MiR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: A novel therapeutic approach

Cardiovascular Research

Volumn 111, Issue 3, 2016, Pages 184-193

  Shi, Lei ^a   Kojonazarov, Baktybek ^b   Elgheznawy, Amro ^a   Popp, Rüdiger ^a   Dahal, Bhola Kumar ^b   Böhm, Mario ^b   Pullamsetti, Soni Savai ^b,c   Ghofrani, Hossein Ardeschir ^b   Gödecke, Axel ^d   Jungmann, Andreas ^e,f   Katus, Hugo A ^e,f   Müller, Oliver J ^e,f   Schermuly, Ralph T ^b   Fisslthaler, Beate ^a   Seeger, Werner ^b,c   Fleming, Ingrid ^a  

^a GOETHE UNIVERSITY   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^d UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

^f DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

Hypertension; Hypoxia; Pulmonary; Pulmonary heart disease

Indexed keywords

ANTAGOMIR; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CCAAT ENHANCER BINDING PROTEIN ALPHA; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; GSK 1904529A; MICRORNA 223; MYOSIN HEAVY CHAIN BETA; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; GSK1904529A; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IGF1R PROTEIN, HUMAN; IMIDAZOLE DERIVATIVE; MICRORNA; MIRN122 MICRORNA, HUMAN; MIRN223 MICRORNA, MOUSE; PYRIDINE DERIVATIVE; SOMATOMEDIN RECEPTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE INACTIVATION; GENE OVEREXPRESSION; HEART AFTERLOAD; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE FAILURE; HEART RIGHT VENTRICLE HYPERTROPHY; HUMAN; HUMAN TISSUE; HYPOXIA; LUNG ARTERY BANDING; MALE; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; COMPLICATION; DEFICIENCY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; HEART FAILURE; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE; HYPERTENSION, PULMONARY; KNOCKOUT MOUSE; LUNG; METABOLISM; PATHOPHYSIOLOGY; PHENOTYPE; PREVENTION AND CONTROL;

ANIMALS; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HEART FAILURE; HEART VENTRICLES; HUMANS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMIDAZOLES; LUNG; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRORNAS; PHENOTYPE; PYRIDINES; RECEPTOR, IGF TYPE 1; RECEPTORS, SOMATOMEDIN; SIGNAL TRANSDUCTION; VENTRICULAR DYSFUNCTION, RIGHT; VENTRICULAR FUNCTION, RIGHT;

EID: 84982972175     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvw065     Document Type: Article

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