mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts

Aging Cell

Volumn 15, Issue 6, 2016, Pages 1103-1112

  Romero, Yair ^a   Bueno, Marta ^b   Ramirez, Remedios ^a   Álvarez, Diana ^b   Sembrat, John C ^b   Goncharova, Elena A ^b   Rojas, Mauricio ^b   Selman, Moisés ^c   Mora, Ana L ^b   Pardo, Annie ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS   (Mexico)

Author keywords

aging; apoptosis; autophagy; idiopathic pulmonary fibrosis; lung fibroblast; mTOR pathway

Indexed keywords

2 (4 AMINO 1 ISOPROPYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 3 YL) 1H INDOL 5 OL; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN;

ADAPTIVE IMMUNITY; AGING; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CONTROLLED STUDY; FIBROSING ALVEOLITIS; HUMAN; HUMAN TISSUE; LUNG FIBROBLAST; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STARVATION; STRESS;

EID: 84983437332     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12514     Document Type: Article

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