Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells

eLife

Volumn 5, Issue JULY, 2016, Pages

  Hengel, Sarah R ^a   Malacaria, Eva ^b   Da Silva Constantino, Laura Folly ^a   Bain, Fletcher E ^a   Diaz, Andrea ^a   Koch, Brandon G ^a   Yu, Liping ^a,c   Wu, Meng ^a   Pichierri, Pietro ^b   Spies, M Ashley ^a   Spies, Maria ^a  

^a UNIVERSITY OF IOWA   (United States)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; RAD52 PROTEIN; BRCA2 PROTEIN, HUMAN; ENZYME INHIBITOR; PROTEIN BINDING; SINGLE STRANDED DNA;

ARTICLE; BINDING AFFINITY; BIOCHEMISTRY; CELL FUNCTION; CELL KILLING; CELL VIABILITY; CHEMICAL BINDING; CHEMICAL STRUCTURE; COMPUTER MODEL; DNA BINDING; DNA DAMAGE CHECKPOINT; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE DISRUPTION; GENE INACTIVATION; HIGH THROUGHPUT SCREENING; IC50; MOLECULAR DOCKING; OLIGOMERIZATION; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN DNA INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; STOICHIOMETRY; STRESS; TUMOR SUPPRESSOR GENE; CELL SURVIVAL; DEFICIENCY; DRUG EFFECTS; FIBROBLAST; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

BRCA2 PROTEIN; CELL LINE, TUMOR; CELL SURVIVAL; DNA, SINGLE-STRANDED; ENZYME INHIBITORS; FIBROBLASTS; HUMANS; PROTEIN BINDING; RAD52 DNA REPAIR AND RECOMBINATION PROTEIN;

EID: 84983032668     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.14740     Document Type: Article

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