Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

Journal of Medicinal Chemistry

Volumn 59, Issue 8, 2016, Pages 3935-3952

  Yokokawa, Fumiaki ^a   Nilar, Shahul ^a   Noble, Christian G ^a   Lim, Siew Pheng ^a   Rao, Ranga ^a   Tania, Stefani ^a   Wang, Gang ^a   Lee, Gladys ^a   Hunziker, Jürg ^a   Karuna, Ratna ^a   Manjunatha, Ujjini ^a   Shi, Pei Yong ^a,b   Smith, Paul W ^a  

^a NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 (5 (3 HYDROXYPROP 1 YN 1 YL) THIOPHEN 2 YL) 4 METHOXYPHENYL)ACETIC ACID; 2,2' (5 (5 (3 HYDROXYPROP 1 YN 1 YL)THIOPHEN 2 YL) 1,3 PHENYLENE)DIACETIC ACID; 2,2' (5 (5 (4 HYDROXYBUT 1 YN 1 YL)THIOPHEN 2 YL) 1,3 PHENYLENE)DIACETIC ACID; 2,2' (5 (5 BROMOTHIOPHEN 2 YL) 1,3 PHENYLENE)DIACETIC ACID; 2,2' (5 (5 CHLOROTHIOPHEN 2 YL) 1,3 PHENYLENE)DIACETIC ACID; 2,2' (5 (5 CYANOTHIOPHEN 2 YL) 1,3 PHENYLENE)DIACETIC ACID; 2,2' (5 (5 METHYLTHIOPHEN 2 YL) 1,3 PHENYLENE)DIACETIC ACID; 2,2' (5 (FURAN 2 YL) 1,3 PHENYLENE)DIACETIC ACID; 2,2' (5 (THIOPHENYL 2 YL) 1,3 PHENYLENE)DIACETIC ACID; 2,2' [(1,1' BIPHENYL) 3,5 DIYL]DIACETIC ACID; 2,2' [2' CHLORO (1,1' BIPHENYL) 3,5 DIYL]DIACETIC ACID; 2,2' [3' CHLORO (1,1' BIPHENYL) 3,5 DIYL]DIACETIC ACID; 2,2' [4' CHLORO (1,1' BIPHENYL) 3,5 DIYL]DIACETIC ACID; 3 (5 (2 METHOXY 5 (1H TETRAZOL 5 YL)PHENYL)THIOPHEN 2 YL)PROP 2 YN 1 OL; 3 (5 (3 HYDROXYPROP 1 YN 1 YL)THIOPHEN 2 YL) 4 METHOXYBENZOIC ACID; 3 (5 (5 (1H IMIDAZOL 2 YL) 2 METHOXY 4 METHYLPHENYL)THIOPHEN 2 YL)PROP 2 YN 1 OL; 3 (5 (5 (3 HYDROXYPROP 1 YN 1 YL)THIOPHEN 2 YL) 4 METHOXY 2 METHYLPHENYL) 1,2,4 OXADIAZOL 5 (4H) ONE; 4 CHLORO 5 (5 (3 HYDROXYPROP 1 YN 1 YL)THIOPHEN 2 YL) 2 METHOXY N ((3 METHOXYPHENYL)SULFONYL)BENZAMIDE; 5 (5 (3 HYDROXYPROP 1 YN 1 YL)THIOPHEN 2 YL) 2,4 DIMETHOXY N ((3 METHOXYPHENYL)SULFONYL)BENZAMIDE; 5 (5 (3 HYDROXYPROP 1 YN 1 YL)THIOPHEN 2 YL) 2,4 DIMETHOXY N (PHENYLSULFONYL)BENZAMIDE; 5 (5 (3 HYDROXYPROP 1 YN 1 YL)THIOPHEN 2 YL) 4 METHOXY 2 METHYL N (PHENYLSULFONYL)BENZAMIDE; 5 (5 (3 HYDROXYPROP 1 YN 1 YL)THIOPHEN 2 YL) 4 METHOXY 2 METHYL N (QUINOLIN 8 YLSULFONYL)BENZAMIDE; 5 (5 (3 HYDROXYPROP 1 YN 1 YL)THIOPHEN 2 YL) 4 METHOXY 2 METHYLBENZOIC ACID; ANTIVIRUS AGENT; N ((5 (5 (3 HYDROXYPROP 1 YN 1 YL)THIOPHEN 2 YL) 4 METHOXY 2 METHYLPHENYL)SULFONYL)ACETAMIDE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RNA DIRECTED RNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; RNA DIRECTED RNA POLYMERASE;

ANTIVIRAL ACTIVITY; ARTICLE; DENGUE VIRUS 1; DENGUE VIRUS 2; DENGUE VIRUS 3; DENGUE VIRUS 4; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; EC50; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; IC50; IN VITRO STUDY; NONHUMAN; PHYSICAL CHEMISTRY; PROCESS OPTIMIZATION; SEROTYPE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CALORIMETRY; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DENGUE VIRUS; ENZYMOLOGY; HUMAN; SURFACE PLASMON RESONANCE;

ANTIVIRAL AGENTS; CALORIMETRY; CELL LINE; DENGUE VIRUS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; RNA REPLICASE; SURFACE PLASMON RESONANCE;

EID: 84966264850     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b00143     Document Type: Article

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