Design, Synthesis, and Evaluation of Acrylamide Derivatives as Direct NLRP3 Inflammasome Inhibitors

ChemMedChem

Volumn , Issue , 2016, Pages 1790-1803

  Cocco, Mattia ^a   Miglio, Gianluca ^a   Giorgis, Marta ^a   Garella, Davide ^a   Marini, Elisabetta ^a   Costale, Annalisa ^a   Regazzoni, Luca ^b   Vistoli, Giulio ^b   Orioli, Marica ^b   Massulaha Ahmed, Raïhane ^c   Détraz Durieux, Isabelle ^c   Groslambert, Marine ^c   Py, Bénédicte F ^c   Bertinaria, Massimo ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c CENTRE INTERNATIONAL DE RECHERCHE EN INFECTIOLOGIE   (France)

Author keywords

acrylamide derivatives; drug design; inflammasomes; inflammation; pyroptosis

Indexed keywords

2 (2 CHLOROBENZYL) N (4 SULFAMOYLPHENETHYL)ACRYLAMIDE; 2 (2 CHLOROBENZYL) N PHENETHYLACRYLAMIDE; 2 (2 CHLOROBENZYL) N PROPYLACRYLAMIDE; 2 (2 CHLOROBENZYL) N [4 [N (CYCLOHEXYLCARBAMOYL)SULFAMOYL]PHENETHYL]ACRYLAMIDE; 2 (2 CHLOROBENZYL)ACRYLIC ACID; 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL] N CYCLOHEXYLACRYLAMIDE; 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL] N PROPYLACRYLAMIDE; 2 [[(TERT BUTYLDIMETHYLSILYL)OXY](2 CHLOROPHENYL)METHYL] N PROPYLACRYLAMIDE; 2 [[(TERT BUTYLDIMETHYLSILYL)OXY](2 CHLOROPHENYL)METHYL]ACRYLIC ACID; 2,5 DIOXOPYRROLIDIN 1 YL 2 (2 CHLOROBENZYL)ACRYLATE; 3 [2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]ACRYLAMIDO]PROPAN 1 AMINIUM 2,2,2 TRIFLUOROACETATE; 4 [2 (2 CHLOROBENZYL)ACRYLAMIDO]BUTANOIC ACID; ACRYLAMIDE DERIVATIVE; ADENOSINE TRIPHOSPHATASE; CRYOPYRIN; ETHYL 2 (2 CHLOROBENZYL)ACRYLATE; ETHYL 2 [[(TERT BUTYLDIMETHYLSILYL)OXY](2 CHLOROPHENYL)METHYL]ACRYLATE; ETHYL 3 (2 CHLOROPHENYL) 2 (DIETHOXYPHOSPHORYL)PROPANOATE; INTERLEUKIN 1BETA; METHYL 4 [2 (2 CHLOROBENZYL)ACRYLAMIDO]BUTANOATE; N (3 AMINOPROPYL) 2 (2 CHLOROBENZYL)ACRYLAMIDE TRIFLUOROACETATE; N BENZYL 2 (2 CHLOROBENZYL)ACRYLAMIDE; N BENZYL 2 [(2 CHLOROPHENYL)(HYDROXY)METHYL]ACRYLAMIDE; N BENZYL 2 [[(TERT BUTYLDIMETHYLSILYL)OXY](2 CHLOROPHENYL)METHYL]ACRYLAMIDE; N,N' (PROPANE 1,3 DIYL)BIS[2 (2 CHLOROBENZYL)ACRYLAMIDE]; TERT BUTYL [3 [2 [[(TERT BUTYLDIMETHYLSILYL)OXY](2 CHLOROPHENYL)METHYL]ACRYLAMIDO]PROPYL]CARBAMATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CINCA SYNDROME; CLINICAL EVALUATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC50; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PYROPTOSIS;

EID: 84983372452     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201600055     Document Type: Article

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