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Volumn 36, Issue 4, 2016, Pages 1631-1639

NFB-associated pathways in progression of chemoresistance to 5-fluorouracil in an in vitro model of colonic carcinoma

Author keywords

5 fluorouracil; Chemoresistance; Colon cancer; MAP3K8; NF B

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DISULFIRAM; FLUOROURACIL; I KAPPA B KINASE INHIBITOR; LUPEOL; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 8; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; RAPAMYCIN; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; VIOLACEIN; WORTMANNIN; ANTINEOPLASTIC ANTIMETABOLITE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAP3K8 PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN KINASE R;

EID: 84982908366     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (26)

References (76)
  • 3
    • 42949142609 scopus 로고    scopus 로고
    • Systemic treatment of colorectal cancer
    • Wolpin BM and Mayer RJ: Systemic treatment of colorectal cancer. Gastroenterology 134: 1296-1310, 2008.
    • (2008) Gastroenterology , vol.134 , pp. 1296-1310
    • Wolpin, B.M.1    Mayer, R.J.2
  • 4
    • 67650296948 scopus 로고    scopus 로고
    • Oxaliplatin or irinotecan as adjuvant therapy for colon cancer: The results are in
    • O'Connell MJ: Oxaliplatin or irinotecan as adjuvant therapy for colon cancer: the results are in. J Clin Oncol 27: 3082-3084, 2009.
    • (2009) J Clin Oncol , vol.27 , pp. 3082-3084
    • O'Connell, M.J.1
  • 5
    • 84860369472 scopus 로고    scopus 로고
    • Critical aspects in rationale design of fluorouracil-based adjuvant therapies for the management of colon cancer
    • Sinha VR and Honey: Critical aspects in rationale design of fluorouracil-based adjuvant therapies for the management of colon cancer. Crit Rev Ther Drug Carrier Syst 29: 89-148, 2012.
    • (2012) Crit Rev Ther Drug Carrier Syst , vol.29 , pp. 89-148
    • Sinha, V.R.1
  • 7
    • 84869078709 scopus 로고    scopus 로고
    • Regulation of colon cancer recurrence and development of therapeutic strategies
    • Kanwar SS, Poolla A and Majumdar AP: Regulation of colon cancer recurrence and development of therapeutic strategies. World J Gastrointest Pathophysiol 3: 1-9, 2012.
    • (2012) World J Gastrointest Pathophysiol , vol.3 , pp. 1-9
    • Kanwar, S.S.1    Poolla, A.2    Majumdar, A.P.3
  • 8
    • 0022930702 scopus 로고
    • Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism
    • Sen R and Baltimore D: Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell 47: 921-928, 1986.
    • (1986) Cell , vol.47 , pp. 921-928
    • Sen, R.1    Baltimore, D.2
  • 9
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
    • Barnes PJ and Karin M: Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336: 1066-1071, 1997.
    • (1997) N Engl J Med , vol.336 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 10
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa B and i kappa B proteins: New discoveries and insights
    • Baldwin AS: The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14: 649-683, 1996.
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-683
    • Baldwin, A.S.1
  • 12
    • 0029836444 scopus 로고    scopus 로고
    • Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice
    • Neurath MF, Pettersson S, Meyer zum Büschenfelde KH and Strober W: Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice. Nat Med 2: 998-1004, 1996.
    • (1996) Nat Med , vol.2 , pp. 998-1004
    • Neurath, M.F.1    Pettersson, S.2    Meyer Zum Büschenfelde, K.H.3    Strober, W.4
  • 15
    • 17844386319 scopus 로고    scopus 로고
    • IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation
    • Lawrence T, Bebien M, Liu GY, Nizet V and Karin M: IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature 434: 1138-1143, 2005.
    • (2005) Nature , vol.434 , pp. 1138-1143
    • Lawrence, T.1    Bebien, M.2    Liu, G.Y.3    Nizet, V.4    Karin, M.5
  • 25
    • 35848969354 scopus 로고    scopus 로고
    • Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factorkappaB/IkappaB kinase signal pathway
    • Lee SH, Son SM, Son DJ, Kim SM, Kim TJ, Song S, Moon DC, Lee HW, Ryu JC, Yoon D-Y and Hong JT: Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factorkappaB/IkappaB kinase signal pathway. Mol Cancer Ther 6: 2786-2797, 2007.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2786-2797
    • Lee, S.H.1    Son, S.M.2    Son, D.J.3    Kim, S.M.4    Kim, T.J.5    Song, S.6    Moon, D.C.7    Lee, H.W.8    Ryu, J.C.9    Yoon, D.-Y.10    Hong, J.T.11
  • 28
    • 11244282153 scopus 로고    scopus 로고
    • Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethaneinduced apoptosis in breast cancer cells
    • Rahman KW and Sarkar FH: Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethaneinduced apoptosis in breast cancer cells. Cancer Res 65: 364-371, 2005.
    • (2005) Cancer Res , vol.65 , pp. 364-371
    • Rahman, K.W.1    Sarkar, F.H.2
  • 29
    • 38149140259 scopus 로고    scopus 로고
    • SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma
    • Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R and Williams CL: SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma. J Biol Chem 283: 963-976, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 963-976
    • Tew, G.W.1    Lorimer, E.L.2    Berg, T.J.3    Zhi, H.4    Li, R.5    Williams, C.L.6
  • 30
    • 4544224979 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression
    • Luo J-L, Maeda S, Hsu L-C, Yagita H and Karin M: Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell 6: 297-305, 2004.
    • (2004) Cancer Cell , vol.6 , pp. 297-305
    • Luo, J.-L.1    Maeda, S.2    Hsu, L.-C.3    Yagita, H.4    Karin, M.5
  • 31
    • 77952452393 scopus 로고    scopus 로고
    • Inhibition of nuclear factor-kappa B differentially affects thyroid cancer cell growth, apoptosis, and invasion
    • Bauerle KT, Schweppe RE and Haugen BR: Inhibition of nuclear factor-kappa B differentially affects thyroid cancer cell growth, apoptosis, and invasion. Mol Cancer 9: 117, 2010.
    • (2010) Mol Cancer , vol.9 , pp. 117
    • Bauerle, K.T.1    Schweppe, R.E.2    Haugen, B.R.3
  • 32
    • 77953533783 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosisinducing ligand (TRAIL) or oxaliplatin
    • Jani TS, DeVecchio J, Mazumdar T, Agyeman A and Houghton J a: Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosisinducing ligand (TRAIL) or oxaliplatin. J Biol Chem 285: 19162-19172, 2010.
    • (2010) J Biol Chem , vol.285 , pp. 19162-19172
    • Jani, T.S.1    DeVecchio, J.2    Mazumdar, T.3    Agyeman, A.4    Houghton, J.A.5
  • 33
    • 0037457481 scopus 로고    scopus 로고
    • Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines
    • Wang W, McLeod HL and Cassidy J: Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines. Int J Cancer 104: 504-511, 2003.
    • (2003) Int J Cancer , vol.104 , pp. 504-511
    • Wang, W.1    McLeod, H.L.2    Cassidy, J.3
  • 34
    • 33644867406 scopus 로고    scopus 로고
    • Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Aktmediated signal transduction in human colorectal cancer cells
    • Kodach LL, Bos CL, Duran N, Peppelenbosch MP, Ferreira C V and Hardwick JC: Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Aktmediated signal transduction in human colorectal cancer cells. Carcinogenesis 27: 508-516, 2006.
    • (2006) Carcinogenesis , vol.27 , pp. 508-516
    • Kodach, L.L.1    Bos, C.L.2    Duran, N.3    Peppelenbosch, M.P.4    Ferreira, C.V.5    Hardwick, J.C.6
  • 36
    • 84875988418 scopus 로고    scopus 로고
    • Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil
    • Vinod BS, Antony J, Nair HH, Puliyappadamba VT, Saikia M, Narayanan SS, Bevin a and Anto RJ: Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil. Cell Death Dis 4: e505, 2013.
    • (2013) Cell Death Dis , vol.4 , pp. e505
    • Vinod, B.S.1    Antony, J.2    Nair, H.H.3    Puliyappadamba, V.T.4    Saikia, M.5    Narayanan, S.S.6    Bevin, A.7    Anto, R.J.8
  • 37
    • 84867024772 scopus 로고    scopus 로고
    • Curcumin potentiates the antitumor effects of 5-FU in treatment of esophageal squamous carcinoma cells through downregulating the activation of NF-?B signaling pathway in vitro and in vivo
    • Tian F, Fan T, Zhang Y, Jiang Y and Zhang X: Curcumin potentiates the antitumor effects of 5-FU in treatment of esophageal squamous carcinoma cells through downregulating the activation of NF-?B signaling pathway in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai) 44: 847-855, 2012.
    • (2012) Acta Biochim Biophys Sin (Shanghai) , vol.44 , pp. 847-855
    • Tian, F.1    Fan, T.2    Zhang, Y.3    Jiang, Y.4    Zhang, X.5
  • 38
    • 84868494287 scopus 로고    scopus 로고
    • Immunohistochemical study of nuclear factor-?B expression in esophageal squamous cell carcinoma: Prognostic significance and sensitivity to treatment with 5-FU
    • Hatata T, Higaki K, Tatebe S, Shomori K and Ikeguchi M: Immunohistochemical study of nuclear factor-?B expression in esophageal squamous cell carcinoma: prognostic significance and sensitivity to treatment with 5-FU. Dis Esophagus 25: 716-722, 2012.
    • (2012) Dis Esophagus , vol.25 , pp. 716-722
    • Hatata, T.1    Higaki, K.2    Tatebe, S.3    Shomori, K.4    Ikeguchi, M.5
  • 39
    • 0033580213 scopus 로고    scopus 로고
    • Cot protooncoprotein activates the dual specificity kinases MEK-1 and SEK-1 and induces differentiation of PC12 cells
    • Hagemann D, Troppmair J and Rapp UR: Cot protooncoprotein activates the dual specificity kinases MEK-1 and SEK-1 and induces differentiation of PC12 cells. Oncogene 18: 1391-400, 1999.
    • (1999) Oncogene , vol.18 , pp. 1391-1400
    • Hagemann, D.1    Troppmair, J.2    Rapp, U.R.3
  • 41
    • 0025778893 scopus 로고
    • Structure and transforming potential of the human cot oncogene encoding a putative protein kinase
    • Miyoshi J, Higashi T, Mukai H, Ohuchi T and Kakunaga T: Structure and transforming potential of the human cot oncogene encoding a putative protein kinase. Mol Cell Biol 11: 4088-4096, 1991.
    • (1991) Mol Cell Biol , vol.11 , pp. 4088-4096
    • Miyoshi, J.1    Higashi, T.2    Mukai, H.3    Ohuchi, T.4    Kakunaga, T.5
  • 44
    • 0033517331 scopus 로고    scopus 로고
    • Overexpression of the Tpl-2/Cot oncogene in human breast cancer
    • Sourvinos G, Tsatsanis C and Spandidos DA: Overexpression of the Tpl-2/Cot oncogene in human breast cancer. Oncogene 18: 4968-4973, 1999.
    • (1999) Oncogene , vol.18 , pp. 4968-4973
    • Sourvinos, G.1    Tsatsanis, C.2    Spandidos, D.A.3
  • 46
    • 0042525945 scopus 로고    scopus 로고
    • Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40
    • Eliopoulos AG, Wang C-C, Dumitru CD and Tsichlis PN: Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40. EMBO J 22: 3855-3864, 2003.
    • (2003) EMBO J , vol.22 , pp. 3855-3864
    • Eliopoulos, A.G.1    Wang, C.-C.2    Dumitru, C.D.3    Tsichlis, P.N.4
  • 48
  • 50
    • 0033611544 scopus 로고    scopus 로고
    • TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105
    • Belich MP, Salmerón a, Johnston LH and Ley SC: TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105. Nature 397: 363-368, 1999.
    • (1999) Nature , vol.397 , pp. 363-368
    • Belich, M.P.1    Salmerón, A.2    Johnston, L.H.3    Ley, S.C.4
  • 54
    • 78650907445 scopus 로고    scopus 로고
    • A single NFkappaB system for both canonical and non-canonical signaling
    • Shih VF, Tsui R, Caldwell A and Hoffmann A: A single NFkappaB system for both canonical and non-canonical signaling. Cell Res 21: 86-102, 2011.
    • (2011) Cell Res , vol.21 , pp. 86-102
    • Shih, V.F.1    Tsui, R.2    Caldwell, A.3    Hoffmann, A.4
  • 56
    • 78650887845 scopus 로고    scopus 로고
    • Regulation and function of TPL-2, an IkappaB kinase-regulated MAP kinase kinase kinase
    • Gantke T, Sriskantharajah S and Ley SC: Regulation and function of TPL-2, an IkappaB kinase-regulated MAP kinase kinase kinase. Cell Res 21: 131-145, 2011.
    • (2011) Cell Res , vol.21 , pp. 131-145
    • Gantke, T.1    Sriskantharajah, S.2    Ley, S.C.3
  • 59
    • 77955495968 scopus 로고    scopus 로고
    • LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells
    • Shin J-Y, Kim J-O, Lee SK, Chae H-S and Kang J-H: LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells. BMC Cancer 10: 425, 2010.
    • (2010) BMC Cancer , vol.10 , pp. 425
    • Shin, J.-Y.1    Kim, J.-O.2    Lee, S.K.3    Chae, H.-S.4    Kang, J.-H.5
  • 60
    • 0033961280 scopus 로고    scopus 로고
    • Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB
    • Madrid L V, Wang CY, Guttridge DC, Schottelius a J, Baldwin a S and Mayo MW: Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol Cell Biol 20: 1626-1638, 2000.
    • (2000) Mol Cell Biol , vol.20 , pp. 1626-1638
    • Madrid, L.V.1    Wang, C.Y.2    Guttridge, D.C.3    Schottelius, A.J.4    Baldwin, A.S.5    Mayo, M.W.6
  • 61
    • 84863092268 scopus 로고    scopus 로고
    • Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis
    • Hussain AR, Ahmed SO, Ahmed M, Khan OS, Al Abdulmohsen S, Platanias LC, Al-Kuraya KS and Uddin S: Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis. PLoS One 7: e39945, 2012.
    • (2012) PLoS One , vol.7 , pp. e39945
    • Hussain, A.R.1    Ahmed, S.O.2    Ahmed, M.3    Khan, O.S.4    Al Abdulmohsen, S.5    Platanias, L.C.6    Al-Kuraya, K.S.7    Uddin, S.8
  • 62
    • 0036316344 scopus 로고    scopus 로고
    • Akt-dependent phosphorylation specifically regulates cot induction of nf-kb-dependent
    • Kane LP, Mollenauer MN, Xu Z, Turck CW and Weiss A: Akt-Dependent Phosphorylation Specifically Regulates Cot Induction of NF-kB-Dependent Transcription 22: 5962-5974, 2002.
    • (2002) Transcription , vol.22 , pp. 5962-5974
    • Kane, L.P.1    Mollenauer, M.N.2    Xu, Z.3    Turck, C.W.4    Weiss, A.5
  • 65
    • 3042668006 scopus 로고    scopus 로고
    • In silico simulation of inhibitor drug effects on nuclear factor-kappaB pathway dynamics
    • Sung MH and Simon R: In silico simulation of inhibitor drug effects on nuclear factor-kappaB pathway dynamics. Mol Pharmacol 66: 70-75, 2004.
    • (2004) Mol Pharmacol , vol.66 , pp. 70-75
    • Sung, M.H.1    Simon, R.2
  • 67
    • 0030991201 scopus 로고    scopus 로고
    • The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMPindependent mechanism
    • Zhong H, SuYang H, Erdjument-Bromage H, Tempst P and Ghosh S: The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMPindependent mechanism. Cell 89: 413-424, 1997.
    • (1997) Cell , vol.89 , pp. 413-424
    • Zhong, H.1    SuYang, H.2    Erdjument-Bromage, H.3    Tempst, P.4    Ghosh, S.5
  • 68
    • 11844269840 scopus 로고    scopus 로고
    • Phosphorylation of NF-kappaB and IkappaB proteins: Implications in cancer and inflammation
    • Viatour P, Merville MP, Bours V and Chariot A: Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem Sci 30: 43-52, 2005.
    • (2005) Trends Biochem Sci , vol.30 , pp. 43-52
    • Viatour, P.1    Merville, M.P.2    Bours, V.3    Chariot, A.4
  • 69
    • 84862986139 scopus 로고    scopus 로고
    • NF-?B p65 phosphorylated at serine-536 is an independent prognostic factor in Swedish colorectal cancer patients
    • Lewander A, Gao J, Carstensen J, Arbman G, Zhang H and Sun X-F: NF-?B p65 phosphorylated at serine-536 is an independent prognostic factor in Swedish colorectal cancer patients. Int J Colorectal Dis 27: 447-452, 2012.
    • (2012) Int J Colorectal Dis , vol.27 , pp. 447-452
    • Lewander, A.1    Gao, J.2    Carstensen, J.3    Arbman, G.4    Zhang, H.5    Sun, X.-F.6
  • 70
    • 0037457481 scopus 로고    scopus 로고
    • Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines
    • Wang W, McLeod HL and Cassidy J: Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines. Int J Cancer 104: 504-511, 2003.
    • (2003) Int J Cancer , vol.104 , pp. 504-511
    • Wang, W.1    McLeod, H.L.2    Cassidy, J.3
  • 72
    • 39049183044 scopus 로고    scopus 로고
    • Regulation and function of IKK and IKK-related kinases
    • Häcker H and Karin M: Regulation and function of IKK and IKK-related kinases. Sci STKE 2006: re13, 2006.
    • (2006) Sci STKE , vol.2006 , pp. re13
    • Häcker, H.1    Karin, M.2
  • 73
    • 58149512851 scopus 로고    scopus 로고
    • Aktdependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis
    • Shant J, Cheng K, Marasa BS, Wang J-Y and Raufman J-P: Aktdependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis. Exp Cell Res 315: 432-450, 2009.
    • (2009) Exp Cell Res , vol.315 , pp. 432-450
    • Shant, J.1    Cheng, K.2    Marasa, B.S.3    Wang, J.-Y.4    Raufman, J.-P.5
  • 74
    • 77249117637 scopus 로고    scopus 로고
    • Disulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines
    • Guo X, Xu B, Pandey S, Goessl E, Brown J, Armesilla AL, Darling JL and Wang W: Disulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines. Cancer Lett 290: 104-113, 2010.
    • (2010) Cancer Lett , vol.290 , pp. 104-113
    • Guo, X.1    Xu, B.2    Pandey, S.3    Goessl, E.4    Brown, J.5    Armesilla, A.L.6    Darling, J.L.7    Wang, W.8
  • 75
    • 0030772376 scopus 로고    scopus 로고
    • Novel inhibitors of cytokine-induced ikappa balpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
    • Pierce JW: Novel Inhibitors of Cytokine-induced Ikappa Balpha Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo. J Biol Chem 272: 21096-21103, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 21096-21103
    • Pierce, J.W.1


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