Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 11, 2013, Pages 3202-3213

  Hofer, Alexandre ^a   Kovacs, Gergely ^a   Zappatini, Anna ^a   Leuenberger, Michele ^a   Hediger, Matthias A ^a   Lochner, Martin ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

2 APB; Calcium entry; Inhibitors; Store operated calcium channels; TRPV6

Indexed keywords

1,1 DIPHENYL 1,3 DIHYDRO [1,3,2]OXAZABOROLO[3,4 A]PYRIDIN 8 IUM 1 UIDE; 1,1 DIPHENYL 2 OXA 5,8 DIAZA 1 BORASPIRO[4,5]DECAN 5 IUM 1 UIDE; 1,1 DIPHENYLHEXAHYDRO 1H PYRROLO[1,2 C][1,3,2]OXAZABORO 7 IUM 1 UIDE; 1,1 DIPHENYLHEXAHYDRO 1H PYRROLO[1,2 C]OXAZABORO 7 IUM 1 UIDE; 1,2 BIS (2 BROMOPHENYL)ETHANE; 2 (BENZHYDRYLOXY)ETHANAMINE; 2 AMINOETHOXYDIPHENYLBORANE; 2,2 BIS(2 METHOXYPHENYL) 1,3,2 OXAZABOROLIDIN 3 IUM 2 UIDE; 2,2 BIS(4 FLUOROPHENYL) 1,3,2 OXAZABOROLIDIN 3 IUM 2 UIDE; 2,2 BIS(4 METHOXYPHENYL) 1,3,2 OXAZABOROLIDIN 3 IUM 2 UIDE; 2,2 BIS[4 (TRIFLUOROMETHYL)PHENYL] 1,3,2 OXAZABOROLIDIN 3 IUM 2 UIDE; 2,2 DI 4 TOLYL 1,3,2 OXAZABOROLIDIN 3 IUM 2 UIDE; 2,2 DIPHENYL 1,3,2 OXAZABORO 7 IUM 1 UIDE; 2,2 DIPHENYL 1,3,2 THIAZABOROLIDIN 3 IUM 2 UIDE; 2,2 DIPHENYL 2H [1,3,2]OXAZABOROLO[5,4,3 IJ]QUINOLIN 3 IUM 2 UIDE; 3,3 DIMETHYL 2,2 DIPHENYL 1,3,2 OXAZABOROLIDIN3 IUM 2 UIDE; 4 (HYDROXYMETHYL) 5 OXO 2,2 DIPHENYL 1,3,2 OXAZABOROLIDIN 3 IUM 2 UIDE; 4 [(1H INDOL 3 YL)METHYL] 5 OXO 2,2 DIPHENYL 1,3,2 OXAZABOROLIDIN 3 IUM 2 UIDE; 5 OXO 2,2 DIPHENYL 1,3,2 OXAZABOROLIDIN 3 IUM 2 UIDE; BENZENE DERIVATIVE; BIS(4 FLUOROPHENYL)(HYDROXY)BORANE; BORINIC ACID DERIVATIVE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; HYDROXYBIS(2 METHOXYPHENYL)BORANE; HYDROXYBIS[4 (TRIFLUOROMETHYL)PHENYL]BORANE; HYDROXYDI 4 TOLYLBORANE; HYDROXYDIPHENYLBORANE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLOID RECEPTOR 6;

ARTICLE; CALCIUM TRANSPORT; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; INHIBITION KINETICS; STRUCTURE ACTIVITY RELATION; TRANSESTERIFICATION;

BORON COMPOUNDS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; DRUG DESIGN; HEK293 CELLS; HUMANS; ION TRANSPORT; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

EID: 84877792275     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.03.037     Document Type: Article

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