Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2′-O methyltransferase activity in dengue virus

Virology

Volumn 402, Issue 1, 2010, Pages 52-60

  Chung, Ka Yan ^a,b   Dong, Hongping ^a   Chao, Alexander Theodore ^a   Shi, Pei Yong ^a   Lescar, Julien ^b   Lim, Siew Pheng ^a  

^a NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

Dengue; Methyltransferase; Processivity; Steady state kinetic parameters

Indexed keywords

2' O METHYLTRANSFERASE; METHYLTRANSFERASE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SINEFUNGIN; UNCLASSIFIED DRUG; VIRUS RNA; ADENOSINE; DRUG DERIVATIVE; ENZYME INHIBITOR; MRNA (GUANINE(N7)) METHYLTRANSFERASE; MRNA (GUANINE(N7))-METHYLTRANSFERASE; MRNA (NUCLEOSIDE O(2')) METHYLTRANSFERASE; MRNA (NUCLEOSIDE-O(2'))-METHYLTRANSFERASE; RNA; VIRUS PROTEIN;

5' UNTRANSLATED REGION; ARTICLE; CATALYSIS; CONTROLLED STUDY; DENGUE VIRUS; DISSOCIATION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; FLAVIVIRUS; IC 50; MICHAELIS CONSTANT; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN METHYLATION; RNA SEQUENCE; SEQUENCE ANALYSIS; STEADY STATE; TURNOVER TIME; ANIMAL; DRUG ANTAGONISM; ENZYMOLOGY; KINETICS; METABOLISM; METHYLATION;

DENGUE VIRUS; FLAVIVIRUS;

ADENOSINE; ANIMALS; DENGUE VIRUS; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; KINETICS; METHYLATION; METHYLTRANSFERASES; RNA; S-ADENOSYLMETHIONINE; VIRAL PROTEINS;

EID: 77952571994     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2010.03.011     Document Type: Article

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