Diminished anabolic signaling response to insulin induced by intramuscular lipid accumulation is associated with inflammation in aging but not obesity

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 310, Issue 7, 2016, Pages R561-R569

  Rivas, Donato A ^a   McDonald, Devin J ^a   Rice, Nicholas P ^a   Haran, Prashanth H ^a   Dolnikowski, Gregory G ^b   Fielding, Roger A ^a  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

Aging; Ceramide; Diacylglycerol; Inflammation; Insulin; Intramuscular lipids; Obesity; Sarcopenia

Indexed keywords

CERAMIDE; DIACYLGLYCEROL; I KAPPA B; I KAPPA B ALPHA; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; LIPID;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INFLAMMATION; INSULIN RESISTANCE; INSULIN RESPONSE; LIPID STORAGE; MALE; MOUSE; MUSCLE FUNCTION; MUSCLE MASS; MUSCLE STRENGTH; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; COMPARATIVE STUDY; DRUG EFFECTS; LIPID METABOLISM; METABOLISM; MYOSITIS; SARCOPENIA;

AGING; ANIMALS; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; LIPIDS; MALE; METABOLISM; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; MYOSITIS; OBESITY; SARCOPENIA; SIGNAL TRANSDUCTION;

EID: 84984638436     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00198.2015     Document Type: Article

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