-
1
-
-
79957449923
-
Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008
-
Z.M.Younossi, M.Stepanova, M.Afendy, et al. Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008. Clin Gastroenterol Hepatol. 2011;9:524–530.
-
(2011)
Clin Gastroenterol Hepatol
, vol.9
, pp. 524-530
-
-
Younossi, Z.M.1
Stepanova, M.2
Afendy, M.3
-
2
-
-
84992157036
-
Prevalence of chronic liver disease and cirrhosis by underlying cause in understudied ethnic groups: the multiethnic cohort
-
V.W.Setiawan, D.O.Stram, J.Porcel, et al. Prevalence of chronic liver disease and cirrhosis by underlying cause in understudied ethnic groups:the multiethnic cohort. Hepatology. 2016 Jun 15. doi:10.1002/hep.28677. [Epub ahead of print]. Available from:http://www.ncbi.nlm.nih.gov/pubmed/27301913.•• Epidemiology study in a multiethnic cohort from the US showing the NAFLD is the most common cause of CLD overall and of cirrhosis in special ethnic groups.
-
(2016)
Hepatology
-
-
Setiawan, V.W.1
Stram, D.O.2
Porcel, J.3
-
3
-
-
11144264156
-
Nonalcoholic fatty liver disease: a review of current understanding and future impact
-
M.Charlton Nonalcoholic fatty liver disease:a review of current understanding and future impact. Clin Gastroenterol Hepatol. 2004;2:1048–1058.
-
(2004)
Clin Gastroenterol Hepatol
, vol.2
, pp. 1048-1058
-
-
Charlton, M.1
-
4
-
-
58949094415
-
Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: selected practical issues in their evaluation and management
-
R.Vuppalanchi, N.Chalasani. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis:selected practical issues in their evaluation and management. Hepatology. 2009;49:306–317.
-
(2009)
Hepatology
, vol.49
, pp. 306-317
-
-
Vuppalanchi, R.1
Chalasani, N.2
-
5
-
-
84888022758
-
Obesity-associated nonalcoholic fatty liver disease
-
Y.Yilmaz, Z.M.Younossi. Obesity-associated nonalcoholic fatty liver disease. Clin Liver Dis. 2014;18:19–31.
-
(2014)
Clin Liver Dis
, vol.18
, pp. 19-31
-
-
Yilmaz, Y.1
Younossi, Z.M.2
-
6
-
-
84902546574
-
World Gastroenterology Organisation global guidelines: nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
-
Review Team, D.R.LaBrecque, Z.Abbas, et al. World Gastroenterology Organisation global guidelines:nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. J Clin Gastroenterol. 2014;48:467–473.• The World Gastroenterology Organisation guidelines on NAFLD/NASH.
-
(2014)
J Clin Gastroenterol
, vol.48
, pp. 467-473
-
-
LaBrecque, D.R.1
Abbas, Z.2
-
7
-
-
84927796763
-
Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management
-
S.McPherson, T.Hardy, E.Henderson, et al. Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies:implications for prognosis and clinical management. J Hepatol. 2015;62:1148–1155.
-
(2015)
J Hepatol
, vol.62
, pp. 1148-1155
-
-
McPherson, S.1
Hardy, T.2
Henderson, E.3
-
8
-
-
84924938800
-
Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies
-
S.Singh, A.M.Allen, Z.Wang, et al. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis:a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol. 2015;13:643–54e1-9; quiz e39–40.
-
(2015)
Clin Gastroenterol Hepatol
, vol.13
-
-
Singh, S.1
Allen, A.M.2
Wang, Z.3
-
9
-
-
33750606061
-
Long-term follow-up of patients with NAFLD and elevated liver enzymes
-
M.Ekstedt, L.E.Franzen, U.L.Mathiesen, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology. 2006;44:865–873.
-
(2006)
Hepatology
, vol.44
, pp. 865-873
-
-
Ekstedt, M.1
Franzen, L.E.2
Mathiesen, U.L.3
-
10
-
-
84866520895
-
Is there any consensus as to what diet or lifestyle approach is the right one for NAFLD patients?
-
C.Finelli, G.Tarantino. Is there any consensus as to what diet or lifestyle approach is the right one for NAFLD patients? J Gastrointestin Liver Dis. 2012;21:293–302.
-
(2012)
J Gastrointestin Liver Dis
, vol.21
, pp. 293-302
-
-
Finelli, C.1
Tarantino, G.2
-
11
-
-
84861901590
-
The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
-
N.Chalasani, Z.Younossi, J.E.Lavine, et al. The diagnosis and management of non-alcoholic fatty liver disease:practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Am J Gastroenterol. 2012;107:811–826.•• The American Association for the Study of Liver Diseases guidelines on NAFLD.
-
(2012)
Am J Gastroenterol
, vol.107
, pp. 811-826
-
-
Chalasani, N.1
Younossi, Z.2
Lavine, J.E.3
-
12
-
-
22344452893
-
The natural history of nonalcoholic fatty liver disease: a population-based cohort study
-
L.A.Adams, J.F.Lymp, J.St Sauver, et al. The natural history of nonalcoholic fatty liver disease:a population-based cohort study. Gastroenterology. 2005;129:113–121.
-
(2005)
Gastroenterology
, vol.129
, pp. 113-121
-
-
Adams, L.A.1
Lymp, J.F.2
St Sauver, J.3
-
13
-
-
70350626532
-
Final results of a long-term, clinical follow-up in fatty liver patients
-
S.Dam-Larsen, U.Becker, M.B.Franzmann, et al. Final results of a long-term, clinical follow-up in fatty liver patients. Scand J Gastroenterol. 2009;44:1236–1243.
-
(2009)
Scand J Gastroenterol
, vol.44
, pp. 1236-1243
-
-
Dam-Larsen, S.1
Becker, U.2
Franzmann, M.B.3
-
14
-
-
50649094716
-
Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study
-
W.Dunn, R.Xu, D.L.Wingard, et al. Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study. Am J Gastroenterol. 2008;103:2263–2271.
-
(2008)
Am J Gastroenterol
, vol.103
, pp. 2263-2271
-
-
Dunn, W.1
Xu, R.2
Wingard, D.L.3
-
15
-
-
77957196987
-
Components of metabolic syndrome are independent predictors of mortality in patients with chronic liver disease: a population-based study
-
M.Stepanova, N.Rafiq, Z.M.Younossi. Components of metabolic syndrome are independent predictors of mortality in patients with chronic liver disease:a population-based study. Gut. 2010;59:1410–1415.
-
(2010)
Gut
, vol.59
, pp. 1410-1415
-
-
Stepanova, M.1
Rafiq, N.2
Younossi, Z.M.3
-
16
-
-
57549107354
-
Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design
-
N.P.Chalasani, A.J.Sanyal, K.V.Kowdley, et al. Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis:PIVENS trial design. Contemp Clin Trials. 2009;30:88–96.
-
(2009)
Contemp Clin Trials
, vol.30
, pp. 88-96
-
-
Chalasani, N.P.1
Sanyal, A.J.2
Kowdley, K.V.3
-
17
-
-
84940573777
-
Recommendations for diagnosis, referral for liver biopsy, and treatment of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
-
E.K.Spengler, R.Loomba. Recommendations for diagnosis, referral for liver biopsy, and treatment of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Mayo Clin Proc. 2015;90:1233–1246.• Review paper on work up and treatment for NAFLD/NASH.
-
(2015)
Mayo Clin Proc
, vol.90
, pp. 1233-1246
-
-
Spengler, E.K.1
Loomba, R.2
-
18
-
-
84929266699
-
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
-
B.A.Neuschwander-Tetri, R.Loomba, A.J.Sanyal, et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT):a multicentre, randomised, placebo-controlled trial. Lancet. 2015;385:956–965.
-
(2015)
Lancet
, vol.385
, pp. 956-965
-
-
Neuschwander-Tetri, B.A.1
Loomba, R.2
Sanyal, A.J.3
-
19
-
-
79959446947
-
Pentoxifylline for the treatment of non-alcoholic steatohepatitis: a randomized controlled trial
-
L.B.Van Wagner, S.W.Koppe, E.M.Brunt, et al. Pentoxifylline for the treatment of non-alcoholic steatohepatitis:a randomized controlled trial. Ann Hepatol. 2011;10:277–286.
-
(2011)
Ann Hepatol
, vol.10
, pp. 277-286
-
-
Van Wagner, L.B.1
Koppe, S.W.2
Brunt, E.M.3
-
20
-
-
84867165316
-
Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism
-
C.O.Zein, R.Lopez, X.Fu, et al. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis:new evidence on the potential therapeutic mechanism. Hepatology. 2012;56:1291–1299.
-
(2012)
Hepatology
, vol.56
, pp. 1291-1299
-
-
Zein, C.O.1
Lopez, R.2
Fu, X.3
-
21
-
-
20044374023
-
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
-
D.E.Kleiner, E.M.Brunt, M.Van Natta, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313–1321.•• Paper on the most validated histological scoring system in NASH.
-
(2005)
Hepatology
, vol.41
, pp. 1313-1321
-
-
Kleiner, D.E.1
Brunt, E.M.2
Van Natta, M.3
-
22
-
-
4043077961
-
Molecular mediators of hepatic steatosis and liver injury
-
J.D.Browning, J.D.Horton. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest. 2004;114:147–152.
-
(2004)
J Clin Invest
, vol.114
, pp. 147-152
-
-
Browning, J.D.1
Horton, J.D.2
-
23
-
-
79959517565
-
Human fatty liver disease: old questions and new insights
-
J.C.Cohen, J.D.Horton, H.H.Hobbs. Human fatty liver disease:old questions and new insights. Science. 2011;332:1519–1523.
-
(2011)
Science
, vol.332
, pp. 1519-1523
-
-
Cohen, J.C.1
Horton, J.D.2
Hobbs, H.H.3
-
24
-
-
84909631649
-
Nonalcoholic fatty liver disease: a comprehensive review of a growing epidemic
-
K.Hassan, V.Bhalla, M.E.El Regal, et al. Nonalcoholic fatty liver disease:a comprehensive review of a growing epidemic. World J Gastroenterol. 2014;20:12082–12101.
-
(2014)
World J Gastroenterol
, vol.20
, pp. 12082-12101
-
-
Hassan, K.1
Bhalla, V.2
El Regal, M.E.3
-
25
-
-
40549135297
-
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
-
C.Postic, J.Girard. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance:lessons from genetically engineered mice. J Clin Invest. 2008;118:829–838.
-
(2008)
J Clin Invest
, vol.118
, pp. 829-838
-
-
Postic, C.1
Girard, J.2
-
26
-
-
2642583241
-
The ins and outs of mitochondrial dysfunction in NASH
-
B.Fromenty, M.A.Robin, A.Igoudjil, et al. The ins and outs of mitochondrial dysfunction in NASH. Diabetes Metab. 2004;30:121–138.
-
(2004)
Diabetes Metab
, vol.30
, pp. 121-138
-
-
Fromenty, B.1
Robin, M.A.2
Igoudjil, A.3
-
27
-
-
82955239838
-
Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
-
N.E.Sunny, E.J.Parks, J.D.Browning, et al. Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab. 2011;14:804–810.
-
(2011)
Cell Metab
, vol.14
, pp. 804-810
-
-
Sunny, N.E.1
Parks, E.J.2
Browning, J.D.3
-
28
-
-
0035084699
-
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
-
A.J.Sanyal, C.Campbell-Sargent, F.Mirshahi, et al. Nonalcoholic steatohepatitis:association of insulin resistance and mitochondrial abnormalities. Gastroenterology. 2001;120:1183–1192.
-
(2001)
Gastroenterology
, vol.120
, pp. 1183-1192
-
-
Sanyal, A.J.1
Campbell-Sargent, C.2
Mirshahi, F.3
-
29
-
-
84930815604
-
Nonalcoholic fatty liver disease: update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine
-
M.Noureddin, J.M.Mato, S.C.Lu. Nonalcoholic fatty liver disease:update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine. Exp Biol Med (Maywood). 2015;240:809–820.• Review paper on the pathogenesis of NAFLD/NASH.
-
(2015)
Exp Biol Med (Maywood)
, vol.240
, pp. 809-820
-
-
Noureddin, M.1
Mato, J.M.2
Lu, S.C.3
-
30
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
-
D.Cai, M.Yuan, D.F.Frantz, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med. 2005;11:183–190.
-
(2005)
Nat Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
-
31
-
-
33646161443
-
Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2
-
J.W.Haukeland, J.K.Damas, Z.Konopski, et al. Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. J Hepatol. 2006;44:1167–1174.
-
(2006)
J Hepatol
, vol.44
, pp. 1167-1174
-
-
Haukeland, J.W.1
Damas, J.K.2
Konopski, Z.3
-
32
-
-
3042744737
-
Beyond insulin resistance in NASH: TNF-alpha or adiponectin?
-
J.M.Hui, A.Hodge, G.C.Farrell, et al. Beyond insulin resistance in NASH:TNF-alpha or adiponectin? Hepatology. 2004;40:46–54.
-
(2004)
Hepatology
, vol.40
, pp. 46-54
-
-
Hui, J.M.1
Hodge, A.2
Farrell, G.C.3
-
33
-
-
0035183475
-
Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
-
J.Crespo, A.Cayon, P.Fernandez-Gil, et al. Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology. 2001;34:1158–1163.
-
(2001)
Hepatology
, vol.34
, pp. 1158-1163
-
-
Crespo, J.1
Cayon, A.2
Fernandez-Gil, P.3
-
34
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
-
M.Yuan, N.Konstantopoulos, J.Lee, et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science. 2001;293:1673–1677.
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
-
35
-
-
84928898387
-
Pathobiology of liver fibrosis: a translational success story
-
Y.A.Lee, M.C.Wallace, S.L.Friedman. Pathobiology of liver fibrosis:a translational success story. Gut. 2015;64:830–841.
-
(2015)
Gut
, vol.64
, pp. 830-841
-
-
Lee, Y.A.1
Wallace, M.C.2
Friedman, S.L.3
-
36
-
-
79952230506
-
Role of toll-like receptors and their downstream molecules in the development of nonalcoholic fatty liver disease
-
K.Miura, E.Seki, H.Ohnishi, et al. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic fatty liver disease. Gastroenterol Res Pract. 2010;2010:362847.
-
(2010)
Gastroenterol Res Pract
, vol.2010
, pp. 362847
-
-
Miura, K.1
Seki, E.2
Ohnishi, H.3
-
37
-
-
47149105036
-
Toll-like receptors and adaptor molecules in liver disease: update
-
E.Seki, D.A.Brenner. Toll-like receptors and adaptor molecules in liver disease:update. Hepatology. 2008;48:322–335.
-
(2008)
Hepatology
, vol.48
, pp. 322-335
-
-
Seki, E.1
Brenner, D.A.2
-
38
-
-
0034320252
-
Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis
-
K.Cope, T.Risby, A.M.Diehl. Increased gastrointestinal ethanol production in obese mice:implications for fatty liver disease pathogenesis. Gastroenterology. 2000;119:1340–1347.
-
(2000)
Gastroenterology
, vol.119
, pp. 1340-1347
-
-
Cope, K.1
Risby, T.2
Diehl, A.M.3
-
39
-
-
0037879075
-
Non-alcoholic fatty liver disease: lumen-liver interactions and possible role for probiotics
-
S.F.Solga, A.M.Diehl. Non-alcoholic fatty liver disease:lumen-liver interactions and possible role for probiotics. J Hepatol. 2003;38:681–687.
-
(2003)
J Hepatol
, vol.38
, pp. 681-687
-
-
Solga, S.F.1
Diehl, A.M.2
-
40
-
-
54549100263
-
Preface. Hepatic fibrosis: pathogenesis, diagnosis, and emerging therapies
-
S.L.Friedman. Preface. Hepatic fibrosis:pathogenesis, diagnosis, and emerging therapies. Clin Liver Dis. 2008;12:xiii–xiv.
-
(2008)
Clin Liver Dis
, vol.12
, pp. xiii-xiv
-
-
Friedman, S.L.1
-
41
-
-
33847367730
-
Liver fibrosis: cellular mechanisms of progression and resolution
-
N.C.Henderson, J.P.Iredale. Liver fibrosis:cellular mechanisms of progression and resolution. Clin Sci (Lond). 2007;112:265–280.
-
(2007)
Clin Sci (Lond)
, vol.112
, pp. 265-280
-
-
Henderson, N.C.1
Iredale, J.P.2
-
42
-
-
83555168507
-
Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis
-
F.Oakley, V.Teoh, A.S.G.Ching, et al. Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis. Gastroenterology. 2009;136(2334–2344):e1.
-
(2009)
Gastroenterology
, vol.136
, Issue.2334-2344
, pp. e1
-
-
Oakley, F.1
Teoh, V.2
Ching, A.S.G.3
-
43
-
-
33644850815
-
Antifibrotic agents for liver disease
-
E.Albanis, S.L.Friedman. Antifibrotic agents for liver disease. Am J Transplant. 2006;6:12–19.
-
(2006)
Am J Transplant
, vol.6
, pp. 12-19
-
-
Albanis, E.1
Friedman, S.L.2
-
44
-
-
33846412916
-
Hepatic fibrosis 2006: report of the third AASLD single topic conference
-
S.L.Friedman, D.C.Rockey, D.M.Bissell. Hepatic fibrosis 2006:report of the third AASLD single topic conference. Hepatology. 2007;45:242–249.
-
(2007)
Hepatology
, vol.45
, pp. 242-249
-
-
Friedman, S.L.1
Rockey, D.C.2
Bissell, D.M.3
-
45
-
-
18044388542
-
Stearoyl-CoA desaturase as a new drug target for obesity treatment
-
A.Dobrzyn, J.M.Ntambi. Stearoyl-CoA desaturase as a new drug target for obesity treatment. Obes Rev. 2005;6:169–174.
-
(2005)
Obes Rev
, vol.6
, pp. 169-174
-
-
Dobrzyn, A.1
Ntambi, J.M.2
-
46
-
-
2342652187
-
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
-
P.Dobrzyn, A.Dobrzyn, M.Miyazaki, et al. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc Natl Acad Sci USA. 2004;101:6409–6414.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 6409-6414
-
-
Dobrzyn, P.1
Dobrzyn, A.2
Miyazaki, M.3
-
47
-
-
56749174738
-
Treatment of preestablished diet-induced fatty liver by oral fatty acid-bile acid conjugates in rodents
-
A.Leikin-Frenkel, I.Goldiner, D.Leikin-Gobbi, et al. Treatment of preestablished diet-induced fatty liver by oral fatty acid-bile acid conjugates in rodents. Eur J Gastroenterol Hepatol. 2008;20:1205–1213.
-
(2008)
Eur J Gastroenterol Hepatol
, vol.20
, pp. 1205-1213
-
-
Leikin-Frenkel, A.1
Goldiner, I.2
Leikin-Gobbi, D.3
-
48
-
-
84918843434
-
The fatty acid-bile acid conjugate aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease
-
R.Safadi, F.M.Konikoff, M.Mahamid, et al. The fatty acid-bile acid conjugate aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2014;12:2085–91 e1.
-
(2014)
Clin Gastroenterol Hepatol
, vol.12
, pp. 2085-91 e1
-
-
Safadi, R.1
Konikoff, F.M.2
Mahamid, M.3
-
49
-
-
84874800718
-
Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology
-
H.Li, J.Zhang, W.Jia. Fibroblast growth factor 21:a novel metabolic regulator from pharmacology to physiology. Front Med. 2013;7:25–30.
-
(2013)
Front Med
, vol.7
, pp. 25-30
-
-
Li, H.1
Zhang, J.2
Jia, W.3
-
50
-
-
80053409251
-
Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes
-
W.Chen, R.L.Hoo, M.Konishi, et al. Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes. J Biol Chem. 2011;286:34559–34566.
-
(2011)
J Biol Chem
, vol.286
, pp. 34559-34566
-
-
Chen, W.1
Hoo, R.L.2
Konishi, M.3
-
51
-
-
80755189417
-
The effects of fibroblast growth factor-21 knockdown and over-expression on its signaling pathway and glucose-lipid metabolism in vitro
-
K.Li, L.Li, M.Yang, et al. The effects of fibroblast growth factor-21 knockdown and over-expression on its signaling pathway and glucose-lipid metabolism in vitro. Mol Cell Endocrinol. 2012;348:21–26.
-
(2012)
Mol Cell Endocrinol
, vol.348
, pp. 21-26
-
-
Li, K.1
Li, L.2
Yang, M.3
-
52
-
-
79960844094
-
The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes
-
Y.Zhang, T.Lei, J.F.Huang, et al. The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes. Mol Cell Endocrinol. 2011;342:41–47.
-
(2011)
Mol Cell Endocrinol
, vol.342
, pp. 41-47
-
-
Zhang, Y.1
Lei, T.2
Huang, J.F.3
-
53
-
-
84921771693
-
The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy
-
J.Liu, Y.Xu, Y.Hu, et al. The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy. Metabolism. 2015;64:380–390.
-
(2015)
Metabolism
, vol.64
, pp. 380-390
-
-
Liu, J.1
Xu, Y.2
Hu, Y.3
-
54
-
-
57349098220
-
Fibroblast growth factor 21 corrects obesity in mice
-
T.Coskun, H.A.Bina, M.A.Schneider, et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology. 2008;149:6018–6027.
-
(2008)
Endocrinology
, vol.149
, pp. 6018-6027
-
-
Coskun, T.1
Bina, H.A.2
Schneider, M.A.3
-
55
-
-
84892721345
-
Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21
-
Y.Li, K.Wong, A.Giles, et al. Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology. 2014;146:539–49 e7.
-
(2014)
Gastroenterology
, vol.146
, pp. 539-49 e7
-
-
Li, Y.1
Wong, K.2
Giles, A.3
-
56
-
-
61649127208
-
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
-
J.Xu, D.J.Lloyd, C.Hale, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes. 2009;58:250–259.
-
(2009)
Diabetes
, vol.58
, pp. 250-259
-
-
Xu, J.1
Lloyd, D.J.2
Hale, C.3
-
57
-
-
84888285959
-
Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
-
B.Staels, A.Rubenstrunk, B.Noel, et al. Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Hepatology. 2013;58:1941–1952.
-
(2013)
Hepatology
, vol.58
, pp. 1941-1952
-
-
Staels, B.1
Rubenstrunk, A.2
Noel, B.3
-
58
-
-
84960140218
-
Elafibranor, an agonist of the peroxisome proliferator-activated receptor-alpha and -delta, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening
-
V.Ratziu, S.A.Harrison, S.Francque, et al. Elafibranor, an agonist of the peroxisome proliferator-activated receptor-alpha and -delta, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening. Gastroenterology. 2016;150:1147–1159 e5.
-
(2016)
Gastroenterology
, vol.150
, pp. 1147-1159 e5
-
-
Ratziu, V.1
Harrison, S.A.2
Francque, S.3
-
59
-
-
53749085064
-
Incretin-based therapies in type 2 diabetes mellitus
-
C.W.Chia, J.M.Egan. Incretin-based therapies in type 2 diabetes mellitus. J Clin Endocrinol Metab. 2008;93:3703–3716.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 3703-3716
-
-
Chia, C.W.1
Egan, J.M.2
-
60
-
-
0027248866
-
Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
-
M.A.Nauck, N.Kleine, C.Orskov, et al. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 1993;36:741–744.
-
(1993)
Diabetologia
, vol.36
, pp. 741-744
-
-
Nauck, M.A.1
Kleine, N.2
Orskov, C.3
-
61
-
-
77956425361
-
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment
-
V.Barry-Hamilton, R.Spangler, D.Marshall, et al. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat Med. 2010;16:1009–1017.
-
(2010)
Nat Med
, vol.16
, pp. 1009-1017
-
-
Barry-Hamilton, V.1
Spangler, R.2
Marshall, D.3
-
62
-
-
84870817823
-
Improved glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists
-
D.J.Cuthbertson, A.Irwin, C.J.Gardner, et al. Improved glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists. PLoS One. 2012;7:e50117.
-
(2012)
PLoS One
, vol.7
, pp. e50117
-
-
Cuthbertson, D.J.1
Irwin, A.2
Gardner, C.J.3
-
63
-
-
79953213304
-
Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice
-
J.Shirakawa, H.Fujii, K.Ohnuma, et al. Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice. Diabetes. 2011;60:1246–1257.
-
(2011)
Diabetes
, vol.60
, pp. 1246-1257
-
-
Shirakawa, J.1
Fujii, H.2
Ohnuma, K.3
-
64
-
-
80052517174
-
Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis
-
G.Svegliati-Baroni, S.Saccomanno, C.Rychlicki, et al. Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis. Liver Int. 2011;31:1285–1297.
-
(2011)
Liver Int
, vol.31
, pp. 1285-1297
-
-
Svegliati-Baroni, G.1
Saccomanno, S.2
Rychlicki, C.3
-
65
-
-
84859763033
-
Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological indices of nonalcoholic steatohepatitis in mice
-
J.L.Trevaskis, P.S.Griffin, C.Wittmer, et al. Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological indices of nonalcoholic steatohepatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2012;302:G762–72.
-
(2012)
Am J Physiol Gastrointest Liver Physiol
, vol.302
, pp. G762-G772
-
-
Trevaskis, J.L.1
Griffin, P.S.2
Wittmer, C.3
-
66
-
-
84957840942
-
Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study
-
M.J.Armstrong, P.Gaunt, G.P.Aithal, et al. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN):a multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet. 2016;387(10019):679–690.
-
(2016)
Lancet
-
-
Armstrong, M.J.1
Gaunt, P.2
Aithal, G.P.3
-
67
-
-
84879090781
-
Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model
-
R.Shimozono, Y.Asaoka, Y.Yoshizawa, et al. Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol Pharmacol. 2013;84:62–70.
-
(2013)
Mol Pharmacol
, vol.84
, pp. 62-70
-
-
Shimozono, R.1
Asaoka, Y.2
Yoshizawa, Y.3
-
68
-
-
84985002523
-
-
65th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), Nov, Boston, MA:
-
W.Kim, J.Sung Lee, C.Kyon Lee, et al. Antisteatotic efficacy and safety of the liver X receptor alpha inhibitor, dithiolethione in patients with nonalcoholic fatty liver disease. 65th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD); 2014 Nov 7–11; Boston, MA.
-
(2014)
Antisteatotic efficacy and safety of the liver X receptor alpha inhibitor, dithiolethione in patients with nonalcoholic fatty liver disease
-
-
Kim, W.1
Sung Lee, J.2
Kyon Lee, C.3
-
69
-
-
84863555133
-
Effects of sitagliptin in diabetic patients with nonalcoholic steatohepatitis
-
Y.Yilmaz, O.Yonal, O.Deyneli, et al. Effects of sitagliptin in diabetic patients with nonalcoholic steatohepatitis. Acta Gastroenterol Belg. 2012;75:240–244.
-
(2012)
Acta Gastroenterol Belg
, vol.75
, pp. 240-244
-
-
Yilmaz, Y.1
Yonal, O.2
Deyneli, O.3
-
70
-
-
84969801284
-
Sitagliptin vs. placebo for nonalcoholic fatty liver disease: a randomized controlled trial
-
J.Cui, L.Philo, P.Nguyen, et al. Sitagliptin vs. placebo for nonalcoholic fatty liver disease:a randomized controlled trial. J Hepatol. 2016;65(2):369–376.
-
(2016)
J Hepatol
-
-
Cui, J.1
Philo, L.2
Nguyen, P.3
-
71
-
-
77950343791
-
Pattern recognition receptors and inflammation
-
O.Takeuchi, S.Akira. Pattern recognition receptors and inflammation. Cell. 2010;140:805–820.
-
(2010)
Cell
, vol.140
, pp. 805-820
-
-
Takeuchi, O.1
Akira, S.2
-
72
-
-
79251563125
-
Current views of toll-like receptor signaling pathways
-
M.Yamamoto, K.Takeda. Current views of toll-like receptor signaling pathways. Gastroenterol Res Pract. 2010;2010:240365.
-
(2010)
Gastroenterol Res Pract
, vol.2010
, pp. 240365
-
-
Yamamoto, M.1
Takeda, K.2
-
73
-
-
34447116244
-
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
-
C.J.Chen, H.Kono, D.Golenbock, et al. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med. 2007;13:851–856.
-
(2007)
Nat Med
, vol.13
, pp. 851-856
-
-
Chen, C.J.1
Kono, H.2
Golenbock, D.3
-
74
-
-
77950275298
-
Circulating mitochondrial DAMPs cause inflammatory responses to injury
-
Q.Zhang, M.Raoof, Y.Chen, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010;464:104–107.
-
(2010)
Nature
, vol.464
, pp. 104-107
-
-
Zhang, Q.1
Raoof, M.2
Chen, Y.3
-
75
-
-
18744399291
-
Toll-like receptor signaling inhibits hepatitis B virus replication in vivo
-
M.Isogawa, M.D.Robek, Y.Furuichi, et al. Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J Virol. 2005;79:7269–7272.
-
(2005)
J Virol
, vol.79
, pp. 7269-7272
-
-
Isogawa, M.1
Robek, M.D.2
Furuichi, Y.3
-
76
-
-
0035865249
-
Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta
-
E.Seki, H.Tsutsui, H.Nakano, et al. Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta. J Immunol. 2001;166:2651–2657.
-
(2001)
J Immunol
, vol.166
, pp. 2651-2657
-
-
Seki, E.1
Tsutsui, H.2
Nakano, H.3
-
77
-
-
75949130109
-
Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific
-
J.Wu, Z.Meng, M.Jiang, et al. Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific. Immunology. 2010;129:363–374.
-
(2010)
Immunology
, vol.129
, pp. 363-374
-
-
Wu, J.1
Meng, Z.2
Jiang, M.3
-
78
-
-
0038185316
-
Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
-
Y.H.Paik, R.F.Schwabe, R.Bataller, et al. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology. 2003;37:1043–1055.
-
(2003)
Hepatology
, vol.37
, pp. 1043-1055
-
-
Paik, Y.H.1
Schwabe, R.F.2
Bataller, R.3
-
79
-
-
35948958955
-
TLR4 enhances TGF-beta signaling and hepatic fibrosis
-
E.Seki, S.De Minicis, C.H.Osterreicher, et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007;13:1324–1332.
-
(2007)
Nat Med
, vol.13
, pp. 1324-1332
-
-
Seki, E.1
De Minicis, S.2
Osterreicher, C.H.3
-
80
-
-
36348997503
-
Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9
-
A.Watanabe, A.Hashmi, D.A.Gomes, et al. Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9. Hepatology. 2007;46:1509–1518.
-
(2007)
Hepatology
, vol.46
, pp. 1509-1518
-
-
Watanabe, A.1
Hashmi, A.2
Gomes, D.A.3
-
81
-
-
84931027253
-
Role of serum toll-like receptors 2 and 4 in non-alcoholic steatohepatitis and liver fibrosis
-
M.Cengiz, S.Ozenirler, S.Elbeg. Role of serum toll-like receptors 2 and 4 in non-alcoholic steatohepatitis and liver fibrosis. J Gastroenterol Hepatol. 2015;30:1190–1196.
-
(2015)
J Gastroenterol Hepatol
, vol.30
, pp. 1190-1196
-
-
Cengiz, M.1
Ozenirler, S.2
Elbeg, S.3
-
82
-
-
79954523464
-
Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice
-
T.Csak, A.Velayudham, I.Hritz, et al. Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. 2011;300:G433–41.
-
(2011)
Am J Physiol Gastrointest Liver Physiol
, vol.300
, pp. G433-G441
-
-
Csak, T.1
Velayudham, A.2
Hritz, I.3
-
83
-
-
33845901507
-
Microbial ecology: human gut microbes associated with obesity
-
R.E.Ley, P.J.Turnbaugh, S.Klein, et al. Microbial ecology:human gut microbes associated with obesity. Nature. 2006;444:1022–1023.
-
(2006)
Nature
, vol.444
, pp. 1022-1023
-
-
Ley, R.E.1
Turnbaugh, P.J.2
Klein, S.3
-
84
-
-
69949111703
-
The core gut microbiome, energy balance and obesity
-
P.J.Turnbaugh, J.I.Gordon. The core gut microbiome, energy balance and obesity. J Physiol. 2009;587:4153–4158.
-
(2009)
J Physiol
, vol.587
, pp. 4153-4158
-
-
Turnbaugh, P.J.1
Gordon, J.I.2
-
85
-
-
68949148889
-
Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
-
L.Miele, V.Valenza, G.La Torre, et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology. 2009;49:1877–1887.
-
(2009)
Hepatology
, vol.49
, pp. 1877-1887
-
-
Miele, L.1
Valenza, V.2
La Torre, G.3
-
86
-
-
79960299110
-
Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms
-
A.Iacono, G.M.Raso, R.B.Canani, et al. Probiotics as an emerging therapeutic strategy to treat NAFLD:focus on molecular and biochemical mechanisms. J Nutr Biochem. 2011;22:699–711.
-
(2011)
J Nutr Biochem
, vol.22
, pp. 699-711
-
-
Iacono, A.1
Raso, G.M.2
Canani, R.B.3
-
87
-
-
80054873943
-
Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial
-
R.Aller, D.A.De Luis, O.Izaola, et al. Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients:a double blind randomized clinical trial. Eur Rev Med Pharmacol Sci. 2011;15:1090–1095.
-
(2011)
Eur Rev Med Pharmacol Sci
, vol.15
, pp. 1090-1095
-
-
Aller, R.1
De Luis, D.A.2
Izaola, O.3
-
88
-
-
84856763599
-
Bifidobacterium longum with fructo-oligosaccharides in patients with non alcoholic steatohepatitis
-
M.Malaguarnera, M.Vacante, T.Antic, et al. Bifidobacterium longum with fructo-oligosaccharides in patients with non alcoholic steatohepatitis. Dig Dis Sci. 2012;57:545–553.
-
(2012)
Dig Dis Sci
, vol.57
, pp. 545-553
-
-
Malaguarnera, M.1
Vacante, M.2
Antic, T.3
-
89
-
-
84896818656
-
Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study
-
T.Eslamparast, H.Poustchi, F.Zamani, et al. Synbiotic supplementation in nonalcoholic fatty liver disease:a randomized, double-blind, placebo-controlled pilot study. Am J Clin Nutr. 2014;99:535–542.
-
(2014)
Am J Clin Nutr
, vol.99
, pp. 535-542
-
-
Eslamparast, T.1
Poustchi, H.2
Zamani, F.3
-
90
-
-
77954595517
-
Mechanisms of action and clinical application of macrolides as immunomodulatory medications
-
S.Kanoh, B.K.Rubin. Mechanisms of action and clinical application of macrolides as immunomodulatory medications. Clin Microbiol Rev. 2010;23:590–615.
-
(2010)
Clin Microbiol Rev
, vol.23
, pp. 590-615
-
-
Kanoh, S.1
Rubin, B.K.2
-
91
-
-
84875413952
-
A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-kappaB inhibition
-
Y.Kobayashi, H.Wada, C.Rossios, et al. A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-kappaB inhibition. J Pharmacol Exp Ther. 2013;345:76–84.
-
(2013)
J Pharmacol Exp Ther
, vol.345
, pp. 76-84
-
-
Kobayashi, Y.1
Wada, H.2
Rossios, C.3
-
92
-
-
85016142798
-
Anti-NASH effects of solithromycin in NASH-HCC mouse model
-
P.Fernandes, T.Hashiguchi, M.Fujii, et al. Anti-NASH effects of solithromycin in NASH-HCC mouse model. Gastroenterology. 2014;146:S–145.
-
(2014)
Gastroenterology
, vol.146
, pp. 145
-
-
Fernandes, P.1
Hashiguchi, T.2
Fujii, M.3
-
93
-
-
84881175910
-
1alpha,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the beta-catenin pathway
-
Y.J.Jiang, A.E.Teichert, F.Fong, et al. 1alpha,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the beta-catenin pathway. J Steroid Biochem Mol Biol. 2013;136:229–232.
-
(2013)
J Steroid Biochem Mol Biol
, vol.136
, pp. 229-232
-
-
Jiang, Y.J.1
Teichert, A.E.2
Fong, F.3
-
94
-
-
84901022347
-
Impact of vitamin D on immune function: lessons learned from genome-wide analysis
-
R.F.Chun, P.T.Liu, R.L.Modlin, et al. Impact of vitamin D on immune function:lessons learned from genome-wide analysis. Front Physiol. 2014;5:151.
-
(2014)
Front Physiol
, vol.5
, pp. 151
-
-
Chun, R.F.1
Liu, P.T.2
Modlin, R.L.3
-
95
-
-
0242417170
-
Identification of a vitamin D response element in the human insulin receptor gene promoter
-
B.Maestro, N.Davila, M.C.Carranza, et al. Identification of a vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Mol Biol. 2003;84:223–230.
-
(2003)
J Steroid Biochem Mol Biol
, vol.84
, pp. 223-230
-
-
Maestro, B.1
Davila, N.2
Carranza, M.C.3
-
96
-
-
0037364216
-
Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor
-
U.Zeitz, K.Weber, D.W.Soegiarto, et al. Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J. 2003;17:509–511.
-
(2003)
FASEB J
, vol.17
, pp. 509-511
-
-
Zeitz, U.1
Weber, K.2
Soegiarto, D.W.3
-
97
-
-
34447514029
-
Vitamin D deficiency
-
M.F.Holick. Vitamin D deficiency. N Engl J Med. 2007;357:266–281.
-
(2007)
N Engl J Med
, vol.357
, pp. 266-281
-
-
Holick, M.F.1
-
99
-
-
84876928036
-
A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response
-
N.Ding, R.T.Yu, N.Subramaniam, et al. A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Cell. 2013;153:601–613.
-
(2013)
Cell
, vol.153
, pp. 601-613
-
-
Ding, N.1
Yu, R.T.2
Subramaniam, N.3
-
100
-
-
79960445022
-
Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats
-
T.Nakano, Y.F.Cheng, C.Y.Lai, et al. Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats. J Hepatol. 2011;55:415–425.
-
(2011)
J Hepatol
, vol.55
, pp. 415-425
-
-
Nakano, T.1
Cheng, Y.F.2
Lai, C.Y.3
-
101
-
-
84879735651
-
Meta-analysis: vitamin D and non-alcoholic fatty liver disease
-
M.Eliades, E.Spyrou, N.Agrawal, et al. Meta-analysis:vitamin D and non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2013;38:246–254.
-
(2013)
Aliment Pharmacol Ther
, vol.38
, pp. 246-254
-
-
Eliades, M.1
Spyrou, E.2
Agrawal, N.3
-
102
-
-
84906940023
-
Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? A randomized clinical trial
-
N.Sharifi, R.Amani, E.Hajiani, et al. Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? A randomized clinical trial. Endocrine. 2014;47:70–80.
-
(2014)
Endocrine
, vol.47
, pp. 70-80
-
-
Sharifi, N.1
Amani, R.2
Hajiani, E.3
-
104
-
-
0347319575
-
Immunomodulation by polyunsaturated fatty acids: mechanisms and effects
-
T.M.Stulnig. Immunomodulation by polyunsaturated fatty acids:mechanisms and effects. Int Arch Allergy Immunol. 2003;132:310–321.
-
(2003)
Int Arch Allergy Immunol
, vol.132
, pp. 310-321
-
-
Stulnig, T.M.1
-
105
-
-
0028707020
-
The metabolism and availability of essential fatty acids in animal and human tissues
-
J.Bezard, J.P.Blond, A.Bernard, et al. The metabolism and availability of essential fatty acids in animal and human tissues. Reprod Nutr Dev. 1994;34:539–568.
-
(1994)
Reprod Nutr Dev
, vol.34
, pp. 539-568
-
-
Bezard, J.1
Blond, J.P.2
Bernard, A.3
-
106
-
-
33645689650
-
Biological significance of essential fatty acids
-
U.N.Das. Biological significance of essential fatty acids. J Assoc Physicians India. 2006;54:309–319.
-
(2006)
J Assoc Physicians India
, vol.54
, pp. 309-319
-
-
Das, U.N.1
-
107
-
-
1542410333
-
Dietary n-3 polyunsaturated fatty acids decrease hepatic triglycerides in Fischer 344 rats
-
J.R.Levy, J.N.Clore, W.Stevens. Dietary n-3 polyunsaturated fatty acids decrease hepatic triglycerides in Fischer 344 rats. Hepatology. 2004;39:608–616.
-
(2004)
Hepatology
, vol.39
, pp. 608-616
-
-
Levy, J.R.1
Clore, J.N.2
Stevens, W.3
-
108
-
-
0345448923
-
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression
-
M.Sekiya, N.Yahagi, T.Matsuzaka, et al. Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression. Hepatology. 2003;38:1529–1539.
-
(2003)
Hepatology
, vol.38
, pp. 1529-1539
-
-
Sekiya, M.1
Yahagi, N.2
Matsuzaka, T.3
-
109
-
-
33947261702
-
Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c
-
M.Teran-Garcia, A.W.Adamson, G.Yu, et al. Polyunsaturated fatty acid suppression of fatty acid synthase (FASN):evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c. Biochem J. 2007;402:591–600.
-
(2007)
Biochem J
, vol.402
, pp. 591-600
-
-
Teran-Garcia, M.1
Adamson, A.W.2
Yu, G.3
-
110
-
-
0032699670
-
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
-
S.Kersten, J.Seydoux, J.M.Peters, et al. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest. 1999;103:1489–1498.
-
(1999)
J Clin Invest
, vol.103
, pp. 1489-1498
-
-
Kersten, S.1
Seydoux, J.2
Peters, J.M.3
-
111
-
-
78349257835
-
Plasma phospholipids n-3 polyunsaturated fatty acid is associated with metabolic syndrome
-
T.Huang, S.Bhulaidok, Z.Cai, et al. Plasma phospholipids n-3 polyunsaturated fatty acid is associated with metabolic syndrome. Mol Nutr Food Res. 2010;54:1628–1635.
-
(2010)
Mol Nutr Food Res
, vol.54
, pp. 1628-1635
-
-
Huang, T.1
Bhulaidok, S.2
Cai, Z.3
-
112
-
-
0001731679
-
Changes in tissue lipids and tissue histology resulting from essential fatty acid deficiency in rats
-
R.B.Alfin-Slater, S.Bernick. Changes in tissue lipids and tissue histology resulting from essential fatty acid deficiency in rats. Am J Clin Nutr. 1958;6:613–624.
-
(1958)
Am J Clin Nutr
, vol.6
, pp. 613-624
-
-
Alfin-Slater, R.B.1
Bernick, S.2
-
113
-
-
1942487764
-
Treatment of EFA deficiency with dietary triglycerides or phospholipids in a murine model of extrahepatic cholestasis
-
A.Werner, R.Havinga, F.Kuipers, et al. Treatment of EFA deficiency with dietary triglycerides or phospholipids in a murine model of extrahepatic cholestasis. Am J Physiol Gastrointest Liver Physiol. 2004;286:G822–G832.
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.286
, pp. G822-G832
-
-
Werner, A.1
Havinga, R.2
Kuipers, F.3
-
114
-
-
14944342635
-
Omega-3 fatty acids improve hepatic steatosis in a murine model: potential implications for the marginal steatotic liver donor
-
I.P.Alwayn, C.Andersson, B.Zauscher, et al. Omega-3 fatty acids improve hepatic steatosis in a murine model:potential implications for the marginal steatotic liver donor. Transplantation. 2005;79:606–608.
-
(2005)
Transplantation
, vol.79
, pp. 606-608
-
-
Alwayn, I.P.1
Andersson, C.2
Zauscher, B.3
-
115
-
-
84867706295
-
S-adenosylmethionine in liver health, injury, and cancer
-
S.C.Lu, J.M.Mato. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012;92:1515–1542.
-
(2012)
Physiol Rev
, vol.92
, pp. 1515-1542
-
-
Lu, S.C.1
Mato, J.M.2
-
116
-
-
84885581366
-
S-adenosylmethionine metabolism and liver disease
-
J.M.Mato, M.L.Martinez-Chantar, S.C.Lu. S-adenosylmethionine metabolism and liver disease. Ann Hepatol. 2013;12:183–189.
-
(2013)
Ann Hepatol
, vol.12
, pp. 183-189
-
-
Mato, J.M.1
Martinez-Chantar, M.L.2
Lu, S.C.3
-
117
-
-
34248653254
-
Role of S-adenosyl-L-methionine in liver health and injury
-
J.M.Mato, S.C.Lu. Role of S-adenosyl-L-methionine in liver health and injury. Hepatology. 2007;45:1306–1312.
-
(2007)
Hepatology
, vol.45
, pp. 1306-1312
-
-
Mato, J.M.1
Lu, S.C.2
-
118
-
-
0036828353
-
S-Adenosyl-L-methionine (SAMe): from the bench to the bedside–molecular basis of a pleiotrophic molecule
-
T.Bottiglieri. S-Adenosyl-L-methionine (SAMe):from the bench to the bedside–molecular basis of a pleiotrophic molecule. Am J Clin Nutr. 2002;76:1151S–7S.
-
(2002)
Am J Clin Nutr
, vol.76
, pp. 1S-7S
-
-
Bottiglieri, T.1
-
119
-
-
33646121972
-
The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis
-
Z.Li, L.B.Agellon, T.M.Allen, et al. The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. Cell Metab. 2006;3:321–331.
-
(2006)
Cell Metab
, vol.3
, pp. 321-331
-
-
Li, Z.1
Agellon, L.B.2
Allen, T.M.3
-
120
-
-
0344867846
-
S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial
-
J.M.Mato, J.Camara, J.Fernandez de Paz, et al. S-adenosylmethionine in alcoholic liver cirrhosis:a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol. 1999;30:1081–1089.
-
(1999)
J Hepatol
, vol.30
, pp. 1081-1089
-
-
Mato, J.M.1
Camara, J.2
Fernandez de Paz, J.3
-
121
-
-
84906558405
-
Significant anti-fibrotic activity of cenicriviroc, a dual CCR2/CCR5 antagonist, in a rat model of thioacetamide- induced liver fibrosis and cirrhosis
-
F.Hong, H.Chou, S.L.Friedman. Significant anti-fibrotic activity of cenicriviroc, a dual CCR2/CCR5 antagonist, in a rat model of thioacetamide- induced liver fibrosis and cirrhosis. Hepatology. 2013;58:1381A–1382A.
-
(2013)
Hepatology
, vol.58
, pp. 1381A-1382A
-
-
Hong, F.1
Chou, H.2
Friedman, S.L.3
-
122
-
-
84928184342
-
Anti-fibrotic and anti-inflammatory activity of the dual CCR2 and CCR5 antagonist cenicriviroc in a mouse model of NASH
-
E.Lefebvre, T.Hashiguchi, H.Jenkins, et al. Anti-fibrotic and anti-inflammatory activity of the dual CCR2 and CCR5 antagonist cenicriviroc in a mouse model of NASH. Hepatology. 2013;58:221A–222A.
-
(2013)
Hepatology
, vol.58
, pp. 221A-222A
-
-
Lefebvre, E.1
Hashiguchi, T.2
Jenkins, H.3
-
123
-
-
80052695709
-
When galectins recognize glycans: from biochemistry to physiology and back again
-
S.Di Lella, V.Sundblad, J.P.Cerliani, et al. When galectins recognize glycans:from biochemistry to physiology and back again. Biochemistry. 2011;50:7842–7857.
-
(2011)
Biochemistry
, vol.50
, pp. 7842-7857
-
-
Di Lella, S.1
Sundblad, V.2
Cerliani, J.P.3
-
125
-
-
67649831425
-
The regulation of inflammation by galectin-3
-
N.C.Henderson, T.Sethi. The regulation of inflammation by galectin-3. Immunol Rev. 2009;230:160–171.
-
(2009)
Immunol Rev
, vol.230
, pp. 160-171
-
-
Henderson, N.C.1
Sethi, T.2
-
127
-
-
84857881755
-
Regulation of transforming growth factor-beta1-driven lung fibrosis by galectin-3
-
A.C.Mackinnon, M.A.Gibbons, S.L.Farnworth, et al. Regulation of transforming growth factor-beta1-driven lung fibrosis by galectin-3. Am J Respir Crit Care Med. 2012;185:537–546.
-
(2012)
Am J Respir Crit Care Med
, vol.185
, pp. 537-546
-
-
Mackinnon, A.C.1
Gibbons, M.A.2
Farnworth, S.L.3
-
128
-
-
84927788389
-
Early phase 1 clinical trial results of GR-MD-02, a galectin-3 inhibitor, in patients having non-alcoholic steatohepatitis (NASH) with advanced fibrosis
-
S.A.Harrison, N.P.Chalasani, E.Lawitz, et al. Early phase 1 clinical trial results of GR-MD-02, a galectin-3 inhibitor, in patients having non-alcoholic steatohepatitis (NASH) with advanced fibrosis. Hepatology. 2014;60:224A–227A.
-
(2014)
Hepatology
, vol.60
, pp. 224A-227A
-
-
Harrison, S.A.1
Chalasani, N.P.2
Lawitz, E.3
-
129
-
-
84984947888
-
Alpha-2 macroglobulin is the simplest serum biomarker for liver fibrosis and fibrogenesis in chronic hepatitis C
-
E.Atanasova, F.Martinova, D.Jelev, et al. Alpha-2 macroglobulin is the simplest serum biomarker for liver fibrosis and fibrogenesis in chronic hepatitis C. Medinform. 2015;2:153–164.
-
(2015)
Medinform
, vol.2
, pp. 153-164
-
-
Atanasova, E.1
Martinova, F.2
Jelev, D.3
-
130
-
-
0141717238
-
Angiotensin-II induces the tissue inhibitor of metalloproteinases-1 through the protein kinase-C signaling pathway in rat liver fibrosis development
-
H.Yoshiji, S.Kuriyama, J.Yoshii, et al. Angiotensin-II induces the tissue inhibitor of metalloproteinases-1 through the protein kinase-C signaling pathway in rat liver fibrosis development. Hepatol Res. 2003;27:51–56.
-
(2003)
Hepatol Res
, vol.27
, pp. 51-56
-
-
Yoshiji, H.1
Kuriyama, S.2
Yoshii, J.3
-
132
-
-
34250323865
-
Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis
-
A.Hirose, M.Ono, T.Saibara, et al. Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis. Hepatology. 2007;45:1375–1381.
-
(2007)
Hepatology
, vol.45
, pp. 1375-1381
-
-
Hirose, A.1
Ono, M.2
Saibara, T.3
-
133
-
-
7044222556
-
Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis
-
S.Yokohama, M.Yoneda, M.Haneda, et al. Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis. Hepatology. 2004;40:1222–1225.
-
(2004)
Hepatology
, vol.40
, pp. 1222-1225
-
-
Yokohama, S.1
Yoneda, M.2
Haneda, M.3
-
135
-
-
84896315255
-
Simtuzumab, an antifibrotic monoclonal antibody against lysyl oxidase-like 2 (LOXL2) enzyme, appears safe and well tolerated in patients with liver disease of diverse etiology
-
A.H.Talal, M.Feron-Rigodon, J.Madere, et al. Simtuzumab, an antifibrotic monoclonal antibody against lysyl oxidase-like 2 (LOXL2) enzyme, appears safe and well tolerated in patients with liver disease of diverse etiology. J Hepatol. 2013;58:S532.
-
(2013)
J Hepatol
, vol.58
, pp. S532
-
-
Talal, A.H.1
Feron-Rigodon, M.2
Madere, J.3
-
136
-
-
84856400671
-
A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis
-
V.Ratziu, M.Y.Sheikh, A.J.Sanyal, et al. A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis. Hepatology. 2012;55:419–428.
-
(2012)
Hepatology
, vol.55
, pp. 419-428
-
-
Ratziu, V.1
Sheikh, M.Y.2
Sanyal, A.J.3
-
137
-
-
77955852465
-
Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis
-
Q.M.Anstee, D.Concas, H.Kudo, et al. Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis. J Hepatol. 2010;53:542–550.
-
(2010)
J Hepatol
, vol.53
, pp. 542-550
-
-
Anstee, Q.M.1
Concas, D.2
Kudo, H.3
-
138
-
-
84922708241
-
The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis
-
F.J.Barreyro, S.Holod, P.V.Finocchietto, et al. The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis. Liver Int. 2015;35:953–966.
-
(2015)
Liver Int
, vol.35
, pp. 953-966
-
-
Barreyro, F.J.1
Holod, S.2
Finocchietto, P.V.3
-
139
-
-
84984984079
-
-
International Liver Congress 2015, the 50th Annual Meeting of the European Association for the Study of the Liver (EASL), Apr, Vienna, Austria:
-
M.Shiffman, B.Freilich, R.Vuppalanchi, et al. A placebo-controlled, multicenter, double-blind, randomised trial of emricasan (IDN-6556) in subjects with non-alcoholic fatty liver disease (NAFLD) and raised transaminases. International Liver Congress 2015, the 50th Annual Meeting of the European Association for the Study of the Liver (EASL); 2015 Apr 22–26; Vienna, Austria.
-
(2015)
A placebo-controlled, multicenter, double-blind, randomised trial of emricasan (IDN-6556) in subjects with non-alcoholic fatty liver disease (NAFLD) and raised transaminases
-
-
Shiffman, M.1
Freilich, B.2
Vuppalanchi, R.3
-
140
-
-
84888298670
-
Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials
-
M.Noureddin, J.Lam, M.R.Peterson, et al. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology. 2013;58:1930–1940.• Study on noninvasive methods to quantify liver fat through MRI.
-
(2013)
Hepatology
, vol.58
, pp. 1930-1940
-
-
Noureddin, M.1
Lam, J.2
Peterson, M.R.3
-
141
-
-
84911948591
-
Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study
-
R.Loomba, T.Wolfson, B.Ang, et al. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease:a prospective study. Hepatology. 2014;60:1920–1928.• Study on noninvasive methods to quantify liver fibrosis through MRI.
-
(2014)
Hepatology
, vol.60
, pp. 1920-1928
-
-
Loomba, R.1
Wolfson, T.2
Ang, B.3
-
142
-
-
84963739666
-
Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis
-
M.Noureddin, Q.M.Anstee, R.Loomba. Review article:emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis. Aliment Pharmacol Ther. 2016;43:1109–1123.
-
(2016)
Aliment Pharmacol Ther
, vol.43
, pp. 1109-1123
-
-
Noureddin, M.1
Anstee, Q.M.2
Loomba, R.3
-
143
-
-
84939268765
-
Statin use and non-alcoholic steatohepatitis in at risk individuals
-
P.Dongiovanni, S.Petta, V.Mannisto, et al. Statin use and non-alcoholic steatohepatitis in at risk individuals. J Hepatol. 2015;63:705–712.
-
(2015)
J Hepatol
, vol.63
, pp. 705-712
-
-
Dongiovanni, P.1
Petta, S.2
Mannisto, V.3
-
144
-
-
84936806639
-
Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome
-
K.Kargiotis, V.G.Athyros, O.Giouleme, et al. Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome. World J Gastroenterol. 2015;21:7860–7868.
-
(2015)
World J Gastroenterol
, vol.21
, pp. 7860-7868
-
-
Kargiotis, K.1
Athyros, V.G.2
Giouleme, O.3
-
145
-
-
84886254094
-
Effect of intensive lipid lowering with atorvastatin on cardiovascular outcomes in coronary heart disease patients with mild-to-moderate baseline elevations in alanine aminotransferase levels
-
M.J.Tikkanen, R.Fayyad, O.Faergeman, et al. Effect of intensive lipid lowering with atorvastatin on cardiovascular outcomes in coronary heart disease patients with mild-to-moderate baseline elevations in alanine aminotransferase levels. Int J Cardiol. 2013;168:3846–3852.
-
(2013)
Int J Cardiol
, vol.168
, pp. 3846-3852
-
-
Tikkanen, M.J.1
Fayyad, R.2
Faergeman, O.3
-
146
-
-
78649890465
-
Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis
-
V.G.Athyros, K.Tziomalos, T.D.Gossios, et al. Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study:a post-hoc analysis. Lancet. 2010;376:1916–1922.
-
(2010)
Lancet
, vol.376
, pp. 1916-1922
-
-
Athyros, V.G.1
Tziomalos, K.2
Gossios, T.D.3
|