Increased Tim-3 expression in peripheral NK cells predicts a poorer prognosis and Tim-3 blockade improves NK cell-mediated cytotoxicity in human lung adenocarcinoma

International Immunopharmacology

Volumn 29, Issue 2, 2015, Pages 635-641

  Xu, Liyun ^a   Huang, Yanyan ^a   Tan, Linlin ^a   Yu, Wei ^a   Chen, Dongdong ^a   Lu, Changchang ^a   He, Jianying ^a   Wu, Guoqing ^b   Liu, Xiaoguang ^a   Zhang, Yongkui ^a  

^a The Zhoushan Hospital of Wenzhou Medical University   (China)

^b ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Cytotoxicity; Human lung adenocarcinoma; Natural killer cells; T cell immunoglobulin and mucin domain containing molecule 3

Indexed keywords

PEPTIDES AND PROTEINS; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING MOLECULE 3; UNCLASSIFIED DRUG; ANTIBODY; CD3 ANTIGEN; CD56 ANTIGEN; HAVCR2 PROTEIN, HUMAN; MEMBRANE PROTEIN; NCAM1 PROTEIN, HUMAN;

ADULT; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR VOLUME; UPREGULATION; ADENOCARCINOMA; CASE CONTROL STUDY; CELL CULTURE; COCULTURE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LUNG TUMOR; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROGNOSIS;

ADENOCARCINOMA; ANTIBODIES; ANTIGENS, CD3; ANTIGENS, CD56; CASE-CONTROL STUDIES; CELLS, CULTURED; COCULTURE TECHNIQUES; GENE EXPRESSION REGULATION; HUMANS; KILLER CELLS, NATURAL; LUNG NEOPLASMS; MEMBRANE PROTEINS; MIDDLE AGED; PROGNOSIS; UP-REGULATION;

EID: 84948461194     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.09.017     Document Type: Article

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