SCOPUS 정보 검색 플랫폼

Angewandte Chemie - International Edition

Volumn 54, Issue 49, 2015, Pages 14748-14752

Optimization of TRPV6 calcium channel inhibitors using a 3D ligand-based virtual screening method

(13) Simonin, Céline a Awale, Mahendra a Brand, Michael a Van Deursen, Ruud a Schwartz, Julian a Fine, Michael a Kovacs, Gergely a Häfliger, Pascal a Gyimesi, Gergely a Sithampari, Abilashan a Charles, Roch Philippe a Hediger, Matthias A a Reymond, Jean Louis a

a UNIVERSITY OF BERN (Switzerland)

Author keywords

calcium channels; drug discovery; TRP channels; virtual screening

Indexed keywords

CALCIUM; CELL GROWTH; CELL PROLIFERATION; DISEASES; GROWTH KINETICS; LIGANDS; MOLECULES; PHARMACODYNAMICS; SYNTHESIS (CHEMICAL);

CALCIUM CHANNELS; CANCER CELL GROWTH; DRUG DISCOVERY; PROSTATE CANCERS; SELECTIVE INHIBITORS; SIMILARITY ALGORITHM; TRP CHANNELS; VIRTUAL SCREENING;

VIRTUAL REALITY;

ANTINEOPLASTIC AGENT; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; LIGAND; TRPV6 PROTEIN, HUMAN; VANILLOID RECEPTOR;

ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HUMAN; PRECLINICAL STUDY; PROCEDURES; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIGANDS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

EID: 84983166376 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201507320 Document Type: Article

Times cited : (50)

References (41)

1
- 33745199815
- G. Klebe, Drug Discovery Today 2006, 11, 580-594;
- (2006) Drug Discovery Today , vol.11 , pp. 580-594
- Klebe, G.¹

2
- 84862027743
- T. Scior, A. Bender, G. Tresadern, J. L. Medina-Franco, K. Martinez-Mayorga, T. Langer, K. Cuanalo-Contreras, D. K. Agrafiotis, J. Chem. Inf. Model. 2012, 52, 867-881;
- (2012) J. Chem. Inf. Model. , vol.52 , pp. 867-881
- Scior, T.¹ Bender, A.² Tresadern, G.³ Medina-Franco, J.L.⁴ Martinez-Mayorga, K.⁵ Langer, T.⁶ Cuanalo-Contreras, K.⁷ Agrafiotis, D.K.⁸

3
- 84871390611
- K. Heikamp, J. Bajorath, Chem. Biol. Drug Des. 2013, 81, 33-40;
- (2013) Chem. Biol. Drug Des. , vol.81 , pp. 33-40
- Heikamp, K.¹ Bajorath, J.²

4
- 84891793035
- M. Reutlinger, T. Rodrigues, P. Schneider, G. Schneider, Angew. Chem. Int. Ed. 2014, 53, 582-585;
- (2014) Angew. Chem. Int. Ed. , vol.53 , pp. 582-585
- Reutlinger, M.¹ Rodrigues, T.² Schneider, P.³ Schneider, G.⁴

5
- 84898665540
- Angew. Chem. 2014, 126, 593-596.
- (2014) Angew. Chem. , vol.126 , pp. 593-596

6
- 84908613024
- J. Blagg, P. Workman, Curr. Opin. Pharmacol. 2014, 17, 87-100.
- (2014) Curr. Opin. Pharmacol. , vol.17 , pp. 87-100
- Blagg, J.¹ Workman, P.²

7
- 0033529713
- J. B. Peng, X. Z. Chen, U. V. Berger, P. M. Vassilev, H. Tsukaguchi, E. M. Brown, M. A. Hediger, J. Biol. Chem. 1999, 274, 22739-22746;
- (1999) J. Biol. Chem. , vol.274 , pp. 22739-22746
- Peng, J.B.¹ Chen, X.Z.² Berger, U.V.³ Vassilev, P.M.⁴ Tsukaguchi, H.⁵ Brown, E.M.⁶ Hediger, M.A.⁷

8
- 0035810243
- L. Yue, J. B. Peng, M. A. Hediger, D. E. Clapham, Nature 2001, 410, 705-709;
- (2001) Nature , vol.410 , pp. 705-709
- Yue, L.¹ Peng, J.B.² Hediger, M.A.³ Clapham, D.E.⁴

9
- 84983164765
- Patent, US6534642, and US7078178, 2006
- M. A. Hediger, E. M. Brown, J. B. Peng, Patent, US6534642, 2003 and US7078178, 2006;
- (2003)
- Hediger, M.A.¹ Brown, E.M.² Peng, J.B.³

10
- 0035378510
- D. E. Clapham, L. W. Runnels, C. Strubing, Nat. Rev. Neurosci. 2001, 2, 387-396;
- (2001) Nat. Rev. Neurosci. , vol.2 , pp. 387-396
- Clapham, D.E.¹ Runnels, L.W.² Strubing, C.³

11
- 73849124317
- K. A. Bolanz, G. G. Kovacs, C. P. Landowski, M. A. Hediger, Mol. Cancer Res. 2009, 7, 2000-2010;
- (2009) Mol. Cancer Res. , vol.7 , pp. 2000-2010
- Bolanz, K.A.¹ Kovacs, G.G.² Landowski, C.P.³ Hediger, M.A.⁴

12
- 84904904184
- C. Fecher-Trost, P. Weissgerber, U. Wissenbach, Handb. Exp. Pharmacol. 2014, 222, 359-384;
- (2014) Handb. Exp. Pharmacol. , vol.222 , pp. 359-384
- Fecher-Trost, C.¹ Weissgerber, P.² Wissenbach, U.³

13
- 84958542415
- U. A. Hellmich, R. Gaudet, Handb. Exp. Pharmacol. 2014, 223, 963-990.
- (2014) Handb. Exp. Pharmacol. , vol.223 , pp. 963-990
- Hellmich, U.A.¹ Gaudet, R.²

14
- 36148992621
- V. Lehen′kyi, M. Flourakis, R. Skryma, N. Prevarskaya, Oncogene 2007, 26, 7380-7385;
- (2007) Oncogene , vol.26 , pp. 7380-7385
- Lehenkyi, V.¹ Flourakis, M.² Skryma, R.³ Prevarskaya, N.⁴

15
- 39749123226
- K. A. Bolanz, M. A. Hediger, C. P. Landowski, Mol. Cancer Ther. 2008, 7, 271-279;
- (2008) Mol. Cancer Ther. , vol.7 , pp. 271-279
- Bolanz, K.A.¹ Hediger, M.A.² Landowski, C.P.³

16
- 84907235984
- EE 3879
- M. Raphaël, V. y. Lehen′kyi, M. Vandenberghe, B. Beck, S. Khalimonchyk, F. Vanden Abeele, L. Farsetti, E. Germain, A. Bokhobza, A. Mihalache, P. Gosset, C. Romanin, P. Clézardin, R. Skryma, N. Prevarskaya, Proc. Natl. Acad. Sci. USA 2014, 111, E 3870 -E 3879.
- (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 3870
- Raphaël, M.¹ Lehenkyi, V.Y.² Vandenberghe, M.³ Beck, B.⁴ Khalimonchyk, S.⁵ Vanden Abeele, F.⁶ Farsetti, L.⁷ Germain, E.⁸ Bokhobza, A.⁹ Mihalache, A.¹⁰ Gosset, P.¹¹ Romanin, C.¹² Clézardin, P.¹³ Skryma, R.¹⁴ Prevarskaya, N.¹⁵

17
- 79952485156
- C. Landowski, K. Bolanz, A. Y. Suzuki, M. A. Hediger, Pharm. Res. 2011, 28, 322-330;
- (2011) Pharm. Res. , vol.28 , pp. 322-330
- Landowski, C.¹ Bolanz, K.² Suzuki, A.Y.³ Hediger, M.A.⁴

18
- 84870296401
- G. Kovacs, N. Montalbetti, A. Simonin, T. Danko, B. Balazs, A. Zsembery, M. A. Hediger, Cell Calcium 2012, 52, 468-480;
- (2012) Cell Calcium , vol.52 , pp. 468-480
- Kovacs, G.¹ Montalbetti, N.² Simonin, A.³ Danko, T.⁴ Balazs, B.⁵ Zsembery, A.⁶ Hediger, M.A.⁷

19
- 84877792275
- A. Hofer, G. Kovacs, A. Zappatini, M. Leuenberger, M. A. Hediger, M. Lochner, Bioorg. Med. Chem. 2013, 21, 3202-3213.
- (2013) Bioorg. Med. Chem. , vol.21 , pp. 3202-3213
- Hofer, A.¹ Kovacs, G.² Zappatini, A.³ Leuenberger, M.⁴ Hediger, M.A.⁵ Lochner, M.⁶

20
- 84889594608
- E. Cao, M. Liao, Y. Cheng, D. Julius, Nature 2013, 504, 113-118.
- (2013) Nature , vol.504 , pp. 113-118
- Cao, E.¹ Liao, M.² Cheng, Y.³ Julius, D.⁴

21
- 84884254531
- M. Lill, Methods Mol. Biol. 2013, 993, 1-12.
- (2013) Methods Mol. Biol. , vol.993 , pp. 1-12
- Lill, M.¹

22
- 84893307473
- A. L. Hopkins, G. M. Keseru, P. D. Leeson, D. C. Rees, C. H. Reynolds, Nat. Rev. Drug Discovery 2014, 13, 105-121.
- (2014) Nat. Rev. Drug Discovery , vol.13 , pp. 105-121
- Hopkins, A.L.¹ Keseru, G.M.² Leeson, P.D.³ Rees, D.C.⁴ Reynolds, C.H.⁵

23
- 0033523672
- G. Schneider, W. Neidhart, T. Giller, G. Schmid, Angew. Chem. Int. Ed. 1999, 38, 2894-2896;
- (1999) Angew. Chem. Int. Ed. , vol.38 , pp. 2894-2896
- Schneider, G.¹ Neidhart, W.² Giller, T.³ Schmid, G.⁴

24
- 0001285510
- Angew. Chem. 1999, 111, 3068-3070.
- (1999) Angew. Chem. , vol.111 , pp. 3068-3070

25
- 44949267284
- S. K. Kearsley, G. Smith, Tet. Comput. Methodol. 1990, 3, 615-633;
- (1990) Tet. Comput. Methodol. , vol.3 , pp. 615-633
- Kearsley, S.K.¹ Smith, G.²

26
- 33750836761
- E. A. Kennewell, P. Willett, P. Ducrot, C. Luttmann, J. Comput.-Aided Mol. Des. 2006, 20, 385-394;
- (2006) J. Comput.-Aided Mol. Des. , vol.20 , pp. 385-394
- Kennewell, E.A.¹ Willett, P.² Ducrot, P.³ Luttmann, C.⁴

27
- 33846212271
- P. C. Hawkins, A. G. Skillman, A. Nicholls, J. Med. Chem. 2007, 50, 74-82.
- (2007) J. Med. Chem. , vol.50 , pp. 74-82
- Hawkins, P.C.¹ Skillman, A.G.² Nicholls, A.³

28
- 85030119508
- M. Awale, X. Jin, J. L. Reymond, J. Cheminf. J. Cheminform. 2015, 7, 3.
- (2015) J. Cheminf. J. Cheminform. , vol.7 , pp. 3
- Awale, M.¹ Jin, X.² Reymond, J.L.³

29
- 0000490166
- J. Sadowski, J. Gasteiger, Chem. Rev. 1993, 93, 2567-2581.
- (1993) Chem. Rev. , vol.93 , pp. 2567-2581
- Sadowski, J.¹ Gasteiger, J.²

30
- 33750434190
- S. Renner, C. H. Schwab, J. Gasteiger, G. Schneider, J. Chem. Inf. Model. 2006, 46, 2324-2332;
- (2006) J. Chem. Inf. Model. , vol.46 , pp. 2324-2332
- Renner, S.¹ Schwab, C.H.² Gasteiger, J.³ Schneider, G.⁴

31
- 78650689245
- V. Venkatraman, V. I. Perez-Nueno, L. Mavridis, D. W. Ritchie, J. Chem. Inf. Model. 2010, 50, 2079-2093.
- (2010) J. Chem. Inf. Model. , vol.50 , pp. 2079-2093
- Venkatraman, V.¹ Perez-Nueno, V.I.² Mavridis, L.³ Ritchie, D.W.⁴

32
- 33750991346
- N. Huang, B. K. Shoichet, J. J. Irwin, J. Med. Chem. 2006, 49, 6789-6801.
- (2006) J. Med. Chem. , vol.49 , pp. 6789-6801
- Huang, N.¹ Shoichet, B.K.² Irwin, J.J.³

33
- 84864199587
- J. J. Irwin, T. Sterling, M. M. Mysinger, E. S. Bolstad, R. G. Coleman, J. Chem. Inf. Model. 2012, 52, 1757-1768.
- (2012) J. Chem. Inf. Model. , vol.52 , pp. 1757-1768
- Irwin, J.J.¹ Sterling, T.² Mysinger, M.M.³ Bolstad, E.S.⁴ Coleman, R.G.⁵

34
- 79955613841
- M. M. Hann, MedChemComm 2011, 2, 349-355;
- (2011) MedChemComm , vol.2 , pp. 349-355
- Hann, M.M.¹

35
- 79961039537
- N. Foloppe, Future Med. Chem. 2011, 3, 1111-1115.
- (2011) Future Med. Chem. , vol.3 , pp. 1111-1115
- Foloppe, N.¹

36
- 77950571108
- J. B. Baell, G. A. Holloway, J. Med. Chem. 2010, 53, 2719-2740.
- (2010) J. Med. Chem. , vol.53 , pp. 2719-2740
- Baell, J.B.¹ Holloway, G.A.²

37
- 79951555023
- G. Kovacs, T. Danko, M. J. Bergeron, B. Balazs, Y. Suzuki, A. Zsembery, M. A. Hediger, Cell Calcium 2011, 49, 43-55.
- (2011) Cell Calcium , vol.49 , pp. 43-55
- Kovacs, G.¹ Danko, T.² Bergeron, M.J.³ Balazs, B.⁴ Suzuki, Y.⁵ Zsembery, A.⁶ Hediger, M.A.⁷

38
- 33751246188
- P. Willett, Drug Discovery Today 2006, 11, 1046-1053;
- (2006) Drug Discovery Today , vol.11 , pp. 1046-1053
- Willett, P.¹

39
- 84904793989
- WW 239
- M. Awale, J. L. Reymond, Nucleic Acids Res. 2014, 42, W 234 -W 239.
- (2014) Nucleic Acids Res. , vol.42 , pp. 234
- Awale, M.¹ Reymond, J.L.²

40
- 57349101704
- F. Berardi, C. Abate, S. Ferorelli, A. F. de Robertis, M. Leopoldo, N. A. Colabufo, M. Niso, R. Perrone, J. Med. Chem. 2008, 51, 7523-7531.
- (2008) J. Med. Chem. , vol.51 , pp. 7523-7531
- Berardi, F.¹ Abate, C.² Ferorelli, S.³ De Robertis, A.F.⁴ Leopoldo, M.⁵ Colabufo, N.A.⁶ Niso, M.⁷ Perrone, R.⁸

41
- 79958831362
- T. Hashimoto, Y. Naganawa, K. Maruoka, J. Am. Chem. Soc. 2011, 133, 8834-8837.
- (2011) J. Am. Chem. Soc. , vol.133 , pp. 8834-8837
- Hashimoto, T.¹ Naganawa, Y.² Maruoka, K.³

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.