Alkaline comet assay in liver and stomach, and micronucleus assay in bone marrow, from rats treated with 2-acetylaminofluorene, azidothymidine, cisplatin, or isobutyraldehyde

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 786-788, Issue , 2015, Pages 77-86

  Kraynak, A R ^a   Barnum, J E ^a   Cunningham, C L ^a   Ng, A ^b   Ykoruk, B A ^a   Bennet, B ^a   Stoffregen, D ^a   Merschman, M ^a   Freeland, E ^a   Galloway, S M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NOVAVAX INC   (United States)

Author keywords

2 Acetylaminofluorene (CASRN: 53 96 3); Azidothymidine (CASRN: 30516 87 1); Bone marrow micronucleus assay; Cisplatin (CASRN: 15663 27 1); In vivo comet assay; Isobutyraldehyde (CASRN: 78 84 2); JaCVAM validation study

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CISPLATIN; ISOBUTYRALDEHYDE; MESYLIC ACID ETHYL ESTER; N (2 FLUORENYL)ACETAMIDE; ZIDOVUDINE; ALDEHYDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; BONE MARROW; COMET ASSAY; CONTROLLED STUDY; DRUG MEGADOSE; GENOTOXICITY; HISTOPATHOLOGY; LIVER; MALE; MAXIMUM TOLERATED DOSE; MICRONUCLEUS TEST; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH MUCOSA; SUSPENSION; TISSUE PREPARATION; VALIDATION STUDY; ANIMAL; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECTS; PROCEDURES; REPRODUCIBILITY; SPRAGUE DAWLEY RAT; STANDARDS; STOMACH;

RATTUS;

2-ACETYLAMINOFLUORENE; ALDEHYDES; ANIMALS; BONE MARROW; CISPLATIN; COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; LIVER; MALE; MICRONUCLEUS TESTS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; STOMACH; ZIDOVUDINE;

EID: 84937970436     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2015.03.005     Document Type: Article

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