Creatine kinase and ATP synthase reaction rates in human frontal lobe measured by 31P magnetization transfer spectroscopy at 4T

Magnetic Resonance Imaging

Volumn 31, Issue 1, 2013, Pages 102-108

  Du, Fei ^a   Cooper, Alissa ^a   Lukas, Scott E ^a   Cohen, Bruce M ^a   Öngür, Dost ^a  

^a MCLEAN HOSPITAL   (United States)

Author keywords

31P MRS; Adenosine triphosphate (ATP); Bioenergetics; Frontal lobe; Magnetization transfer

Indexed keywords

CREATINE KINASE; PHOSPHATE; PHOSPHORUS 31; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ADULT; ARTICLE; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME METABOLISM; EXPERIMENTAL DESIGN; FEMALE; FRONTAL LOBE; HUMAN; HUMAN EXPERIMENT; HYDROLYSIS; IMAGE PROCESSING; MALE; NORMAL HUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

ADULT; ATP SYNTHETASE COMPLEXES; CREATINE KINASE; ENZYME ACTIVATION; FEMALE; FRONTAL LOBE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLIC CLEARANCE RATE; PHOSPHORUS ISOTOPES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION;

EID: 84870357969     PISSN: 0730725X     EISSN: 18735894     Source Type: Journal    
DOI: 10.1016/j.mri.2012.06.018     Document Type: Article

References (41)

1. Rezin G.T., Amboni G., Zugno A.I., Quevedo J., Streck E.L. Mitochondrial dysfunction and psychiatric disorders. Neurochem Res 2009, 34(6):1021-1029.
2. Stork C., Renshaw P.F. Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research. Mol Psychiatry 2005, 10(10):900-919.
3. 31P-MR spectroscopy reveals frontal and thalamic metabolic abnormalities in schizophrenia. Neuroimage 2007, 35(2):729-737.
4. Ongur D., Prescot A.P., Jensen J.E., Cohen B.M., Renshaw P.F. Creatine abnormalities in schizophrenia and bipolar disorder. Psychiatry Res 2009, 172(1):44-48.
5. Cataldo A.M., McPhie D.L., Lange N.T., Punzell S., Elmiligy S., Ye N.Z., et al. Abnormalities in mitochondrial structure in cells from patients with bipolar disorder. Am J Pathol 2010, 177(2):575-585.
6. Marchbanks R.M., Mulcrone J., Whatley S.A. Aspects of oxidative metabolism in schizophrenia. Br J Psychiatry 1995, 167(3):293-298.
7. Ben-Shachar D., Laifenfeld D. Mitochondria, synaptic plasticity, and schizophrenia. Int Rev Neurobiol 2004, 59:273-296.
8. Attwell D., Laughlin S.B. An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab 2001, 21(10):1133-1145.
9. Slater E.C., Holton F.A. Oxidative phosphorylation coupled with the oxidation of alpha-ketoglutarate by heart-muscle sarcosomes I. Kinetics of the oxidative phosphorylation reaction and adenine nucleotide specificity. Biochem J 1953, 55(3):530-544.
10. Saks V.A., Ventura-Clapier R., Aliev M.K. Metabolic control and metabolic capacity: two aspects of creatine kinase functioning in the cells. Biochim Biophys Acta 1996, 1274(3):81-88.
11. Kemp G.J. Non-invasive methods for studying brain energy metabolism: what they show and what it means. Dev Neurosci 2000, 22(5-6):418-428.
12. 31P MRS for measuring brain ATP synthesis. Proc Natl Acad Sci USA 2009, 106(10):3988-3993.
13. Du F., Zhu X.H., Zhang Y., Friedman M., Zhang N., Ugurbil K., et al. Tightly coupled brain activity and cerebral ATP metabolic rate. Proc Natl Acad Sci USA 2008, 105(17):6409-6414.
14. 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain. Magn Reson Med 2007, 57(1):103-114.
15. 31P nuclear magnetic resonance measurements of ATPase kinetics in aerobic Escherichia coli cells. Proc Natl Acad Sci USA 1977, 74(12):5551-5553.
16. de Graaf R.A., Luo Y., Garwood M., Nicolay K. B1-insensitive, single-shot localization and water suppression. J Magn Reson B 1996, 113(1):35-45.
17. 31P-nuclear magnetic resonance double saturation transfer measurements. Biophys J 1988, 54(5):921-929.
18. van den Boogaart A., Van Hecke A., Van Huffel P., Graveron-Demilly S., van Ormondt D., de Beer R. MRUI: a graphical user interface for accurate routine MRS data analysis 1996, 318. Prague.
19. 31P NMR saturation- and inversion-transfer study. Biochemistry 1985, 24(20):5510-5516.
20. 31P spectroscopic imaging of human brain at 4 Tesla: assessment of gray and white matter differences of phosphocreatine and ATP. Magn Reson Med 2001, 45(1):46-52.
21. Siesjo B.K. Brain energy metabolism 1978, Wiley, New York, 101-110p.
22. 31P magnetization transfer studies in the monkey brain. Magn Reson Med 1992, 26(1):100-115.
23. 31P NMR saturation transfer. 13th Proc Intl Soc Mag Reson Med 2005, 2767.
24. 31P magnetic resonance spectroscopy. Proc Natl Acad Sci USA 2003, 100(24):14409-14414.
25. 31P metabolite differences in human cerebral gray and white matter. Magn Reson Med 1998, 39(3):346-353.
26. Du F., Zhang Y., Iltis I., Marjanska M., Zhu X.H., Henry P.G., et al. In vivo proton MRS to quantify anesthetic effects of pentobarbital on cerebral metabolism and brain activity in rat. Magn Reson Med 2009, 62(6):1385-1393.
27. 31P spin-lattice relaxation times and resonance linewidths of rat tissue in vivo: dependence upon the static magnetic field strength. Magn Reson Med 1985, 2(4):410-417.
28. Xiong Q., Du F., Zhu X., Zhang P., Suntharalingam P., Ippolito J., et al. ATP production rate via creatine kinase or ATP synthase in vivo: a novel superfast magnetization saturation transfer method. Circ Res 2011, 108(6):653-663.
29. 31P MRS of human brain at high/ultrahigh fields: a quantitative comparison of NMR detection sensitivity and spectral resolution between 4 T and 7 T. Magn Reson Imaging 2006, 24(10):1281-1286.
30. 31P relaxation times in the human calf muscle: a comparison between 3 T and 7 T in vivo. Magn Reson Med 2009, 62(3):574-582.
31. Horska A., Horsky J., Spencer R.G.S. Measurement of Spin-lattice Relaxation Times in Systems Undergoing Chemcial Exchange. J Magn Reson Series A 1994, 110:82-89.
32. Weiss R.G., Gerstenblith G., Bottomley P.A. ATP flux through creatine kinase in the normal, stressed, and failing human heart. Proc Natl Acad Sci USA 2005, 102(3):808-813.
33. Joubert F., Mateo P., Gillet B., Beloeil J.C., Mazet J.L., Hoerter J.A. CK flux or direct ATP transfer: versatility of energy transfer pathways evidenced by NMR in the perfused heart. Mol Cell Biochem 2004, 256-257(1-2):43-58.
34. 31P NMR. J Magn Reson 1992, 99:443-448.
35. 31P saturation transfer and phosphocreatine imaging in the monkey brain. Proc Natl Acad Sci USA 1991, 88(19):8372-8376.
36. 31P NMR magnetization-transfer measurements of ATP turnover during steady-state isometric muscle contraction in the rat hind limb in vivo. Biochemistry 1989, 28(11):4887-4893.
37. 31P spectroscopy. The definition of localized volumes, dealing with saturation and the technique-dependence of quantification. NMR Biomed 1989, 2(5-6):284-289.
38. Sture Forsen R.A.H. Study of moderately rapid chemical exchange reactions by means of nuclear magnetic resonance. J Chem Phys 1963, 39(11):2892-2901.
39. Bottomley P.A., Ouwerkerk R., Lee R.F., Weiss R.G. Four-angle saturation transfer (FAST) method for measuring creatine kinase reaction rates in vivo. Magn Reson Med 2002, 47(5):850-863.
40. 31P spectroscopy for measuring human creatine kinase reaction kinetics. Magn Reson Med 2010, 63(6):1493-1501.
41. nom for rapidly measuring and quantifying CK activity in the rat brain. Joint Annual Meeting of ISMRM -ESMRMB 2010, 1111. Stockholm, Sweden.