Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1

eLife

Volumn 5, Issue AUGUST, 2016, Pages

  Lehrbach, Nicolas J ^a,b   Ruvkun, Gary ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE; BORTEZOMIB; DNA DAMAGE INDUCIBLE PROTEIN 1; GREEN FLUORESCENT PROTEIN; MESYLIC ACID ETHYL ESTER; PROTEASOME; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR SKN 1A; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; DDI-1 PROTEIN, C ELEGANS; DNA BINDING PROTEIN; SKN-1 PROTEIN, C ELEGANS;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; CRISPR CAS SYSTEM; DRUG SENSITIVITY; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; GENE MUTATION; GENOME; MICROSCOPY; NONHUMAN; PROTEASOME DYSFUNCTION; PROTEIN CLEAVAGE; PROTEIN DISRUPTION; PROTEIN HOMEOSTASIS; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; RECEPTOR UPREGULATION; TRANSGENICS; WESTERN BLOTTING; ANIMAL; ENZYMOLOGY; GENE EXPRESSION REGULATION; METABOLISM;

ANIMALS; ASPARTIC ACID PROTEASES; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; PROTEASOME ENDOPEPTIDASE COMPLEX; TRANSCRIPTION FACTORS;

EID: 84983027579     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.17721.001     Document Type: Article

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