AIM2 inhibits autophagy and IFN-β production during M. bovis infection

Oncotarget

Volumn 7, Issue 30, 2016, Pages 46972-46987

  Liu, Chunfa ^a   Yue, Ruichao ^a   Yang, Yang ^b   Cui, Yongyong ^a   Yang, Lifeng ^a   Zhao, Deming ^a   Zhou, Xiangmei ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b ZHEJIANG A F UNIVERSITY   (China)

Author keywords

AIM2 inflammasome; Autophagy; Immune response; Immunity; Immunology and Microbiology Section; M. bovis; STING

Indexed keywords

ABSENT IN MELANOMA 2 PROTEIN; BETA INTERFERON; CELL PROTEIN; DNA; INFLAMMASOME; PROTEIN TBK1; REGULATOR PROTEIN; STIMULATOR OF INTERFERON GENE PROTEIN; UNCLASSIFIED DRUG; AIM2 PROTEIN, MOUSE; BACTERIAL DNA; DNA BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MEMBRANE PROTEIN; MPYS PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BOVINE TUBERCULOSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HOST PATHOGEN INTERACTION; INTRACELLULAR SIGNALING; MACROPHAGE; METABOLIC INHIBITION; MOUSE; MYCOBACTERIUM BOVIS; NONHUMAN; PROTEIN DNA BINDING; PROTEIN INDUCTION; PROTEIN SYNTHESIS INHIBITION; REAL TIME POLYMERASE CHAIN REACTION; SELECTIVE AUTOPHAGY; ANIMAL; AUTOPHAGY; BOVINE; C57BL MOUSE; CELL LINE; CYTOSOL; FEMALE; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; PRIMARY CELL CULTURE; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

ANIMALS; AUTOPHAGY; CASPASE 1; CATTLE; CELL LINE; CYTOSOL; DNA, BACTERIAL; DNA-BINDING PROTEINS; FEMALE; INFLAMMASOMES; INTERFERON-BETA; INTERLEUKIN-1BETA; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MYCOBACTERIUM BOVIS; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; TUBERCULOSIS, BOVINE;

EID: 84982834076     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.10503     Document Type: Article

References (46)

1. Waters WR, Palmer MV, Thacker TC, Davis WC, Sreevatsan S, Coussens P, Meade KG, Hope JC and Estes DM. Tuberculosis immunity: opportunities from studies with cattle. Clinical & developmental immunology. 2011; 2011:11.
2. Vergne I, Chua J, Singh SB and Deretic V. Cell biology of mycobacterium tuberculosis phagosome. Annual review of cell and developmental biology. 2004; 20:367-394.
3. Giorgio Ferrari HL, Makoto Naito, and Jean Pieters. A Coat Protein on Phagosomes Involved in the Intracellular Survival of Mycobacteria. Cell Press. 1999; 97:435-447.
4. Deretic V, Singh S, Master S, Harris J, Roberts E, Kyei G, Davis A, de Haro S, Naylor J, Lee HH and Vergne I. Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism. Cellular microbiology. 2006; 8:719-727.
5. Deretic V. Autophagy: an emerging immunological paradigm. Journal of immunology. 2012; 189:15-20.
6. Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI and Deretic V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell. 2004; 119:753-766.
7. Singh SB, Davis AS, Taylor GA and Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science. 2006; 313:1438-1441.
8. Kim JJ, Lee HM, Shin DM, Kim W, Yuk JM, Jin HS, Lee SH, Cha GH, Kim JM, Lee ZW, Shin SJ, Yoo H, Park YK, et al. Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action. Cell host & microbe. 2012; 11:457-468.
9. Biswas D, Qureshi OS, Lee WY, Croudace JE, Mura M and Lammas DA. ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages. BMC immunology. 2008; 9:35.
10. Yuk JM, Shin DM, Lee HM, Yang CS, Jin HS, Kim KK, Lee ZW, Lee SH, Kim JM and Jo EK. Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell host & microbe. 2009; 6:231-243.
11. Shin DM, Jeon BY, Lee HM, Jin HS, Yuk JM, Song CH, Lee SH, Lee ZW, Cho SN, Kim JM, Friedman RL and Jo EK. Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling. PLoS pathogens. 2010; 6:e1001230.
12. Castillo EF, Dekonenko A, Arko-Mensah J, Mandell MA, Dupont N, Jiang S, Delgado-Vargas M, Timmins GS, Bhattacharya D, Yang H, Hutt J, Lyons CR, Dobos KM and Deretic V. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109:E3168-3176.
13. Watson RO, Manzanillo PS and Cox JS. Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway. Cell. 2012; 150:803-815.
14. Fernandes-Alnemri T, Yu JW, Datta P, Wu J and Alnemri ES. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 2009; 458:509-513.
15. Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E and Fitzgerald KA. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature. 2009; 458:514-518.
16. Yang Y, Zhou X, Kouadir M, Shi F, Ding T, Liu C, Liu J, Wang M, Yang L, Yin X and Zhao D. the AIM2 inflammasome is involved in macrophage activation during infection with virulent Mycobacterium bovis strain. The Journal of infectious diseases. 2013; 208:1849-1858.
17. Saiga H, Kitada S, Shimada Y, Kamiyama N, Okuyama M, Makino M, Yamamoto M and Takeda K. Critical role of AIM2 in Mycobacterium tuberculosis infection. International immunology. 2012; 24:637-644.
18. Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L, Vanaja SK, Monks BG, Ganesan S, Latz E, Hornung V, Vogel SN, Szomolanyi-Tsuda E and Fitzgerald KA. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nature immunology. 2010; 11:395-402.
19. Man SM, Karki R, Malireddi RK, Neale G, Vogel P, Yamamoto M, Lamkanfi M and Kanneganti TD. The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection. Nature immunology. 2015; 16:467-475.
20. van der Wel N, Hava D, Houben D, Fluitsma D, van Zon M, Pierson J, Brenner M and Peters PJ. M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. Cell. 2007; 129:1287-1298.
21. Saiga H, Nieuwenhuizen N, Gengenbacher M, Koehler A, Schuerer S, Moura-Alves P, Wagner I, Mollenkopf H, Dorhoi A and Kaufmann SH. The Recombinant BCG DeltaureC::hly Vaccine Targets the AIM2 Inflammasome to Induce Autophagy and Inflammation. The Journal of infectious diseases. 2014; 211:1831-1841.
22. Shi CS, Shenderov K, Huang NN, Kabat J, Abu-Asab M, Fitzgerald KA, Sher A and Kehrl JH. Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction. Nature immunology. 2012; 13:255-263.
23. Manzanillo PS, Shiloh MU, Portnoy DA and Cox JS. Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages. Cell host & microbe. 2012; 11:469-480.
24. Ishikawa H and Barber GN. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature. 2008; 455:674-678.
25. Collins AC, Cai H, Li T, Franco LH, Li XD, Nair VR, Scharn CR, Stamm CE, Levine B, Chen ZJ and Shiloh MU. Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis. Cell host & microbe. 2015; 17:820-828.
26. Christian F, Anthony DF, Vadrevu S, Riddell T, Day JP, McLeod R, Adams DR, Baillie GS and Houslay MD. p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways. Cellular Signalling. 2010; 22:1576-1596.
27. Pilli M, Arko-Mensah J, Ponpuak M, Roberts E, Master S, Mandell MA, Dupont N, Ornatowski W, Jiang S, Bradfute SB, Bruun JA, Hansen TE, Johansen T and Deretic V. TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation. Immunity. 2012; 37:223-234.
28. Manzanillo Paolo S, Shiloh Michael U, Portnoy Daniel A and Cox Jeffery S. Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages. Cell host & microbe. 2012; 11:469-480.
29. Mayer-Barber Katrin D, Andrade Bruno B, Barber Daniel L, Hieny S, Feng Carl G, Caspar P, Oland S, Gordon S and Sher A. Innate and Adaptive Interferons Suppress IL-1 and IL-1 Production by Distinct Pulmonary Myeloid Subsets during Mycobacterium tuberculosis Infection. Immunity. 2011; 35:1023-1034.
30. Teles RMB, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Iyer SS, Sarno EN, Rea TH, Hewison M, et al. Type I Interferon Suppresses Type II Interferon-Triggered Human Anti-Mycobacterial Responses. Science. 2013; 339:1448-1453.
31. Schmeisser H, Bekisz J and Zoon KC. New Function of Type I IFN: Induction of Autophagy. Journal of Interferon & Cytokine Research. 2014; 34:71-78.
32. Simeone R, Sayes F, Song O, Groschel MI, Brodin P, Brosch R and Majlessi L. Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo. PLoS pathogens. 2015; 11:e1004650.
33. Watson RO, Bell SL, MacDuff DA, Kimmey JM, Diner EJ, Olivas J, Vance RE, Stallings CL, Virgin HW and Cox JS. The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy. Cell host & microbe. 2015; 17:811-819.
34. Wassermann R, Gulen MF, Sala C, Perin SG, Lou Y, Rybniker J, Schmid-Burgk JL, Schmidt T, Hornung V, Cole ST and Ablasser A. Mycobacterium tuberculosis Differentially Activates cGAS-and Inflammasome-Dependent Intracellular Immune Responses through ESX-1. Cell host & microbe. 2015; 17:799-810.
35. Collins Angela C, Cai H, Li T, Franco Luis H, Li X-D, Nair Vidhya R, Scharn Caitlyn R, Stamm Chelsea E, Levine B, Chen Zhijian J and Shiloh Michael U. Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis. Cell host & microbe. 2015; 17:820-828.
36. Romagnoli A, Etna MP, Giacomini E, Pardini M, Remoli ME, Corazzari M, Falasca L, Goletti D, Gafa V, Simeone R, Delogu G, Piacentini M, Brosch R, Fimia GM and Coccia EM. ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells. Autophagy. 2012; 8:1357-1370.
37. Petruccioli E, Romagnoli A, Corazzari M, Coccia EM, Butera O, Delogu G, Piacentini M, Girardi E, Fimia GM and Goletti D. Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages. The Journal of infectious diseases. 2012; 205:1425-1435.
38. Seto S, Tsujimura K, Horii T and Koide Y. Autophagy adaptor protein p62/SQSTM1 and autophagy-related gene Atg5 mediate autophagosome formation in response to Mycobacterium tuberculosis infection in dendritic cells. PloS one. 2013; 8:e86017.
39. Zhou Y, DZ, RY, SHK, SZAS, XY, LY, ZZ and XZ. Inflammasomes-dependent regulation of IL-1beta secretion induced by the virulent Mycobacterium bovis Beijing strain in THP-1 macrophages. Antonie van Leeuwenhoek. 2015; 108:163-171.
40. Kelly M. Storek NAG, Maikke B. Ohlson and Denise M. Monack and cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection. The Journal of Immunology. 2015; 194:3236-3245.
41. Kathrine Hansen TP, Anders Laustsen, Sofie E Jørgensen, Stine H Rahbæk, Søren B Jensen, Rikke Nielsen, Jess H Leber, Thomas Decker, Kristy A Horan, Martin R Jakobsen, Søren R Paludan. Listeria monocytogenes induces IFNbeta expression through an IFI16-, cGAS-and STING-dependent pathway. The EMBO journal. 2014; 33:1654-1666.
42. Dey B and Bishai WR. Crosstalk between Mycobacterium tuberculosis and the host cell. Seminars in Immunology. 2014; 26:486-496.
43. Manca C, Tsenova, L., Bergtold, A., Freeman, S., Tovey, M., Musser, J. M., Kaplan, G. . Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-alpha/beta. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98:5752-5757
44. Bouchonnet F. Alpha/Beta Interferon Impairs the Ability of Human Macrophages To Control Growth of Mycobacterium bovis BCG. Infection and Immunity. 2002; 70:3020-3025.
45. Manca C, Tsenova L, Bergtold A, Freeman S, Tovey M, Musser JM, Barry CE, 3rd, Freedman VH and Kaplan G. Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-alpha/beta. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98:5752-5757.
46. Dorhoi A, Yeremeev, V., Nouailles, G., Weiner, J., Jörg, S., Heinemann, E., Kaufmann, S. H. E. . Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics. European journal of immunology. 2014; 44:2380-2393.