Complex ii of the mitochondrial respiratory chain is the key mediator of divalent manganese-induced hydrogen peroxide production in microglia

Toxicological Sciences

Volumn 132, Issue 2, 2013, Pages 298-306

  Liu, Yue ^a   Barber, David S ^b   Zhang, Ping ^a   Liu, Bin ^a  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b University of Florida   (United States)

Author keywords

Electron transport chain; Glia; Heavy metal; Neuroinflammation; Reactive oxygen species

Indexed keywords

CADMIUM; COBALT; COPPER ION; HYDROGEN PEROXIDE; IRON; MANGANESE; NICKEL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); ZINC ION;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL FRACTIONATION; CONTROLLED STUDY; CYTOSOL; MICROGLIA; MITOCHONDRION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT; RESPIRATORY CHAIN;

ANIMALS; BLOTTING, WESTERN; CATIONS, DIVALENT; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX II; HYDROGEN PEROXIDE; MANGANESE; MICROGLIA; MITOCHONDRIA; RATS; REACTIVE OXYGEN SPECIES;

EID: 84875245126     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs344     Document Type: Article

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