Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 17, 2016, Pages 4711-4716

  Kapoor, Khyati ^a   Finer Moore, Janet S ^a   Pedersen, Bjørn P ^a,b   Caboni, Laura ^a   Waight, Andrew ^a,e   Hillig, Roman C ^c   Bringmann, Peter ^d   Heisler, Iring ^c   Müller, Thomas ^c   Siebeneicher, Holger ^c   Stroud, Robert M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b AARHUS UNIVERSITY   (Denmark)

^c BAYER PHARMA AG   (Germany)

^d Bayer Healthcare   (United States)

^e SEATTLE GENETICS INC   (United States)

Author keywords

Cytochalasin B; Glucose facilitator; GLUT inhibitor; Human MFS transporter; X ray structure

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMIDE; BROMINE; CYTOCHALASIN B; GLUCOSE; GLUCOSE TRANSPORTER 1; HYDROGEN; LUCIFERIN; PHENYLALANINE; CYTOCHALASIN; CYTOCHALASIN A; PHENYLALANINE AMIDE; PROTEIN BINDING; SLC2A1 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; CELL ASSAY; CONFORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; CRYSTALLOGRAPHY; GLUCOSE TRANSPORT; GLYCOSYLATION; HIGH THROUGHPUT SCREENING; HUMAN; HYDROGEN BOND; LUMINESCENCE; MOLECULAR MECHANICS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; STEREOSPECIFICITY; AMINO ACID SEQUENCE; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; CONSERVED SEQUENCE; MOLECULAR MODEL; PROTEIN CONFORMATION; ULTRASTRUCTURE;

AMINO ACID SEQUENCE; BINDING SITES; COMPUTER SIMULATION; CONSERVED SEQUENCE; CYTOCHALASINS; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; PHENYLALANINE; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 84964725539     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1603735113     Document Type: Article

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