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Volumn 21, Issue 14, 2015, Pages 3113-3120

Boosting cancer immunotherapy with anti-CD137 antibody therapy

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; ANTINEOPLASTIC AGENT; BEVACIZUMAB; BLINATUMOMAB; BRENTUXIMAB VEDOTIN; CD137 MONOCLONAL ANTIBODY; CD20 ANTIBODY; CETUXIMAB; DINUTUXIMAB; ELOTUZUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR 2 MONOCLONAL ANTIBODY; GEMTUZUMAB OZOGAMICIN; IBRITUMOMAB TIUXETAN; IPILIMUMAB; MB 20 11; MONOCLONAL ANTIBODY; NIVOLUMAB; OFATUMUMAB; PANITUMUMAB; PEMBROLIZUMAB; PERTUZUMAB; PF 05082566; RAMUCIRUMAB; RITUXIMAB; TOSITUMOMAB I 131; TRASTUZUMAB; TRASTUZUMAB EMTANSINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; URELUMAB; VASCULOTROPIN ANTIBODY; CD137 ANTIGEN;

EID: 84942853584     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-15-0263     Document Type: Review
Times cited : (112)

References (70)
  • 1
    • 84883821225 scopus 로고    scopus 로고
    • Antibody therapeutics in cancer
    • Sliwkowski MX, Mellman I. Antibody therapeutics in cancer. Science 2013; 341: 1192-8.
    • (2013) Science , vol.341 , pp. 1192-1198
    • Sliwkowski, M.X.1    Mellman, I.2
  • 2
    • 17144455839 scopus 로고    scopus 로고
    • IDEC-C2B8: Results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma
    • Maloney DG, Grillo-Lopez AJ, Bodkin DJ, White CA, Liles TM, Royston I, et al. IDEC-C2B8: results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma. J Clin Oncol 1997; 15: 3266-74.
    • (1997) J Clin Oncol , vol.15 , pp. 3266-3274
    • Maloney, D.G.1    Grillo-Lopez, A.J.2    Bodkin, D.J.3    White, C.A.4    Liles, T.M.5    Royston, I.6
  • 3
    • 1842368507 scopus 로고    scopus 로고
    • IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma
    • Maloney DG, Grillo-Lopez AJ, White CA, Bodkin D, Schilder RJ, Neidhart JA, et al. IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma. Blood 1997; 90: 2188-95.
    • (1997) Blood , vol.90 , pp. 2188-2195
    • Maloney, D.G.1    Grillo-Lopez, A.J.2    White, C.A.3    Bodkin, D.4    Schilder, R.J.5    Neidhart, J.A.6
  • 4
    • 84905218251 scopus 로고    scopus 로고
    • Current approaches and emerging directions in HER2-resistant breast cancer
    • Brufsky AM Current approaches and emerging directions in HER2-resistant breast cancer. Breast Cancer 2014; 8: 109-18.
    • (2014) Breast Cancer , vol.8 , pp. 109-118
    • Brufsky, A.M.1
  • 6
    • 77957965500 scopus 로고    scopus 로고
    • Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era
    • Gisselbrecht C, Glass B, Mounier N, Singh Gill D, Linch DC, Trneny M, et al. Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era. J Clin Oncol 2010; 28: 4184-90.
    • (2010) J Clin Oncol , vol.28 , pp. 4184-4190
    • Gisselbrecht, C.1    Glass, B.2    Mounier, N.3    Singh Gill, D.4    Linch, D.C.5    Trneny, M.6
  • 7
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms of T cell co-stimulation and coinhibition
    • Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and coinhibition. Nat Rev Immunol 2013; 13: 227-42.
    • (2013) Nat Rev Immunol , vol.13 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 8
    • 84873372202 scopus 로고    scopus 로고
    • Advancesintargeting cell surface signalling molecules for immune modulation
    • Yao S, Zhu Y, Chen L. Advancesintargeting cell surface signalling molecules for immune modulation. Nat Rev Drug Discov 2013; 12: 130-46.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 130-146
    • Yao, S.1    Zhu, Y.2    Chen, L.3
  • 9
    • 84884822262 scopus 로고    scopus 로고
    • Immunotherapy ofmelanoma with the immunecostimulatory monoclonal antibodies targeting CD137
    • Li SY, Liu Y. Immunotherapy ofmelanoma with the immunecostimulatory monoclonal antibodies targeting CD137. Clin Pharmacol 2013; 5: 47-53.
    • (2013) Clin Pharmacol , vol.5 , pp. 47-53
    • Li, S.Y.1    Liu, Y.2
  • 10
    • 84890829415 scopus 로고    scopus 로고
    • Cancer immunotherapy
    • McNutt M. Cancer immunotherapy. Science 2013; 342: 1417.
    • (2013) Science , vol.342 , pp. 1417
    • McNutt, M.1
  • 11
    • 85052489064 scopus 로고    scopus 로고
    • Areas to watch in 2015
    • Areas to watch in 2015. Science 2014; 346: 1450.
    • (2014) Science , vol.346 , pp. 1450
  • 14
    • 84916639631 scopus 로고    scopus 로고
    • Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia
    • Topp MS, Gokbuget N, Zugmaier G, Klappers P, Stelljes M, Neumann S, et al. Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia. J Clin Oncol 2014; 32: 4134-40.
    • (2014) J Clin Oncol , vol.32 , pp. 4134-4140
    • Topp, M.S.1    Gokbuget, N.2    Zugmaier, G.3    Klappers, P.4    Stelljes, M.5    Neumann, S.6
  • 16
    • 84862739640 scopus 로고    scopus 로고
    • Immunotherapy of cancer with 4-1BB
    • Vinay DS, Kwon BS. Immunotherapy of cancer with 4-1BB. Mol Cancer Ther 2012; 11: 1062-70.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1062-1070
    • Vinay, D.S.1    Kwon, B.S.2
  • 17
    • 84886944363 scopus 로고    scopus 로고
    • Boosting antibody-dependent cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody
    • Houot R, Kohrt H, Levy R. Boosting antibody-dependent cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody. Oncoimmunology 2012; 1: 957-8.
    • (2012) Oncoimmunology , vol.1 , pp. 957-958
    • Houot, R.1    Kohrt, H.2    Levy, R.3
  • 18
    • 0344247505 scopus 로고
    • cDNA sequences of two inducible T-cell genes
    • Kwon BS, Weissman SM. cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci U S A 1989; 86: 1963-7.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 1963-1967
    • Kwon, B.S.1    Weissman, S.M.2
  • 20
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • Melero I, Shuford WW, Newby SA, Aruffo A, Ledbetter JA, Hellstrom KE, et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 1997; 3: 682-5.
    • (1997) Nat Med , vol.3 , pp. 682-685
    • Melero, I.1    Shuford, W.W.2    Newby, S.A.3    Aruffo, A.4    Ledbetter, J.A.5    Hellstrom, K.E.6
  • 21
    • 22944477731 scopus 로고    scopus 로고
    • Immunity to melanoma mediated by 4-1BB is associated with enhanced activity of tumour-infiltrating lymphocytes
    • Ju SA, Lee SC, Kwon TH, Heo SK, Park SM, Paek HN, et al. Immunity to melanoma mediated by 4-1BB is associated with enhanced activity of tumour-infiltrating lymphocytes. Immunol Cell Biol 2005; 83: 344-51.
    • (2005) Immunol Cell Biol , vol.83 , pp. 344-351
    • Ju, S.A.1    Lee, S.C.2    Kwon, T.H.3    Heo, S.K.4    Park, S.M.5    Paek, H.N.6
  • 23
    • 0036195860 scopus 로고    scopus 로고
    • Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors
    • Wilcox RA, Flies DB, Zhu G, Johnson AJ, Tamada K, Chapoval AI, et al. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J Clin Invest 2002; 109: 651-9.
    • (2002) J Clin Invest , vol.109 , pp. 651-659
    • Wilcox, R.A.1    Flies, D.B.2    Zhu, G.3    Johnson, A.J.4    Tamada, K.5    Chapoval, A.I.6
  • 24
    • 79953041310 scopus 로고    scopus 로고
    • Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function
    • Hernandez-Chacon JA, Li Y, Wu RC, Bernatchez C, Wang Y, Weber JS, et al. Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function. J Immunother 2011; 34: 236-50.
    • (2011) J Immunother , vol.34 , pp. 236-250
    • Hernandez-Chacon, J.A.1    Li, Y.2    Wu, R.C.3    Bernatchez, C.4    Wang, Y.5    Weber, J.S.6
  • 25
    • 63149163677 scopus 로고    scopus 로고
    • The role of TNF superfamily members in T-cell function and diseases
    • Croft M. The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol 2009; 9: 271-85.
    • (2009) Nat Rev Immunol , vol.9 , pp. 271-285
    • Croft, M.1
  • 26
  • 27
    • 79955785050 scopus 로고    scopus 로고
    • Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production
    • Curran MA, Kim M, Montalvo W, Al-Shamkhani A, Allison JP. Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production. PLoS One 2011; 6: e19499.
    • (2011) PLoS One , vol.6
    • Curran, M.A.1    Kim, M.2    Montalvo, W.3    Al-Shamkhani, A.4    Allison, J.P.5
  • 28
    • 84883853182 scopus 로고    scopus 로고
    • Combined TIM-3 blockade and CD137 activation affords the long-term protection in a murine model of ovarian cancer
    • Guo Z, Cheng D, Xia Z, Luan M, Wu L, Wang G, et al. Combined TIM-3 blockade and CD137 activation affords the long-term protection in a murine model of ovarian cancer. J Transl Med 2013; 11: 215.
    • (2013) J Transl Med , vol.11 , pp. 215
    • Guo, Z.1    Cheng, D.2    Xia, Z.3    Luan, M.4    Wu, L.5    Wang, G.6
  • 29
    • 84863229631 scopus 로고    scopus 로고
    • Adoptive cell therapy for lymphoma with CD4 T cells depleted of CD137-expressing regulatory T cells
    • Goldstein MJ, Kohrt HE, Houot R, Varghese B, Lin JT, Swanson E, et al. Adoptive cell therapy for lymphoma with CD4 T cells depleted of CD137-expressing regulatory T cells. Cancer Res 2012; 72: 1239-47.
    • (2012) Cancer Res , vol.72 , pp. 1239-1247
    • Goldstein, M.J.1    Kohrt, H.E.2    Houot, R.3    Varghese, B.4    Lin, J.T.5    Swanson, E.6
  • 30
    • 70350713055 scopus 로고    scopus 로고
    • Therapeutic effect of CD137 immunomodulation in lymphoma and Its enhancement by Treg depletion
    • Houot R, Goldstein MJ, Kohrt HE, Myklebust JH, Alizadeh AA, Lin JT, et al. Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion. Blood 2009; 114: 3431-8.
    • (2009) Blood , vol.114 , pp. 3431-3438
    • Houot, R.1    Goldstein, M.J.2    Kohrt, H.E.3    Myklebust, J.H.4    Alizadeh, A.A.5    Lin, J.T.6
  • 31
    • 0037103147 scopus 로고    scopus 로고
    • 4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8T cells in a CD40-dependent-dependent manner
    • Miller RE, Jones J, Le T, Whitmore J, Boiani N, Gliniak B, et al. 4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8T cells in a CD40-dependent-dependent manner. J Immunol 2002; 169: 1792-800.
    • (2002) J Immunol , vol.169 , pp. 1792-1800
    • Miller, R.E.1    Jones, J.2    Le, T.3    Whitmore, J.4    Boiani, N.5    Gliniak, B.6
  • 32
    • 70349243743 scopus 로고    scopus 로고
    • In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb
    • Murillo O, Dubrot J, Palazon A, Arina A, Azpilikueta A, Alfaro C, et al. In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb. Eur J Immunol 2009; 39: 2424-36.
    • (2009) Eur J Immunol , vol.39 , pp. 2424-2436
    • Murillo, O.1    Dubrot, J.2    Palazon, A.3    Arina, A.4    Azpilikueta, A.5    Alfaro, C.6
  • 33
    • 8544249166 scopus 로고    scopus 로고
    • Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines
    • Ito F, Li Q, Shreiner AB, Okuyama R, Jure-Kunkel MN, Teitz-Tennenbaum S, et al. Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines. Cancer Res 2004; 64: 8411-9.
    • (2004) Cancer Res , vol.64 , pp. 8411-8419
    • Ito, F.1    Li, Q.2    Shreiner, A.B.3    Okuyama, R.4    Jure-Kunkel, M.N.5    Teitz-Tennenbaum, S.6
  • 34
    • 80052351833 scopus 로고    scopus 로고
    • Extracellular domain of human 4-1BBL enhanced the function of cytotoxic T-lymphocyte induced by dendritic cell
    • Wu C, Guo H, Wang Y, Gao Y, Zhu Z, Du Z. Extracellular domain of human 4-1BBL enhanced the function of cytotoxic T-lymphocyte induced by dendritic cell. Cell Immunol 2011; 271: 118-23.
    • (2011) Cell Immunol , vol.271 , pp. 118-123
    • Wu, C.1    Guo, H.2    Wang, Y.3    Gao, Y.4    Zhu, Z.5    Du, Z.6
  • 35
    • 84977177265 scopus 로고    scopus 로고
    • Invariant natural killer T cells regulate anti-tumor immunity by controlling the population of dendritic cells in tumor and draining lymph nodes
    • Pilones KA, Aryankalayil J, Babb JS, Demaria S. Invariant natural killer T cells regulate anti-tumor immunity by controlling the population of dendritic cells in tumor and draining lymph nodes. J Immunother Cancer 2014; 2: 37.
    • (2014) J Immunother Cancer , vol.2 , pp. 37
    • Pilones, K.A.1    Aryankalayil, J.2    Babb, J.S.3    Demaria, S.4
  • 36
    • 84892187345 scopus 로고    scopus 로고
    • Signatures of human NK cell development and terminal differentiation
    • Luetke-Eversloh M, Killig M, Romagnani C. Signatures of human NK cell development and terminal differentiation. Front Immunol 2013; 4: 499.
    • (2013) Front Immunol , vol.4 , pp. 499
    • Luetke-Eversloh, M.1    Killig, M.2    Romagnani, C.3
  • 37
    • 50949124847 scopus 로고    scopus 로고
    • Human natural killer cells
    • Caligiuri MA Human natural killer cells. Blood 2008; 112: 461-9.
    • (2008) Blood , vol.112 , pp. 461-469
    • Caligiuri, M.A.1
  • 38
    • 0032535119 scopus 로고    scopus 로고
    • NK1.1 cellsexpress 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies
    • Melero I, Johnston JV, Shufford WW, Mittler RS, Chen L. NK1.1 cellsexpress 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell Immunol 1998; 190: 167-72.
    • (1998) Cell Immunol , vol.190 , pp. 167-172
    • Melero, I.1    Johnston, J.V.2    Shufford, W.W.3    Mittler, R.S.4    Chen, L.5
  • 39
    • 79952124960 scopus 로고    scopus 로고
    • CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies
    • Kohrt HE, Houot R, Goldstein MJ, Weiskopf K, Alizadeh AA, Brody J, et al. CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies. Blood 2011; 117: 2423-32.
    • (2011) Blood , vol.117 , pp. 2423-2432
    • Kohrt, H.E.1    Houot, R.2    Goldstein, M.J.3    Weiskopf, K.4    Alizadeh, A.A.5    Brody, J.6
  • 40
    • 84863230537 scopus 로고    scopus 로고
    • Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer
    • Kohrt HE, Houot R, Weiskopf K, Goldstein MJ, Scheeren F, Czerwinski D, et al. Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer. J Clin Invest 2012; 122: 1066-75.
    • (2012) J Clin Invest , vol.122 , pp. 1066-1075
    • Kohrt, H.E.1    Houot, R.2    Weiskopf, K.3    Goldstein, M.J.4    Scheeren, F.5    Czerwinski, D.6
  • 42
    • 0035266427 scopus 로고    scopus 로고
    • Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation
    • Kim JA, Averbook BJ, Chambers K, Rothchild K, Kjaergaard J, Papay R, et al. Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation. Cancer Res 2001; 61: 2031-7.
    • (2001) Cancer Res , vol.61 , pp. 2031-2037
    • Kim, J.A.1    Averbook, B.J.2    Chambers, K.3    Rothchild, K.4    Kjaergaard, J.5    Papay, R.6
  • 43
    • 33746924449 scopus 로고    scopus 로고
    • Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity
    • Kocak E, Lute K, Chang X, May KF Jr, Exten KR, Zhang H, et al. Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity. Cancer Res 2006; 66: 7276-84.
    • (2006) Cancer Res , vol.66 , pp. 7276-7284
    • Kocak, E.1    Lute, K.2    Chang, X.3    May, K.F.4    Exten, K.R.5    Zhang, H.6
  • 44
    • 84904536509 scopus 로고    scopus 로고
    • Combination anti-CD137 and anti-CD40 antibody therapy in murine myc-driven hematological cancers
    • Westwood JA, Matthews GM, Shortt J, Faulkner D, Pegram HJ, Duong CP, et al. Combination anti-CD137 and anti-CD40 antibody therapy in murine myc-driven hematological cancers. Leuk Res 2014; 38: 948-54.
    • (2014) Leuk Res , vol.38 , pp. 948-954
    • Westwood, J.A.1    Matthews, G.M.2    Shortt, J.3    Faulkner, D.4    Pegram, H.J.5    Duong, C.P.6
  • 45
    • 33744987907 scopus 로고    scopus 로고
    • Eradication of established tumors in mice by a combination antibody-based therapy
    • Uno T, Takeda K, Kojima Y, Yoshizawa H, Akiba H, Mittler RS, et al. Eradication of established tumors in mice by a combination antibody-based therapy. Nat Med 2006; 12: 693-8.
    • (2006) Nat Med , vol.12 , pp. 693-698
    • Uno, T.1    Takeda, K.2    Kojima, Y.3    Yoshizawa, H.4    Akiba, H.5    Mittler, R.S.6
  • 46
    • 77954704783 scopus 로고    scopus 로고
    • Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules
    • Takeda K, Kojima Y, Uno T, Hayakawa Y, Teng MW, Yoshizawa H, et al. Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules. J Immunol 2010; 184: 5493-501.
    • (2010) J Immunol , vol.184 , pp. 5493-5501
    • Takeda, K.1    Kojima, Y.2    Uno, T.3    Hayakawa, Y.4    Teng, M.W.5    Yoshizawa, H.6
  • 47
    • 68149132103 scopus 로고    scopus 로고
    • CD1d-based combination therapy eradicates established tumors in mice
    • Teng MW, Sharkey J, McLaughlin NM, Exley MA, Smyth MJ. CD1d-based combination therapy eradicates established tumors in mice. J Immunol 2009; 183: 1911-20.
    • (2009) J Immunol , vol.183 , pp. 1911-1920
    • Teng, M.W.1    Sharkey, J.2    McLaughlin, N.M.3    Exley, M.A.4    Smyth, M.J.5
  • 48
    • 4344718859 scopus 로고    scopus 로고
    • 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function
    • Lee SJ, Myers L, Muralimohan G, Dai J, Qiao Y, Li Z, et al. 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function. J Immunol 2004; 173: 3002-12.
    • (2004) J Immunol , vol.173 , pp. 3002-3012
    • Lee, S.J.1    Myers, L.2    Muralimohan, G.3    Dai, J.4    Qiao, Y.5    Li, Z.6
  • 49
    • 84893199565 scopus 로고    scopus 로고
    • Combinatorial PD-1 blockade and CD137 activation has therapeutic efficacy in murine cancer models and synergizes with cisplatin
    • Wei H, Zhao L, Li W, Fan K, Qian W, Hou S, et al. Combinatorial PD-1 blockade and CD137 activation has therapeutic efficacy in murine cancer models and synergizes with cisplatin. PLoS One 2013; 8: e84927.
    • (2013) PLoS One , vol.8
    • Wei, H.1    Zhao, L.2    Li, W.3    Fan, K.4    Qian, W.5    Hou, S.6
  • 50
    • 84934277025 scopus 로고    scopus 로고
    • Combination of 4-1BB agonist and PD-1 antagonist promotes antitumor effector/memory CD8 T cells in a poorly immunogenic tumor model
    • Chen S, Lee LF, Fisher TS, Jessen B, Elliott M, Evering W, et al. Combination of 4-1BB agonist and PD-1 antagonist promotes antitumor effector/memory CD8 T cells in a poorly immunogenic tumor model. Cancer Immunol Res 2015; 3: 149-60.
    • (2015) Cancer Immunol Res , vol.3 , pp. 149-160
    • Chen, S.1    Lee, L.F.2    Fisher, T.S.3    Jessen, B.4    Elliott, M.5    Evering, W.6
  • 51
    • 84920448880 scopus 로고    scopus 로고
    • Combination immunotherapy with 4-1BB activation and PD-1 blockade enhances antitumor efficacy in a mouse model of subcutaneous tumor
    • Shindo Y, Yoshimura K, Kuramasu A, Watanabe Y, Ito H, Kondo T, et al. Combination immunotherapy with 4-1BB activation and PD-1 blockade enhances antitumor efficacy in a mouse model of subcutaneous tumor. Anticancer Res 2015; 35: 129-36.
    • (2015) Anticancer Res , vol.35 , pp. 129-136
    • Shindo, Y.1    Yoshimura, K.2    Kuramasu, A.3    Watanabe, Y.4    Ito, H.5    Kondo, T.6
  • 52
    • 79958237139 scopus 로고    scopus 로고
    • Combinatorial therapy for liver metastatic colon cancer: Dendritic cell vaccine and low-dose agonistic anti-4-1BB antibody co-stimulatory signal
    • Lee H, Park HJ, Sohn HJ, Kim JM, Kim SJ. Combinatorial therapy for liver metastatic colon cancer: dendritic cell vaccine and low-dose agonistic anti-4-1BB antibody co-stimulatory signal. J Surg Res 2011; 169: e43-50.
    • (2011) J Surg Res , vol.169 , pp. e43-50
    • Lee, H.1    Park, H.J.2    Sohn, H.J.3    Kim, J.M.4    Kim, S.J.5
  • 53
    • 23944461007 scopus 로고    scopus 로고
    • Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti-OX40 and anti-4-1BB monoclonal antibodies induces Tcell-mediated protective immunity in Her-2/neu transgenic mice
    • Cuadros C, Dominguez AL, Lollini PL, Croft M, Mittler RS, Borgstrom P, et al. Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti-OX40 and anti-4-1BB monoclonal antibodies induces Tcell-mediated protective immunity in Her-2/neu transgenic mice. Int J Cancer 2005; 116: 934-43.
    • (2005) Int J Cancer , vol.116 , pp. 934-943
    • Cuadros, C.1    Dominguez, A.L.2    Lollini, P.L.3    Croft, M.4    Mittler, R.S.5    Borgstrom, P.6
  • 55
    • 84873100024 scopus 로고    scopus 로고
    • Combined stimulation of TLR9 and 4.1BB augments Trp2 peptide vaccine-mediated melanoma rejection by increasing Ag-specific CTL activity and infiltration into tumor sites
    • Sin JI, Kim H, Ahn E, Jeon YH, Park WS, Lee SY, et al. Combined stimulation of TLR9 and 4.1BB augments Trp2 peptide vaccine-mediated melanoma rejection by increasing Ag-specific CTL activity and infiltration into tumor sites. Cancer Lett 2013; 330: 190-9.
    • (2013) Cancer Lett , vol.330 , pp. 190-199
    • Sin, J.I.1    Kim, H.2    Ahn, E.3    Jeon, Y.H.4    Park, W.S.5    Lee, S.Y.6
  • 56
    • 84858762241 scopus 로고    scopus 로고
    • Oncolytic virus and anti-4-1BB combination therapy elicits strong antitumor immunity against established cancer
    • John LB, Howland LJ, Flynn JK, West AC, Devaud C, Duong CP, et al. Oncolytic virus and anti-4-1BB combination therapy elicits strong antitumor immunity against established cancer. Cancer Res 2012; 72: 1651-60.
    • (2012) Cancer Res , vol.72 , pp. 1651-1660
    • John, L.B.1    Howland, L.J.2    Flynn, J.K.3    West, A.C.4    Devaud, C.5    Duong, C.P.6
  • 57
    • 84878957075 scopus 로고    scopus 로고
    • The availability of a functional tumor targeting T-cell repertoire determines the anti-tumor efficiency of combination therapy with anti-CTLA-4 and anti-4-1BB antibodies
    • Jensen BA, Pedersen SR, Christensen JP, Thomsen AR. The availability of a functional tumor targeting T-cell repertoire determines the anti-tumor efficiency of combination therapy with anti-CTLA-4 and anti-4-1BB antibodies. PLoS One 2013; 8: e66081.
    • (2013) PLoS One , vol.8
    • Jensen, B.A.1    Pedersen, S.R.2    Christensen, J.P.3    Thomsen, A.R.4
  • 59
    • 79955570584 scopus 로고    scopus 로고
    • Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy
    • Stagg J, Loi S, Divisekera U, Ngiow SF, Duret H, Yagita H, et al. Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy. Proc Natl Acad Sci U S A 2011; 108: 7142-7.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 7142-7147
    • Stagg, J.1    Loi, S.2    Divisekera, U.3    Ngiow, S.F.4    Duret, H.5    Yagita, H.6
  • 60
    • 84891373595 scopus 로고    scopus 로고
    • Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: A single group, open-label, phase 2 trial
    • Westin JR, Chu F, Zhang M, Fayad LE, Kwak LW, Fowler N, et al. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial. Lancet Oncol 2014; 15: 69-77.
    • (2014) Lancet Oncol , vol.15 , pp. 69-77
    • Westin, J.R.1    Chu, F.2    Zhang, M.3    Fayad, L.E.4    Kwak, L.W.5    Fowler, N.6
  • 61
    • 84920999004 scopus 로고    scopus 로고
    • Dual antibody therapy to harness the innate anti-tumor immune response to enhance antibody targeting of tumors
    • Chester C, Marabelle A, Houot R, Kohrt HE. Dual antibody therapy to harness the innate anti-tumor immune response to enhance antibody targeting of tumors. Curr Opin Immunol 2015; 33C: 1-8.
    • (2015) Curr Opin Immunol , vol.33 C , pp. 1-8
    • Chester, C.1    Marabelle, A.2    Houot, R.3    Kohrt, H.E.4
  • 62
    • 55949113750 scopus 로고    scopus 로고
    • Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA)
    • Sznol M, Hodi FS, Margolin K, McDermott DF, Ernstoff MS, Kirkwood JM, et al. Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA). J Clin Oncol 2008; 26 (15 suppl 3007).
    • (2008) J Clin Oncol , vol.26 , Issue.15
    • Sznol, M.1    Hodi, F.S.2    Margolin, K.3    McDermott, D.F.4    Ernstoff, M.S.5    Kirkwood, J.M.6
  • 63
    • 33947696816 scopus 로고    scopus 로고
    • Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice
    • Niu L, Strahotin S, Hewes B, Zhang B, Zhang Y, Archer D, et al. Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice. J Immunol 2007; 178: 4194-213.
    • (2007) J Immunol , vol.178 , pp. 4194-4213
    • Niu, L.1    Strahotin, S.2    Hewes, B.3    Zhang, B.4    Zhang, Y.5    Archer, D.6
  • 64
    • 4644245852 scopus 로고    scopus 로고
    • CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses
    • Vinay DS, Choi BK, Bae JS, Kim WY, Gebhardt BM, Kwon BS. CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses. J Immunol 2004; 173: 4218-29.
    • (2004) J Immunol , vol.173 , pp. 4218-4229
    • Vinay, D.S.1    Choi, B.K.2    Bae, J.S.3    Kim, W.Y.4    Gebhardt, B.M.5    Kwon, B.S.6
  • 65
    • 84880709088 scopus 로고    scopus 로고
    • A phase Ib, open-label, multicenter study of urelumab (BMS-663513) in combination with rituximab in subjects with relapsed/refractory B-cell malignancies
    • TPS3108
    • Kohrt HE, Godwin JE, Lossos IS, Williams ME, Timmerman J, Link BK, et al. A phase Ib, open-label, multicenter study of urelumab (BMS-663513) in combination with rituximab in subjects with relapsed/refractory B-cell malignancies. J Clin Oncol 31, 2013 (suppl; abstr TPS3108).
    • (2013) J Clin Oncol , vol.31
    • Kohrt, H.E.1    Godwin, J.E.2    Lossos, I.S.3    Williams, M.E.4    Timmerman, J.5    Link, B.K.6
  • 66
    • 84938336437 scopus 로고    scopus 로고
    • Biomarker characterization using mass cytometry in a phase 1 trial of urelumab (BMS-663513) in subjects with advanced solid tumors and relapsed/refractory B-cell non-Hodgkin lymphoma
    • 3017
    • Chester C, Chang S, Kurland JF, Sagiv-Barfi I, Czerwinski D, Rajapaksa A, et al. Biomarker characterization using mass cytometry in a phase 1 trial of urelumab (BMS-663513) in subjects with advanced solid tumors and relapsed/refractory B-cell non-Hodgkin lymphoma. J Clin Oncol 32: 5s, 2014 (suppl; abstr 3017).
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Chester, C.1    Chang, S.2    Kurland, J.F.3    Sagiv-Barfi, I.4    Czerwinski, D.5    Rajapaksa, A.6
  • 67
    • 84923279483 scopus 로고    scopus 로고
    • A phase I study of the safety, tolerability, pharmacokinetics, and immunoregulatory activity of urelumab (BMS-663513) in subjects with advanced and/or metastatic solid tumors and relapsed/refractory B-cell non-Hodgkin's lymphoma (B-NHL)
    • TPS3107
    • Melero I, Gangadhar TC, Kohrt HE, Segal NH, Logan T, Urba WJ, et al. A phase I study of the safety, tolerability, pharmacokinetics, and immunoregulatory activity of urelumab (BMS-663513) in subjects with advanced and/or metastatic solid tumors and relapsed/refractory B-cell non-Hodgkin's lymphoma (B-NHL). J Clin Oncol 31, 2013 (suppl; abstr TPS3107).
    • (2013) J Clin Oncol , vol.31
    • Melero, I.1    Gangadhar, T.C.2    Kohrt, H.E.3    Segal, N.H.4    Logan, T.5    Urba, W.J.6
  • 68
    • 84923303086 scopus 로고    scopus 로고
    • A phase 1 study of PF-05082566 (anti-4-1BB) in patients with advanced cancer
    • 3007
    • Segal NH, Gopal AK, Bhatia S, Kohrt HE, Levy R, Pishvaian MJ, et al. A phase 1 study of PF-05082566 (anti-4-1BB) in patients with advanced cancer. J Clin Oncol 32: 5s, 2014 (suppl; abstr 3007).
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Segal, N.H.1    Gopal, A.K.2    Bhatia, S.3    Kohrt, H.E.4    Levy, R.5    Pishvaian, M.J.6
  • 69
    • 84864224592 scopus 로고    scopus 로고
    • Targeting spatiotemporal expression of CD137 on tumor-infiltrating cytotoxic T lymphocytes as a novel strategy for agonistic antibody therapy
    • Noji S, Hosoi A, Takeda K, Matsushita H, Morishita Y, Seto Y, et al. Targeting spatiotemporal expression of CD137 on tumor-infiltrating cytotoxic T lymphocytes as a novel strategy for agonistic antibody therapy. J Immunother 2012; 35: 460-72.
    • (2012) J Immunother , vol.35 , pp. 460-472
    • Noji, S.1    Hosoi, A.2    Takeda, K.3    Matsushita, H.4    Morishita, Y.5    Seto, Y.6
  • 70
    • 1542405768 scopus 로고    scopus 로고
    • +T cell-mediated eradication of poorly immunogenic B16-F10 melanoma by the combined action of IL-12 gene therapy and 4-1BB costimulation
    • +T cell-mediated eradication of poorly immunogenic B16-F10 melanoma by the combined action of IL-12 gene therapy and 4-1BB costimulation. Int J Cancer 2004; 109: 499-506.
    • (2004) Int J Cancer , vol.109 , pp. 499-506
    • Xu, D.1    Gu, P.2    Pan, P.Y.3    Li, Q.4    Sato, A.I.5    Chen, S.H.6


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