Suppression of GLI sensitizes medulloblastoma cells to mitochondria-mediated apoptosis

Journal of Cancer Research and Clinical Oncology

Volumn 142, Issue 12, 2016, Pages 2469-2478

  Lin, Zhongxiao ^a   Li, Sisi ^a   Sheng, Hansong ^a   Cai, Ming ^a   Ma, Lin Yuan Si ^a   Hu, Liuxun ^a   Xu, Shangyu ^a   Yu, Li Sheng ^a   Zhang, Nu ^a  

^a THE SECOND AFFILIATED HOSPITAL AND YUYING CHILDREN S HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Bcl 2; GANT61; GLI; Medulloblastoma; Mitochondria mediated apoptosis; SHH signalling pathway

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CISPLATIN; GANT 61 PROTEIN INHIBITOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN INHIBITOR; RHODAMINE 123; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; UNCLASSIFIED DRUG; GANT 61; GLI1 PROTEIN, HUMAN; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; SHH PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CANCER INCIDENCE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DAOY MEDULLOBLASTOMA CELL LINE; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC50; MEDULLOBLASTOMA CELL LINE; METASTASIS; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL MOTION; CEREBELLAR NEOPLASMS; DRUG EFFECTS; GENETICS; MEDULLOBLASTOMA; METABOLISM; MITOCHONDRION; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; TUMOR INVASION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CEREBELLAR NEOPLASMS; HEDGEHOG PROTEINS; HUMANS; MEDULLOBLASTOMA; MITOCHONDRIA; MOLECULAR TARGETED THERAPY; NEOPLASM INVASIVENESS; PYRIDINES; PYRIMIDINES; SIGNAL TRANSDUCTION; ZINC FINGER PROTEIN GLI1;

EID: 84986269243     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-016-2241-1     Document Type: Article

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