Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

PLoS Pathogens

Volumn 12, Issue 8, 2016, Pages

  Lim, Siew Pheng ^a   Noble, Christian Guy ^a   Seh, Cheah Chen ^a   Soh, Tingjin Sherryl ^a,b   El Sahili, Abbas ^b   Chan, Grace Kar Yarn ^b   Lescar, Julien ^b,c   Arora, Rishi ^d   Benson, Timothy ^d   Nilar, Shahul ^a   Manjunatha, Ujjini ^a   Wan, Kah Fei ^a   Dong, Hongping ^a   Xie, Xuping ^a,e   Shi, Pei Yong ^a,e   Yokokawa, Fumiaki ^a  

^a NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^e University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NONSTRUCTURAL PROTEIN 5; RNA DIRECTED RNA POLYMERASE; ANTIVIRUS AGENT; NS5 PROTEIN, DENGUE VIRUS; NUCLEIC ACID SYNTHESIS INHIBITOR; VIRAL PROTEIN;

ALLOSTERISM; ANTIVIRAL THERAPY; ARTICLE; BINDING AFFINITY; BIOCHEMICAL ANALYSIS; CC50; CONTROLLED STUDY; DENGUE VIRUS; EC50; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION ASSAY; FLAVIVIRUS; GENE EXPRESSION; IC50; LUCIFERASE ASSAY; NONHUMAN; PROTEIN EXPRESSION; REVERSE GENETICS; VIRUS MORPHOLOGY; VIRUS REPLICATION; X RAY CRYSTALLOGRAPHY; ZIKA VIRUS; A-549 CELL LINE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DENGUE; DRUG DESIGN; DRUG EFFECTS; HUMAN; PROTEIN DOMAIN; SURFACE PLASMON RESONANCE;

A549 CELLS; ANTIVIRAL AGENTS; CRYSTALLOGRAPHY, X-RAY; DENGUE; DENGUE VIRUS; DRUG DESIGN; HUMANS; NUCLEIC ACID SYNTHESIS INHIBITORS; PROTEIN DOMAINS; RNA REPLICASE; SURFACE PLASMON RESONANCE; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84984824834     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005737     Document Type: Article

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