CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance

Cell Reports

Volumn 4, Issue 3, 2013, Pages 437-444

  Putz, EvaMaria ^a   Gotthardt, Dagmar ^a   Hoermann, Gregor ^b   Csiszar, Agnes ^c   Wirth, Silvia ^c   Berger, Angelika ^a   Straka, Elisabeth ^a   Rigler, Doris ^a   Wallner, Barbara ^a   Jamieson, AmandaM ^d   Pickl, WinfriedF ^e   Zebedin Brandl, EvaMaria ^b   Müller, Mathias ^a   Decker, Thomas ^d   Sexl, Veronika ^a  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^d UNIVERSITY OF VIENNA   (Austria)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD27 ANTIGEN; CYCLIN DEPENDENT KINASE 8; GAMMA INTERFERON; GRANZYME B; NATURAL KILLER CELL LECTIN LIKE RECEPTOR; NATURAL KILLER CELL RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2A; NATURAL KILLER CELL RECEPTOR NKG2C; NATURAL KILLER CELL RECEPTOR NKG2E; PERFORIN; PROTEIN KLRG1; STAT1 PROTEIN; STAT1 PROTEIN S727; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER IMMUNOLOGY; CANCER SURVIVAL; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE CLEARANCE; GENE SILENCING; IMMUNOSTIMULATION; IMMUNOSURVEILLANCE; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA; LEUKOCYTE COUNT; LUNG METASTASIS; MELANOMA; MOUSE; MOUSE MUTANT; MYELOID DERIVED SUPPRESSOR CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SUPPRESSOR CELL; SURVIVAL RATE;

MUS;

ANIMALS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 8; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; IMMUNOLOGIC SURVEILLANCE; KILLER CELLS, NATURAL; LEUKEMIA, EXPERIMENTAL; MAMMARY NEOPLASMS, EXPERIMENTAL; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR;

EID: 84881614850     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.07.012     Document Type: Article

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