Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876

ChemMedChem

Volumn 11, Issue 20, 2016, Pages 2261-2271

  Siebeneicher, Holger ^a   Cleve, Arwed ^a   Rehwinkel, Hartmut ^a   Neuhaus, Roland ^a   Heisler, Iring ^a   Müller, Thomas ^a   Bauser, Marcus ^a   Buchmann, Bernd ^a  

^a BAYER AG   (Germany)

Author keywords

GLUT1 inhibitors; medicinal chemistry; quinoline carboxamides; structure activity relationships; Warburg effect

Indexed keywords

AMIDE; ANTINEOPLASTIC AGENT; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 1 INHIBITOR; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 3; GLUCOSE TRANSPORTER 4; N4 [1 (4 CYANOBENZYL) 5 METHYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL] 7 FLUOROQUINOLINE 2,4 DICARBOXAMIDE; PYRAZOLE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; BAY-876; SLC2A1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BEAGLE; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SELECTIVITY; HAPLORHINI; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; METABOLIC STABILITY; MOLECULAR LIBRARY; MOUSE; NONHUMAN; PHARMACOKINETIC PARAMETERS; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; BIOAVAILABILITY; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; BIOLOGICAL AVAILABILITY; GLUCOSE TRANSPORTER TYPE 1; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR STRUCTURE; PYRAZOLES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84983261329     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201600276     Document Type: Article

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