Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes

Aging Cell

Volumn 14, Issue 1, 2015, Pages 35-48

  Ayyadevara, Srinivas ^a,b   Balasubramaniam, Meenakshisundaram ^b,c   Gao, Yuan ^d   Yu, Li Rong ^d   Alla, Ramani ^a   Shmookler Reis, Robert ^a,b,e  

^a CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^e UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

C. elegans; (protein) aggregation; Alzheimer (disease); Huntington (disease); Neurodegeneration; Proteasome

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; ASPARAGINE; CHAPERONE; GLUTAMINE; POLYGLUTAMINE; PROTEASOME; UBIQUITIN; AMYLOID BETA PROTEIN; CAENORHABDITIS ELEGANS PROTEIN; PROTEASOME INHIBITOR; PROTEIN AGGREGATE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY ISOLATION; ARTICLE; CAENORHABDITIS ELEGANS; CYTOTOXICITY; HUNTINGTON CHOREA; HYDROPHOBICITY; LIFESPAN; MASS SPECTROMETRY; MOLECULAR DYNAMICS; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEOMICS; RNA INTERFERENCE; WILD TYPE; WORM; ANIMAL; CELL DEATH; DEGENERATIVE DISEASE; DISEASE MODEL; DRUG EFFECTS; FERTILITY; FLUORESCENT ANTIBODY TECHNIQUE; GENE SILENCING; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY; PROTEIN MULTIMERIZATION; WESTERN BLOTTING;

CAENORHABDITIS ELEGANS; NEMATODA;

AMYLOID BETA-PEPTIDES; ANIMALS; BLOTTING, WESTERN; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL DEATH; DISEASE MODELS, ANIMAL; FERTILITY; FLUORESCENT ANTIBODY TECHNIQUE; GENE KNOCKDOWN TECHNIQUES; MOLECULAR DYNAMICS SIMULATION; NEURODEGENERATIVE DISEASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PROTEIN AGGREGATES; PROTEIN MULTIMERIZATION; RNA INTERFERENCE; UBIQUITIN;

EID: 84922679198     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12296     Document Type: Article

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