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Volumn 17, Issue 11, 2015, Pages 1594-1603

A phase I/II trial of interleukin-15-stimulated natural killer cell infusion after haplo-identical stem cell transplantation for pediatric refractory solid tumors

Author keywords

Haplo identical stem cell transplantation; IL 15 stimulated NK cells; Pediatric solid tumors

Indexed keywords

INTERLEUKIN 15;

EID: 84942551827     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2015.07.011     Document Type: Article
Times cited : (64)

References (51)
  • 1
    • 84905970560 scopus 로고    scopus 로고
    • Therapeutic applications: natural killer cells in the clinic
    • Miller J.S. Therapeutic applications: natural killer cells in the clinic. Hematology Am Soc Hematol Educ Program 2013, 2013:247-253.
    • (2013) Hematology Am Soc Hematol Educ Program , vol.2013 , pp. 247-253
    • Miller, J.S.1
  • 2
    • 0033819721 scopus 로고    scopus 로고
    • Adoptive cellular immunotherapy: NK cells and bone marrow transplantation
    • Koh C.Y., Welniak L.A., Murphy W.J. Adoptive cellular immunotherapy: NK cells and bone marrow transplantation. Histol Histopathol 2000, 15:1201-1210.
    • (2000) Histol Histopathol , vol.15 , pp. 1201-1210
    • Koh, C.Y.1    Welniak, L.A.2    Murphy, W.J.3
  • 3
    • 34147184372 scopus 로고    scopus 로고
    • Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors
    • Lundqvist A., McCoy J.P., Samsel L., Childs R. Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors. Blood 2007, 109:3603-3606.
    • (2007) Blood , vol.109 , pp. 3603-3606
    • Lundqvist, A.1    McCoy, J.P.2    Samsel, L.3    Childs, R.4
  • 4
    • 0037086131 scopus 로고    scopus 로고
    • Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    • Ruggeri L., Mancusi A., Burchielli E., Capanni M., Carotti A., Aloisi T., et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2002, 295:2097-2100.
    • (2002) Science , vol.295 , pp. 2097-2100
    • Ruggeri, L.1    Mancusi, A.2    Burchielli, E.3    Capanni, M.4    Carotti, A.5    Aloisi, T.6
  • 5
    • 0347994940 scopus 로고    scopus 로고
    • Determinants of antileukemia effects of allogeneic NK cells
    • Leung W., Iyengar R., Turner V., Lang P., Bader P., Conn P., et al. Determinants of antileukemia effects of allogeneic NK cells. J Immunol 2004, 172:644-650.
    • (2004) J Immunol , vol.172 , pp. 644-650
    • Leung, W.1    Iyengar, R.2    Turner, V.3    Lang, P.4    Bader, P.5    Conn, P.6
  • 6
    • 66149091543 scopus 로고    scopus 로고
    • KIR-HLA receptor-ligand mismatch associated with a graft-versus-tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumors
    • Pérez-Martínez A., Leung W., Muñoz E., Iyengar R., Ramírez M., Vicario J.L., et al. KIR-HLA receptor-ligand mismatch associated with a graft-versus-tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumors. Pediatr Blood Cancer 2009, 53:120-124.
    • (2009) Pediatr Blood Cancer , vol.53 , pp. 120-124
    • Pérez-Martínez, A.1    Leung, W.2    Muñoz, E.3    Iyengar, R.4    Ramírez, M.5    Vicario, J.L.6
  • 7
    • 84867399026 scopus 로고    scopus 로고
    • Natural killer cells can exert a graft-vs-tumor effect in haploidentical stem cell transplantation for pediatric solid tumors
    • Pérez-Martínez A., de Prada Vicente I., Fernández L., González-Vicent M., Valentín J., Martín R., et al. Natural killer cells can exert a graft-vs-tumor effect in haploidentical stem cell transplantation for pediatric solid tumors. Exp Hematol 2012, 40:882-891.
    • (2012) Exp Hematol , vol.40 , pp. 882-891
    • Pérez-Martínez, A.1    de Prada Vicente, I.2    Fernández, L.3    González-Vicent, M.4    Valentín, J.5    Martín, R.6
  • 8
    • 20144388509 scopus 로고    scopus 로고
    • Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
    • Miller J.S., Soignier Y., Panoskaltsis-Mortari A., McNearney S.A., Yun G.H., Fautsch S.K., et al. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood 2005, 105:3051-3057.
    • (2005) Blood , vol.105 , pp. 3051-3057
    • Miller, J.S.1    Soignier, Y.2    Panoskaltsis-Mortari, A.3    McNearney, S.A.4    Yun, G.H.5    Fautsch, S.K.6
  • 9
    • 77949898005 scopus 로고    scopus 로고
    • NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia
    • Rubnitz J.E., Inaba H., Ribeiro R.C., Pounds S., Rooney B., Bell T., et al. NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia. J Clin Oncol 2010, 28:955-959.
    • (2010) J Clin Oncol , vol.28 , pp. 955-959
    • Rubnitz, J.E.1    Inaba, H.2    Ribeiro, R.C.3    Pounds, S.4    Rooney, B.5    Bell, T.6
  • 10
    • 78650400901 scopus 로고    scopus 로고
    • A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer
    • Geller M.A., Cooley S., Judson P.L., Ghebre R., Carson L.F., Argenta P.A., et al. A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer. Cytotherapy 2011, 13:98-107.
    • (2011) Cytotherapy , vol.13 , pp. 98-107
    • Geller, M.A.1    Cooley, S.2    Judson, P.L.3    Ghebre, R.4    Carson, L.F.5    Argenta, P.A.6
  • 11
    • 84911021644 scopus 로고    scopus 로고
    • Interleukin-15 in the treatment of cancer
    • Waldmann T.A. Interleukin-15 in the treatment of cancer. Expert Rev Clin Immunol 2014, 10:1689-1701.
    • (2014) Expert Rev Clin Immunol , vol.10 , pp. 1689-1701
    • Waldmann, T.A.1
  • 12
    • 84920577302 scopus 로고    scopus 로고
    • Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer
    • Conlon K.C., Lugli E., Welles H.C., Rosenberg S.A., Fojo A.T., Morris J.C., et al. Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer. J Clin Oncol 2015, 33:74-82.
    • (2015) J Clin Oncol , vol.33 , pp. 74-82
    • Conlon, K.C.1    Lugli, E.2    Welles, H.C.3    Rosenberg, S.A.4    Fojo, A.T.5    Morris, J.C.6
  • 14
    • 11244262924 scopus 로고    scopus 로고
    • Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation
    • Alpdogan O., Eng J.M., Muriglan S.J., Willis L.M., Hubbard V.M., Tjoe K.H., et al. Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation. Blood 2005, 105:865-873.
    • (2005) Blood , vol.105 , pp. 865-873
    • Alpdogan, O.1    Eng, J.M.2    Muriglan, S.J.3    Willis, L.M.4    Hubbard, V.M.5    Tjoe, K.H.6
  • 15
    • 41149176392 scopus 로고    scopus 로고
    • Interleukin-15 improves cytotoxicity of natural killer cells via up-regulating NKG2D and cytotoxic effector molecule expression as well as STAT1 and ERK1/2 phosphorylation
    • Zhang C., Zhang J., Niu J., Zhang J., Tian Z. Interleukin-15 improves cytotoxicity of natural killer cells via up-regulating NKG2D and cytotoxic effector molecule expression as well as STAT1 and ERK1/2 phosphorylation. Cytokine 2008, 42:128-136.
    • (2008) Cytokine , vol.42 , pp. 128-136
    • Zhang, C.1    Zhang, J.2    Niu, J.3    Zhang, J.4    Tian, Z.5
  • 16
    • 7444260211 scopus 로고    scopus 로고
    • IL-2 activated NK cell immunotherapy of three children after haploidentical stem cell transplantation
    • Koehl U., Sörensen J., Esser R., Zimmermann S., Grüttner H.P., Tonn T., et al. IL-2 activated NK cell immunotherapy of three children after haploidentical stem cell transplantation. Blood Cells Mol Dis 2004, 33:261-266.
    • (2004) Blood Cells Mol Dis , vol.33 , pp. 261-266
    • Koehl, U.1    Sörensen, J.2    Esser, R.3    Zimmermann, S.4    Grüttner, H.P.5    Tonn, T.6
  • 17
    • 84875230309 scopus 로고    scopus 로고
    • Pre-emptive immunotherapy with purified natural killer cells after haploidentical SCT: a prospective phase II study in two centers
    • Stern M., Passweg J.R., Meyer-Monard S., Esser R., Tonn T., Soerensen J., et al. Pre-emptive immunotherapy with purified natural killer cells after haploidentical SCT: a prospective phase II study in two centers. Bone Marrow Transplant 2013, 48:433-438.
    • (2013) Bone Marrow Transplant , vol.48 , pp. 433-438
    • Stern, M.1    Passweg, J.R.2    Meyer-Monard, S.3    Esser, R.4    Tonn, T.5    Soerensen, J.6
  • 20
    • 84869090132 scopus 로고    scopus 로고
    • IL-15-stimulated CD3/CD19-depleted stem-cell boosts in relapsed pediatric patients after haploidentical SCT
    • Pfeiffer M.M., Schumm M., Müller I., Handgretinger R., Lang P. IL-15-stimulated CD3/CD19-depleted stem-cell boosts in relapsed pediatric patients after haploidentical SCT. Leukemia 2012, 26:2435-2439.
    • (2012) Leukemia , vol.26 , pp. 2435-2439
    • Pfeiffer, M.M.1    Schumm, M.2    Müller, I.3    Handgretinger, R.4    Lang, P.5
  • 22
    • 77955117141 scopus 로고    scopus 로고
    • Killing the killer: natural killer cells to treat Ewing's sarcoma
    • Ahn Y.O., Weigel B., Verneris M.R. Killing the killer: natural killer cells to treat Ewing's sarcoma. Clin Cancer Res 2010, 16:3819-3821.
    • (2010) Clin Cancer Res , vol.16 , pp. 3819-3821
    • Ahn, Y.O.1    Weigel, B.2    Verneris, M.R.3
  • 24
    • 0036776248 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor alone at 12 microg/kg twice a day for 4 days for peripheral blood progenitor cell priming in pediatric patients
    • Sevilla J., González-Vicent M., Madero L., García-Sánchez F., Díaz M.A. Granulocyte colony-stimulating factor alone at 12 microg/kg twice a day for 4 days for peripheral blood progenitor cell priming in pediatric patients. Bone Marrow Transplant 2002, 30:417-420.
    • (2002) Bone Marrow Transplant , vol.30 , pp. 417-420
    • Sevilla, J.1    González-Vicent, M.2    Madero, L.3    García-Sánchez, F.4    Díaz, M.A.5
  • 25
    • 84869093444 scopus 로고    scopus 로고
    • Early evaluation of immune reconstitution following allogeneic CD3/CD19-depleted grafts from alternative donors in childhood acute leukemia
    • Pérez-Martínez A., González-Vicent M., Valentín J., Aleo E., Lassaletta A., Sevilla J., et al. Early evaluation of immune reconstitution following allogeneic CD3/CD19-depleted grafts from alternative donors in childhood acute leukemia. Bone Marrow Transplant 2012, 47:1419-1427.
    • (2012) Bone Marrow Transplant , vol.47 , pp. 1419-1427
    • Pérez-Martínez, A.1    González-Vicent, M.2    Valentín, J.3    Aleo, E.4    Lassaletta, A.5    Sevilla, J.6
  • 27
    • 2942552479 scopus 로고    scopus 로고
    • Comparative genomic analysis, diversity and evolution of two KIR haplotypes A and B
    • Martin A.M., Kulski J.K., Gaudieri S., Witt C.S., Freitas E.M., Trowsdale J., et al. Comparative genomic analysis, diversity and evolution of two KIR haplotypes A and B. Gene 2004, 335:121-131.
    • (2004) Gene , vol.335 , pp. 121-131
    • Martin, A.M.1    Kulski, J.K.2    Gaudieri, S.3    Witt, C.S.4    Freitas, E.M.5    Trowsdale, J.6
  • 28
    • 0022654917 scopus 로고
    • Europium-labelled target cells in an assay of natural killer cell activity. I. A novel non-radioactive method based on time-resolved fluorescence
    • Blomberg K., Granberg C., Hemmilä I., Lövgren T. Europium-labelled target cells in an assay of natural killer cell activity. I. A novel non-radioactive method based on time-resolved fluorescence. J Immunol Methods 1986, 86:225-229.
    • (1986) J Immunol Methods , vol.86 , pp. 225-229
    • Blomberg, K.1    Granberg, C.2    Hemmilä, I.3    Lövgren, T.4
  • 30
    • 0037115305 scopus 로고    scopus 로고
    • Immune reconstitution at 6 months following T-cell depleted hematopoietic stem cell transplantation is predictive for treatment outcome
    • Novitzky N., Davison G.M., Hale G., Waldmann H. Immune reconstitution at 6 months following T-cell depleted hematopoietic stem cell transplantation is predictive for treatment outcome. Transplantation 2002, 74:1551-1559.
    • (2002) Transplantation , vol.74 , pp. 1551-1559
    • Novitzky, N.1    Davison, G.M.2    Hale, G.3    Waldmann, H.4
  • 31
    • 7944238168 scopus 로고    scopus 로고
    • An update on graft-versus-host and graft-versus-leukemia reactions: a summary of the sixth International Symposium held in Schloss Ellmau, Germany, January 22-24, 2004
    • Munker R., Schmid C., Madrigal J.A., Kolb H.J. An update on graft-versus-host and graft-versus-leukemia reactions: a summary of the sixth International Symposium held in Schloss Ellmau, Germany, January 22-24, 2004. Bone Marrow Transplant 2004, 34:767-780.
    • (2004) Bone Marrow Transplant , vol.34 , pp. 767-780
    • Munker, R.1    Schmid, C.2    Madrigal, J.A.3    Kolb, H.J.4
  • 32
    • 84876329801 scopus 로고    scopus 로고
    • Graft-versus-host disease and graft-versus-tumor effects after allogeneic hematopoietic cell transplantation
    • Storb R., Gyurkocza B., Storer B.E., Sorror M.L., Blume K., Niederwieser D., et al. Graft-versus-host disease and graft-versus-tumor effects after allogeneic hematopoietic cell transplantation. J Clin Oncol 2013, 31:1530-1538.
    • (2013) J Clin Oncol , vol.31 , pp. 1530-1538
    • Storb, R.1    Gyurkocza, B.2    Storer, B.E.3    Sorror, M.L.4    Blume, K.5    Niederwieser, D.6
  • 33
    • 84921805688 scopus 로고    scopus 로고
    • Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following T-cell-depleted stem cell transplantation
    • Shah N.N., Baird K., Delbrook C.P., Fleisher T.A., Kohler M.E., Rampertaap S., et al. Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following T-cell-depleted stem cell transplantation. Blood 2015, 125:784-792.
    • (2015) Blood , vol.125 , pp. 784-792
    • Shah, N.N.1    Baird, K.2    Delbrook, C.P.3    Fleisher, T.A.4    Kohler, M.E.5    Rampertaap, S.6
  • 34
    • 79953805065 scopus 로고    scopus 로고
    • Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells
    • Buddingh E.P., Schilham M.W., Ruslan S.E., Berghuis D., Szuhai K., Suurmond J., et al. Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells. Cancer Immunol Immunother 2011, 60:575-586.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 575-586
    • Buddingh, E.P.1    Schilham, M.W.2    Ruslan, S.E.3    Berghuis, D.4    Szuhai, K.5    Suurmond, J.6
  • 35
    • 51049088214 scopus 로고    scopus 로고
    • Activity of recombinant human interleukin-15 against tumor recurrence and metastasis in mice
    • Tang F., Zhao L.T., Jiang Y., Ba de N., Cui L.X., He W. Activity of recombinant human interleukin-15 against tumor recurrence and metastasis in mice. Cell Mol Immunol 2008, 5:189-196.
    • (2008) Cell Mol Immunol , vol.5 , pp. 189-196
    • Tang, F.1    Zhao, L.T.2    Jiang, Y.3    Ba de, N.4    Cui, L.X.5    He, W.6
  • 37
    • 33947379469 scopus 로고    scopus 로고
    • Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells
    • Chiossone L., Vitale C., Cottalasso F., Moretti S., Azzarone B., Moretta L., et al. Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells. Blood 2007, 109:3767-3775.
    • (2007) Blood , vol.109 , pp. 3767-3775
    • Chiossone, L.1    Vitale, C.2    Cottalasso, F.3    Moretti, S.4    Azzarone, B.5    Moretta, L.6
  • 38
    • 77956021364 scopus 로고    scopus 로고
    • Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T- and B-cell depleted grafts in children
    • Pfeiffer M.M., Feuchtinger T., Teltschik H.M., Schumm M., Müller I., Handgretinger R., et al. Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T- and B-cell depleted grafts in children. Haematologica 2010, 95:1381-1388.
    • (2010) Haematologica , vol.95 , pp. 1381-1388
    • Pfeiffer, M.M.1    Feuchtinger, T.2    Teltschik, H.M.3    Schumm, M.4    Müller, I.5    Handgretinger, R.6
  • 39
    • 84930420507 scopus 로고    scopus 로고
    • Favorable NK cell activity after haploidentical hematopoietic stem cell transplantation in stage IV relapsed Ewing's sarcoma patients
    • Schlegel P., Feuchtinger T., Nitschke-Gérard C., Eva Seidel U.J., Lang A.M., Kyzirakos C., et al. Favorable NK cell activity after haploidentical hematopoietic stem cell transplantation in stage IV relapsed Ewing's sarcoma patients. Bone Marrow Transplant 2015, (50 Suppl 2):S72-S76.
    • (2015) Bone Marrow Transplant , Issue.50 , pp. S72-S76
    • Schlegel, P.1    Feuchtinger, T.2    Nitschke-Gérard, C.3    Eva Seidel, U.J.4    Lang, A.M.5    Kyzirakos, C.6
  • 40
    • 38149136619 scopus 로고    scopus 로고
    • Rapamycin, but not cyclosporine or FK506, alters natural killer cell function
    • Wai L.E., Fujiki M., Takeda S., Martinez O.M., Krams S.M. Rapamycin, but not cyclosporine or FK506, alters natural killer cell function. Transplantation 2008, 85:145-149.
    • (2008) Transplantation , vol.85 , pp. 145-149
    • Wai, L.E.1    Fujiki, M.2    Takeda, S.3    Martinez, O.M.4    Krams, S.M.5
  • 41
    • 34548825933 scopus 로고    scopus 로고
    • The unexpected effect of cyclosporin A on CD56+CD16 and CD56+CD16+ natural killer cell subpopulations
    • Wang H., Grzywacz B., Sukovich D., McCullar V., Cao Q., Lee A.B., et al. The unexpected effect of cyclosporin A on CD56+CD16 and CD56+CD16+ natural killer cell subpopulations. Blood 2007, 110:1530-1539.
    • (2007) Blood , vol.110 , pp. 1530-1539
    • Wang, H.1    Grzywacz, B.2    Sukovich, D.3    McCullar, V.4    Cao, Q.5    Lee, A.B.6
  • 43
    • 77956167822 scopus 로고    scopus 로고
    • Rapamycin and MPA, but not CsA, impair human NK cell cytotoxicity due to differential effects on NK cell phenotype
    • Eissens D.N., Van Der Meer A., Van Cranenbroek B., Preijers F.W., Joosten I. Rapamycin and MPA, but not CsA, impair human NK cell cytotoxicity due to differential effects on NK cell phenotype. Am J Transplant 2010, 10:1981-1990.
    • (2010) Am J Transplant , vol.10 , pp. 1981-1990
    • Eissens, D.N.1    Van Der Meer, A.2    Van Cranenbroek, B.3    Preijers, F.W.4    Joosten, I.5
  • 44
    • 0020684770 scopus 로고
    • Effect of in vitro cyclosporin. A treatment on human natural and antibody-dependent cell-mediated cytotoxicity
    • Shao-Hsien C., Lang I., Gunn H., Lydyard P. Effect of in vitro cyclosporin. A treatment on human natural and antibody-dependent cell-mediated cytotoxicity. Transplantation 1983, 35:127-129.
    • (1983) Transplantation , vol.35 , pp. 127-129
    • Shao-Hsien, C.1    Lang, I.2    Gunn, H.3    Lydyard, P.4
  • 46
    • 78149428750 scopus 로고    scopus 로고
    • Renal transplant immunosuppression impairs natural killer cell function in vitro and in vivo
    • Morteau O., Blundell S., Chakera A., Bennett S., Christou C.M., Mason P.D., et al. Renal transplant immunosuppression impairs natural killer cell function in vitro and in vivo. PLoS One 2010, 5:e13294.
    • (2010) PLoS One , vol.5
    • Morteau, O.1    Blundell, S.2    Chakera, A.3    Bennett, S.4    Christou, C.M.5    Mason, P.D.6
  • 47
    • 0025969985 scopus 로고
    • Effect of FK506 versus cyclosporine on human natural and antibody-dependent cytotoxicity reactions in vitro
    • Wasik M., Gorski A., Stepien-Sopniewska B., Lagodzinski Z. Effect of FK506 versus cyclosporine on human natural and antibody-dependent cytotoxicity reactions in vitro. Transplantation 1991, 51:268-270.
    • (1991) Transplantation , vol.51 , pp. 268-270
    • Wasik, M.1    Gorski, A.2    Stepien-Sopniewska, B.3    Lagodzinski, Z.4
  • 48
    • 84875338319 scopus 로고    scopus 로고
    • Impact of commonly used transplant immunosuppressive drugs on human NK cell function is dependent upon stimulation condition
    • Meehan A.C., Mifsud N.A., Nguyen T.H., Levvey B.J., Snell G.I., Kotsimbos T.C., et al. Impact of commonly used transplant immunosuppressive drugs on human NK cell function is dependent upon stimulation condition. PLoS One 2013, 8:e60144.
    • (2013) PLoS One , vol.8
    • Meehan, A.C.1    Mifsud, N.A.2    Nguyen, T.H.3    Levvey, B.J.4    Snell, G.I.5    Kotsimbos, T.C.6
  • 49
    • 79151469287 scopus 로고    scopus 로고
    • Mycophenolic acid inhibits natural killer cell proliferation and cytotoxic function: a possible disadvantage of including mycophenolate mofetil in the graft-versus-host disease prophylaxis regimen
    • Ohata K., Espinoza J.L., Lu X., Kondo Y., Nakao S. Mycophenolic acid inhibits natural killer cell proliferation and cytotoxic function: a possible disadvantage of including mycophenolate mofetil in the graft-versus-host disease prophylaxis regimen. Biol Blood Marrow Transplant 2011, 17:205-213.
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 205-213
    • Ohata, K.1    Espinoza, J.L.2    Lu, X.3    Kondo, Y.4    Nakao, S.5
  • 50
    • 0141650530 scopus 로고    scopus 로고
    • The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44)
    • De Maria A., Fogli M., Costa P., Murdaca G., Puppo F., Mavilio D., et al. The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44). Eur J Immunol 2003, 33:2410-2418.
    • (2003) Eur J Immunol , vol.33 , pp. 2410-2418
    • De Maria, A.1    Fogli, M.2    Costa, P.3    Murdaca, G.4    Puppo, F.5    Mavilio, D.6
  • 51
    • 0142215546 scopus 로고    scopus 로고
    • T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical pediatric bone marrow transplantation
    • Lowe E.J., Turner V., Handgretinger R., Horwitz E.M., Benaim E., Hale G.A., et al. T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical pediatric bone marrow transplantation. Br J Haematol 2003, 123:323-326.
    • (2003) Br J Haematol , vol.123 , pp. 323-326
    • Lowe, E.J.1    Turner, V.2    Handgretinger, R.3    Horwitz, E.M.4    Benaim, E.5    Hale, G.A.6


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