Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization-independent activation of the nuclear factor-κB/IκB kinase signal pathway

Molecular Cancer Therapeutics

Volumn 6, Issue 10, 2007, Pages 2786-2797

  Seung, Ho Lee ^a   Seung, Mo Son ^a   Dong, Ju Son ^a   Sun, Mi Kim ^a   Tack, Joong Kim ^a   Song, Sukgil ^a   Dong, Cheul Moon ^a   Hyo, Won Lee ^b   Jae, Chun Ryu ^c   Yoon, Do Young ^d   Jin, Tae Hong ^a,b  

^a Chungbuk BIT Research Oriented University Consortium ^*  (South Korea)

^b Chungbuk National University   (South Korea)

^c Korea Institute of Science and Technology   (South Korea)

^d Konkuk University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TUBULIN; CASPASE 3; CASPASE 3 INHIBITOR; EPOTHILONE B; EPOTHILONE D; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUTANT PROTEIN; PACLITAXEL; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P50; PROTEIN P53; SALICYLATE SODIUM; SYNAPTOTAGMIN I;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL NUCLEUS; COLON CANCER; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MICROTUBULE ASSEMBLY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASE 3; CELL NUCLEUS; COLONIC NEOPLASMS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EPOTHILONES; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; I-KAPPA B KINASE; IN SITU NICK-END LABELING; LUCIFERASES; MICROTUBULES; NF-KAPPA B; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; SALICYLIC ACID; SIGNAL TRANSDUCTION; TUBULIN; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 35848969354     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-07-0002     Document Type: Article

References (40)

1. Jordan MA, Wilson L. Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr Opin Cell Biol 1998;10:123-30.
2. Watkins EB, Chittiboyina AG, Jung JC, Avery MA. The epothilones and related analogues - a review of their syntheses and anti-cancer activities. Curr Pharm Des 2005;11:1615-53.
3. Wu KD, Cho YS, Katz J, et al. Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo. Proc Natl Acad Sci U S A 2005;102:10640-5.
4. Goodin S, Kane MP, Rubin EH. Epothilones: mechanism of action and biologic activity. J Clin Oncol 2004;22:2015-25.
5. Earhart RH. Docetaxel (Taxotere): preclinical and general clinical information. Semin Oncol 1999;26:8-13.
6. Mann J. Natural products in cancer chemotherapy: past, present and future. Nat Rev Cancer 2002;2:143-8.
7. Wang LG, Liu XM, Kreis W, Budman DR. The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review. Cancer Chemother Pharmacol 1999;44:355-61.
8. Bhalla KN. Microtubule-targeted anticancer agents and apoptosis. Oncogene 2003;22:9075-86.
9. Bourgarel-Rey V, Vallee S, Rimet O, et al. Involvement of nuclear factor κB in c-Myc induction by tubulin polymerization inhibitors. Mol Pharmacol 2001;59:1165-70.
10. Bava SV, Puliappadamba VT, Deepti A, Nair A, Karunagaran D, Anto RJ. Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-κB and the serine/threonine kinase Akt and is independent of tubulin polymerization. J Biol Chem 2005;280:6301-8.
11. Viatour P, Merville MP, Bours V, Chariot A. Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation. Trends Biochem Sci 2005;30:43-52.
12. Baldwin AS. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-83.
13. Huang Y, Johnson KR, Norris JS, Fan W. Nuclear factor-κB/IκB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res 2000;60:4426-32.
14. Huang Y, Fang Y, Dziadyk JM, Norris JS, Fan W. The possible correlation between activation of NF-κB/IκB pathway and the susceptibility of tumor cells to paclitaxel-induced apoptosis. Oncol Res 2002;13:113-22.
15. Huang Y, Fan W. IκB kinase activation is involved in regulation of paclitaxel-induced apoptosis in human tumor cell lines. Mol Pharmacol 2002;61:105-13.
16. Fan W, Sui M, Huang Y. Glucocorticoids selectively inhibit paclitaxel-induced apoptosis: mechanisms and its clinical impact. Curr Med Chem 2004;11:403-11.
17. Kapahi P, Takahashi T, Natoli G, et al. Inhibition of NF-κ B activation by arsenite through reaction with a critical cysteine in the activation loop of IκB kinase. J Biol Chem 2000;275:36 062-6.
18. Huang Y, Fang Y, Wu J, et al. Regulation of Vinca alkaloid - induced apoptosis by NF-κB/IκB pathway in human tumor cells. Mol Cancer Ther 2004;3:271-7.
19. Lee HY, Hong YD, Lee-Choi IY. Synthesis toward epothilone A: coupling reaction between the sulfone of C1 - 10 and the allylic bromide of C11 - 21. Bull Korean Chem Soc 1999;20:403-4.
20. Lee SH, Lee CW, Lee JW, et al. Induction of apoptotic cell death by 2′-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-κB in TNF-α-treated SW620 colon cancer cells. Biochem Pharmacol 2005;70:1147-57.
21. Jeon KI, Byun MS, Jue DM Gold compound auranofin inhibits IκB kinase (IKK) by modifying Cys-179 of IKKβ subunit. Exp Mol Med 2003;35:61-6.
22. Bellarosa D, Binaschi M, Maggi CA, Goso C. Sabarubicin (MEN 10755) and paclitaxel show different kinetics in nuclear factor-κB (NF-κB) activation: effect of parthenolide on their cytotoxicity. Anticancer Res 2005;25:2119-28.
23. Chen GG, Liang NC, Lee JF, et al. Over-expression of Bcl-2 against Pteris semipinnata L. - induced apoptosis of human colon cancer cells via a NF-κB - related pathway. Apoptosis 2004;9:619-27.
24. Rouet-Benzineb P, Aparicio T, Guilmeau S, et al. Leptin counteracts sodiumbutyrate-ind uced apoptosis in human colon cancer HT-29 cells via NF-κB signaling. J Biol Chem2004;279:16 495-502.
25. Nakahara C, Nakamura K, Yamanaka N, et al. Cyclosporin-A enhances docetaxel-induced apoptosis through inhibition of nuclear factor-κB activation in human gastric carcinoma cells. Clin Cancer Res 2003;9:5409-16.
26. Farhana L, Dawson MI, Fontana JA. Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-κB activation. Cancer Res 2005;65:4909-17.
27. Hu MC, Hung MC. Role of IκB kinase in tumorigenesis. Future Oncol 2005;1:67-78.
28. Hehner SP, Hofmann TG, Droge W, Schmitz ML. The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-κB by targeting the IκB kinase complex. J Immunol 1999;163:5617-23.
29. Koch E, Klaas CA, Rungeler P, et al. Inhibition of inflammatory cytokine production and lymphocyte proliferation by structurally different sesquiterpene lactones correlates with their effect on activation of NF-κB. Biochem Pharmacol 2001;62:795-801.
30. Lee JH, Koo TH, Hwang BY, Lee JJ. Kaurane diterpene, kamebakaurin, inhibits NF-κB by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-κB target genes. J Biol Chem 2002;277:18 411-20.
31. Cernuda-Morollon E, Pineda-Molina E, Canada FJ, Perez-Sala D. 15-Deoxy-Δ12,14-prostaglandin J2 inhibition of NF-κB-DNA binding through covalent modification of the p50 subunit. J Biol Chem 2001;276:35530-6.
32. Liang MC, Bardhan S, Pace EA, et al. Inhibition of transcription factor NF-κB signaling proteins IKKβ and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity. Biochem Pharmacol 2006;71:634-45.
33. Liang MC, Bardhan S, Li C, Pace EA, Porco JA, Jr., Gilmore TD. Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor κB by inhibiting the inhibitor of κB kinase. Mol Pharmacol 2003;64:123-31.
34. Alfonso J, Garcia P, Victor C, Gerardo M, Thomas JS, Elisabeth S. Cysteine 38 in p65/NF-κB plays a crucial role in DNA binding inhibition by sesquiterpene lactones. J Biol Chem 2001;276:39713-20.
35. Ji C, Kozak KR, Marnett LJ. IκB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. J Biol Chem 2001;276:18 223-8.
36. Huang YT, Huang DM, Guh JH, Chen IL, Tzeng CC, Teng CM. CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line. J Biol Chem 2005;280:27 71-9.
37. Jackson SJ, Singletary KW. Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization. Carcinogenesis 2004;25:219-27.
38. Ling YH, Jiang JD, Holland JF, Perez-Soler R. Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines. Mol Pharmacol 2002;62:529-38.
39. Ho WC, Dickson KM, Barker PA. Nuclear factor-κB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-κB - dependent transcription in cancer cells. Cancer Res 2005;65:4273-81.
40. Beswick RW, Ambrose HE, Wagner SD. Nocodazole, a microtubule de-polymerising agent, induces apoptosis of chronic lymphocytic leukaemia cells associated with changes in Bcl-2 phosphorylation and expression. Leuk Res 2006;30:427-36.