Engineering Intracellular Delivery Nanocarriers and Nanoreactors from Oxidation-Responsive Polymersomes via Synchronized Bilayer Cross-Linking and Permeabilizing Inside Live Cells

Journal of the American Chemical Society

Volumn 138, Issue 33, 2016, Pages 10452-10466

  Deng, Zhengyu ^a   Qian, Yinfeng ^b   Yu, Yongqiang ^b   Liu, Guhuan ^a   Hu, Jinming ^a   Zhang, Guoying ^a   Liu, Shiyong ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCK COPOLYMERS; CELL ENGINEERING; CHEMOTHERAPY; CROSSLINKING; DRUG PRODUCTS; HYDROPHILICITY; HYDROPHOBICITY; MAGNETIC RESONANCE; NANOREACTORS; OXIDATION; SELF ASSEMBLY;

AMPHIPHILIC BLOCK COPOLYMERS; BIOACTIVE MACROMOLECULES; HYDROPHOBIC TO HYDROPHILIC TRANSITIONS; INTRACELLULAR DELIVERY; MEMBRANE PERMEABILITY; REACTIVE OXYGEN SPECIES; SURFACE FUNCTIONALIZATION; SUSTAINED DRUG RELEASE;

POLYMERS;

AMINE; COPOLYMER; DOUBLE STRANDED DNA; DOXORUBICIN; ESTER; ETHANOLAMINE; FLUORESCEIN DIACETATE; GADOTERIC ACID; HYDROGEN; HYDROGEN PEROXIDE; MONOMER; NANOCARRIER; NANOMATERIAL; NANOPARTICLE; NANOREACTOR; PACLITAXEL; PHORBOL 13 ACETATE 12 MYRISTATE; POLYMER; POLYMERSOME; QUINONE DERIVATIVE; TERTIARY AMINE; UMBELLIFERONE; UMBELLIFERONE DERIVATIVE; UNCLASSIFIED DRUG; DRUG CARRIER; THIOL DERIVATIVE;

ADDITION REACTION; AMIDATION; ARTICLE; BILAYER MEMBRANE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL DEATH; CELL PERMEABILIZATION; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; CLICK CHEMISTRY; COCULTURE; COMPARATIVE STUDY; CONFOCAL LASER SCANNING MICROSCOPY; CONJUGATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CROSS LINKING; DECARBOXYLATION; DEPOLYMERIZATION; DILUTION; DISPERSION; ELUTION; ENCAPSULATION; FEMALE; FLUORESCENCE IMAGING; HELA CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDRODYNAMICS; HYDROGEN BOND; HYDROLYSIS; HYDROPHILICITY; HYDROPHOBICITY; INCUBATION TIME; INTERNALIZATION; LIGHT SCATTERING; MEMBRANE PERMEABILITY; MICELLE; MICHAEL ADDITION; MITOCHONDRION; MTT ASSAY; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATION; OXIDATION KINETICS; OXIDATIVE STRESS; PH; PHOTON CORRELATION SPECTROSCOPY; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; QUANTITATIVE ANALYSIS; REACTION ANALYSIS; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; SUSTAINED DRUG RELEASE; SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY; ULTRAVIOLET IRRADIATION; ULTRAVIOLET RADIATION; X RAY PHOTOELECTRON SPECTROSCOPY; ZETA POTENTIAL; CHEMICAL PHENOMENA; CHEMISTRY; DRUG RELEASE; INTRACELLULAR SPACE; METABOLISM; NANOTECHNOLOGY; OXIDATION REDUCTION REACTION; PERMEABILITY;

DRUG CARRIERS; DRUG LIBERATION; HELA CELLS; HUMANS; HYDROGEN PEROXIDE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INTRACELLULAR SPACE; NANOTECHNOLOGY; OXIDATION-REDUCTION; PERMEABILITY; POLYMERS; SULFHYDRYL COMPOUNDS;

EID: 84983646518     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.6b04115     Document Type: Article

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