Mitochondrial dysfunction in heart failure

Heart Failure Reviews

Volumn 18, Issue 5, 2013, Pages 607-622

  Rosca, Mariana G ^a   Hoppel, Charles L ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Heart; Heart failure; Mitochondria; Oxidative phosphorylation; Skeletal muscle

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; CYTOKINE; INTERLEUKIN 6; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TUMOR NECROSIS FACTOR ALPHA;

ADRENERGIC STIMULATION; BIOACCUMULATION; BIOGENESIS; CELL ENERGY; CELL FUNCTION; CELL POPULATION; CELL STRUCTURE; CONFERENCE PAPER; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE COURSE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON TRANSPORT; ENERGY YIELD; HEART FAILURE; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HUMAN; MITOCHONDRIAL RESPIRATION; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MOLECULAR PATHOLOGY; MUSCLE CELL; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN DETERMINATION; PROTEIN FUNCTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

ANIMALS; HEART FAILURE; HUMANS; MITOCHONDRIA, HEART; MYOCARDIUM; PHOSPHORYLATION;

EID: 84885218123     PISSN: 13824147     EISSN: 15737322     Source Type: Journal    
DOI: 10.1007/s10741-012-9340-0     Document Type: Conference Paper

References (154)

1. Stanley WC, Recchia FA, Lopaschuk GD (2005) Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 85(3):1093-1129
2. Barth AS, Kumordzie A, Frangakis C, Margulies KB, Cappola TP, Tomaselli GF (2011) Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure. Circ Cardiovasc Genet 4(5):475-483
3. Okita K, Yonezawa K, Nishijima H, Hanada A, Ohtsubo M, Kohya T et al (1998) Skeletal muscle metabolism limits exercise capacity in patients with chronic heart failure. Circulation 98(18):1886-1891
4. Stratton JR, Kemp GJ, Daly RC, Yacoub M, Rajagopalan B (1994) Effects of cardiac transplantation on bioenergetic abnormalities of skeletal muscle in congestive heart failure. Circulation 89(4):1624-1631
5. Palmer JW, Tandler B, Hoppel CL (1985) Biochemical differences between subsarcolemmal and interfibrillar mitochondria from rat cardiac muscle: effects of procedural manipulations. Arch Biochem Biophys 236(2):691-702
6. Hoppel CL, Tandler B, Fujioka H, Riva A (2009) Dynamic organization of mitochondria in human heart and in myocardial disease. Int J Biochem Cell Biol 41(10):1949-1956
7. 2+ signaling. Int J Biochem Cell Biol 41(10):1957-1971
8. Tsyplenkova VG, Beskrovnova NN (1993) The comparative morphological and morphometric characteristics of the myocardium in patients with a clinical diagnosis of hypertrophic cardiomyopathy. Arkhiv patologii 55(3):26-29
9. Takemura G, Takatsu Y, Sakaguchi H, Fujiwara H (1997) Intranuclear mitochondria in human myocardial cells. Pathol Res Pract 193(4):305-311
10. Skulachev VP, Bakeeva LE, Chernyak BV, Domnina LV, Minin AA, Pletjushkina OY et al (2004) Thread-grain transition of mitochondrial reticulum as a step of mitoptosis and apoptosis. Mol Cellular Biochemistry 256-257(1-2):341-358
11. Dabkowski ER, Williamson CL, Bukowski VC, Chapman RS, Leonard SS, Peer CJ et al (2009) Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations. Am J Physiol 296(2):H359-H369
12. Riva A, Tandler B, Loffredo F, Vazquez E, Hoppel C (2005) Structural differences in two biochemically defined populations of cardiac mitochondria. Am J Physiol 289(2):H868-H872
13. Kaasik A, Veksler V, Boehm E, Novotova M, Minajeva A, Ventura-Clapier R (2001) Energetic crosstalk between organelles: architectural integration of energy production and utilization. Circ Res 89(2):153-159
14. Su X, Sekiguchi M, Endo M (2000) An ultrastructural study of cardiac myocytes in postmyocardial infarction ventricular aneurysm representative of chronic ischemic myocardium using semiquantitative and quantitative assessment. Cardiovasc Pathol 9(1):1-8
15. Coleman R, Silbermann M, Gershon D, Reznick AZ (1987) Giant mitochondria in the myocardium of aging and endurance-trained mice. Gerontology 33(1):34-39
16. Baandrup U, Florio RA, Roters F, Olsen EG (1981) Electron microscopic investigation of endomyocardial biopsy samples in hypertrophy and cardiomyopathy. A semiquantitative study in 48 patients. Circulation 63(6):1289-1298
17. Sharov VG, Goussev A, Lesch M, Goldstein S, Sabbah HN (1998) Abnormal mitochondrial function in myocardium of dogs with chronic heart failure. J Mol Cell Cardiol 30(9):1757-1762
18. Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Perkins G, Murphy AN, Naviaux R et al (2012) Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa. Clin Transl Sci 5(1):43-47
19. Munzel T, Kurz S, Drexler H (1993) Are alterations of skeletal muscle ultrastructure in patients with heart failure reversible under treatment with ACE-inhibitors? Herz 18(Suppl 1):400-405
20. Lai L, Leone TC, Zechner C, Schaeffer PJ, Kelly SM, Flanagan DP et al (2008) Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Genes Dev 22(14):1948-1961
21. Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, Kelly DP (2000) Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Investig 106(7):847-856
22. Garnier A, Fortin D, Zoll J, N'Guessan B, Mettauer B, Lampert E et al (2005) Coordinated changes in mitochondrial function and biogenesis in healthy and diseased human skeletal muscle. Faseb J 19(1):43-52
23. Toledo FG, Watkins S, Kelley DE (2006) Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and women. J Clin Endocrinol Metab 91(8):3224-3227
24. Ritov VB, Menshikova EV, He J, Ferrell RE, Goodpaster BH, Kelley DE (2005) Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 54(1):8-14
25. Iemitsu M, Miyauchi T, Maeda S, Sakai S, Fujii N, Miyazaki H et al (2003) Cardiac hypertrophy by hypertension and exercise training exhibits different gene expression of enzymes in energy metabolism. Hypertens Res 26(10):829-837
26. Nishio ML, Ornatsky OI, Craig EE, Hood DA (1995) Mitochondrial biogenesis during pressure overload induced cardiac hypertrophy in adult rats. Can J Physiol Pharmacol 73(5):630-637
27. Wang S, Fu C, Wang H, Shi Y, Xu X, Chen J et al (2007) Polymorphisms of the peroxisome proliferator-activated receptor-gamma coactivator-1alpha gene are associated with hypertrophic cardiomyopathy and not with hypertension hypertrophy. Clin Chem Lab Med 45(8):962-967
28. Dai DF, Johnson SC, Villarin JJ, Chin MT, Nieves-Cintron M, Chen T et al (2011) Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure. Circ Res 108(7):837-846
29. Barger PM, Brandt JM, Leone TC, Weinheimer CJ, Kelly DP (2000) Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth. J Clin Investig 105(12):1723-1730
30. Garnier A, Fortin D, Delomenie C, Momken I, Veksler V, Ventura-Clapier R (2003) Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles. J Physiol 551(Pt 2):491-501
31. Gundewar S, Calvert JW, Jha S, Toedt-Pingel I, Ji SY, Nunez D et al (2009) Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. Circ Res 104(3):403-411
32. Tian R, Musi N, D'Agostino J, Hirshman MF, Goodyear LJ (2001) Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy. Circulation 104(14):1664-1669
33. Scheubel RJ, Tostlebe M, Simm A, Rohrbach S, Prondzinsky R, Gellerich FN et al (2002) Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression. J Am Coll Cardiol 40(12):2174-2181
34. Ventura-Clapier R, Garnier A, Veksler V (2004) Energy metabolism in heart failure. J Physiol 555(Pt 1):1-13
35. Toth MJ, Miller MS, Ward KA, Ades PA (2012) Skeletal muscle mitochondrial density, gene expression and enzyme activities in human heart failure: minimal effects of the disease and resistance training. J Appl Physiol 112(11):1864-1874
36. Drexler H, Riede U, Munzel T, Konig H, Funke E, Just H (1992) Alterations of skeletal muscle in chronic heart failure. Circulation 85(5):1751-1759
37. Ribera F, N'Guessan B, Zoll J, Fortin D, Serrurier B, Mettauer B et al (2003) Mitochondrial electron transport chain function is enhanced in inspiratory muscles of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 167(6):873-879
38. Gosker HR, Hesselink MK, Duimel H, Ward KA, Schols AM (2007) Reduced mitochondrial density in the vastus lateralis muscle of patients with COPD. Eur Respir J 30(1):73-79
39. Picard M, Godin R, Sinnreich M, Baril J, Bourbeau J, Perrault H et al (2008) The mitochondrial phenotype of peripheral muscle in chronic obstructive pulmonary disease: disuse or dysfunction? Am J Respir Crit Care Med 178(10):1040-1047
40. Sebastiani M, Giordano C, Nediani C, Travaglini C, Borchi E, Zani M et al (2007) Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathies. J Am Coll Cardiol 50(14):1362-1369
41. Graham BH, Waymire KG, Cottrell B, Trounce IA, MacGregor GR, Wallace DC (1997) A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. Nat Genet 16(3):226-234
42. Puccio H, Simon D, Cossee M, Criqui-Filipe P, Tiziano F, Melki J et al (2001) Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits. Nat Genet 27(2):181-186
43. Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL et al (1995) Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 11(4):376-381
44. Hansson A, Hance N, Dufour E, Rantanen A, Hultenby K, Clayton DA et al (2004) A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts. Proc Nat Acad Sci USA 101(9):3136-3141
45. Ago T, Liu T, Zhai P, Chen W, Li H, Molkentin JD et al (2008) A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell 133(6):978-993
46. St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jager S et al (2006) Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127(2):397-408
47. Zhang M, Brewer AC, Schroder K, Santos CX, Grieve DJ, Wang M et al (2010) NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Nat Acad Sci USA 107(42):18121-18126
48. Buchwald A, Till H, Unterberg C, Oberschmidt R, Figulla HR, Wiegand V (1990) Alterations of the mitochondrial respiratory chain in human dilated cardiomyopathy. Eur Heart J 11(6):509-516
49. Ide T, Tsutsui H, Kinugawa S, Utsumi H, Kang D, Hattori N et al (1999) Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. Circ Res 85(4):357-363
50. Jarreta D, Orus J, Barrientos A, Miro O, Roig E, Heras M et al (2000) Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy. Cardiovasc Res 45(4):860-865
51. Marin-Garcia J, Goldenthal MJ, Moe GW (2001) Abnormal cardiac and skeletal muscle mitochondrial function in pacing-induced cardiac failure. Cardiovasc Res 52(1):103-110
52. Marin-Garcia J, Goldenthal MJ, Moe GW (2001) Mitochondrial pathology in cardiac failure. Cardiovasc Res 49(1):17-26
53. Moe GW, Marin-Garcia J, Konig A, Goldenthal M, Lu X, Feng Q (2004) In vivo TNF-alpha inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure. Am J Physiol 287(4):H1813-H1820
54. Heymes C, Bendall JK, Ratajczak P, Cave AC, Samuel JL, Hasenfuss G et al (2003) Increased myocardial NADPH oxidase activity in human heart failure. J Am Coll Cardiol 41(12):2164-2171
55. Kuroda J, Ago T, Matsushima S, Zhai P, Schneider MD, Sadoshima J (2010) NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Nat Acad Sci USA 107(35):15565-15570
56. Palmer JW, Tandler B, Hoppel CL (1977) Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle. J Biol Chem 252(23):8731-8739
57. Fannin SW, Lesnefsky EJ, Slabe TJ, Hassan MO, Hoppel CL (1999) Aging selectively decreases oxidative capacity in rat heart interfibrillar mitochondria. Arch Biochem Biophys 372(2):399-407
58. Hoppel CL, Tandler B, Parland W, Turkaly JS, Albers LD (1982) Hamster cardiomyopathy. A defect in oxidative phosphorylation in the cardiac interfibrillar mitochondria. J Biol Chem 257(3):1540-1548
59. Weinstein ES, Benson DW, Fry DE (1986) Subpopulations of human heart mitochondria. J Surg Res 40(5):495-498
60. Palmer JW, Tandler B, Hoppel CL (1986) Heterogeneous response of subsarcolemmal heart mitochondria to calcium. Am J Physiol 250(5 Pt 2):H741-H748
61. Duan J, Karmazyn M (1989) Relationship between oxidative phosphorylation and adenine nucleotide translocase activity of two populations of cardiac mitochondria and mechanical recovery of ischemic hearts following reperfusion. Can J Physiol Pharmacol 67(7):704-709
62. Lesnefsky EJ, Tandler B, Ye J, Slabe TJ, Turkaly J, Hoppel CL (1997) Myocardial ischemia decreases oxidative phosphorylation through cytochrome oxidase in subsarcolemmal mitochondria. Am J Physiol 273(3 Pt 2):H1544-H1554
63. Lesnefsky EJ, Chen Q, Moghaddas S, Hassan MO, Tandler B, Hoppel CL (2004) Blockade of electron transport during ischemia protects cardiac mitochondria. J Biol Chem 279(46):47961-47967
64. Hofer T, Servais S, Seo AY, Marzetti E, Hiona A, Upadhyay SJ et al (2009) Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction. Mech Age Dev 130(5):297-307
65. Lesnefsky EJ, Gudz TI, Migita CT, Ikeda-Saito M, Hassan MO, Turkaly PJ et al (2001) Ischemic injury to mitochondrial electron transport in the aging heart: damage to the iron-sulfur protein subunit of electron transport complex III. Arch Biochem Biophys 385(1):117-128
66. Judge S, Jang YM, Smith A, Hagen T, Leeuwenburgh C (2005) Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging. Faseb J 19(3):419-421
67. Williamson CL, Dabkowski ER, Baseler WA, Croston TL, Alway SE, Hollander JM (2010) Enhanced apoptotic propensity in diabetic cardiac mitochondria: influence of subcellular spatial location. Am J Physiol 298(2):H633-H642
68. Heather LC, Carr CA, Stuckey DJ, Pope S, Morten KJ, Carter EE et al (2010) Critical role of complex III in the early metabolic changes following myocardial infarction. Cardiovasc Res 85(1):127-136
69. Sparagna GC, Chicco AJ, Murphy RC, Bristow MR, Johnson CA, Rees ML et al (2007) Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure. J Lipid Res 48(7):1559-1570
70. Rosca MG, Vazquez EJ, Kerner J, Parland W, Chandler MP, Stanley W et al (2008) Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation. Cardiovasc Res 80(1):30-39
71. Rosca M, Minkler P, Hoppel CL (2011) Cardiac mitochondria in heart failure: normal cardiolipin profile and increased threonine phosphorylation of complex IV. Biochim Biophys Acta 1807(11):1373-1382
72. Rosca MG, Okere IA, Sharma N, Stanley WC, Recchia FA, Hoppel CL (2009) Altered expression of the adenine nucleotide translocase isoforms and decreased ATP synthase activity in skeletal muscle mitochondria in heart failure. J Mol Cell Cardiol 46(6):927-935
73. Cogswell AM, Stevens RJ, Hood DA (1993) Properties of skeletal muscle mitochondria isolated from subsarcolemmal and intermyofibrillar regions. Am J Physiol 264(2 Pt 1):C383-C389
74. Takahashi M, Hood DA (1996) Protein import into subsarcolemmal and intermyofibrillar skeletal muscle mitochondria. Differential import regulation in distinct subcellular regions. J Biol Chem 271(44):27285-27291
75. Adhihetty PJ, Ljubicic V, Hood DA (2007) Effect of chronic contractile activity on SS and IMF mitochondrial apoptotic susceptibility in skeletal muscle. Am J Physiol Endocrinol Metab 292(3):E748-E755
76. Adhihetty PJ, Ljubicic V, Menzies KJ, Hood DA (2005) Differential susceptibility of subsarcolemmal and intermyofibrillar mitochondria to apoptotic stimuli. Am J Physiol Cell Physiol 289(4):C994-C1001
77. Shinde SB, Save VC, Patil ND, Mishra KP, Tendolkar AG (2007) Impairment of mitochondrial respiratory chain enzyme activities in tetralogy of Fallot. Int J Clin Chem 377(1-2):138-143
78. Doenst T, Pytel G, Schrepper A, Amorim P, Farber G, Shingu Y et al (2010) Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload. Cardiovasc Res 86(3):461-470
79. Gong G, Liu J, Liang P, Guo T, Hu Q, Ochiai K et al (2003) Oxidative capacity in failing hearts. Am J Physiol 285(2):H541-H548
80. Schrepper A, Schwarzer M, Schope M, Amorim PA, Doenst T (2012) Biphasic response of skeletal muscle mitochondria to chronic cardiac pressure overload - role of respiratory chain complex activity. J Mol Cell Cardiol 52(1):125-135
81. Sanbe A, Tanonaka K, Niwano Y, Takeo S (1994) Improvement of cardiac function and myocardial energy metabolism of rats with chronic heart failure by long-term coenzyme Q10 treatment. J Pharmacol Experi Ther 269(1):51-56
82. Sharov VG, Todor AV, Silverman N, Goldstein S, Sabbah HN (2000) Abnormal mitochondrial respiration in failed human myocardium. J Mol Cell Cardiol 32(12):2361-2367
83. Sanbe A, Tanonaka K, Hanaoka Y, Katoh T, Takeo S (1993) Regional energy metabolism of failing hearts following myocardial infarction. J Mol Cell Cardiol 25(9):995-1013
84. Lemieux H, Semsroth S, Antretter H, Hofer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int J Biochem Cell Biol 43(12):1729-1738
85. Lindenmayer GE, Sordahl LA, Schwartz A (1968) Reevaluation of oxidative phosphorylation in cardiac mitochondria from normal animals and animals in heart failure. Circ Res 23(3):439-450
86. Sordahl LA, McCollum WB, Wood WG, Schwartz A (1973) Mitochondria and sarcoplasmic reticulum function in cardiac hypertrophy and failure. Am J Physiol 224(3):497-502
87. Lindenmayer GE, Harigaya S, Bajusz E, Schwartz A (1970) Oxidative phosphorylation and calcium transport of mitochondria isolated from cardiomyopathic hamster hearts. J Mol Cell Cardiol 1(3):249-259
88. Wrogemann K, Blanchaer MC, Jacobson BE (1972) Oxidative phosphorylation in cardiomyopathic hamsters. Am J Physiol 222(6):1453-1457
89. Rosca MG, Hoppel CL (2009) New aspects of impaired mitochondrial function in heart failure. J Bioenerg Biomembr 41(2):107-112
90. Rosca MG, Hoppel CL (2010) Mitochondria in heart failure. Cardiovasc Res 88(1):40-50
91. Liu J, Wang C, Murakami Y, Gong G, Ishibashi Y, Prody C et al (2001) Mitochondrial ATPase and high-energy phosphates in failing hearts. Am J Physiol 281(3):H1319-H1326
92. McCutcheon LJ, Cory CR, Nowack L, Shen H, Mirsalami M, Lahucky R et al (1992) Respiratory chain defect of myocardial mitochondria in idiopathic dilated cardiomyopathy of Doberman pinscher dogs. Can J Physiol Pharmacol 70(11):1529-1533
93. Unverferth DV, Lee SW, Wallick ET (1988) Human myocardial adenosine triphosphatase activities in health and heart failure. Am Heart J 115(1 Pt 1):139-146
94. Schultheiss HP, Bolte HD (1985) Immunological analysis of auto-antibodies against the adenine nucleotide translocator in dilated cardiomyopathy. J Mol Cell Cardiol 17(6):603-617
95. Schultheiss HP (1992) Dysfunction of the ADP/ATP carrier as a causative factor for the disturbance of the myocardial energy metabolism in dilated cardiomyopathy. Basic Res Cardiol 87(Suppl 1):311-320
96. Sylven C, Lin L, Jansson E, Sotonyi P, Fu LX, Waagstein F et al (1993) Ventricular adenine nucleotide translocator mRNA is upregulated in dilated cardiomyopathy. Cardiovasc Res 27(7):1295-1299
97. Dorner A, Schultheiss HP (2000) The myocardial expression of the adenine nucleotide translocator isoforms is specifically altered in dilated cardiomyopathy. Herz 25(3):176-180
98. Dorner A, Giessen S, Gaub R, Grosse Siestrup H, Schwimmbeck PL, Hetzer R et al (2006) An isoform shift in the cardiac adenine nucleotide translocase expression alters the kinetic properties of the carrier in dilated cardiomyopathy. Eur J Heart Fail 8(1):81-89
99. Beyer K, Nuscher B (1996) Specific cardiolipin binding interferes with labeling of sulfhydryl residues in the adenosine diphosphate/adenosine triphosphate carrier protein from beef heart mitochondria. Biochemistry 35(49):15784-15790
100. Ellis CE, Murphy EJ, Mitchell DC, Golovko MY, Scaglia F, Barcelo-Coblijn GC et al (2005) Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein. Mol Cell Biol 25(22):10190-10201
101. Fry M, Green DE (1980) Cardiolipin requirement by cytochrome oxidase and the catalytic role of phospholipid. Biochem Biophys Res Commun 93(4):1238-1246
102. Hoch FL (1992) Cardiolipins and biomembrane function. Biochim Biophys Acta 1113(1):71-133
103. Hoch FL (1998) Cardiolipins and mitochondrial proton-selective leakage. J Bioenerg Biomembr 30(6):511-532
104. Nalecz KA, Bolli R, Wojtczak L, Azzi A (1986) The monocarboxylate carrier from bovine heart mitochondria: partial purification and its substrate-transporting properties in a reconstituted system. Biochim Biophys Acta 851(1):29-37
105. Paradies G, Petrosillo G, Ruggiero FM (1997) Cardiolipin-dependent decrease of cytochrome c oxidase activity in heart mitochondria from hypothyroid rats. Biochim Biophys Acta 1319(1):5-8
106. Pfeiffer K, Gohil V, Stuart RA, Hunte C, Brandt U, Greenberg ML et al (2003) Cardiolipin stabilizes respiratory chain supercomplexes. J Biol Chem 278(52):52873-52880
107. Robinson NC (1993) Functional binding of cardiolipin to cytochrome c oxidase. J Bioenerg Biomembr 25(2):153-163
108. Schlame M, Rua D, Greenberg ML (2000) The biosynthesis and functional role of cardiolipin. Prog Lipid Res 39(3):257-288
109. Tuominen EK, Wallace CJ, Kinnunen PK (2002) Phospholipid-cytochrome c interaction: evidence for the extended lipid anchorage. J Biol Chem 277(11):8822-8826
110. Quigley AF, Kapsa RM, Esmore D, Hale G, Byrne E (2000) Mitochondrial respiratory chain activity in idiopathic dilated cardiomyopathy. J Cardiac Fail 6(1):47-55
111. Dorner A, Pauschinger M, Schwimmbeck PL, Kuhl U, Schultheiss HP (2000) The shift in the myocardial adenine nucleotide translocator isoform expression pattern is associated with an enteroviral infection in the absence of an active T-cell dependent immune response in human inflammatory heart disease. J Am Coll Cardiol 35(7):1778-1784
112. Puchowicz MA, Varnes ME, Cohen BH, Friedman NR, Kerr DS, Hoppel CL (2004) Oxidative phosphorylation analysis: assessing the integrated functional activity of human skeletal muscle mitochondria - case studies. Mitochondrion 4(5-6):377-385
113. Faustin B, Rossignol R, Rocher C, Benard G, Malgat M, Letellier T (2004) Mobilization of adenine nucleotide translocators as molecular bases of the biochemical threshold effect observed in mitochondrial diseases. J Biol Chem 279(19):20411-20421
114. Rossignol R, Malgat M, Mazat JP, Letellier T (1999) Threshold effect and tissue specificity. Implication for mitochondrial cytopathies. J Biol Chem 274(47):33426-33432
115. Groen AK, Wanders RJ, Westerhoff HV, van der Meer R, Tager JM (1982) Quantification of the contribution of various steps to the control of mitochondrial respiration. J Biol Chem 257(6):2754-2757
116. Gellerich FN, Bohnensack R, Kunz W (1983) Control of mitochondrial respiration. The contribution of the adenine nucleotide translocator depends on the ATP- and ADP-consuming enzymes. Biochim Biophys Acta 722(2):381-391
117. Villani G, Attardi G (2000) In vivo control of respiration by cytochrome c oxidase in human cells. Free Radical Biol Med 29(3-4):202-210
118. Kadenbach B, Huttemann M, Arnold S, Lee I, Bender E (2000) Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase. Free Radical Biol Med 29(3-4):211-221
119. Xiao RP (2001) Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins. Sci STKE 2001(104):RE15
120. Bristow MR (2000) Beta-adrenergic receptor blockade in chronic heart failure. Circulation 101(5):558-569
121. Hjalmarson A, Goldstein S, Fagerberg B, Wedel H, Waagstein F, Kjekshus J et al (2000) Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the metoprolol CR/XL randomized intervention trial in congestive heart failure (MERIT-HF). MERIT-HF study group. Jama 283(10):1295-1302
122. Bijur GN, Jope RS (2003) Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation. J Neurochem 87(6):1427-1435
123. Miura S, Kawanaka K, Kai Y, Tamura M, Goto M, Shiuchi T et al (2007) An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation. Endocrinology 148(7):3441-3448
124. Robinson MM, Richards JC, Hickey MS, Moore DR, Phillips SM, Bell C et al (2010) Acute {beta}-adrenergic stimulation does not alter mitochondrial protein synthesis or markers of mitochondrial biogenesis in adult men. Am J Physiol Regul Integr Comp Physiol 298(1):R25-R33
125. Benson DW, Foley-Nelson T, Chance WT, Zhang FS, James JH, Fischer JE (1991) Decreased myofibrillar protein breakdown following treatment with clenbuterol. J Surg Res 50(1):1-5
126. Hoshino D, Yoshida Y, Holloway GP, Lally J, Hatta H, Bonen A (2012) Clenbuterol, a beta2-adrenergic agonist, reciprocally alters PGC-1 alpha and RIP140 and reduces fatty acid and pyruvate oxidation in rat skeletal muscle. Am J Physiol Regul Integr Comp Physiol 302(3):R373-R384
127. Cooper DM, Mons N, Karpen JW (1995) Adenylyl cyclases and the interaction between calcium and cAMP signalling. Nature 374(6521):421-424
128. DiPilato LM, Cheng X, Zhang J (2004) Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Nat Acad Sci USA 101(47):16513-16518
129. Pagliarini DJ, Dixon JE (2006) Mitochondrial modulation: reversible phosphorylation takes center stage? Trends in biochemical sciences. 31(1):26-34
130. Schwoch G, Trinczek B, Bode C (1990) Localization of catalytic and regulatory subunits of cyclic AMP-dependent protein kinases in mitochondria from various rat tissues. Biochem J 270(1):181-188
131. Sardanelli AM, Technikova-Dobrova Z, Scacco SC, Speranza F, Papa S (1995) Characterization of proteins phosphorylated by the cAMP-dependent protein kinase of bovine heart mitochondria. FEBS Lett 377(3):470-474
132. Sardanelli AM, Technikova-Dobrova Z, Speranza F, Mazzocca A, Scacco S, Papa S (1996) Topology of the mitochondrial cAMP-dependent protein kinase and its substrates. FEBS Lett 396(2-3):276-278
133. Acin-Perez R, Salazar E, Kamenetsky M, Buck J, Levin LR, Manfredi G (2009) Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metab 9(3):265-276
134. Kawai K, Qin F, Shite J, Mao W, Fukuoka S, Liang CS (2004) Importance of antioxidant and antiapoptotic effects of beta-receptor blockers in heart failure therapy. Am J Physiol 287(3):H1003-H1012
135. Bartholomeu JB, Vanzelli AS, Rolim NP, Ferreira JC, Bechara LR, Tanaka LY et al (2008) Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure. J Mol Cell Cardiol 45(2):240-249
136. Nagatomo Y, Yoshikawa T, Kohno T, Yoshizawa A, Anzai T, Meguro T et al (2007) Effects of beta-blocker therapy on high sensitivity c-reactive protein, oxidative stress, and cardiac function in patients with congestive heart failure. J Cardiac Fail 13(5):365-371
137. Fedorova M, Kuleva N, Hoffmann R (2010) Identification, quantification, and functional aspects of skeletal muscle protein-carbonylation in vivo during acute oxidative stress. J Proteome Res 9(5):2516-2526
138. Costa VM, Silva R, Ferreira R, Amado F, Carvalho F, de Lourdes Bastos M et al (2009) Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes. Toxicology 257(1-2):70-79
139. Yamada T, Mishima T, Sakamoto M, Sugiyama M, Matsunaga S, Wada M (2007) Myofibrillar protein oxidation and contractile dysfunction in hyperthyroid rat
140. Zhao W, Swanson SA, Ye J, Li X, Shelton JM, Zhang W et al (2006) Reactive oxygen species impair sympathetic vasoregulation in skeletal muscle in angiotensin II-dependent hypertension. Hypertension 48(4):637-643
141. Wei Y, Sowers JR, Nistala R, Gong H, Uptergrove GM, Clark SE et al (2006) Angiotensin II-induced NADPH oxidase activation impairs insulin signaling in skeletal muscle cells. J Biol Chem 281(46):35137-35146
142. Semprun-Prieto LC, Sukhanov S, Yoshida T, Rezk BM, Gonzalez-Villalobos RA, Vaughn C et al (2011) Angiotensin II induced catabolic effect and muscle atrophy are redox dependent. Biochem Biophys Res Commun 409(2):217-221
143. Kimura S, Zhang GX, Nishiyama A, Shokoji T, Yao L, Fan YY et al (2005) Role of NAD(P)H oxidase- and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II. Hypertension 45(5):860-866
144. Brink M, Wellen J, Delafontaine P (1996) Angiotensin II causes weight loss and decreases circulating insulin-like growth factor I in rats through a pressor-independent mechanism. J Clin Investig 97(11):2509-2516
145. Thaveau F, Zoll J, Bouitbir J, N'Guessan B, Plobner P, Chakfe N et al (2010) Effect of chronic pre-treatment with angiotensin converting enzyme inhibition on skeletal muscle mitochondrial recovery after ischemia/reperfusion. Fundam Clin Pharmacol 24(3):333-340
146. van Kimmenade RR, Januzzi JL Jr (2012) Emerging biomarkers in heart failure. Clin Chem 58(1):127-138
147. Fischer P, Hilfiker-Kleiner D (2007) Survival pathways in hypertrophy and heart failure: the gp130-STAT axis. Basic Res Cardiol 102(5):393-411
148. Smart N, Mojet MH, Latchman DS, Marber MS, Duchen MR, Heads RJ (2006) IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes. Cardiovasc Res 69(1):164-177
149. Szczepanek K, Chen Q, Derecka M, Salloum FN, Zhang Q, Szelag M et al (2011) Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species. J Biol Chem 286(34):29610-29620
150. Bozkurt B, Kribbs SB, Clubb FJ Jr, Michael LH, Didenko VV, Hornsby PJ et al (1998) Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats. Circulation 97(14):1382-1391
151. Ozcan C, Bienengraeber M, Hodgson DM, Mann DL, Terzic A (2003) Mitochondrial tolerance to stress impaired in failing heart. J Mol Cell Cardiol 35(9):1161-1166
152. Nakamura K, Fushimi K, Kouchi H, Mihara K, Miyazaki M, Ohe T et al (1998) Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II. Circulation 98(8):794-799
153. Suematsu N, Tsutsui H, Wen J, Kang D, Ikeuchi M, Ide T et al (2003) Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes. Circulation 107(10):1418-1423
154. Song W, Lu X, Feng Q (2000) Tumor necrosis factor-alpha induces apoptosis via inducible nitric oxide synthase in neonatal mouse cardiomyocytes. Cardiovasc Res 45(3):595-602