RNAseq analyses identify tumor necrosis factor-mediated inflammation as a major abnormality in ALS spinal cord

PLoS ONE

Volumn 11, Issue 8, 2016, Pages

  Brohawn, David G ^a   O'Brien, Laura C ^a   Bennett, James P ^a,b,c  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Neurodegeneration Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RNA; TRANSCRIPTION FACTOR REL; TUMOR NECROSIS FACTOR; TNF PROTEIN, HUMAN;

AMYOTROPHIC LATERAL SCLEROSIS; ANALYSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENETIC ALGORITHM; GENETIC DISORDER; HUMAN; HUMAN CELL; HUMAN GENOME; INFLAMMATION; INGENUITY PATHWAYS ANALYSIS; MACROPHAGE FUNCTION; NEXT GENERATION SEQUENCING; NFKB GENE; NFKB1 GENE; NR1H2 GENE; REL GENE; RNA SEQUENCE; RXRA GENE; SEQUENCE ALIGNMENT; TNFAIP2 GENE; WEIGHTED GENE CO EXPRESSION NETWORK ANALYSIS; AUTOPSY; CASE CONTROL STUDY; COMPLICATION; GENE REGULATORY NETWORK; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HIGH THROUGHPUT SEQUENCING; IMMUNOLOGY; METABOLISM; MOTONEURON; PATHOLOGY; PHYSIOLOGY; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SPINAL CORD;

AMYOTROPHIC LATERAL SCLEROSIS; AUTOPSY; CASE-CONTROL STUDIES; GENE REGULATORY NETWORKS; GENOME-WIDE ASSOCIATION STUDY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; INFLAMMATION; MOTOR NEURONS; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; SPINAL CORD; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84983071394     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0160520     Document Type: Article

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