3-Hydroxy-3-methylglutaric and 3-methylglutaric acids impair redox status and energy production and transfer in rat heart: relevance for the pathophysiology of cardiac dysfunction in 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency

Free Radical Research

Volumn 50, Issue 9, 2016, Pages 997-1010

  da Rosa, Mateus Struecker ^a   Seminotti, Bianca ^a   Ribeiro, César Augusto João ^b   Parmeggiani, Belisa ^a   Grings, Mateus ^a   Wajner, Moacir ^a,c   Leipnitz, Guilhian ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSIDADE FEDERAL DO ABC   (Brazil)

^c HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

3 Hydroxy 3 methylglutaric acid; 3 methylglutaric acid; energy metabolism; heart; oxidative stress

Indexed keywords

3 HYDROXY 3 METHYLGLUTARIC ACID; 3 METHYLGLUTARIC ACID; ALLOPURINOL; CARBONYL DERIVATIVE; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; CREATINE KINASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A LYASE; LIPID; MELATONIN; REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE DISMUTASE; THIOCTIC ACID; UBIQUINOL CYTOCHROME C REDUCTASE; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A LYASE; 3-METHYLGLUTARIC ACID; LYASE;

3 HYDROXY 3 METHYLGLUTARYL COENZYME A LYASE DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CARDIOMYOPATHY; CONTROLLED STUDY; ENERGY TRANSFER; ENERGY YIELD; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; MOLECULAR PATHOLOGY; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PROTEIN CONTENT; RAT; ANALOGS AND DERIVATIVES; ANIMAL; DEFICIENCY; DISEASE MODEL; GENETICS; HEART DISEASE; HUMAN; OXIDATION REDUCTION REACTION; WISTAR RAT;

ANIMALS; DISEASE MODELS, ANIMAL; HEART DISEASES; HUMANS; MEGLUTOL; OXIDATION-REDUCTION; OXO-ACID-LYASES; RATS; RATS, WISTAR;

EID: 84983372398     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715762.2016.1214952     Document Type: Article

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