Enhanced ethanol catabolism in orphan nuclear receptor SHP-null mice

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 310, Issue 10, 2016, Pages G799-G807

  Park, Jung Eun ^a   Lee, Mikang ^a   Mifflin, Ryan ^a   Lee, Yoon Kwang ^a  

^a Northeastern Ohio Medical University   (United States)

Author keywords

Acetaldehyde dehydrogenase; Alcoholic fatty liver disease; Inflammation; Small heterodimer partner

Indexed keywords

ACETIC ACID; ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; MESSENGER RNA; ORPHAN NUCLEAR RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; SMALL HETERODIMER PARTNER; UNCLASSIFIED DRUG; ACETIC ACID DERIVATIVE; ALDH2 PROTEIN, MOUSE; CELL RECEPTOR; NUCLEAR RECEPTOR SUBFAMILY 0, GROUP B, MEMBER 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ALCOHOL BLOOD LEVEL; ALCOHOL METABOLISM; ALCOHOLIC FATTY LIVER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EPIGENETIC REPRESSION; HEPATIC CLEARANCE; INFLAMMATION; LIPID DIET; LIPID PEROXIDATION; LIPID STORAGE; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ALCOHOL LIVER DISEASE; ANIMAL; BLOOD; C57BL MOUSE; DEFICIENCY; DRUG EFFECTS; GENETICS; LIVER; METABOLISM;

ACETATES; ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; ANIMALS; ETHANOL; LIPID PEROXIDATION; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; MICE; MICE, INBRED C57BL; PPAR GAMMA; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84984605151     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00343.2015     Document Type: Article

References (45)

1. Bertola A, Mathews S, Ki SH, Wang H, Gao B. Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nat Protoc 8: 627-637, 2013.
2. Cederbaum AI. Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity. Dig Dis 28: 802-811, 2010.
3. Clugston RD, Blaner WS. The adverse effects of alcohol on vitamin A metabolism. Nutrients 4: 356-371, 2012.
4. Crabb DW, Pinaire J, Chou WY, Sissom S, Peters JM, Harris RA, Stewart M. Peroxisome proliferator-activated receptors (PPAR) and the mitochondrial aldehyde dehydrogenase (ALDH2) promoter in vitro and in vivo. Alcohol Clin Exp Res 25: 945-952, 2001.
5. Deltour L, Foglio MH, Duester G. Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid. J Biol Chem 274: 16796-16801, 1999.
6. Edvardsson U, Bergstrom M, Alexandersson M, Bamberg K, Ljung B, Dahllof B. Rosiglitazone (BRL49653), a PPAR+-selective agonist, causes peroxisome proliferator-like liver effects in obese mice. J Lipid Res 40: 1177-1184, 1999.
7. Fajas L, Auboeuf D, Raspe E, Schoonjans K, Lefebvre AM, Saladin R, Najib J, Laville M, Fruchart JC, Deeb S, Vidal-Puig A, Flier J, Briggs MR, Staels B, Vidal H, Auwerx J. The organization, promoter analysis, and expression of the human PPAR+ gene. J Biol Chem 272: 18779-18789, 1997.
8. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509, 1957.
9. Gavrilova O, Haluzik M, Matsusue K, Cutson JJ, Johnson L, Dietz KR, Nicol CJ, Vinson C, Gonzalez FJ, Reitman ML. Liver peroxisome proliferator-activated receptor-γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem 278: 34268-34276, 2003.
10. Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, Galardi C, Wilson JG, Lewis MC, Roth ME, Maloney PR, Willson TM, Kliewer SA. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 6: 517-526, 2000.
11. Grunnet N, Kondrup J. The effect of ethanol on the β-oxidation of fatty acids. Alcohol Clin Exp Res 10: 64S-68S, 1986.
12. Hartman HB, Lai K, Evans MJ. Loss of small heterodimer partner expression in the liver protects against dyslipidemia. J Lipid Res 50: 193-203, 2009.
13. Ki SH, Park O, Zheng M, Morales-Ibanez O, Kolls JK, Bataller R, Gao B. Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology 52: 1291-1300, 2010.
14. Kim SC, Kim CK, Axe D, Cook A, Lee M, Li T, Smallwood N, Chiang JY, Hardwick JP, Moore DD, Lee YK. All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade. Hepatology 59: 1750-1760, 2014.
15. Kim YS, Han CY, Kim SW, Kim JH, Lee SK, Jung DJ, Park SY, Kang H, Choi HS, Lee JW, Pak YK. The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear factor-B in oxidized low density lipoprotein-treated macrophage cell line RAW 264.7. J Biol Chem 276: 33736-33740, 2001.
16. Kono H, Bradford BU, Yin M, Sulik KK, Koop DR, Peters JM, Gonzalez FJ, McDonald T, Dikalova A, Kadiiska MB, Mason RP, Thurman RG. CYP2E1 is not involved in early alcohol-induced liver injury. Am J Physiol Gastrointest Liver Physiol 277: G1259-G1267, 1999.
17. Kono H, Rusyn I, Yin M, Gabele E, Yamashina S, Dikalova A, Kadiiska MB, Connor HD, Mason RP, Segal BH, Bradford BU, Holland SM, Thurman RG. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest 106: 867-872, 2000.
18. Kwon HJ, Won YS, Park O, Chang B, Duryee MJ, Thiele GE, Matsumoto A, Singh S, Abdelmegeed MA, Song BJ, Kawamoto T, Vasiliou V, Thiele GM, Gao B. Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice. Hepatology 60: 146-157, 2014.
19. Langhi C, Pedraz-Cuesta E, Haro D, Marrero PF, Rodriguez JC. Regulation of human class I alcohol dehydrogenases by bile acids. J Lipid Res 54: 2475-2484, 2013.
20. Lee JM, Seo WY, Song KH, Chanda D, Kim YD, Kim DK, Lee MW, Ryu D, Kim YH, Noh JR, Lee CH, Chiang JY, Koo SH, Choi HS. AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB·CRTC2 complex by orphan nuclear receptor small heterodimer partner. J Biol Chem 285: 32182-32191, 2010.
21. Lee YJ, Ko EH, Kim JE, Kim E, Lee H, Choi H, Yu JH, Kim HJ, Seong JK, Kim KS, Kim JW. Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis. Proc Natl Acad Sci USA 109: 13656-13661, 2012.
22. Lee YK, Dell H, Dowhan DH, Hadzopoulou-Cladaras M, Moore DD. The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression. Mol Cell Biol 20: 187-195, 2000.
23. Lee YK, Moore DD. Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner. J Biol Chem 277: 2463-2467, 2002.
24. Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, Mangelsdorf DJ. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell 6: 507-515, 2000.
25. Luong A, Hannah VC, Brown MS, Goldstein JL. Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins. J Biol Chem 275: 26458-26466, 2000.
26. Matsusue K, Haluzik M, Lambert G, Yim SH, Gavrilova O, Ward JM, Brewer B Jr, Reitman ML, Gonzalez FJ. Liver-specific disruption of PPAR+ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest 111: 737-747, 2003.
27. Matsusue K, Kusakabe T, Noguchi T, Takiguchi S, Suzuki T, Yamano S, Gonzalez FJ. Hepatic steatosis in leptin-deficient mice is promoted by the PPAR+ target gene Fsp27. Cell Metab 7: 302-311, 2008.
28. Moran-Salvador E, Lopez-Parra M, Garcia-Alonso V, Titos E, Martinez-Clemente M, Gonzalez-Periz A, Lopez-Vicario C, Barak Y, Arroyo V, Claria J. Role for PPAR+ in obesity-induced hepatic steatosis as determined by hepatocyte-and macrophage-specific conditional knockouts. FASEB J 25: 2538-2550, 2011.
29. Ontko JA. Effects of ethanol on the metabolism of free fatty acids in isolated liver cells. J Lipid Res 14: 78-86, 1973.
30. Oyama T, Kim YD, Isse T, Phuong PT, Ogawa M, Yamaguchi T, Kinaga T, Yashima Y, Kim H, Kawamoto T. A pilot study on subacute ethanol treatment of ALDH2 KO mice. J Toxicol Sci 32: 421-428, 2007.
31. Park YJ, Kim SC, Kim J, Anakk S, Lee JM, Tseng HT, Yechoor V, Park J, Choi JS, Jang HC, Lee KU, Novak CM, Moore DD, Lee YK. Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner. J Lipid Res 52: 2234-2244, 2011.
32. Pettinelli P, Videla LA. Up-regulation of PPAR-γ mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction. J Clin Endocrinol Metab 96: 1424-1430, 2011.
33. γ1reactivates adipogenesis. Genes Dev 16: 27-32, 2002.
34. Seol W, Choi HS, Moore DD. An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science 272: 1336-1339, 1996.
35. Seol W, Hanstein B, Brown M, Moore DD. Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner). Mol Endocrinol 12: 1551-1557, 1998.
36. Sone H, Shimano H, Sakakura Y, Inoue N, Amemiya-Kudo M, Yahagi N, Osawa M, Suzuki H, Yokoo T, Takahashi A, Iida K, Toyoshima H, Iwama A, Yamada N. Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status. Am J Physiol Endocrinol Metab 282: E222-E230, 2002.
37. Stewart MJ, Dipple KM, Estonius M, Nakshatri H, Everett LM, Crabb DW. Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4. Biochim Biophys Acta 1399: 181-186, 1998.
38. Traslavina RP, King EJ, Loar AS, Riedel ER, Garvey MS, Ricart-Arbona R, Wolf FR, Couto SS. Euthanasia by CO2 inhalation affects potassium levels in mice. J Am Assoc Lab Anim Sci 49: 316-322, 2010.
39. Wang L, Han Y, Kim CS, Lee YK, Moore DD. Resistance of SHP-null mice to bile acid induced liver damage. J Biol Chem 278: 44475-44481, 2003.
40. Wang XD, Liu C, Chung J, Stickel F, Seitz HK, Russell RM. Chronic alcohol intake reduces retinoic acid concentration and enhances AP-1 (c-Jun and c-Fos) expression in rat liver. Hepatology 28: 744-750, 1998.
41. Xu MJ, Cai Y, Wang H, Altamirano J, Chang B, Bertola A, Odena G, Lu J, Tanaka N, Matsusue K, Matsubara T, Mukhopadhyay P, Kimura S, Pacher P, Gonzalez FJ, Bataller R, Gao B. Fat-specific protein 27/CIDEC promotes development of alcoholic steatohepatitis in mice and humans. Gastroenterology 149: 1030-1041, 2015.
42. 2knockdown improves fatty liver induced by high-saturated fat. J Nutr Biochem 22: 543-553, 2011.
43. γ1) overexpression. J Biol Chem 278: 498-505, 2003.
44. Yuk JM, Shin DM, Lee HM, Kim JJ, Kim SW, Jin HS, Yang CS, Park KA, Chanda D, Kim DK, Huang SM, Lee SK, Lee CH, Kim JM, Song CH, Lee SY, Hur GM, Moore DD, Choi HS, Jo EK. The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Nat Immunol 12: 742-751, 2011.
45. Zhu Y, Qi C, Korenberg JR, Chen XN, Noya D, Rao MS, Reddy JK. Structural organization of mouse peroxisome proliferator-activated receptor-γ (mPPARγ) gene: alternative promoter use and different splicing yield two mPPARγ isoforms. Proc Natl Acad Sci USA 92: 7921-7925, 1995.