Extravasation of poly(amidoamine) (PAMAM) dendrimers across microvascular network endothelium

Pharmaceutical Research

Volumn 18, Issue 1, 2001, Pages 23-28

  El Sayed, M ^a   Kiani, M F ^b   Naimark, M D ^b   Hikal, A H ^c,d   Ghandehari, H ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF MISSISSIPPI   (United States)

^d Amriya Pharmaceutical Industry   (Egypt)

Author keywords

Drug delivery; Endothelial barrier; Intravital microscopy; Microvascular extravasation; Poly(amidoamine) dendrimers; Poly(ethylene glycol)

Indexed keywords

DENDRIMER; DRUG CARRIER; FLUORESCEIN ISOTHIOCYANATE; POLYAMIDOAMINE; UNCLASSIFIED DRUG;

ARTICLE; CREMASTER MUSCLE; DEVICE; DRUG DELIVERY SYSTEM; EXTRAVASATION; GEL PERMEATION CHROMATOGRAPHY; MOLECULAR WEIGHT; PRIORITY JOURNAL;

ANIMALS; CRICETINAE; DRUG DELIVERY SYSTEMS; ENDOTHELIUM, VASCULAR; EXTRAVASATION OF DIAGNOSTIC AND THERAPEUTIC MATERIALS; MALE; MESOCRICETUS; MICROCIRCULATION; POLYAMINES;

EID: 0035050793     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011066408283     Document Type: Article

References (27)

1. StarburstTM/cascade dendrimers: Fundamental building blocks for a new nanoscopic chemistry set
2. Dendritic macromolecules: Synthesis of starburst dendrimers
3. A new class of polymers: Starburst-dendritic macromolecules
4. Starburst dendrimers: Molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter
5. Star polymers and dendrimers: Prospects of their use in drug delivery and pharmaceutical applications
6. Characterization of complexes of oligonucleotides with polyamidoamine starburst dendrimers and effects on intracellular delivery
7. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture
8. In vitro gene delivery by degraded polyamidamine dendrimers
9. The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes
10. PAMAM dendrimers as a potential oral drug delivery system: Dendrimer complexes with piroxicam
11. Biotin reagents for antibody pretargeting. 3. Synthesis, radioiodination, and evaluation of biotinylated starburst dendrimers
12. Light scattering and fluorescence photobleaching recovery study of poly(amidoamine) cascade polymers in aquous solution
13. A "Geographic Information Systems" based technique for the study of microvascular networks
14. An open cremaster muscle preparation for the study of blood vessels by in vivo microscopy
15. Quantitation of erythrocyte photohemolysis by light microscopy
16. Differentiation of light-dye effects in the microcirculation
17. Statistics of "Starburst" polymers
18. Hindered diffusion of watersoluble macromolecules in membranes
19. Plasma proteins modify the endothelial cell glycocalyx of frog mesenteric microvessels
20. Quantitative comparisons of hydraulic permeability and endothelial intercellular cleft dimensions in single frog capillaries
21. A fiber matrix model of capillary permeability
22. Structural basis of permeability in sequential segments of the microvasculature of the diaphragm. II. Pathways followed by microperoxidase across the endothelium
23. Ultrastructure of microvessel wall: Functional correlations
24. Identification of the small pore in muscle capillaries
25. Pathways through the intercellular clefts of frog mesenteric capillaries
26. Filtration, diffusion and molecular sieving through peripheral capillary membranes. A contribution to the pore theory of capillary permeability
27. Modulation of microvessel wall charge by plasma glycoprotein orosomucoid