies to combat cancer. Nat Rev Cancer 2015; 15:457-72; PMID:26205340; http://dx.doi.org/10.1038/nrc3973
-
(2015)
Nat Rev Cancer
, vol.15
, pp. 457-472
-
-
Melero, I.1
Berman, D.M.2
Aznar, M.A.3
Korman, A.J.4
Pérez Gracia, J.L.5
Haanen, J.6
-
83
-
-
84977138755
-
Immunotherapy Combined or Sequenced With Targeted Therapy in the Treatment of Solid Tumors: Current Perspectives
-
26839346
-
M.B.Atkins, J.Larkin. Immunotherapy Combined or Sequenced With Targeted Therapy in the Treatment of Solid Tumors:Current Perspectives. J Natl Cancer Inst 2016; 108:djv414; PMID:26839346
-
(2016)
J Natl Cancer Inst
, vol.108
, pp. djv414
-
-
Atkins, M.B.1
Larkin, J.2
-
84
-
-
84863115998
-
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
-
22186141
-
S.R.Woo, M.E.Turnis, M.V.Goldberg, J.Bankoti, M.Selby, C.J.Nirschl, M.L.Bettini, D.M.Gravano, P.Vogel, C.L.Liu, et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res 2012; 72:917-27; PMID:22186141; http://dx.doi.org/10.1158/0008-5472.CAN-11-1620
-
(2012)
Cancer Res
, vol.72
, pp. 917-927
-
-
Woo, S.R.1
Turnis, M.E.2
Goldberg, M.V.3
Bankoti, J.4
Selby, M.5
Nirschl, C.J.6
Bettini, M.L.7
Gravano, D.M.8
Vogel, P.9
Liu, C.L.10
-
85
-
-
77957723967
-
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients
-
20819923
-
J.Fourcade, Z.Sun, M.Benallaoua, P.Guillaume, I.F.Luescher, C.Sander, J.M.Kirkwood, V.Kuchroo, H.M.Zarour. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J Exp Med 2010; 207:2175-86; PMID:20819923; http://dx.doi.org/10.1084/jem.20100637
-
(2010)
J Exp Med
, vol.207
, pp. 2175-2186
-
-
Fourcade, J.1
Sun, Z.2
Benallaoua, M.3
Guillaume, P.4
Luescher, I.F.5
Sander, C.6
Kirkwood, J.M.7
Kuchroo, V.8
Zarour, H.M.9
-
86
-
-
77957744369
-
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
-
20819927
-
K.Sakuishi, L.Apetoh, J.M.Sullivan, B.R.Blazar, V.K.Kuchroo, A.C.Anderson. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med 2010; 207:2187-94; PMID:20819927; http://dx.doi.org/10.1084/jem.20100643
-
(2010)
J Exp Med
, vol.207
, pp. 2187-2194
-
-
Sakuishi, K.1
Apetoh, L.2
Sullivan, J.M.3
Blazar, B.R.4
Kuchroo, V.K.5
Anderson, A.C.6
-
87
-
-
84948466049
-
Rationale for anti-OX40 cancer immunotherapy
-
26645943
-
S.Aspeslagh, S.Postel-Vinay, S.Rusakiewicz, J.C.Soria, L.Zitvogel, A.Marabelle. Rationale for anti-OX40 cancer immunotherapy. Eur J Cancer 2016; 52:50-66; PMID:26645943; http://dx.doi.org/10.1016/j.ejca.2015.08.021
-
(2016)
Eur J Cancer
, vol.52
, pp. 50-66
-
-
Aspeslagh, S.1
Postel-Vinay, S.2
Rusakiewicz, S.3
Soria, J.C.4
Zitvogel, L.5
Marabelle, A.6
-
88
-
-
84942853584
-
Boosting Cancer Immunotherapy with Anti-CD137 Antibody Therapy
-
25908780
-
A.Yonezawa, S.Dutt, C.Chester, J.Kim, H.E.Kohrt. Boosting Cancer Immunotherapy with Anti-CD137 Antibody Therapy. Clin Cancer Res 2015; 21:3113-20; PMID:25908780; http://dx.doi.org/10.1158/1078-0432.CCR-15-0263
-
(2015)
Clin Cancer Res
, vol.21
, pp. 3113-3120
-
-
Yonezawa, A.1
Dutt, S.2
Chester, C.3
Kim, J.4
Kohrt, H.E.5
-
89
-
-
84875552922
-
Immunogenic cell death in cancer therapy
-
23157435
-
G.Kroemer, L.Galluzzi, O.Kepp, L.Zitvogel. Immunogenic cell death in cancer therapy. Annu Rev Immunol 2013; 31:51-72; PMID:23157435; http://dx.doi.org/10.1146/annurev-immunol-032712-100008
-
(2013)
Annu Rev Immunol
, vol.31
, pp. 51-72
-
-
Kroemer, G.1
Galluzzi, L.2
Kepp, O.3
Zitvogel, L.4
-
90
-
-
84875039618
-
Combining radiotherapy and cancer immunotherapy: a paradigm shift
-
23291374
-
S.C.Formenti, S.Demaria. Combining radiotherapy and cancer immunotherapy:a paradigm shift. J Natl Cancer Inst 2013; 105:256-65; PMID:23291374; http://dx.doi.org/10.1093/jnci/djs629
-
(2013)
J Natl Cancer Inst
, vol.105
, pp. 256-265
-
-
Formenti, S.C.1
Demaria, S.2
-
91
-
-
84940372582
-
The Next Hurdle in Cancer Immunotherapy: Overcoming the Non-T-Cell-Inflamed Tumor Microenvironment
-
26320069
-
T.F.Gajewski. The Next Hurdle in Cancer Immunotherapy:Overcoming the Non-T-Cell-Inflamed Tumor Microenvironment. Semin Oncol 2015; 42:663-71; PMID:26320069; http://dx.doi.org/10.1053/j.seminoncol.2015.05.011
-
(2015)
Semin Oncol
, vol.42
, pp. 663-671
-
-
Gajewski, T.F.1
-
92
-
-
84877072174
-
Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment
-
23579075
-
T.F.Gajewski, S.R.Woo, Y.Zha, R.Spaapen, Y.Zheng, L.Corrales, S.Spranger. Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment. Curr Opin Immunol 2013; 25:268-76; PMID:23579075; http://dx.doi.org/10.1016/j.coi.2013.02.009
-
(2013)
Curr Opin Immunol
, vol.25
, pp. 268-276
-
-
Gajewski, T.F.1
Woo, S.R.2
Zha, Y.3
Spaapen, R.4
Zheng, Y.5
Corrales, L.6
Spranger, S.7
-
93
-
-
84936147067
-
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
-
26398076
-
J.Larkin, F.S.Hodi, J.D.Wolchok. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. N Engl J Med 2015; 373:1270-1; PMID:26398076; http://dx.doi.org/10.1056/NEJMoa1504030
-
(2015)
N Engl J Med
, vol.373
, pp. 1270-1271
-
-
Larkin, J.1
Hodi, F.S.2
Wolchok, J.D.3
|