Chemical inhibitors of the calcium entry channel TRPV6

Pharmaceutical Research

Volumn 28, Issue 2, 2011, Pages 322-330

  Landowski, Christopher P ^a,b   Bolanz, Katrin A ^a,c   Suzuki, Yoshiro ^a,d   Hediger, Matthias A ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^c AGROSCOPE   (Switzerland)

^d NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

breast cancer; calcium channel; chemical inhibitors; prostate cancer; TRPV6

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIUM ION; ECONAZOLE; MESSENGER RNA; MICONAZOLE; SMALL INTERFERING RNA; TH 1177; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 5; VANILLOID RECEPTOR 6; VANILLOID RECEPTOR 6 ANTAGONIST; VANILLOID RECEPTOR ANTAGONIST;

ANIMAL CELL; ARTICLE; BREAST CANCER; CALCIUM TRANSPORT; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROSTATE CANCER; XENOPUS;

ANIMALS; BREAST NEOPLASMS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELL PROLIFERATION; CELLS, CULTURED; ECONAZOLE; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MICONAZOLE; PROSTATIC NEOPLASMS; PYRROLIDINES; RNA, SMALL INTERFERING; TRPV CATION CHANNELS;

EID: 79952485156     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0249-9     Document Type: Article

References (38)

1. Mettlin C, JonesGW, Murphy GP. Trends in prostate cancer care in the United States, 1974-1990: observations from the patient care evaluation studies of the American College of Surgeons Commission on Cancer. CA Cancer J Clin. 1993;43:83-91.
2. Mundy GR. Mechanisms of bone metastasis. Cancer. 1997;80:1546-56. (Pubitemid 27444026)
3. Orr FW, Sanchez-SweatmanOH,Kostenuik P, SinghG. Tumor-bone interactions in skeletal metastasis. ClinOrthopRelatRes 19-33 (1995).
4. Saitoh H, Hida M, Shimbo T, Nakamura K, Yamagata J, Satoh T. Metastatic patterns of prostatic cancer. Correlation between sites and number of organs involved. Cancer. 1984;54:3078-84.
5. Chanand JM, Giovannucci EL. Dairy products, calcium, and vitamin D and risk of prostate cancer. Epidemiol Rev. 2001;23:87-92. (Pubitemid 32906618)
6. Clinton SK, Giovannucci E. Diet, nutrition, and prostate cancer. Annu Rev Nutr. 1998;18:413-40. (Pubitemid 28366874)
7. Tavani A, Gallus S, Franceschi S, La Vecchia C. Calcium, dairy products, and the risk of prostate cancer. Prostate. 2001;48:118-21. (Pubitemid 32613874)
8. Putney Jr JW. A model for receptor-regulated calcium entry. Cell Calcium. 1986;7:1-12. (Pubitemid 16130733)
9. Putney Jr JW. Type 3 inositol 1, 4, 5-trisphosphate receptor and capacitative calcium entry. Cell Calcium. 1997;21:257-61.
10. Putney Jr JW. Capacitative calcium entry in the nervous system. Cell Calcium. 2003;34:339-44. (Pubitemid 37025100)
11. Hoth M, Penner R. Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature. 1992;355:353-6.
12. Lewis RS, Cahalan MD. Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells. Cell Regul. 1989;1:99-112.
13. Zweifach A, Lewis RS. Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores. Proc Natl Acad Sci U S A. 1993;90:6295-9. (Pubitemid 23191502)
14. Shuba YM, Prevarskaya N, Lemonnier L, Van Coppenolle F, Kostyuk PG, Mauroy B, et al. Volume-regulated chloride conductance in the LNCaP human prostate cancer cell line. Am J Physiol Cell Physiol. 2000;279:C1144-54.
15. Zweifach A, Lewis RS. Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback. J Gen Physiol. 1995;105:209-26.
16. Abdullaev IF, Bisaillon JM, Potier M, Gonzalez JC, Motiani RK, Trebak M. Stim1 and Orai1 mediate CRAC currents and storeoperated calcium entry important for endothelial cell proliferation. Circ Res. 2008;103:1289-99.
17. Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A. Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium. 2007;42:145-56. (Pubitemid 47029605)
18. Ng SW, di Capite J, Singaravelu K, Parekh AB. Sustained activation of the tyrosine kinase Syk by antigen in mast cells requires local Ca2+ influx through Ca2+ release-activated Ca2+ channels. J Biol Chem. 2008;283:31348-55.
19. Stiber J, Hawkins A, Zhang ZS, Wang S, Burch J, Graham V, et al. STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle. Nat Cell Biol. 2008;10:688-97. (Pubitemid 351772934)
20. Perret S, Cantereau A, Audin J, Dufy B, Georgescauld D. Interplay between Ca2+ release and Ca2+ influx underlies localized hyperpolarization-induced [Ca2+]i waves in prostatic cells. Cell Calcium. 1999;25:297-311. (Pubitemid 29353719)
21. Vanden Abeele F, Lemonnier L, Thebault S, Lepage G, Parys JB, Shuba Y, et al. Two types of store-operated Ca2+ channels with different activation modes and molecular origin in LNCaP human prostate cancer epithelial cells. J Biol Chem. 2004;279:30326-37. (Pubitemid 38937960)
22. Vanden Abeele F, Roudbaraki M, Shuba Y, Skryma R, Prevarskaya N. Store-operated Ca2+ current in prostate cancer epithelial cells. Role of endogenous Ca2+ transporter type 1. J Biol Chem. 2003;278:15381-9. (Pubitemid 36799877)
23. Legrand G, Humez S, Slomianny C, Dewailly E, Vanden Abeele F, Mariot P, et al. Ca2+ pools and cell growth. Evidence for sarcoendoplasmic Ca2 + -ATPases 2B involvement in human prostate cancer cell growth control. J Biol Chem. 2001;276:47608-14.
24. Tombal B, Weeraratna AT, Denmeade SR, Isaacs JT. Thapsigargin induces a calmodulin/calcineurin-dependent apoptotic cascade responsible for the death of prostatic cancer cells. Prostate. 2000;43:303-17. (Pubitemid 30367966)
25. Wertz IE, Dixit VM. Characterization of calcium release-activated apoptosis of LNCaP prostate cancer cells. J Biol Chem. 2000;275:11470-7. (Pubitemid 30212802)
26. Skryma R, Mariot P, Bourhis XL, Coppenolle FV, Shuba Y, Vanden Abeele F, et al. Store depletion and store-operated Ca2+ current in human prostate cancer LNCaP cells: involvement in apoptosis. J Physiol. 2000;527(Pt 1):71-83. (Pubitemid 30649585)
27. Vanden Abeele F, Skryma R, Shuba Y, Van Coppenolle F, Slomianny C, Roudbaraki M, et al. Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells. Cancer Cell. 2002;1:169-79.
28. Wissenbach U, Niemeyer BA, Fixemer T, Schneidewind A, Trost C, Cavalie A, et al. Expression of CaT-like, a novel calciumselective channel, correlates with the malignancy of prostate cancer. J Biol Chem. 2001;276:19461-8.
29. Fixemer T, Wissenbach U, Flockerzi V, Bonkhoff H. Expression of the Ca2+ -selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene. 2003;22:7858-61. (Pubitemid 37485545)
30. Zhuang L, Peng JB, Tou L, Takanaga H, Adam RM, Hediger MA, et al. Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab Invest. 2002;82:1755-64. (Pubitemid 35462988)
31. Bolanz KA, Hediger MA, Landowski CP. The role of TRPV6 in breast carcinogenesis. Mol Cancer Ther. 2008;7:271-9. (Pubitemid 351302521)
32. Bodding M, Flockerzi V. Ca2+ dependence of the Ca2+-selective TRPV6 channel. J Biol Chem. 2004;279:36546-52.
33. Schindl R, Kahr H, Graz I, Groschner K, Romanin C. Store depletion-activated CaT1 currents in rat basophilic leukemia mast cells are inhibited by 2-aminoethoxydiphenyl borate. Evidence for a regulatory component that controls activation of both CaT1 and CRAC (Ca(2+) release-activated Ca(2+) channel) channels. J Biol Chem. 2002;277:26950-8. (Pubitemid 34951705)
34. Lehen'kyi V, Flourakis M, Skryma R, Prevarskaya N. TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/ NFAT-dependent pathways. Oncogene. 2007;26:7380-5.
35. Haverstick DM, Heady TN, Macdonald TL, Gray LS. Inhibition of human prostate cancer proliferation in vitro and in a mouse model by a compound synthesized to block Ca2+ entry. Cancer Res. 2000;60:1002-8. (Pubitemid 30129537)
36. Peng JB, Chen XZ, Berger UV, Vassilev PM, Tsukaguchi H, Brown EM, et al. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J Biol Chem. 1999;274:22739-46.
37. Peng JB, Zhuang L, Berger UV, Adam RM, Williams BJ, Brown EM, et al. CaT1 expression correlates with tumor grade in prostate cancer. Biochem Biophys Res Commun. 2001;282:729-34. (Pubitemid 32924618)
38. Imai YN, Ryu S, Oiki S. Docking model of drug binding to the human ether-a-go-go potassium channel guided by tandem dimer mutant patch-clamp data: a synergic approach. J Med Chem. 2009;52:1630-8.