The retroviral proteinase active site and the N-terminus of Ddi1 are required for repression of protein secretion

FEBS Letters

Volumn 585, Issue 1, 2011, Pages 139-142

  White, Rhian E ^a   Dickinson, J Richard ^a   Semple, Colin A M ^b   Powell, David J ^c   Berry, Colin ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Aspartic; Ddi1; Protein secretion; Proteinase; Saccharomyces; Ubiquitin; VSM1

Indexed keywords

ASPARTIC PROTEINASE; DNA DAMAGE INDUCIBLE PROTEIN 1; TRANSCRIPTION FACTOR; UBIQUITIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE REGULATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SECRETION; RETROVIRUS; SACCHAROMYCES CEREVISIAE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ASPARTIC ACID PROTEASES; BLOTTING, WESTERN; CATALYTIC DOMAIN; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SECRETORY PATHWAY;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 78650868214     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.11.026     Document Type: Article

References (25)

1. A.J. Barrett, N.D. Rawlings, and J.F. Woessner Handbook of Proteolytic Enzymes 2004 Elsevier Academic Press London
2. N.A. Roberts Rational design of peptide-based HIV proteinase inhibitors Science 248 1990 358 361
3. R. Lapatto X-ray analysis of HIV-1 proteinase at 2.7 resolution confirms structural homology among retroviral enzymes Nature 342 1989 299 302
4. V. Rhiemeier A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin Am. J. Pathol. 168 2006 1354 1364
5. D.M. Krylov, and E.V. Koonin A novel family of predicted retroviral-like aspartyl proteases with a possible key role in eukaryotic cell cycle control Curr. Biol. 11 2001 R584 R587
6. R. Sirkis, J.E. Gerst, and D. Fass Ddi1, a eukaryotic protein with the retroviral protease fold J. Mol. Biol. 364 2006 376 387
7. A.S. Fatimababy, Y.L. Lin, R. Usharani, R. Radjacommare, H.T. Wang, H.L. Tsai, Y. Lee, and H. Fu Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis FEBS J. 277 2010 796 816
8. B.L. Bertolaet, D.J. Clarke, M. Wolff, M.H. Watson, M. Henze, G. Divita, and S.I. Reed UBA domains mediate protein-protein interactions between two DNA damage-inducible proteins J. Mol. Biol. 313 2001 955 963 (Pubitemid 33081893)
9. D.J. Clarke, G. Mondesert, M. Segal, B.L. Bertolaet, S. Jensen, M. Wolff, M. Henze, and S.I. Reed Dosage suppressors of pds1 implicate ubiquitin-associated domains in checkpoint control Mol. Cell. Biol. 21 2001 1997 2007
10. B.L. Bertolaet, D.J. Clarke, M. Wolff, M.H. Watson, M. Henze, G. Divita, and S.I. Reed UBA domains of DNA damage-inducible proteins interact with ubiquitin Nat. Struct. Biol. 8 2001 417 422
11. Y. Kang, R.A. Vossler, L.A. Diaz-Martinez, N.S. Winter, D.J. Clarke, and K.J. Walters UBL/UBA ubiquitin receptor proteins bind a common tetraubiquitin chain J. Mol. Biol. 356 2006 1027 1035
12. L. Kaplun, R. Tzirkin, A. Bakhrat, N. Shabek, Y. Ivantsiv, and D. Raveh The DNA damage-inducible UbL-UbA protein Ddi1 participates in Mec1-mediated degradation of Ho endonuclease Mol. Cell. Biol. 25 2005 5355 5362
13. L.A. Diaz-Martinez, Y. Kang, K.J. Walters, and D.J. Clarke Yeast UBL-UBA proteins have partially redundant functions in cell cycle control Cell Div. 1 2006 28
14. Y. Ivantsiv, L. Kaplun, R. Tzirkin-Goldin, N. Shabek, and D. Raveh Unique role for the UbL-UbA protein Ddi1 in turnover of SCFUfo1 complexes Mol. Cell. Biol. 26 2006 1579 1588
15. G. Gabriely, R. Kama, R. Gelin-Licht, and J.E. Gerst Different domains of the UBL-UBA ubiquitin receptor, Ddi1/Vsm1, are involved in its multiple cellular roles Mol. Biol. Cell 19 2008 3625 3637
16. V. Lustgarten, and J.E. Gerst Yeast VSM1 encodes a v-SNARE binding protein that may act as a negative regulator of constitutive exocytosis Mol. Cell. Biol. 19 1999 4480 4494
17. M. Marash, and J.E. Gerst Phosphorylation of the autoinhibitory domain of the Sso t-SNAREs promotes binding of the Vsm1 SNARE regulator in yeast Mol. Biol. Cell 14 2003 3114 3125
18. K. Melcher A modular set of prokaryotic and eukaryotic expression vectors Anal. Biochem. 277 2000 109 120
19. H. Ito, Y. Fukuda, K. Murata, and A. Kimura Transformation of intact yeast cells treated with alkali cations J. Bacteriol. 153 1983 163 168
20. V.V. Kushnirov Rapid and reliable protein extraction from yeast Yeast 16 2000 857 860
21. J. Gough, K. Karplus, R. Hughey, and C. Chothia Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structure J. Mol. Biol. 313 2001 903 919
22. R.D. Finn The Pfam protein families database Nucleic Acids Res. 38 2010 D211 D222
23. S.R. Eddy Profile hidden Markov models Bioinformatics 14 1998 755 763
24. L.A. Kelley, and M.J. Sternberg Protein structure prediction on the Web: a case study using the Phyre server Nat. Protoc. 4 2009 363 371
25. C. Cole, J.D. Barber, and G.J. Barton The Jpred 3 secondary structure prediction server Nucleic Acids Res. 36 2008 W197 W201