MiR-223 suppresses cell proliferation by targeting IGF-1R

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Jia, Cheng You ^a   Li, Hui Hui ^a   Zhu, Xu Chao ^a   Dong, Yi Wei ^a   Fu, Da ^a   Zhao, Qian Lei ^a   Wu, Wei ^a   Wu, Xing Zhong ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LENTIVIRUS VECTOR; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; MICRORNA 223; PROTEIN KINASE B; RAS PROTEIN; RASA1 PROTEIN; S6 KINASE; SHORT HAIRPIN RNA; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; MIRN223 MICRORNA, HUMAN; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL PROLIFERATION INHIBITION; CONTROLLED STUDY; FEMALE; GROWTH INHIBITION; HELA CELL; HEPATOMA CELL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; GENE SILENCING; GENETICS; METABOLISM; PHYSIOLOGY;

LENTIVIRUS; MUS MUSCULUS;

CELL PROLIFERATION; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; MICRORNAS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 80355143393     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027008     Document Type: Article

References (30)

1. Bartel DP, (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
2. Winter J, Jung S, Keller S, Gregory RI, Diederichs S, (2009) Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 11: 228-234.
3. Chen CZ, Li L, Lodish HF, Bartel DP, (2004) MicroRNAs modulate hematopoietic lineage differentiation. Science 303: 83-86.
4. Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP, (2003) Vertebrate microRNA genes. Science 299: 1540.
5. Fazi F, Rosa A, Fatica A, Gelmetti V, De Marchis ML, et al. (2005) A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell 123: 819-831.
6. Fukao T, Fukuda Y, Kiga K, Sharif J, Hino K, et al. (2007) An evolutionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling. Cell 129: 617-631.
7. Felli N, Pedini F, Romania P, Biffoni M, Morsilli O, et al. (2009) MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis. Haematologica 94: 479-486.
8. Fazi F, Racanicchi S, Zardo G, Starnes LM, Mancini M, et al. (2007) Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein. Cancer Cell 12: 457-466.
9. Wu XZ, Shao GY, Chen SR, Wang XW, Wang ZY, (1989) Studies on the Relationship between Protein-Kinase C and Differentiation of Human Promyelocytic Leukemia-Cells Induced by Retinoic Acid. Leukemia Research 13: 869-874.
10. Wu XZ, Shao GY, Chen SR, Huang ME, Wang ZY, (1991) Protein kinase C in the promyelocytic leukemia cell differentiation of granulocytes. Chin MedJ(Engl) 104: 32-35.
11. Park S, Chapuis N, Tamburini J, Bardet V, Cornillet-Lefebvre P, et al. Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia. Haematologica 95: 819-828.
12. Li R, Pourpak A, Morris SW, (2009) Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach. J Med Chem 52: 4981-5004.
13. LoPiccolo J, Blumenthal GM, Bernstein WB, Dennis PA, (2008) Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat 11: 32-50.
14. Johnnidis JB, Harris MH, Wheeler RT, Stehling-Sun S, Lam MH, et al. (2008) Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 451: 1125-1129.
15. Gottardo F, Liu CG, Ferracin M, Calin GA, Fassan M, et al. (2007) Micro-RNA profiling in kidney and bladder cancers. Urol Oncol 25: 387-392.
16. Laios A, O'Toole S, Flavin R, Martin C, Kelly L, et al. (2008) Potential role of miR-9 and miR-223 in recurrent ovarian cancer. Mol Cancer 7: 35.
17. Su H, Yang JR, Xu T, Huang J, Xu L, et al. (2009) MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity. Cancer Res 69: 1135-1142.
18. Wong QW, Lung RW, Law PT, Lai PB, Chan KY, et al. (2008) MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. Gastroenterology 135: 257-269.
19. Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, et al. (2003) A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 33: 401-406.
20. Scherr M, Venturini L, Eder M, Lentiviral vector-mediated expression of pre-miRNAs and antagomiRs. Methods Mol Biol 614: 175-185.
21. Liu LZ, Zheng JZ, Wang XR, Jiang BH, (2008) Endothelial p70 S6 kinase 1 in regulating tumor angiogenesis. Cancer Res 68: 8183-8188.
22. Heron-Milhavet L, LeRoith D, (2002) Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage. J Biol Chem 277: 15600-15606.
23. Xu Y, Sengupta T, Kukreja L, Minella AC, MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7. J Biol Chem 285: 34439-34446.
24. Tidyman WE, Rauen KA, (2009) The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation. Curr Opin Genet Dev 19: 230-236.
25. Wu XZ, Shi PC, Hu P, Chen Y, Ding SS, (2006) N-all-trans-retinoyl-L-proline inhibits metastatic potential of hepatocellular carcinoma cells. Cell Biology International 30: 672-680.
26. Wu XZ, Lin JW, Yang ZC, Wang XW, Qian XP, et al. (1996) Detection of PML-RAR alpha in patients with APL during follow-up period. Chinese Medical Journal 109: 295-299.
27. Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, et al. (2005) Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 33: e179.
28. Wu L, Zhao Q, Zhu X, Peng M, Jia C, et al. (2010) A novel function of microRNA let-7d in regulation of galectin-3 expression in attention deficit hyperactivity disorder rat brain. Brain Pathol 20: 1042-1054.
29. Wu XZ, Honke K, Zhang YL, Zha XL, Taniguchi N, (2004) Lactosylsulfatide expression in hepatocellular carcinoma cells enhances cell adhesion to vitronectin and intrahepatic metastasis in nude mice. International Journal of Cancer 110: 504-510.
30. Zheng J, Bao WQ, Sheng WQ, Guo L, Zhang HL, et al. (2009) Serum 3′-sulfo-Lea indication of gastric cancer metastasis. Clin Chim Acta 405: 119-126.