Dietary zinc deficiency predisposes mice to the development of preneoplastic lesions in chemically-induced hepatocarcinogenesis

Food and Chemical Toxicology

Volumn 96, Issue , 2016, Pages 280-289

  Romualdo, Guilherme Ribeiro ^a   Goto, Renata Leme ^a   Henrique Fernandes, Ana Angélica ^a   Cogliati, Bruno ^b   Barbisan, Luis Fernando ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Antioxidant defense; Diethylnitrosamine; Mouse hepatocarcinogenesis; Preneoplasia; Zinc deficiency; Zinc supplementation

Indexed keywords

2 ACETYLAMINEFLUORENE; DIETHYLNITROSAMINE; FLUORENE DERIVATIVE; GLUTATHIONE; PROTEIN P53; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ALKYLATING AGENT; ANTIOXIDANT; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CANCER SUSCEPTIBILITY; CELL PROLIFERATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DIETARY INTAKE; DIETARY SUPPLEMENT; DISEASE COURSE; DISEASE SEVERITY; GENOTOXICITY; HEPATOCELLULAR PRENEOPLASTIC LESION; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER TOXICITY; MALE; MOUSE; NEWBORN; NONHUMAN; PRECANCER; PROTEIN EXPRESSION; ZINC DEFICIENCY; ADVERSE EFFECTS; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; CARCINOMA, HEPATOCELLULAR; DEFICIENCY; DIET; DNA DAMAGE; DRUG EFFECTS; FEMALE; HUMAN; LIVER NEOPLASMS, EXPERIMENTAL; METABOLISM; ORGAN SIZE; PATHOLOGY;

ALKYLATING AGENTS; ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; DIET; DIETARY SUPPLEMENTS; DIETHYLNITROSAMINE; DNA DAMAGE; FEMALE; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, INBRED BALB C; ORGAN SIZE; TUMOR SUPPRESSOR PROTEIN P53; ZINC;

EID: 84983491176     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2016.08.020     Document Type: Article

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