메뉴 건너뛰기




Volumn 59, Issue 9, 2009, Pages 605-622

Molecular pathology of early stage chemically induced hepatocarcinogenesis

Author keywords

Hepatocarcinogenesis; Isolation; Preneoplastic hepatocytes; Selection; Transformation

Indexed keywords

BETA CATENIN; CANCER GROWTH FACTOR; CARCINOGEN; CYCLIN D; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; CYTOCHROME P450; EPIDERMAL GROWTH FACTOR RECEPTOR; EPOXIDE HYDROLASE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN PHOSPHORYLASE; HYPOXIA INDUCIBLE FACTOR 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; NERVE GROWTH FACTOR; SOMATOMEDIN B; STAT3 PROTEIN;

EID: 68949142885     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2009.02416.x     Document Type: Review
Times cited : (28)

References (57)
  • 1
    • 11144316367 scopus 로고    scopus 로고
    • Accessed 6 February 2009. Available from
    • World Health Organization. Mortality database Accessed 6 February 2009.) Available from: http://www.who.int/whosis/en
    • Mortality Database
  • 2
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular carcinoma in the United States
    • El-serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999 340 : 745 50.
    • (1999) N Engl J Med , vol.340 , pp. 745-750
    • El-Serag, H.B.1    Mason, A.C.2
  • 4
    • 20344392430 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology, risk factors, and screening
    • Sherman M. Hepatocellular carcinoma: Epidemiology, risk factors, and screening. Semin Liver Dis 2005 25 : 143 54.
    • (2005) Semin Liver Dis , vol.25 , pp. 143-154
    • Sherman, M.1
  • 5
    • 55949086924 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis
    • Gomaa AI, Khan SA, Toledano MB et al. Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis. World J Gastroenterol 2008 14 : 4300 308.
    • (2008) World J Gastroenterol , vol.14 , pp. 4300-4308
    • Gomaa, A.I.1    Khan, S.A.2    Toledano, M.B.3
  • 6
    • 0036291076 scopus 로고    scopus 로고
    • Epidemiology, risk factors, and natural history of hepatocellular carcinoma
    • Montalto G, Cervello M, Giannitrapani L et al. Epidemiology, risk factors, and natural history of hepatocellular carcinoma. Ann N Y Acad Sci 2002 963 : 13 20.
    • (2002) Ann N Y Acad Sci , vol.963 , pp. 13-20
    • Montalto, G.1    Cervello, M.2    Giannitrapani, L.3
  • 7
    • 13444292555 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatocarcinogenesis in transgenic mouse models of liver cancer
    • Calvisi DS, Thorgeirsson SS. Molecular mechanisms of hepatocarcinogenesis in transgenic mouse models of liver cancer. Toxicol Pathol 2005 33 : 181 4.
    • (2005) Toxicol Pathol , vol.33 , pp. 181-184
    • Calvisi, D.S.1    Thorgeirsson, S.S.2
  • 8
    • 0034219938 scopus 로고    scopus 로고
    • Transgenic mouse models and hepatocellular carcinoma: Future prospects
    • Lakhtakia R, Panda SK. Transgenic mouse models and hepatocellular carcinoma: Future prospects. Trop Gastroenterol 2000 21 : 91 4.
    • (2000) Trop Gastroenterol , vol.21 , pp. 91-94
    • Lakhtakia, R.1    Panda, S.K.2
  • 9
    • 0242549626 scopus 로고    scopus 로고
    • A review of nomenclature and diagnostic criteria for proliferative lesions in the liver of rats by a working group of the Japanese Society of Toxicologic Pathology
    • Narama IK, Iwata H, Nakae D et al. A review of nomenclature and diagnostic criteria for proliferative lesions in the liver of rats by a working group of the Japanese Society of Toxicologic Pathology. J Toxicol Pathol 2003 16 : 1 17.
    • (2003) J Toxicol Pathol , vol.16 , pp. 1-17
    • Narama, I.K.1    Iwata, H.2    Nakae, D.3
  • 10
    • 0022456596 scopus 로고
    • National toxicology program nomenclature for hepatoproliferative lesions of rats
    • Maronpot RR, Montgomery CA Jr., Boorman GA et al. National toxicology program nomenclature for hepatoproliferative lesions of rats. Toxicol Pathol 1986 14 : 263 73.
    • (1986) Toxicol Pathol , vol.14 , pp. 263-273
    • Maronpot, R.R.1    Montgomery Jr., C.A.2    Boorman, G.A.3
  • 11
    • 0024357972 scopus 로고
    • The sequential development of cancer: A morphological perspective
    • Eustis SL. The sequential development of cancer: A morphological perspective. Toxicol Lett 1989 49 : 267 81.
    • (1989) Toxicol Lett , vol.49 , pp. 267-281
    • Eustis, S.L.1
  • 12
    • 0019490449 scopus 로고
    • Spontaneous occurrence of γ-glutamyl transpeptidase-positive hepatocytic foci in 105-week-old Wistar and 72-week-old Fischer 34 male rats
    • Ogawa K, Onoe T, Takeuchi M. Spontaneous occurrence of γ-glutamyl transpeptidase-positive hepatocytic foci in 105-week-old Wistar and 72-week-old Fischer 34 male rats. J Natl Cancer Inst 1981 67 : 407 12.
    • (1981) J Natl Cancer Inst , vol.67 , pp. 407-412
    • Ogawa, K.1    Onoe, T.2    Takeuchi, M.3
  • 13
    • 0032610838 scopus 로고    scopus 로고
    • Genetic and hormonal regulation of murine hepatocarcinogenesis
    • Chiaverotti T, Carabeo R, Drinkwater N. Genetic and hormonal regulation of murine hepatocarcinogenesis. Prog Exp Tumor Res 1999 35 : 131 42.
    • (1999) Prog Exp Tumor Res , vol.35 , pp. 131-142
    • Chiaverotti, T.1    Carabeo, R.2    Drinkwater, N.3
  • 14
    • 0002121055 scopus 로고
    • The pathology of experimental liver cell cancer
    • Cameron, H.M. Linsell, D.A. Warwick, G.P. eds. Amsterdam: Elsevier
    • Farber E. The pathology of experimental liver cell cancer. In : Cameron HM, Linsell DA, Warwick GP, eds. Liver Cell Cancer. Amsterdam : Elsevier, 1976 243 77.
    • (1976) Liver Cell Cancer , pp. 243-277
    • Farber, E.1
  • 15
    • 0023860323 scopus 로고
    • Lack of albumin as genotypic marker of preneoplastic analbuminemic rat hepatocytes transplanted within albumin-positive liver
    • Yokota K, Ogawa K, Mori M et al. Lack of albumin as genotypic marker of preneoplastic analbuminemic rat hepatocytes transplanted within albumin-positive liver. Cancer Res 1988 15 : 387 92.
    • (1988) Cancer Res , vol.15 , pp. 387-392
    • Yokota, K.1    Ogawa, K.2    Mori, M.3
  • 16
    • 0020603511 scopus 로고
    • Kinetics of diethylnitrosamine hepatocarcinogenesis in the infant mouse
    • Vesselinovitch SD, Mihailovich N. Kinetics of diethylnitrosamine hepatocarcinogenesis in the infant mouse. Cancer Res 1983 43 : 4253 9.
    • (1983) Cancer Res , vol.43 , pp. 4253-4259
    • Vesselinovitch, S.D.1    Mihailovich, N.2
  • 17
    • 0018840528 scopus 로고
    • Phenotypic diversity as an early property of putative preneoplastic hepatocytes populations in liver carcinogenesis
    • Ogawa K, Solt DB, Farber E. Phenotypic diversity as an early property of putative preneoplastic hepatocytes populations in liver carcinogenesis. Cancer Res 1980 40 : 725 33.
    • (1980) Cancer Res , vol.40 , pp. 725-733
    • Ogawa, K.1    Solt, D.B.2    Farber, E.3
  • 18
    • 0023215479 scopus 로고
    • Single GST-P positive liver cells: Putative initiated hepatocytes
    • Moore MA, Nakagawa N, Satoh K et al. Single GST-P positive liver cells: Putative initiated hepatocytes. Carcinogenesis 1987 8 : 483 6.
    • (1987) Carcinogenesis , vol.8 , pp. 483-486
    • Moore, M.A.1    Nakagawa, N.2    Satoh, K.3
  • 19
    • 1542399102 scopus 로고    scopus 로고
    • Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue
    • Suzuki S, Asamoto M, Tsujimura K et al. Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue. Carcinogenesis 2004 25 : 439 43.
    • (2004) Carcinogenesis , vol.25 , pp. 439-443
    • Suzuki, S.1    Asamoto, M.2    Tsujimura, K.3
  • 20
    • 38749091805 scopus 로고    scopus 로고
    • Gene expression analysis on the dicyclanil-induced hepatocellular tumors in mice
    • Moto M, Okamura M, Muguruma M et al. Gene expression analysis on the dicyclanil-induced hepatocellular tumors in mice. Toxicol Pathol 2006 34 : 744 51.
    • (2006) Toxicol Pathol , vol.34 , pp. 744-751
    • Moto, M.1    Okamura, M.2    Muguruma, M.3
  • 21
    • 0042889217 scopus 로고    scopus 로고
    • Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression
    • Kinoshita A, Wanibuchi H, Morimura K et al. Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression. Carcinogenesis 2003 24 : 1389 99.
    • (2003) Carcinogenesis , vol.24 , pp. 1389-1399
    • Kinoshita, A.1    Wanibuchi, H.2    Morimura, K.3
  • 22
    • 0021363045 scopus 로고
    • Studies on the proliferation and fate of oval cells in the liver of rats treated with 2-acetylaminofluorene and partial hepatectomy
    • Tatematsu M, Ho RH, Kaku T et al. Studies on the proliferation and fate of oval cells in the liver of rats treated with 2-acetylaminofluorene and partial hepatectomy. Am J Pathol 1984 114 : 418 30.
    • (1984) Am J Pathol , vol.114 , pp. 418-430
    • Tatematsu, M.1    Ho, R.H.2    Kaku, T.3
  • 23
    • 0016328138 scopus 로고
    • Demonstration of glucose 6-phosphatase activity in the oval cells of rat liver and the significance of the oval cells in azo dye carcinogenesis
    • Ogawa K, Minase T, Onoe T. Demonstration of glucose 6-phosphatase activity in the oval cells of rat liver and the significance of the oval cells in azo dye carcinogenesis. Cancer Res 1974 34 : 3379 86.
    • (1974) Cancer Res , vol.34 , pp. 3379-3386
    • Ogawa, K.1    Minase, T.2    Onoe, T.3
  • 24
    • 0020572995 scopus 로고
    • Thioacetamide hepatocarcinogenesis
    • Becker FF. Thioacetamide hepatocarcinogenesis. J Natl Cancer Inst 1983 71 : 553 8.
    • (1983) J Natl Cancer Inst , vol.71 , pp. 553-558
    • Becker, F.F.1
  • 25
    • 0033497604 scopus 로고    scopus 로고
    • Endogeneous liver carcinogenesis in the rat
    • Nakae D. Endogeneous liver carcinogenesis in the rat. Pathol Int 1999 49 : 1028 42.
    • (1999) Pathol Int , vol.49 , pp. 1028-1042
    • Nakae, D.1
  • 26
    • 0025141973 scopus 로고
    • Perinatal mouse liver carcinogenesis as a sensitive carcinogenesis model and the role of the sex hormonal environment in tumor development
    • Vesslinovitch SD. Perinatal mouse liver carcinogenesis as a sensitive carcinogenesis model and the role of the sex hormonal environment in tumor development. Prog Clin Biol Res 1990 331 : 53 68.
    • (1990) Prog Clin Biol Res , vol.331 , pp. 53-68
    • Vesslinovitch, S.D.1
  • 27
    • 0026801325 scopus 로고
    • Association between expression of transforming growth factor-α and progression of hepatocellular foci to neoplasms
    • Kaufmann WK, Zhang Y, Kaufman DG. Association between expression of transforming growth factor-α and progression of hepatocellular foci to neoplasms. Carcinogenesis 1992 13 : 1481 3.
    • (1992) Carcinogenesis , vol.13 , pp. 1481-1483
    • Kaufmann, W.K.1    Zhang, Y.2    Kaufman, D.G.3
  • 28
    • 0031659796 scopus 로고    scopus 로고
    • Presence of threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat
    • Kitano M, Ichihara T, Matsuda T et al. Presence of threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat. Carcinogenesis 1998 19 : 1475 80.
    • (1998) Carcinogenesis , vol.19 , pp. 1475-1480
    • Kitano, M.1    Ichihara, T.2    Matsuda, T.3
  • 29
    • 0028168016 scopus 로고
    • Abundant TGFα precursor and EGF receptor expression as a possible mechanism for the preferential growth of carcinogen-induced preneoplastic and neoplastic hepatocytes in rats
    • Tanno S, Ogawa K. Abundant TGFα precursor and EGF receptor expression as a possible mechanism for the preferential growth of carcinogen-induced preneoplastic and neoplastic hepatocytes in rats. Carcinogenesis 1994 15 : 1689 94.
    • (1994) Carcinogenesis , vol.15 , pp. 1689-1694
    • Tanno, S.1    Ogawa, K.2
  • 30
    • 0017166164 scopus 로고
    • New principle for the analysis of hepatocarcinogenesis
    • Solt DB, Farber E. New principle for the analysis of hepatocarcinogenesis. Nature 1976 263 : 701 6.
    • (1976) Nature , vol.263 , pp. 701-706
    • Solt, D.B.1    Farber, E.2
  • 31
    • 41849105045 scopus 로고    scopus 로고
    • Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma
    • Breuhahn K, Schirmacher P. Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma. World J Gastroenterol 2008 11 : 1690 98.
    • (2008) World J Gastroenterol , vol.11 , pp. 1690-1698
    • Breuhahn, K.1    Schirmacher, P.2
  • 32
    • 0026635934 scopus 로고
    • Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth
    • Schirmacher P, Held WA, Yang D et al. Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth. Cancer Res 1992 52 : 2549 56.
    • (1992) Cancer Res , vol.52 , pp. 2549-2556
    • Schirmacher, P.1    Held, W.A.2    Yang, D.3
  • 33
    • 41149151320 scopus 로고    scopus 로고
    • Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma
    • Jang HS, Kang KM, Choi BO et al. Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma. World J Gastroenterol 2008 14 : 1394 8.
    • (2008) World J Gastroenterol , vol.14 , pp. 1394-1398
    • Jang, H.S.1    Kang, K.M.2    Choi, B.O.3
  • 34
    • 0032422489 scopus 로고    scopus 로고
    • Loss of imprinting of the insulin-like growth factor II gene in mouse hepatocellular carcinoma cell lines
    • Ooasa T, Karasaki H, Kanda H et al. Loss of imprinting of the insulin-like growth factor II gene in mouse hepatocellular carcinoma cell lines. Mol Carcinog 1998 23 : 248 53.
    • (1998) Mol Carcinog , vol.23 , pp. 248-253
    • Ooasa, T.1    Karasaki, H.2    Kanda, H.3
  • 35
    • 0037458616 scopus 로고    scopus 로고
    • Loss of Igf2 imprinting in monoclonal mouse hepatic tumor cells is not associated with abnormal methylation patterns for the H19, Igf2, and Kulqt1 differentially methylated regions
    • Ishizaki T, Yoshie M, Yaginuma Y et al. Loss of Igf2 imprinting in monoclonal mouse hepatic tumor cells is not associated with abnormal methylation patterns for the H19, Igf2, and Kulqt1 differentially methylated regions. J Biol Chem 2003 278 : 6222 8.
    • (2003) J Biol Chem , vol.278 , pp. 6222-6228
    • Ishizaki, T.1    Yoshie, M.2    Yaginuma, Y.3
  • 36
    • 0345006147 scopus 로고    scopus 로고
    • Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas
    • De La Coste A, Rinagbiki B, Billuart P et al. Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci USA 1998 95 : 8847 51.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8847-8851
    • De La Coste, A.1    Rinagbiki, B.2    Billuart, P.3
  • 37
    • 0033561676 scopus 로고    scopus 로고
    • B-Catenin mutations are frequent in hepatocellular carcinomas but absent in adenomas induced by diethylnitrosamine in B6C3F1 mice
    • Ogawa K, Yamada Y, Kishibe K et al. b-Catenin mutations are frequent in hepatocellular carcinomas but absent in adenomas induced by diethylnitrosamine in B6C3F1 mice. Cancer Res 1999 59 : 1830 33.
    • (1999) Cancer Res , vol.59 , pp. 1830-1833
    • Ogawa, K.1    Yamada, Y.2    Kishibe, K.3
  • 38
    • 0035936026 scopus 로고    scopus 로고
    • Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of b-catenin-mutated mouse liver tumors
    • Aydinlik H, Nguyen TD, Moennikes O et al. Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of b-catenin-mutated mouse liver tumors. Oncogene 2001 20 : 7812 6.
    • (2001) Oncogene , vol.20 , pp. 7812-7816
    • Aydinlik, H.1    Nguyen, T.D.2    Moennikes, O.3
  • 39
    • 0035266134 scopus 로고    scopus 로고
    • Activation of b-catenin during hepatocarcinogenesis in transgenic mouse models: Relationship to phenotype and tumor grade
    • Calvisi DF, Factor VM, Loi R et al. Activation of b-catenin during hepatocarcinogenesis in transgenic mouse models: Relationship to phenotype and tumor grade. Cancer Res 2001 61 : 2085 91.
    • (2001) Cancer Res , vol.61 , pp. 2085-2091
    • Calvisi, D.F.1    Factor, V.M.2    Loi, R.3
  • 40
    • 0345700813 scopus 로고    scopus 로고
    • Cyclin D1 over-expression correlates with b-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3b and ERK1/2 in mouse hepatic carcinogenesis
    • Gotoh J, Obata M, Yoshie M et al. Cyclin D1 over-expression correlates with b-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3b and ERK1/2 in mouse hepatic carcinogenesis. Carcinogenesis 2003 24 : 435 42.
    • (2003) Carcinogenesis , vol.24 , pp. 435-442
    • Gotoh, J.1    Obata, M.2    Yoshie, M.3
  • 41
    • 1642535593 scopus 로고    scopus 로고
    • Hepatocarcinogenesis in mice with b-catenin and Ha-ras gene mutations
    • Harada N, Oshima H, Katoh M et al. Hepatocarcinogenesis in mice with b-catenin and Ha-ras gene mutations. Cancer Res 2004 64 : 48 54.
    • (2004) Cancer Res , vol.64 , pp. 48-54
    • Harada, N.1    Oshima, H.2    Katoh, M.3
  • 42
    • 33845803145 scopus 로고    scopus 로고
    • Hypoxia-independent overexpression of hypoxia-inducible factor 1a as an early change in mouse hepatocarcinogenesis
    • Tanaka H, Yamamoto M, Hashimoto N et al. Hypoxia-independent overexpression of hypoxia-inducible factor 1a as an early change in mouse hepatocarcinogenesis. Cancer Res 2006 66 : 11 263 70.
    • (2006) Cancer Res , vol.66 , pp. 11263-11270
    • Tanaka, H.1    Yamamoto, M.2    Hashimoto, N.3
  • 43
    • 52949104437 scopus 로고    scopus 로고
    • Paradigm shifts in the cell biology of STAT signaling. Sem Cell
    • Sehgal PB. Paradigm shifts in the cell biology of STAT signaling. Sem Cell. Dev Biol 2008 19 : 329 40.
    • (2008) Dev Biol , vol.19 , pp. 329-340
    • Sehgal, P.B.1
  • 44
    • 68949160286 scopus 로고    scopus 로고
    • Stat3 activation as early change in multi-step hepatocarcingenesis
    • Miyakoshi M, Tanaka H, Hashimoto N et al. Stat3 activation as early change in multi-step hepatocarcingenesis. Proc Am Assoc Cancer Res 2008 49 : 202 3.
    • (2008) Proc Am Assoc Cancer Res , vol.49 , pp. 202-203
    • Miyakoshi, M.1    Tanaka, H.2    Hashimoto, N.3
  • 45
    • 33845382726 scopus 로고    scopus 로고
    • Neoplastic hepatocyte growth associated with cyclin D1 redistribution from the cytoplasm to the nucleus in mouse hepatocarcinogenesis
    • Yamamoto M, Tamakawa S, Yoshie M et al. Neoplastic hepatocyte growth associated with cyclin D1 redistribution from the cytoplasm to the nucleus in mouse hepatocarcinogenesis. Mol Carcinog 2006 45 : 901 13.
    • (2006) Mol Carcinog , vol.45 , pp. 901-913
    • Yamamoto, M.1    Tamakawa, S.2    Yoshie, M.3
  • 46
    • 68949150174 scopus 로고    scopus 로고
    • Possible role of the microenvironment created by neoplastic hepatocytes during hepatic carcinogenesis
    • Ogawa K, Yoshie M, Tamakawa S et al. Possible role of the microenvironment created by neoplastic hepatocytes during hepatic carcinogenesis. Appl Genom Proteom 2003 2 : 135 43.
    • (2003) Appl Genom Proteom , vol.2 , pp. 135-143
    • Ogawa, K.1    Yoshie, M.2    Tamakawa, S.3
  • 47
    • 0036080064 scopus 로고    scopus 로고
    • Production of nerve growth factor by mouse hepatocellular carcinoma cells and expression of TrkA in tumor-associated arteries in mice
    • Kishibe K, Yamada Y, Ogawa K. Production of nerve growth factor by mouse hepatocellular carcinoma cells and expression of TrkA in tumor-associated arteries in mice. Gastroenterology 2002 122 : 1978 86.
    • (2002) Gastroenterology , vol.122 , pp. 1978-1986
    • Kishibe, K.1    Yamada, Y.2    Ogawa, K.3
  • 48
    • 33646787070 scopus 로고    scopus 로고
    • Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis on nerve growth factor stimulation
    • Asai K, Tamakawa S, Yamamoto M et al. Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis on nerve growth factor stimulation. Liver Int 2006 26 : 595 603.
    • (2006) Liver Int , vol.26 , pp. 595-603
    • Asai, K.1    Tamakawa, S.2    Yamamoto, M.3
  • 49
    • 0029979369 scopus 로고    scopus 로고
    • Biologic basis for interleukin-1 in disease
    • Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 2009 87 : 2095 147.
    • (2009) Blood , vol.87 , pp. 2095-2147
    • Dinarello, C.A.1
  • 50
    • 0024268731 scopus 로고
    • Inteleukin-1β is a potent growth inhibitor of adult rat hepatocytes in primary culture
    • Nakamura T, Arakaki R, Ichihara A. Inteleukin-1β is a potent growth inhibitor of adult rat hepatocytes in primary culture. Exp Cell Res 1988 179 : 488 97.
    • (1988) Exp Cell Res , vol.179 , pp. 488-497
    • Nakamura, T.1    Arakaki, R.2    Ichihara, A.3
  • 51
    • 0032852891 scopus 로고    scopus 로고
    • Expression of an IL-1 receptor antagonist during mouse hepatocarcinogenesis demonstrated by differential display analysis
    • Yamada Y, Karasaki H, Matsushima K et al. Expression of an IL-1 receptor antagonist during mouse hepatocarcinogenesis demonstrated by differential display analysis. Lab Invest 1999 79 : 1059 67.
    • (1999) Lab Invest , vol.79 , pp. 1059-1067
    • Yamada, Y.1    Karasaki, H.2    Matsushima, K.3
  • 52
    • 0034213713 scopus 로고    scopus 로고
    • Genetic resistance to chemical carcinogen-induced proneoplastic hepatic lesions in DRH strain rats
    • Zeng ZZ, Higashi S, Kitayama W et al. Genetic resistance to chemical carcinogen-induced proneoplastic hepatic lesions in DRH strain rats. Cancer Res 2000 60 : 2876 81.
    • (2000) Cancer Res , vol.60 , pp. 2876-2881
    • Zeng, Z.Z.1    Higashi, S.2    Kitayama, W.3
  • 53
    • 4143062921 scopus 로고    scopus 로고
    • Genetic resistance to chemical hepatocarcinogenesis in the DRH rat strain
    • Higashi K, Denda A, Higashi T, Hiai H. Genetic resistance to chemical hepatocarcinogenesis in the DRH rat strain. Comp Med 2004 54 : 373 7.
    • (2004) Comp Med , vol.54 , pp. 373-377
    • Higashi, K.1    Denda, A.2    Higashi, T.3    Hiai, H.4
  • 54
    • 39049196178 scopus 로고    scopus 로고
    • Low selection of preneoplastic hepatocytes after treatment with the 2-acetylaminofluorene diet-partial hepatectomy regimen in the liver of hepatocarcinogenesis-resistant DRH strain rats
    • Imai K, Yamamoto M, Tanaka H et al. Low selection of preneoplastic hepatocytes after treatment with the 2-acetylaminofluorene diet-partial hepatectomy regimen in the liver of hepatocarcinogenesis-resistant DRH strain rats. Oncol Rep 2007 17 : 55 60.
    • (2007) Oncol Rep , vol.17 , pp. 55-60
    • Imai, K.1    Yamamoto, M.2    Tanaka, H.3
  • 55
    • 34548781877 scopus 로고    scopus 로고
    • Low p38 MAPK and JNK activation in cultured hepatocytes of DRH rats; A strain highly resistant to hepatocarcinogenesis
    • Honmo S, Ozaki A, Yamamoto M et al. Low p38 MAPK and JNK activation in cultured hepatocytes of DRH rats; a strain highly resistant to hepatocarcinogenesis. Mol Carcinog 2007 46 : 758 65.
    • (2007) Mol Carcinog , vol.46 , pp. 758-765
    • Honmo, S.1    Ozaki, A.2    Yamamoto, M.3
  • 56
    • 26044460465 scopus 로고    scopus 로고
    • Differential growth capacity between infant and adult mouse hepatocytes in vitro correlates to the cyclin D1 level without relation to oxidative DNA damage
    • Imamura E, Yamamoto M, Miyakoshi M et al. Differential growth capacity between infant and adult mouse hepatocytes in vitro correlates to the cyclin D1 level without relation to oxidative DNA damage. Liver Int 2005 25 : 1036 43.
    • (2005) Liver Int , vol.25 , pp. 1036-1043
    • Imamura, E.1    Yamamoto, M.2    Miyakoshi, M.3
  • 57
    • 0021971058 scopus 로고
    • Effect of aging on proliferative activity of normal and carcinogen-altered hepatocytes in rat liver after a two-thirds partial hepatectomy
    • Ogawa K, Mukai S, Onoe T. Effect of aging on proliferative activity of normal and carcinogen-altered hepatocytes in rat liver after a two-thirds partial hepatectomy. Jpn J Cancer Res 1985 76 : 779 84.
    • (1985) Jpn J Cancer Res , vol.76 , pp. 779-784
    • Ogawa, K.1    Mukai, S.2    Onoe, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.