Leukaemic cells from chronic lymphocytic leukaemia patients undergo apoptosis following microtubule depolymerization and Lyn inhibition by nocodazole

British Journal of Haematology

Volumn 165, Issue 5, 2014, Pages 659-672

  Frezzato, Federica ^a,b   Trimarco, Valentina ^a,b   Martini, Veronica ^a,b   Gattazzo, Cristina ^a,b   Ave, Elisa ^a,b   Visentin, Andrea ^a,b   Cabrelle, Anna ^a   Olivieri, Valeria ^a,b   Zambello, Renato ^a,b   Facco, Monica ^a,b   Zonta, Francesca ^c   Cristiani, Andrea ^d   Brunati, Anna Maria ^c   Moro, Stefano ^c   Semenzato, Gianpietro ^a,b   Trentin, Livio ^a,b  

^a VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^b UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d CRS4 Parco Polaris ^*  (Italy)

Author keywords

Apoptosis; Chronic lymphocytic leukaemia; Inhibitor; Lyn; Nocodazole

Indexed keywords

NOCODAZOLE; PROTEIN KINASE LYN; TYROSINE; ANTINEOPLASTIC AGENT; BREAKPOINT CLUSTER REGION PROTEIN; LYN PROTEIN-TYROSINE KINASE; PROTEIN TYROSINE KINASE; TUBULIN MODULATOR;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER PROGNOSIS; CELL MEMBRANE DEPOLARIZATION; CELL SURVIVAL; CELL VIABILITY; CHRONIC LYMPHATIC LEUKEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLYMERIZATION; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; MAJOR CLINICAL STUDY; MALE; MESENCHYMAL STROMA CELL; MICROTUBULE; MITOCHONDRIAL MEMBRANE; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; VERY ELDERLY; ANTAGONISTS AND INHIBITORS; B LYMPHOCYTE; CELL COMMUNICATION; COCULTURE; CONFOCAL MICROSCOPY; DRUG EFFECTS; DRUG SCREENING; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; PROCEDURES; PROGNOSIS; TUMOR CELL CULTURE;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; APOPTOSIS; B-LYMPHOCYTES; CELL COMMUNICATION; COCULTURE TECHNIQUES; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MESENCHYMAL STROMAL CELLS; MICROSCOPY, CONFOCAL; MICROTUBULES; MIDDLE AGED; NOCODAZOLE; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-BCR; SRC-FAMILY KINASES; T-LYMPHOCYTES; TUBULIN MODULATORS; TUMOR CELLS, CULTURED;

EID: 84900484963     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12815     Document Type: Article

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