메뉴 건너뛰기




Volumn 125, Issue 21, 2015, Pages 3297-3305

Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA IMMUNOGLOBULIN M; B LYMPHOCYTE RECEPTOR; BREAKPOINT CLUSTER REGION PROTEIN; CD37 ANTIGEN; CD63 ANTIGEN; CD9 ANTIGEN; IBRUTINIB; IMMUNOGLOBULIN; MICRORNA; MICRORNA 1246; MICRORNA 150; MICRORNA 155; MICRORNA 191; MICRORNA 223; MICRORNA 29; MICRORNA 29A; MICRORNA 29B; MICRORNA 29C; MICRORNA 302D; MICRORNA 579; MICRORNA 630; MICRORNA LET 7D; UNCLASSIFIED DRUG; LYMPHOCYTE ANTIGEN RECEPTOR; TRANSCRIPTOME;

EID: 84983456248     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-12-618470     Document Type: Article
Times cited : (139)

References (71)
  • 1
    • 84892868891 scopus 로고    scopus 로고
    • The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: Insight into disease biology and new targeted therapies
    • Burger JA, Gribben JG. The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: insight into disease biology and new targeted therapies. Semin Cancer Biol. 2014;24:71-81.
    • (2014) Semin Cancer Biol. , vol.24 , pp. 71-81
    • Burger, J.A.1    Gribben, J.G.2
  • 2
    • 84875802229 scopus 로고    scopus 로고
    • Biology of chronic lymphocytic leukemia in different microenvironments: Clinical and therapeutic implications
    • Herishanu Y, Katz BZ, Lipsky A, Wiestner A. Biology of chronic lymphocytic leukemia in different microenvironments: clinical and therapeutic implications. Hematol Oncol Clin North Am. 2013;27(2):173-206.
    • (2013) Hematol Oncol Clin North Am. , vol.27 , Issue.2 , pp. 173-206
    • Herishanu, Y.1    Katz, B.Z.2    Lipsky, A.3    Wiestner, A.4
  • 3
    • 84897901864 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)
    • Woyach JA, Bojnik E, Ruppert AS, et al. Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL). Blood. 2014;123(8):1207-1213.
    • (2014) Blood , vol.123 , Issue.8 , pp. 1207-1213
    • Woyach, J.A.1    Bojnik, E.2    Ruppert, A.S.3
  • 4
    • 84888440844 scopus 로고    scopus 로고
    • B cell receptor signaling in chronic lymphocytic leukemia
    • Burger JA, Chiorazzi N. B cell receptor signaling in chronic lymphocytic leukemia. Trends Immunol. 2013;34(12):592-601.
    • (2013) Trends Immunol. , vol.34 , Issue.12 , pp. 592-601
    • Burger, J.A.1    Chiorazzi, N.2
  • 5
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999;94(6):1840-1847.
    • (1999) Blood , vol.94 , Issue.6 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 6
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94(6): 1848-1854.
    • (1999) Blood , vol.94 , Issue.6 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 7
    • 0035803371 scopus 로고    scopus 로고
    • Relation of gene expression phenotype to immunoglobulin mutation genotype in B cellchronic lymphocytic leukemia
    • Rosenwald A, Alizadeh AA, Widhopf G, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cellchronic lymphocytic leukemia. J Exp Med. 2001; 194(11):1639-1647.
    • (2001) J Exp Med. , vol.194 , Issue.11 , pp. 1639-1647
    • Rosenwald, A.1    Alizadeh, A.A.2    Widhopf, G.3
  • 8
    • 10744222814 scopus 로고    scopus 로고
    • ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile
    • Wiestner A, Rosenwald A, Barry TS, et al. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. Blood. 2003;101(12): 4944-4951.
    • (2003) Blood , vol.101 , Issue.12 , pp. 4944-4951
    • Wiestner, A.1    Rosenwald, A.2    Barry, T.S.3
  • 9
    • 0037306842 scopus 로고    scopus 로고
    • Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia
    • Lanham S, Hamblin T, Oscier D, Ibbotson R, Stevenson F, Packham G. Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia. Blood. 2003;101(3): 1087-1093.
    • (2003) Blood , vol.101 , Issue.3 , pp. 1087-1093
    • Lanham, S.1    Hamblin, T.2    Oscier, D.3    Ibbotson, R.4    Stevenson, F.5    Packham, G.6
  • 10
    • 84897451152 scopus 로고    scopus 로고
    • A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor
    • Burke RT, Meadows S, Loriaux MM, et al. A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor. Oncotarget. 2014;5(4):908-915.
    • (2014) Oncotarget , vol.5 , Issue.4 , pp. 908-915
    • Burke, R.T.1    Meadows, S.2    Loriaux, M.M.3
  • 11
    • 84900484963 scopus 로고    scopus 로고
    • Leukaemic cells from chronic lymphocytic leukaemia patients undergo apoptosis following microtubule depolymerization and Lyn inhibition by nocodazole
    • Frezzato F, Trimarco V, Martini V, et al. Leukaemic cells from chronic lymphocytic leukaemia patients undergo apoptosis following microtubule depolymerization and Lyn inhibition by nocodazole. Br J Haematol. 2014;165(5): 659-672.
    • (2014) Br J Haematol. , vol.165 , Issue.5 , pp. 659-672
    • Frezzato, F.1    Trimarco, V.2    Martini, V.3
  • 12
    • 84884523966 scopus 로고    scopus 로고
    • Ibrutinib in relapsed chronic lymphocytic leukemia
    • Byrd JC, O'Brien S, James DF. Ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med. 2013;369(13):1278-1279.
    • (2013) N Engl J Med. , vol.369 , Issue.13 , pp. 1278-1279
    • Byrd, J.C.1    O'Brien, S.2    James, D.F.3
  • 13
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumormicroenvironment
    • Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumormicroenvironment. Cancer Cell. 2012;21(3): 309-322.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 14
    • 84861116448 scopus 로고    scopus 로고
    • Tumor microenvironment complexity: Emerging roles in cancer therapy
    • Swartz MA, Iida N, Roberts EW, et al. Tumor microenvironment complexity: emerging roles in cancer therapy. Cancer Res. 2012;72(10): 2473-2480.
    • (2012) Cancer Res. , vol.72 , Issue.10 , pp. 2473-2480
    • Swartz, M.A.1    Iida, N.2    Roberts, E.W.3
  • 15
    • 84862618600 scopus 로고    scopus 로고
    • Tumor-derived microvesicles: Shedding light on novel microenvironment modulators and prospective cancer biomarkers
    • D'Souza-Schorey C, Clancy JW. Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers. Genes Dev. 2012;26(12): 1287-1299.
    • (2012) Genes Dev. , vol.26 , Issue.12 , pp. 1287-1299
    • D'Souza-Schorey, C.1    Clancy, J.W.2
  • 16
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: Exosomes, microvesicles, and friends
    • Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200(4):373-383.
    • (2013) J Cell Biol. , vol.200 , Issue.4 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 17
    • 84880280703 scopus 로고    scopus 로고
    • Extracellular vesicles in chronic lymphocytic leukemia
    • Haderk F, Hanna B, Richter K, et al. Extracellular vesicles in chronic lymphocytic leukemia. Leuk Lymphoma. 2013;54(8):1826-1830.
    • (2013) Leuk Lymphoma , vol.54 , Issue.8 , pp. 1826-1830
    • Haderk, F.1    Hanna, B.2    Richter, K.3
  • 18
    • 85027933779 scopus 로고    scopus 로고
    • Exosomes: Immune properties and potential clinical implementations
    • Chaput N, Théry C. Exosomes: immune properties and potential clinical implementations. Semin Immunopathol. 2011;33(5):419-440.
    • (2011) Semin Immunopathol. , vol.33 , Issue.5 , pp. 419-440
    • Chaput, N.1    Théry, C.2
  • 19
    • 77950352713 scopus 로고    scopus 로고
    • Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: Implications for disease progression
    • Ghosh AK, Secreto CR, Knox TR, Ding W, Mukhopadhyay D, Kay NE. Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression. Blood. 2010;115(9):1755-1764.
    • (2010) Blood , vol.115 , Issue.9 , pp. 1755-1764
    • Ghosh, A.K.1    Secreto, C.R.2    Knox, T.R.3    Ding, W.4    Mukhopadhyay, D.5    Kay, N.E.6
  • 20
    • 79951470770 scopus 로고    scopus 로고
    • The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases:implications for therapy
    • Ghosh AK, Secreto C, Boysen J, et al. The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases:implications for therapy. Blood. 2011;117(6): 1928-1937.
    • (2011) Blood , vol.117 , Issue.6 , pp. 1928-1937
    • Ghosh, A.K.1    Secreto, C.2    Boysen, J.3
  • 21
    • 84886367490 scopus 로고    scopus 로고
    • Prognostic value of MIR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia
    • Ferrajoli A, Shanafelt TD, Ivan C, et al. Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia. Blood. 2013;122(11): 1891-1899.
    • (2013) Blood , vol.122 , Issue.11 , pp. 1891-1899
    • Ferrajoli, A.1    Shanafelt, T.D.2    Ivan, C.3
  • 22
    • 79955582317 scopus 로고    scopus 로고
    • MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia
    • Moussay E, Wang K, Cho JH, et al. MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia. Proc Natl Acad Sci USA. 2011;108(16):6573-6578.
    • (2011) Proc Natl Acad Sci USA. , vol.108 , Issue.16 , pp. 6573-6578
    • Moussay, E.1    Wang, K.2    Cho, J.H.3
  • 23
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Théry C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009;9(8):581-593.
    • (2009) Nat Rev Immunol. , vol.9 , Issue.8 , pp. 581-593
    • Théry, C.1    Ostrowski, M.2    Segura, E.3
  • 24
    • 0022201056 scopus 로고
    • Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
    • Pan BT, Teng K, Wu C, Adam M, Johnstone RM. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol. 1985;101(3): 942-948.
    • (1985) J Cell Biol. , vol.101 , Issue.3 , pp. 942-948
    • Pan, B.T.1    Teng, K.2    Wu, C.3    Adam, M.4    Johnstone, R.M.5
  • 25
    • 0033485648 scopus 로고    scopus 로고
    • Activated platelets release two types of membrane vesicles: Microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules
    • Heijnen HF, Schiel AE, Fijnheer R, Geuze HJ, Sixma JJ. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood. 1999;94(11):3791-3799.
    • (1999) Blood , vol.94 , Issue.11 , pp. 3791-3799
    • Heijnen, H.F.1    Schiel, A.E.2    Fijnheer, R.3    Geuze, H.J.4    Sixma, J.J.5
  • 26
    • 43249109372 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    • 1-3.22.29
    • Thery C, Amigorena S, Raposo G, et al. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol. 2006:3.22.1-3.22.29.
    • (2006) Curr Protoc Cell Biol. , vol.3 , pp. 22
    • Thery, C.1    Amigorena, S.2    Raposo, G.3
  • 27
    • 0037490207 scopus 로고    scopus 로고
    • Exosome release is regulated by a calciumdependent mechanism in K562 cells
    • Savina A, Furlán M, Vidal M, Colombo MI. Exosome release is regulated by a calciumdependent mechanism in K562 cells. J Biol Chem. 2003;278(22):20083-20090.
    • (2003) J Biol Chem. , vol.278 , Issue.22 , pp. 20083-20090
    • Savina, A.1    Furlán, M.2    Vidal, M.3    Colombo, M.I.4
  • 28
    • 81055157988 scopus 로고    scopus 로고
    • Exosome secretion: Molecular mechanisms and roles in immune responses
    • Bobrie A, Colombo M, Raposo G, Théry C. Exosome secretion: molecular mechanisms and roles in immune responses. Traffic. 2011;12(12): 1659-1668.
    • (2011) Traffic , vol.12 , Issue.12 , pp. 1659-1668
    • Bobrie, A.1    Colombo, M.2    Raposo, G.3    Théry, C.4
  • 29
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    • Peinado H, Aleeč;ković M, Lavotshkin S, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012;18(6): 883-891.
    • (2012) Nat Med. , Issue.18 , pp. 883-891
    • Peinado, H.1    Aleeč Ković, M.2    Lavotshkin, S.3
  • 30
    • 84864503916 scopus 로고    scopus 로고
    • MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
    • Fabbri M, Paone A, Calore F, et al. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci USA. 2012;109(31):E2110-E2116.
    • (2012) Proc Natl Acad Sci USA. , vol.109 , Issue.31 , pp. E2110-E2116
    • Fabbri, M.1    Paone, A.2    Calore, F.3
  • 31
    • 84905643012 scopus 로고    scopus 로고
    • Hypoxiainducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
    • Wang T, Gilkes DM, Takano N, et al. Hypoxiainducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proc Natl Acad Sci USA. 2014;111(31):E3234-E3242.
    • (2014) Proc Natl Acad Sci USA. , vol.111 , Issue.31 , pp. E3234-E3242
    • Wang, T.1    Gilkes, D.M.2    Takano, N.3
  • 32
    • 84904868088 scopus 로고    scopus 로고
    • Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells
    • Wang J, Hendrix A, Hernot S, et al. Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells. Blood. 2014;124(4):555-566.
    • (2014) Blood , vol.124 , Issue.4 , pp. 555-566
    • Wang, J.1    Hendrix, A.2    Hernot, S.3
  • 33
    • 84876927914 scopus 로고    scopus 로고
    • Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development
    • Kucharzewska P, Christianson HC, Welch JE, et al. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc Natl Acad Sci USA. 2013; 110(18):7312-7317.
    • (2013) Proc Natl Acad Sci USA. , vol.110 , Issue.18 , pp. 7312-7317
    • Kucharzewska, P.1    Christianson, H.C.2    Welch, J.E.3
  • 34
    • 76649097628 scopus 로고    scopus 로고
    • Membraneassociated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
    • Chalmin F, Ladoire S, Mignot G, et al. Membraneassociated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest. 2010;120(2): 457-471.
    • (2010) J Clin Invest. , vol.120 , Issue.2 , pp. 457-471
    • Chalmin, F.1    Ladoire, S.2    Mignot, G.3
  • 35
    • 84871563123 scopus 로고    scopus 로고
    • Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration
    • Luga V, Zhang L, Viloria-Petit AM, et al. Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell. 2012;151(7):1542-1556.
    • (2012) Cell , vol.151 , Issue.7 , pp. 1542-1556
    • Luga, V.1    Zhang, L.2    Viloria-Petit, A.M.3
  • 36
    • 77957195392 scopus 로고    scopus 로고
    • Exosome release of b-catenin: A novel mechanism that antagonizes Wnt signaling
    • Chairoungdua A, Smith DL, Pochard P, Hull M, Caplan MJ. Exosome release of b-catenin: a novel mechanism that antagonizes Wnt signaling. J Cell Biol. 2010;190(6):1079-1091.
    • (2010) J Cell Biol. , vol.190 , Issue.6 , pp. 1079-1091
    • Chairoungdua, A.1    Smith, D.L.2    Pochard, P.3    Hull, M.4    Caplan, M.J.5
  • 37
    • 78649958307 scopus 로고    scopus 로고
    • Cancer exosomes trigger fibroblast to myofibroblast differentiation
    • Webber J, Steadman R, Mason MD, Tabi Z, Clayton A. Cancer exosomes trigger fibroblast to myofibroblast differentiation. Cancer Res. 2010;70(23):9621-9630.
    • (2010) Cancer Res. , vol.70 , Issue.23 , pp. 9621-9630
    • Webber, J.1    Steadman, R.2    Mason, M.D.3    Tabi, Z.4    Clayton, A.5
  • 38
    • 45149100665 scopus 로고    scopus 로고
    • International workshop on chronic lymphocytic leukemia. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the international workshop on chronic lymphocytic leukemia updating the national cancer institute-working group 1996
    • Hallek M, Cheson BD, Catovsky D, et al; International Workshop on Chronic Lymphocytic Leukemia. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111(12):5446-5456.
    • (2008) Guidelines. Blood , vol.111 , Issue.12 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3
  • 39
    • 84871236598 scopus 로고    scopus 로고
    • The novel cyclin-dependent kinase inhibitor dinaciclib (SCH727965) promotes apoptosis and abrogates microenvironmental cytokine protection in chronic lymphocytic leukemia cells
    • Johnson AJ, Yeh YY, Smith LL, et al. The novel cyclin-dependent kinase inhibitor dinaciclib (SCH727965) promotes apoptosis and abrogates microenvironmental cytokine protection in chronic lymphocytic leukemia cells. Leukemia. 2012; 26(12):2554-2557.
    • (2012) Leukemia , vol.26 , Issue.12 , pp. 2554-2557
    • Johnson, A.J.1    Yeh, Y.Y.2    Smith, L.L.3
  • 40
    • 80055118968 scopus 로고    scopus 로고
    • Sizing and phenotyping of cellular vesicles using nanoparticle tracking analysis
    • Dragovic RA, Gardiner C, Brooks AS, et al. Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis. Nanomedicine (Lond Print). 2011;7(6):780-788.
    • (2011) Nanomedicine (Lond Print) , vol.7 , Issue.6 , pp. 780-788
    • Dragovic, R.A.1    Gardiner, C.2    Brooks, A.S.3
  • 41
    • 84923281763 scopus 로고    scopus 로고
    • Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia
    • Yeh YY, Chen R, Hessler J, et al. Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia. Oncotarget. 2015;6(5):2667-2679.
    • (2015) Oncotarget , vol.6 , Issue.5 , pp. 2667-2679
    • Yeh, Y.Y.1    Chen, R.2    Hessler, J.3
  • 42
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • RESEARCH0034
    • Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3(7): RESEARCH0034.
    • (2002) Genome Biol. , vol.3 , Issue.7
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3
  • 43
    • 84878771209 scopus 로고    scopus 로고
    • Gene feature discovery in RNA-seq experiments from multiple sources
    • Ozer HG, Parvin JD, Huang K. DFI: gene feature discovery in RNA-seq experiments from multiple sources. BMC Genomics. 2012;13(Suppl 8):S11.
    • (2012) BMC Genomics , vol.13 , pp. S11
    • Ozer, H.G.1    Parvin, J.D.2    Dfi, H.K.3
  • 44
    • 84903186936 scopus 로고    scopus 로고
    • Non-inhibited MIRNAs shape the cellular response to anti-MIR
    • Androsavich JR, Chau BN. Non-inhibited miRNAs shape the cellular response to anti-miR. Nucleic Acids Res. 2014;42(11):6945-6955.
    • (2014) Nucleic Acids Res. , vol.42 , Issue.11 , pp. 6945-6955
    • Androsavich, J.R.1    Chau, B.N.2
  • 45
    • 84894286325 scopus 로고    scopus 로고
    • Dynamic impacts of the inhibition of the molecular chaperone Hsp90 on the T-cell proteome have implications for anticancer therapy
    • Fierro-Monti I, Echeverria P, Racle J, Hernandez C, Picard D, Quadroni M. Dynamic impacts of the inhibition of the molecular chaperone Hsp90 on the T-cell proteome have implications for anticancer therapy. PLoS ONE. 2013;8(11):e80425.
    • (2013) PLoS ONE , vol.8 , Issue.11 , pp. e80425
    • Fierro-Monti, I.1    Echeverria, P.2    Racle, J.3    Hernandez, C.4    Picard, D.5    Quadroni, M.6
  • 46
    • 0036533633 scopus 로고    scopus 로고
    • TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex
    • Blanchard N, Lankar D, Faure F, et al. TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex. J Immunol. 2002;168(7):3235-3241.
    • (2002) J Immunol. , vol.168 , Issue.7 , pp. 3235-3241
    • Blanchard, N.1    Lankar, D.2    Faure, F.3
  • 47
    • 0035166047 scopus 로고    scopus 로고
    • Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry
    • Clayton A, Court J, Navabi H, et al. Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry. J Immunol Methods. 2001;247(1-2):163-174.
    • (2001) J Immunol Methods , vol.247 , Issue.1-2 , pp. 163-174
    • Clayton, A.1    Court, J.2    Navabi, H.3
  • 48
    • 84866152581 scopus 로고    scopus 로고
    • Immune surveillance properties of human NK cell-derived exosomes
    • Lugini L, Cecchetti S, Huber V, et al. Immune surveillance properties of human NK cell-derived exosomes. J Immunol. 2012;189(6):2833-2842.
    • (2012) J Immunol. , vol.189 , Issue.6 , pp. 2833-2842
    • Lugini, L.1    Cecchetti, S.2    Huber, V.3
  • 49
    • 0040089526 scopus 로고    scopus 로고
    • Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73
    • Théry C, Regnault A, Garin J, et al. Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73. J Cell Biol. 1999;147(3): 599-610.
    • (1999) J Cell Biol. , vol.147 , Issue.3 , pp. 599-610
    • Théry, C.1    Regnault, A.2    Garin, J.3    Et, A.4
  • 50
    • 20244373139 scopus 로고    scopus 로고
    • Tumorderived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
    • Wolfers J, Lozier A, Raposo G, et al. Tumorderived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med. 2001;7(3):297-303.
    • (2001) Nat Med. , vol.7 , Issue.3 , pp. 297-303
    • Wolfers, J.1    Lozier, A.2    Raposo, G.3
  • 51
    • 84892607130 scopus 로고    scopus 로고
    • Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion
    • Atay S, Banskota S, Crow J, Sethi G, Rink L, Godwin AK. Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion. Proc Natl Acad Sci USA. 2014;111(2): 711-716.
    • (2014) Proc Natl Acad Sci USA. , vol.111 , Issue.2 , pp. 711-716
    • Atay, S.1    Banskota, S.2    Crow, J.3    Sethi, G.4    Rink, L.5    Godwin, A.K.6
  • 52
    • 50949130683 scopus 로고    scopus 로고
    • Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor
    • Saunderson SC, Schuberth PC, Dunn AC, et al. Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor. J Immunol. 2008;180(12):8146-8152.
    • (2008) J Immunol. , vol.180 , Issue.12 , pp. 8146-8152
    • Saunderson, S.C.1    Schuberth, P.C.2    Dunn, A.C.3
  • 53
    • 22044447897 scopus 로고    scopus 로고
    • ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming
    • Segura E, Nicco C, Lombard B, et al. ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming. Blood. 2005;106(1): 216-223.
    • (2005) Blood , vol.106 , Issue.1 , pp. 216-223
    • Segura, E.1    Nicco, C.2    Lombard, B.3
  • 54
    • 84866152172 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
    • Dühren-von Minden M, Übelhart R, Schneider D, et al. Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature. 2012;489(7415):309-312.
    • (2012) Nature , vol.489 , Issue.7415 , pp. 309-312
    • Dühren-Von Minden, M.1    Übelhart, R.2    Schneider, D.3
  • 55
    • 79959404661 scopus 로고    scopus 로고
    • Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
    • Herman SE, Gordon AL, Hertlein E, et al. Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood. 2011;117(23):6287-6296.
    • (2011) Blood , vol.117 , Issue.23 , pp. 6287-6296
    • Herman, S.E.1    Gordon, A.L.2    Hertlein, E.3
  • 56
    • 84879748062 scopus 로고    scopus 로고
    • Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
    • Byrd JC, Furman RR, Coutre SE, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med. 2013;369(1):32-42.
    • (2013) N Engl J Med. , vol.369 , Issue.1 , pp. 32-42
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.E.3
  • 57
    • 84872534918 scopus 로고    scopus 로고
    • RNA trafficking by acute myelogenous leukemia exosomes
    • Huan J, Hornick NI, Shurtleff MJ, et al. RNA trafficking by acute myelogenous leukemia exosomes. Cancer Res. 2013;73(2):918-929.
    • (2013) Cancer Res. , vol.73 , Issue.2 , pp. 918-929
    • Huan, J.1    Hornick, N.I.2    Shurtleff, M.J.3
  • 58
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654-659.
    • (2007) Nat Cell Biol. , vol.9 , Issue.6 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 59
    • 27244434788 scopus 로고    scopus 로고
    • A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    • Calin GA, Ferracin M, Cimmino A, et al. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 2005;353(17):1793-1801.
    • (2005) N Engl J Med. , vol.353 , Issue.17 , pp. 1793-1801
    • Calin, G.A.1    Ferracin, M.2    Cimmino, A.3
  • 60
    • 25444520537 scopus 로고    scopus 로고
    • MIR-15 and MIR-16 induce apoptosis by targeting BCL2
    • Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA. 2005;102(39):13944-13949.
    • (2005) Proc Natl Acad Sci USA. , vol.102 , Issue.39 , pp. 13944-13949
    • Cimmino, A.1    Calin, G.A.2    Fabbri, M.3
  • 61
    • 84904887947 scopus 로고    scopus 로고
    • MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia
    • Cui B, Chen L, Zhang S, et al. MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. Blood. 2014;124(4): 546-554.
    • (2014) Blood , vol.124 , Issue.4 , pp. 546-554
    • Cui, B.1    Chen, L.2    Zhang, S.3
  • 62
    • 70449713652 scopus 로고    scopus 로고
    • Karyotype-specific microRNA signature in chronic lymphocytic leukemia
    • Visone R, Rassenti LZ, Veronese A, et al. Karyotype-specific microRNA signature in chronic lymphocytic leukemia. Blood. 2009;114(18): 3872-3879.
    • (2009) Blood , vol.114 , Issue.18 , pp. 3872-3879
    • Visone, R.1    Rassenti, L.Z.2    Veronese, A.3
  • 63
    • 67149147424 scopus 로고    scopus 로고
    • MicroRNA-29c and microRNA-223 downregulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification
    • Stamatopoulos B, Meuleman N, Haibe-Kains B, et al. microRNA-29c and microRNA-223 downregulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification. Blood. 2009;113(21):5237-5245.
    • (2009) Blood , vol.113 , Issue.21 , pp. 5237-5245
    • Stamatopoulos, B.1    Meuleman, N.2    Haibe-Kains, B.3
  • 64
    • 84903977667 scopus 로고    scopus 로고
    • MIR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1
    • Mraz M, Chen L, Rassenti LZ, et al. miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1. Blood. 2014;124(1):84-95.
    • (2014) Blood , vol.124 , Issue.1 , pp. 84-95
    • Mraz, M.1    Chen, L.2    Rassenti, L.Z.3
  • 65
    • 42449141513 scopus 로고    scopus 로고
    • MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
    • Garzon R, Volinia S, Liu CG, et al. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood. 2008;111(6):3183-3189.
    • (2008) Blood , vol.111 , Issue.6 , pp. 3183-3189
    • Garzon, R.1    Volinia, S.2    Liu, C.G.3
  • 66
    • 84898000670 scopus 로고    scopus 로고
    • Increased microRNA-630 expression in gastric cancer is associated with poor overall survival
    • Chu D, Zhao Z, Li Y, et al. Increased microRNA-630 expression in gastric cancer is associated with poor overall survival. PLoS ONE. 2014;9(3): e90526.
    • (2014) PLoS ONE , vol.9 , Issue.3 , pp. e90526
    • Chu, D.1    Zhao, Z.2    Li, Y.3
  • 67
    • 84923025327 scopus 로고    scopus 로고
    • Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1
    • Ma X, Li C, Sun L, et al. Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1. Nat Commun. 2014;5:5212.
    • (2014) Nat Commun. , vol.5 , pp. 5212
    • Ma, X.1    Li, C.2    Sun, L.3
  • 68
    • 77950839553 scopus 로고    scopus 로고
    • Children's cancer and leukaemia group malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets
    • Palmer RD, Murray MJ, Saini HK, et al; Children's Cancer and Leukaemia Group. Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets. Cancer Res. 2010;70(7): 2911-2923.
    • (2010) Cancer Res. , vol.70 , Issue.7 , pp. 2911-2923
    • Palmer, R.D.1    Murray, M.J.2    Saini, H.K.3
  • 69
    • 84859129420 scopus 로고    scopus 로고
    • Mirna expression profiles identify drivers in colorectal and pancreatic cancers
    • Piepoli A, Tavano F, Copetti M, et al. Mirna expression profiles identify drivers in colorectal and pancreatic cancers. PLoS ONE. 2012;7(3): e33663.
    • (2012) PLoS ONE , vol.7 , Issue.3 , pp. e33663
    • Piepoli, A.1    Tavano, F.2    Copetti, M.3
  • 70
    • 41449093809 scopus 로고    scopus 로고
    • B-cell receptor activation induces BIC/MIR-155 expression through a conserved AP-1 element
    • Yin Q, Wang X, McBride J, Fewell C, Flemington E. B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element. J Biol Chem. 2008;283(5):2654-2662.
    • (2008) J Biol Chem. , vol.283 , Issue.5 , pp. 2654-2662
    • Yin, Q.1    Wang, X.2    McBride, J.3    Fewell, C.4    Flemington, E.5
  • 71
    • 84983462314 scopus 로고    scopus 로고
    • Aberrant PD-L1 expression in CLL as a result of adaptive immune resistance mediated by tumor-secreted circulating miRNA binding to Toll-like receptor 7 [abstract]
    • Abstract 716
    • McClanahan F, Calore F, Zanesi N, et al. Aberrant PD-L1 expression in CLL as a result of adaptive immune resistance mediated by tumor-secreted circulating miRNA binding to Toll-like receptor 7 [abstract]. Blood. 2014; 124(21). Abstract 716.
    • (2014) Blood , vol.124 , Issue.21
    • McClanahan, F.1    Calore, F.2    Zanesi, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.