Transcription and activity of 5-fluorouracil converting enzymes in fluoropyrimidine resistance in colon cancer in vitro

Biochemical Pharmacology

Volumn 54, Issue 11, 1997, Pages 1233-1242

  Mader, Robert M ^a,c   Sieder, Anna E ^a   Braun, Johanna ^a   Rizovski, Blanka ^a   Kalipciyan, Maria ^a   Mueller, Manfred W ^b   Jakesz, Raimund ^d   Rainer, Hugo ^a   Steger, Guenther G ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b Vienna Biocenter   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d NONE

Author keywords

Colon cancer; Enzyme activity; Enzyme transcription; Fluoropyrimidines; Metabolism; Resistance

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; FLOXURIDINE; FLOXURIDINE PHOSPHATE; FLUOROPYRIMIDINE; FLUOROURACIL; FLUOROURIDINE; OROTATE PHOSPHORIBOSYLTRANSFERASE; RIBONUCLEOTIDE REDUCTASE; THYMIDINE PHOSPHORYLASE; URIDINE PHOSPHORYLASE;

ARTICLE; CELL CULTURE; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG METABOLISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA SYNTHESIS; TUMOR CELL LINE;

ANTIMETABOLITES, ANTINEOPLASTIC; COLONIC NEOPLASMS; DNA; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; HUMANS; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN BIOSYNTHESIS; RNA; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0030709199     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00330-4     Document Type: Article

References (36)

1. Parker WB and Cheng YC, Metabolism and mechanism of action of 5-fluorouracil. Pharmac Ther 48: 381-395, 1990.
2. Peters GJ, Van Groeningen CJ, Van der Wilt CL, Meijer S, Smid K, Laurensse E and Pinedo HM, Time-course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin. Semin Oncol 19: 26-35, 1992.
3. Berger SH and Berger FG, Thymidylate synthase as a determinant of 5-fluoro-2′-deoxyuridine response in human colonic tumor cell lines. Mol Pharmacol 34: 474-479, 1988.
4. Van der Wilt CL, Pinedo HM, Smid K and Peters GJ, Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors. Cancer Res 52: 4922-4928, 1992.
5. Maehara Y, Moriguchi S, Emi Y, Watanabe A, Kohnoe S, Tsujitani S and Sugimachi K, Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas. Cancer 66: 156-161, 1990.
6. Radparvar S, Houghton PJ, Germain G, Pennington J, Rahman A and Houghton JA, Cellular pharmacology of 5-fluorouracil in a human colon adenocarcinoma cell line selected for thymidine kinase deficiency. Biochem Pharmacol 39: 1759-1765, 1990.
7. Finan PJ, Koklitis PA, Chisholm EM and Giles GR, Comparative levels of tissue enzymes concerned in the early metabolism of 5-fluorouracil in normal and malignant human colorectal tissue. Br J Cancer 50: 711-715, 1984.
8. Ahmed NK, Haggitt RC and Welch AD, Enzymes of salvage and de novo pathways of synthesis of pyrimidine nucleotides in human colorectal adenocarcinomas. Biochem Pharmacol 31: 2485-2488, 1982.
9. Wang FS, Aschele C, Sobrero A, Chang YM and Bertino JR, Decreased folylpolyglutamate synthetase expression: a novel mechanism of fluorouracil resistance. Cancer Res 53: 3677-3680, 1993.
10. Zhang ZG, Harstrick A and Rustum YM, Mechanisms of resistance to fluoropyrimidines. Semin Oncol 19: 4-9, 1992.
11. Aschele C, Sobrero A, Faderan MA and Bertino JR, Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HTC-8) sublines following exposure to two different clinically relevant dose schedules. Cancer Res 52: 1855-1864, 1992.
12. Inaba M, Mitsuhashi J, Sawada H, Miike N, Naoe Y, Daimon A, Koizumi K, Tsujimoto H and Fukushima M, Reduced activity of anabolizing enzymes in 5-fluorouracil resistant human stomach cancer cells. Jpn J Cancer Res 87: 212-220, 1996.
13. Schwartz EL, Baptiste N, Wadler S and Makower D, Thymidine phosphorylase mediates the sensitivity of human colon carcinoma cells to 5-fluorouracil. J Biol Chem 270: 19073-19077, 1995.
14. Klubes P, Cerna I, Connelly K, Geelhoed GW and Mandel HG, Effects of 5-fluorouracil on human colon carcinoma and solid rat Walker 256 carcinosarcoma evaluation as in vitro predictors of clinical response. Cancer Treat Rep 62: 1065-1073, 1978.
15. Ardalan B, Macdonald J, Cooney D, Lippman M and Schein P, Prediction of clinical response to 5-fluorouracil-containing chemotherapy: preliminary results of in vitro assay in human breast cancer. Recent Results Cancer Res 74: 84-90, 1980.
16. Ardalan B, Macdonald J, Cooney D, Lippman M and Schein P, The potential for clinical application of in vitro assays predicting 5-FU sensitivity in man. Cancer Treat Rep 65: 57-61, 1981.
17. Nord LD and Martin DS, Loss of murine tumor thymidine kinase activity in vivo following 5-fluorouracil (FUra) treatment by incorporation of FUra into RNA. Biochem Pharmacol 42: 2369-2375, 1991.
18. Washtien WL, Comparison of 5-fluorouracil metabolism in two human gastrointestinal tumor cell lines. Cancer Res 44: 909-914, 1994.
19. Spiegelman S, Sawyer R, Nayak R, Ritzi E, Stolfi R and Martin D, Improving the anti-tumor activity of 5-fluorouracil by increasing its incorporation into RNA via metabolic modulation. Proc Natl Acad Sci USA 77: 4966-4970, 1980.
20. Wilkinson DS and Crumley J, Metabolism of 5-fluorouracil in sensitive and resistant Novikoff hepatoma cells. J Biol Chem 252: 1051-1056, 1977.
21. Ghosal K and Jacob ST, Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-Fluorouracil. Cancer Res 54: 632-636, 1994.
22. Greenhalgh DA and Parish JH, Effect of 5-fluorouracil combination therapy of RNA processing in human colonic carcinoma cells. Br J Cancer 61: 415-419, 1990.
23. Peters GJ, Van der Wilt CL, Van Groeningen CJ, Smid K, Meijer S and Pinedo HM, Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil. J Clin Oncol 12: 2035-2042, 1994.
24. Johnston PG, Lenz HJ, Leichman CG, Danenberg KD, Allegra CJ, Danenberg PV and Leichman L, Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in colorectal and gastric tumors. Cancer Res 55: 1407-1412, 1995.
25. Bradford M, A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
26. Fleck A and Munro HN, The precision of ultraviolet absorption measurements in the Schmidt-Thannhauser procedure for nucleic acid estimation. Biochim Biophys Acta 55: 571-583, 1962.
27. Hillier L, Clark N, Dubuque T, Elliston K, Hawkins M, Holman N, Hultman M, Kucaba T, Le N, Lennon S, Marra M, Parsons J, Rifkin L, Rohlfing T, Soares M, Tan F, Trevaskis F, Waterston R, Williamson A, Wohldmann P and Wilson R, "The WashU-Merck EST Project"; GenBank Accession# R22017.
28. Finnis C, Goodey AR, Courtney N and Sleep D, Expression of recombinant platelet-derived growth factor in the yeast Saccharomyces cerevisiae; GenBank Accession# M63193.
29. Bradshaw HD Jr and Deininger PL, Human thymidine kinase gene: Molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells. Mol Cell Biol 4: 2316-2320, 1984.
30. Takeishi K, Kaneda S, Ayusawa D, Shimizu K, Gotoh O and Seno T, Nucleotide sequence of a functional cDNA for human thymidylate synthase. Nucl Acids Res 13: 2035-2043, 1985.
31. Suttle DP, Bugg BY, Winkler JK and Kanalas JJ, Molecular cloning and nucleotide sequence for the complete coding region of human UMP synthase. Proc Natl Acad Sci USA 85: 1754-1758, 1988.
32. Pavloff N, Rivard D, Masson S, Shen SH and Mes-Masson AM, Sequence analysis of the large and small subunits of human ribonucleotide reductase. DNA Seq 2: 227-234, 1992.
33. Ponte P, Ng SY, Engel J, Gunning P and Kedes L, Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human β-actin cDNA. Nucl Acids Res 12: 1687-1696, 1984.
34. Johnston PG, Fisher ER, Rockette HE, Fisher B, Wolmark N, Drake JC, Chabner BA and Allegra CJ, The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. J Clin Oncol 12: 2640-2647, 1994.
35. Kemeny N, Conti JA, Cohen A, Campana P, Huang Y, Shi WJ, Botet J, Pulliam S and Bertino JR, Phase II study of hepatic arterial floxuridine, leucovorin, and dexamethasone for unresectable liver metastases from colorectal carcinoma. J Clin Oncol 12: 2288-2295, 1994.
36. Schmittgen TD, Danenberg KD, Horikoshi T, Lenz HJ and Danenberg PV, Effect of 5-fluoro- and 5-bromouracil substitution on the translation of human thymidylate synthase mRNA. J Biol Chem 269: 16269-16275, 1994.