The selective NADPH oxidase inhibitor apocynin has potential prophylactic effects on melamine-related nephrolithiasis in vitro and in vivo

Molecular and Cellular Biochemistry

Volumn 399, Issue 1-2, 2015, Pages 167-178

  Li, Xiaoran ^a   Lu, Jianzhong ^a   Shang, Panfeng ^a   Bao, Junsheng ^a   Yue, Zhongjin ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

Apocynin; Melamine; Nephrolithiasis; Oxidative stress; Rats

Indexed keywords

APOCYNIN; CREATININE; MALONALDEHYDE; MELAMINE; OSTEOPONTIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE DISMUTASE; SYNAPTOPHYSIN; UREA; ACETOPHENONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; TRIAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CRYSTALLIZATION; DRUG MECHANISM; ENZYME ACTIVITY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LIPID PEROXIDATION; MALE; NEPHROLITHIASIS; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT MODEL; UREA BLOOD LEVEL; WEIGHT; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMICALLY INDUCED; DRUG EFFECTS; FOOD CONTAMINATION; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ACETOPHENONES; ANIMALS; CELL LINE; FOOD CONTAMINATION; HUMANS; KIDNEY; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; NADPH OXIDASE; NEPHROLITHIASIS; OSTEOPONTIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; TRIAZINES;

EID: 84916885136     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2243-8     Document Type: Article

References (43)

1. He J, Zheng W, Zhao Y, Liu L, Yong J (2013) Diagnosis and therapy of acute urolithiasis caused by melamine contamination in infant formula milk. Exp Ther Med 5:1301–1304. doi:10.3892/etm.2013.1011
2. Mast RW, Jeffcoat AR, Sadler BM, Kraska RC, Friedman MA (1983) Metabolism, disposition and excretion of [14C] melamine in male Fischer 344 rats. Food Chem Toxicol 21:807–810
3. Dobson RL, Motlagh S, Quijano M, Cambron RT, Baker TR, Pullen AM, Regg BT, Bigalow-Kern AS, Vennard T, Fix A, Reimschuessel R, Overmann G, Shan Y, Daston GP (2008) Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs. Toxicol Sci 106:251–262. doi:10.1093/toxsci/kfn160
4. Park D, Kim TK, Choi YJ, Lee SH, Bae DK, Yang G, Yang YH, Joo SS, Choi EK, Ahn B, Kim JC, Kim KS, Kim YB (2011) Increased nephrotoxicity after combined administration of melamine and cyanuric Acid in rats. Lab Anim Res 27:25–28. doi:10.5625/lar.2011.27.1.25
5. Gamboa da Costa G, Jacob CC, Von Tungeln LS, Hasbrouck NR, Olson GR, Hattan DG, Reimschuessel R, Beland FA (2012) Dose-response assessment of nephrotoxicity from a twenty-eight-day combined-exposure to melamine and cyanuric acid in F344 rats. Toxicol Appl Pharmacol 262:99–106. doi:10.1016/j.taap.2012.04.031
6. Panfeng S, Hong C, Zhongjin Y, Wei Z, Wenhui L, Baoguang S, Junsheng B, Liingjun Z, Zizhen H (2011) Management of pediatric urolithiasis induced by melamine-contaminated powdered formula (report of 619 cases). Urology 78:411–416. doi:10.1016/j.urology.2011.02.020
7. Guo C, Yuan H, He Z (2012) Melamine causes apoptosis of rat kidney epithelial cell line (NRK-52e cells) via excessive intracellular ROS (reactive oxygen species) and the activation of p38 MAPK pathway. Cell Biol Int 36:383–389. doi:10.1042/cbi20110504
8. Han YG, Liu SC, Zhang T, Yang Z (2011) Induction of apoptosis by melamine in differentiated PC12 cells. Cell Mol Neurobiol 31:65–71. doi:10.1007/s10571-010-9554-4
9. Kuo FC, Tseng YT, Wu SR, Wu MT, Lo YC (2013) Melamine activates NFkappaB/COX-2/PGE2 pathway and increases NADPH oxidase-dependent ROS production in macrophages and human embryonic kidney cells. Toxicol In Vitro 27:1603–1611. doi:10.1016/j.tiv.2013.04.011
10. Khan SR (2006) Renal tubular damage/dysfunction: key to the formation of kidney stones. Urol Res 34:86–91. doi:10.1007/s00240-005-0016-2
11. Khan SR, Kok DJ (2004) Modulators of urinary stone formation. Front Biosci 9:1450–1482
12. Khan SR (2005) Hyperoxaluria-induced oxidative stress and antioxidants for renal protection. Urol Res 33:349–357. doi:10.1007/s00240-005-0492-4
13. Impellizzeri D, Esposito E, Mazzon E, Paterniti I, Di Paola R, Bramanti P, Cuzzocrea S (2011) Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol 81:636–648. doi:10.1016/j.bcp.2010.12.006
14. Chen YT, Hsuan SL, Jiann BP, Chou CC, Chang SC, Lee YF, Chien MS, Lee WC, Tsai FJ, Liao JW (2013) Effects of sodium citrate on melamine-cyanuric acid mixture-induced urolithiasis in rats. Clin Chim Acta 424:76–82. doi:10.1016/j.cca.2013.05.016
15. Lafeber FP, Beukelman CJ, van den Worm E, van Roy JL, Vianen ME, van Roon JA, van Dijk H, Bijlsma JW (1999) Apocynin, a plant-derived, cartilage-saving drug, might be useful in the treatment of rheumatoid arthritis. Rheumatology (Oxford) 38:1088–1093
16. Daly JW, Axelrod J, Witkop B (1960) Dynamic aspects of enzymatic O-methylation and -demethylation of catechols in vitro and in vivo. J Biol Chem 235:1155–1159
17. Li CY, Deng YL, Sun BH (2009) Effects of apocynin and losartan treatment on renal oxidative stress in a rat model of calcium oxalate nephrolithiasis. Int Urol Nephrol 41:823–833. doi:10.1007/s11255-009-9534-0
18. Yamaguchi S, Wiessner JH, Hasegawa AT, Hung LY, Mandel GS, Mandel NS (2005) Study of a rat model for calcium oxalate crystal formation without severe renal damage in selected conditions. Int J Urol 12:290–298. doi:10.1111/j.1442-2042.2005.01038.x
19. Mi J, Duan J, Zhang J, Lu J, Wang H, Wang Z (2012) Evaluation of antiurolithic effect and the possible mechanisms of Desmodium styracifolium and Pyrrosiae petiolosa in rats. Urol Res 40:151–161. doi:10.1007/s00240-011-0401-y
20. Khan SR (2011) Crystal/cell interaction and nephrolithiasis. Arch Ital Urol Androl 83:1–5
21. Khan SR (2013) Reactive oxygen species as the molecular modulators of calcium oxalate kidney stone formation: evidence from clinical and experimental investigations. J Urol 189:803–811. doi:10.1016/j.juro.2012.05.078
22. Xie Y, Sakatsume M, Nishi S, Narita I, Arakawa M, Gejyo F (2001) Expression, roles, receptors, and regulation of osteopontin in the kidney. Kidney Int 60:1645–1657. doi:10.1046/j.1523-1755.2001.00032.x
23. Hudkins KL, Giachelli CM, Cui Y, Couser WG, Johnson RJ, Alpers CE (1999) Osteopontin expression in fetal and mature human kidney. J Am Soc Nephrol 10:444–457
24. Khan SR, Johnson JM, Peck AB, Cornelius JG, Glenton PA (2002) Expression of osteopontin in rat kidneys: induction during ethylene glycol induced calcium oxalate nephrolithiasis. J Urol 168:1173–1181. doi:10.1097/01.ju.0000024398.45396.6c
25. Hsieh TJ, Chen R, Zhang SL, Liu F, Brezniceanu ML, Whiteside CI, Fantus IG, Ingelfinger JR, Hamet P, Chan JS (2006) Upregulation of osteopontin gene expression in diabetic rat proximal tubular cells revealed by microarray profiling. Kidney Int 69:1005–1015. doi:10.1038/sj.ki.5000206
26. Konya E, Umekawa T, Iguchi M, Kurita T (2003) The role of osteopontin on calcium oxalate crystal formation. Eur Urol 43:564–571
27. Kyriakis JM, Avruch J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807–869
28. An L, Li Z, Yang Z, Zhang T (2012) Melamine induced cognitive impairment associated with oxidative damage in rat’s hippocampus. Pharmacol Biochem Behav 102:196–202. doi:10.1016/j.pbb.2012.04.009
29. Guo C, He Z, Wen L, Zhu L, Lu Y, Deng S, Yang Y, Wei Q, Yuan H (2012) Cytoprotective effect of trolox against oxidative damage and apoptosis in the NRK-52e cells induced by melamine. Cell Biol Int 36:183–188. doi:10.1042/cbi20110036
30. Orient A, Donko A, Szabo A, Leto TL, Geiszt M (2007) Novel sources of reactive oxygen species in the human body. Nephrol Dial Transplant 22:1281–1288. doi:10.1093/ndt/gfm077
31. Etoh T, Inoguchi T, Kakimoto M, Sonoda N, Kobayashi K, Kuroda J, Sumimoto H, Nawata H (2003) Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment. Diabetologia 46:1428–1437. doi:10.1007/s00125-003-1205-6
32. Fujii M, Inoguchi T, Maeda Y, Sasaki S, Sawada F, Saito R, Kobayashi K, Sumimoto H, Takayanagi R (2007) Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice. Kidney Int 72:473–480. doi:10.1038/sj.ki.5002366
33. Gill PS, Wilcox CS (2006) NADPH oxidases in the kidney. Antioxid Redox Signal 8:1597–1607. doi:10.1089/ars.2006.8.1597
34. Hanna IR, Taniyama Y, Szocs K, Rocic P, Griendling KK (2002) NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling. Antioxid Redox Signal 4:899–914. doi:10.1089/152308602762197443
35. Wilcox CS, Welch WJ (2001) Oxidative stress: cause or consequence of hypertension. Exp Biol Med (Maywood) 226:619–620
36. Engels F, Renirie BF, Hart BA, Labadie RP, Nijkamp FP (1992) Effects of apocynin, a drug isolated from the roots of Picrorhiza kurroa, on arachidonic acid metabolism. FEBS Lett 305:254–256
37. Chirino YI, Sanchez-Gonzalez DJ, Martinez-Martinez CM, Cruz C, Pedraza-Chaverri J (2008) Protective effects of apocynin against cisplatin-induced oxidative stress and nephrotoxicity. Toxicology 245:18–23. doi:10.1016/j.tox.2007.12.007
38. Thamilselvan S, Hackett RL, Khan SR (1997) Lipid peroxidation in ethylene glycol induced hyperoxaluria and calcium oxalate nephrolithiasis. J Urol 157:1059–1063
39. Green ML, Freel RW, Hatch M (2005) Lipid peroxidation is not the underlying cause of renal injury in hyperoxaluric rats. Kidney Int 68:2629–2638. doi:10.1111/j.1523-1755.2005.00735.x
40. Huang HS, Ma MC, Chen J, Chen CF (2002) Changes in the oxidant–antioxidant balance in the kidney of rats with nephrolithiasis induced by ethylene glycol. J Urol 167:2584–2593
41. Lee HJ, Jeong SJ, Park MN, Linnes M, Han HJ, Kim JH, Lieske JC, Kim SH (2012) Gallotannin suppresses calcium oxalate crystal binding and oxalate-induced oxidative stress in renal epithelial cells. Biol Pharm Bull 35:539–544
42. Kim HB, Shanu A, Wood S, Parry SN, Collet M, McMahon A, Witting PK (2011) Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction. Free Radic Res 45:1000–1012. doi:10.3109/10715762.2011.590137
43. Zuo J, Khan A, Glenton PA, Khan SR (2011) Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-l-proline-induced hyperoxaluria in the male Sprague–Dawley rats. Nephrol Dial Transplant 26:1785–1796. doi:10.1093/ndt/gfr035