Tuberculosis immunity: Opportunities from studies with cattle

Clinical and Developmental Immunology

Volumn 2011, Issue , 2011, Pages

  Waters, W Ray ^a   Palmer, Mitchell V ^a   Thacker, Tyler C ^a   Davis, William C ^b   Sreevatsan, Srinand ^c   Coussens, Paul ^d   Meade, Kieran G ^e   Hope, Jayne C ^f   Estes, D Mark ^g  

^a NATIONAL ANIMAL DISEASE CENTER   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d MICHIGAN STATE UNIVERSITY   (United States)

^e TEAGASC   (Ireland)

^f INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^g University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIGEN; BIOLOGICAL MARKER; CELL PROTEIN; SIGNAL REGULATORY PROTEIN ALPHA; UNCLASSIFIED DRUG; VACCINE; BACTERIAL ANTIGEN; BCG VACCINE; IMMUNOGLOBULIN RECEPTOR;

ANTIBODY RESPONSE; BCG VACCINATION; BOVINE TUBERCULOSIS; CATTLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CORRELATION ANALYSIS; CYTOTOXIC LYMPHOCYTE; DENDRITIC CELL; GAMMADELTA T CELL; GENE EXPRESSION; GIANT CELL; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; INNATE IMMUNITY; MACROPHAGE; MEMORY T LYMPHOCYTE; MICROBIAL ACTIVITY; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIMATE; PRIORITY JOURNAL; REVIEW; SKIN TEST; T LYMPHOCYTE; TUBERCULOSIS; ANIMAL; DRUG POTENTIATION; GENE EXPRESSION PROFILING; GENETICS; IMMUNITY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MACACA FASCICULARIS; MALE; METHODOLOGY; MOUSE; NEWBORN; VACCINATION;

ANIMALS; ANIMALS, NEWBORN; ANTIGENS, BACTERIAL; BIOLOGICAL MARKERS; CATTLE; GENE EXPRESSION PROFILING; HUMANS; IMMUNITY; IMMUNOLOGIC MEMORY; MACACA FASCICULARIS; MALE; MICE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTES; TUBERCULOSIS; TUBERCULOSIS VACCINES; TUBERCULOSIS, BOVINE; VACCINATION;

EID: 79251590223     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2011/768542     Document Type: Review

References (121)

1. Calmette A., Guerin C., Recherches exprimentales sur la defense de lorganisme contre linfection tuberculose Annals Institut Pasteuer 1911 25 625 641
2. Marshall C. J., Progress in controlling bovine tuberculosis Journal of the American Veterinary Association 1932 80 625 633
3. Wood P. R., Corner L. A., Plackett P., Development of a simple, rapid in vitro cellular assay for bovine tuberculosis based on the production of gamma interferon Research in veterinary science 1990 49 1 46 49
4. von Behring E., Serum therapy in therapeutics and medical science Nobel Lectures Physiology or Medicine 19011921 1901 River Edge, NJ, USA World Scientific
5. Brockington C. F., The evidence for compulsory pasteurization of milk British Medical Journal 1937 1 667 668
6. Francis J., The work of the British Royal Commission on tuberculosis, 19011911 Tubercle 1959 40 2 124 132
7. Ravenel M. P., Tuberculosis of bovine origin American Journal of Public Health and the Nation's Health 1933 23 316 318
8. Wirth T., Hildebrand F., Allix-Bguec C., Wlbeling F., Kubica T., Kremer K., Van Soolingen D., Rsch-Gerdes S., Locht C., Brisse S., Meyer A., Supply P., Niemann S., Origin, spread and demography of the Mycobacterium tuberculosis complex PLoS Pathogens 2008 4 9
9. Whelan A. O., Coad M., Cockle P. J., Hewinson G., Vordermeier M., Gordon S. V., Revisiting host preference in the Mycobacterium tuberculosis complex: experimental infection shows M. tuberculosis H37Rv to be avirulent in cattle PLoS One 2010 5 1, article e8527
10. Ernst H. C., Infectiousness of Milk: Result of Investigations Made for the Trustees of the Massachusetts Society for Promoting Agriculture 1895 Cambridge, UK The Riverside Press
11. Waters W. R., Whelan A. O., Lyashchenko K. P., Greenwald R., Palmer M. V., Harris B. N., Hewinson R. G., Vordermeier H. M., Immune responses in cattle inoculated with Mycobacterium bovis, Mycobacterium tuberculosis, or Mycobacterium kansasii Clinical and Vaccine Immunology 2010 17 2 247 252
12. Palmer M. V., Waters W. R., Whipple D. L., Aerosol delivery of virulent Mycobacterium bovis to cattle Tuberculosis 2002 82 6 275 282
13. Sambandamurthy V. K., Wang X., Chen B., Russell R. G., Derrick S., Collins F. M., Morris S. L., Jacobs W. R. Jr. , A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis Nature Medicine 2002 8 10 1171 1174
14. Derrick S. C., Evering T. H., Sambandamurthy V. K., Jalapathy K. V., Hsu T., Chen B., Chen M., Russell R. G., Junqueira-Kipnis A. P., Orme I. M., Porcelli S. A., Jacobs W. R. Jr. , Morris S. L., Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine Immunology 2007 120 2 192 206
15. Waters W. R., Palmer M. V., Nonnecke B. J., Thacker T. C., Scherer C. F. C., Estes D. M., Jacobs W. R. Jr. , Glatman-Freedman A., Larsen M. H., Failure of a Mycobacterium tuberculosis RD1 pan CD double deletion mutant in a neonatal calf aerosol M. bovis challenge model: comparisons to responses elicited by M. bovis bacille Calmette Guerin Vaccine 2007 25 45 7832 7840
16. Larsen M. H., Biermann K., Chen B., Hsu T., Sambandamurthy V. K., Lackner A. A., Aye P. P., Didier P., Huang D., Shao L., Wei H., Letvin N. L., Frothingham R., Haynes B. F., Chen Z. W., Jacobs W. R. Jr. , Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates Vaccine 2009 27 34 4709 4717
17. Swaim L. E., Connolly L. E., Volkman H. E., Humbert O., Born D. E., Ramakrishnan L., Mycobacterium marinum infection of adult zebrafish causes caseating granulomatous tuberculosis and is moderated by adaptive immunity Infection and Immunity 2006 74 11 6108 6117
18. Swaim L. E., Connolly L. E., Volkman H. E., Humbert O., Born D. E., Ramakrishnan L., Erratum: mycobacterium marinum infection of adult zebrafish causes caseating granulomatous tuberculosis and is moderated by adaptive immunity (Infection and Immunity (2006) 74, 11 (61086117)) Infection and Immunity 2007 75 3 1540
19. de Jonge M. I., Pehau-Arnaudet G., Fretz M. M., Romain F., Bottai D., Brodin P., Honor N., Marchal G., Jiskoot W., England P., Cole S. T., Brosch R., ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity Journal of Bacteriology 2007 189 16 6028 6034
20. Hsu T., Hingley-Wilson S. M., Chen B., Chen M., Dai A. Z., Morin P. M., Marks C. B., Padiyar J., Goulding C., Gingery M., Eisenberg D., Russell R. G., Derrick S. C., Collins F. M., Morris S. L., King C. H., Jacobs W. R. Jr. , The primary mechanism of attenuation of bacillus Calmette-Gurin is a loss of secreted lytic function required for invasion of lung interstitial tissue Proceedings of the National Academy of Sciences of the United States of America 2003 100 21 12420 12425
21. Volkman H. E., Clay H., Beery D., Chang J. C. W., Sherman D. R., Ramakrishnan L., Tuberculous granuloma formation is enhanced by a Mycobacterium virulence determinant PLoS Biology 2004 2 11, article e367
22. Davis J. M., Ramakrishnan L., The role of the granuloma in expansion and dissemination of early tuberculous infection Cell 2009 136 1 37 49
23. Renshaw P. S., Lightbody K. L., Veverka V., Muskett F. W., Kelly G., Frenkiel T. A., Gordon S. V., Hewinson R. G., Burke B., Norman J., Williamson R. A., Carr M. D., Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6 EMBO Journal 2005 24 14 2491 2498
24. Ganguly N., Siddiqui I., Sharma P., Role of M. tuberculosis RD-1 region encoded secretory proteins in protective response and virulence Tuberculosis 2008 88 6 510 517
25. Pathak S. K., Basu S., Basu K. K., Banerjee A., Pathak S., Bhattacharyya A., Kaisho T., Kundu M., Basu J., Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages Nature Immunology 2007 8 6 610 618
26. Waters W. R., Palmer M. V., Nonnecke B. J., Thacker T. C., Estes D. M., Larsen M. H., Jacobs Jr. W. R., Andersen P., McNair J., Minion F. C., Lyaschenko K. P., Hewinson R. G., Vordermeier H. M., Sacco R. E., Signal regulatory protein (SIRP ) + cells in the adaptive response to ESAT-6/CFP-10 protein of tuberculous mycobacteria PLoS One 2009 4 7 article e6414
27. Hagnerud S., Manna P. P., Cella M., Stenberg., Frazier W. A., Colonna M., Oldenborg P.-A., Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration Journal of Immunology 2006 176 10 5772 5778
28. Van V. Q., Lesage S., Bouguermouh S., Gautier P., Rubio M., Levesque M., Nguyen S., Galibert L., Sarfati M., Expression of the self-marker CD47 on dendritic cells governs their trafficking to secondary lymphoid organs EMBO Journal 2006 25 23 5560 5568
29. Goddeeris B. M., Pastoret P. P., Griebel P., Bazin H., Govaerts A., Immunology of cattle Handbook of Vertebrate Immunology 1998 San Diego, Calif, USA Academic Press 439 484
30. Ottenhoff T. H. M., Verreck F. A. W., Hoeve M. A., Van De Vosse E., Control of human host immunity to mycobacteria Tuberculosis 2005 85 1-2 53 64
31. Pollock J. M., Neill S. D., Mycobacterium bovis infection and tuberculosis in cattle Veterinary Journal 2002 163 2 115 127
32. Pollock J. M., McNair J., Welsh M. D., Girvin R. M., Kennedy H. E., Mackie D. P., Neill S. D., Immune responses in bovine tuberculosis Tuberculosis 2001 81 1-2 103 107
33. Endsley J. J., Endsley M. A., Estes D. M., Bovine natural killer cells acquire cytotoxic/effector activity following activation with IL-12/15 and reduce Mycobacterium bovis BCG in infected macrophages Journal of Leukocyte Biology 2006 79 1 71 79
34. Endsley J. J., Furrer J. L., Endsley M. A., McIntosh M. A., Maue A. C., Waters W. R., Lee D. R., Estes D. M., Characterization of bovine homologues of granulysin and NK-lysin Journal of Immunology 2004 173 4 2607 2614
35. Endsley J. J., Hogg A., Shell L. J., McAulay M., Coffey T., Howard C., Capinos Scherer C. F., Waters W. R., Nonnecke B., Estes D. M., Villarreal-Ramos B., Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity Vaccine 2007 25 50 8384 8394
36. Cassidy J. P., Bryson D. G., Gutirrez Cancela M. M., Forster F., Pollock J. M., Neill S. D., Lymphocyte subtypes in experimentally induced early-stage bovine tuberculous lesions Journal of Comparative Pathology 2001 124 1 46 51
37. Smith R. A., Kreeger J. M., Alvarez A. J., Goin J. C., Davis W. C., Whipple D. L., Estes D. M., Role of CD8+ and WC-1+ / T cells in resistance to Mycobacterium bovis infection in the SCID-bo mouse Journal of Leukocyte Biology 1999 65 1 28 34
38. Villarreal-Ramos B., McAulay M., Chance V., Martin M., Morgan J., Howard C. J., Investigation of the role of CD8+ T cells in bovine tuberculosis in vivo Infection and Immunity 2003 71 8 4297 4303
39. Waters W. R., Nonnecke B. J., Foote M. R., Maue A. C., Rahner I. E., Palmer M. V., Whipple D. L., Horst R. L., Estes D. M., Mycobacterium bovis bacille Calmette-Guerin vaccination of cattle: activation of bovine CD4+ and TCR+ cells and modulation by 1,25-dihydroxyvitamin D3 Tuberculosis 2003 83 5 287 297
40. Waters W. R., Palmer M. V., Whipple D. L., Carlson M. P., Nonnecke B. J., Diagnostic implications of antigen-induced gamma interferon, nitric oxide, and tumor necrosis factor alpha production by peripheral blood mononuclear cells from Mycobacterium bovis-infected cattle Clinical and Diagnostic Laboratory Immunology 2003 10 5 960 966
41. Libana E., Aranaz A., Welsh M., Neill S. D., Pollock J. M., In vitro T-cell activation of monocyte-derived macrophages by soluble messengers or cell-to-cell contact in bovine tuberculosis Immunology 2000 100 2 194 202
42. Skinner M. A., Parlane N., Mccarthy A., Buddle B. M., Cytotoxic T-cell responses to Mycobacterium bovis during experimental infection of cattle with bovine tuberculosis Immunology 2003 110 2 234 241
43. Buddle B. M., Ryan T. J., Pollock J. M., Andersen P., De Lisle G. W., Use of ESAT-6 in the interferon- test for diagnosis of bovine tuberculosis following skin testing Veterinary Microbiology 2001 80 1 37 46
44. Vordermeier H. M., Chambers M. A., Cockle P. J., Whelan A. O., Simmons J., Hewinson R. G., Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis Infection and Immunity 2002 70 6 3026 3032
45. Buddle B. M., Skinner M. A., Wedlock D. N., De Lisle G. W., Vordermeier H. M., Hewinson R. G., Cattle as a model for development of vaccines against human tuberculosis Tuberculosis 2005 85 1-2 19 24
46. Flynn J. L., Immunology of tuberculosis and implications in vaccine development Tuberculosis 2004 84 1-2 93 101
47. Pollock J. M., Welsh M. D., McNair J., Immune responses in bovine tuberculosis: towards new strategies for the diagnosis and control of disease Veterinary Immunology and Immunopathology 2005 108 1-2 37 43
48. Buddle B. M., Pollock J. M., Skinner M. A., Wedlock D. N., Development of vaccines to control bovine tuberculosis in cattle and relationship to vaccine development for other intracellular pathogens International Journal for Parasitology 2003 33 5-6 555 566
49. Leonard W. J., Spolski R., Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation Nature Reviews Immunology 2005 5 9 688 698
50. Price S., Davies M., Villarreal-Ramos B., Hope J., Differential distribution of WC1 + TCR + T lymphocyte subsets within lymphoid tissues of the head and respiratory tract and effects of intranasal M. bovis BCG vaccination Veterinary Immunology and Immunopathology 2010 136 1-2 133 137
51. Ahn J. S., Konno A., Gebe J. A., Aruffo A., Hamilton M. J., Park Y. H., Davis W. C., Scavenger receptor cysteine-rich domains 9 and 11 of WC1 are receptors for the WC1 counter receptor Journal of Leukocyte Biology 2002 72 2 382 390
52. Jutila M. A., Holderness J., Graff J. C., Hedges J. F., Antigen-independent priming: a transitional response of bovine gammadelta T-cells to infection Animal Health Research Reviews 2008 9 1 47 57
53. Wilson E., Aydintug M. K., Jutila M. A., A circulating bovine T cell subset, which is found in large numbers in the spleen, accumulates inefficiently in an artificial site of inflammation: correlation with lack of expression of E-selectin ligands and L-selectin Journal of Immunology 1999 162 8 4914 4919
54. Wilson E., Walcheck B., Davis W. C., Jutila M. A., Preferential tissue localization of bovine T cell subsets defined by anti-T cell receptor for antigen antibodies Immunology Letters 1998 64 1 39 44
55. Blumerman S. L., Herzig C. T.A., Rogers A. N., Telfer J. C., Baldwin C. L., Differential TCR gene usage between WC1 - and WC1 + ruminant T cell subpopulations including those responding to bacterial antigen Immunogenetics 2006 58 8 680 692
56. Carr M. M., Howard C. J., Sopp P., Manser J. M., Parsons K. R., Expression on porcine lymphocytes of a phylogenetically conserved surface antigen previously restricted in expression to ruminant T lymphocytes Immunology 1994 81 1 36 40
57. Davis W. C., Heirman L. R., Hamilton M. J., Parish S. M., Barrington G. M., Loftis A., Rogers M., Flow cytometric analysis of an immunodeficiency disorder affecting juvenile llamas Veterinary Immunology and Immunopathology 2000 74 1-2 103 120
58. Morrison W. I., Davis W. C., Differentiation antigens expressed predominantly on CD4- CD8- T lymphocytes (WC1, WC2) Veterinary Immunology and Immunopathology 1991 27 13 71 76
59. Davis W. C., Hamilton M. J., Use of flow cytometry to characterize immunodeficiency syndromes in camelids Small Ruminant Research 2006 61 2-3 187 193
60. Davis W. C., Brown W. C., Hamilton M. J., Wyatt C. R., Orden J. A., Khalid A. M., Naessens J., Analysis of monoclonal antibodies specific for the TcR Veterinary Immunology and Immunopathology 1996 52 4 275 283
61. MacHugh N. D., Wijngaard P. L. J., Clevers H. C., Davis W. C., Clustering of monoclonal antibodies recognizing different members of the WC1 gene family Veterinary Immunology and Immunopathology 1993 39 13 155 160
62. Rogers A. N., Vanburen D. G., Hedblom E., Tilahun M. E., Telfer J. C., Baldwin C. L., Function of ruminant T cells is defined by WC1.1 or WC1.2 isoform expression Veterinary Immunology and Immunopathology 2005 108 1-2 211 217
63. Price S. J., Sopp P., Howard C. J., Hope J. C., Workshop cluster 1+ T-cell receptor+ T cells from calves express high levels of interferon- in response to stimulation with interleukin-12 and -18 Immunology 2006 120 1 57 65
64. Waters W. R., Palmer M. V., Pesch B. A., Olsen S. C., Wannemuehler M. J., Whipple D. L., Lymphocyte subset proliferative responses of Mycobacterium bovis-infected cattle to purified protein derivative Veterinary Immunology and Immunopathology 2000 77 3-4 257 273
65. Welsh M. D., Kennedy H. E., Smyth A. J., Girvin R. M., Andersen P., Pollock J. M., Responses of bovine WC1 + T cells to protein and nonprotein antigens of Mycobacterium bovis Infection and Immunity 2002 70 11 6114 6120
66. Pollock J. M., Pollock D. A., Campbell D. G., Girvin R. M., Crockard A. D., Neill S. D., Mackie D. P., Dynamic changes in circulating and antigen-responsive T-cell subpopulations post-Mycobacterium bovis infection in cattle Immunology 1996 87 2 236 241
67. Buza J., Kiros T., Zerihun A., Abraham I., Ameni G., Vaccination of calves with Mycobacteria bovis Bacilli Calmete Guerin (BCG) induced rapid increase in the proportion of peripheral blood T cells Veterinary Immunology and Immunopathology 2009 130 3-4 251 255
68. McNair J., Welsh M. D., Pollock J. M., The immunology of bovine tuberculosis and progression toward improved disease control strategies Vaccine 2007 25 30 5504 5511
69. Cassidy J. P., Bryson D. G., Pollock J. M., Evans R. T., Forster F., Neill S. D., Early lesion formation in cattle experimentally infected with Mycobacterium bovis Journal of Comparative Pathology 1998 119 1 27 44
70. Kennedy H. E., Welsh M. D., Bryson D. G., Cassidy J. P., Forster F. I., Howard C. J., Collins R. A., Pollock J. M., Modulation of immune responses to Mycobacterium bovis in cattle depleted of WC1 + T cells Infection and Immunity 2002 70 3 1488 1500
71. D'Souza C. D., Cooper A. M., Frank A. A., Mazzaccaro R. J., Bloom B. R., Orme I. M., An anti-inflammatory role for T lymphocytes in acquired immunity to Mycobacterium tuberculosis Journal of Immunology 1997 158 3 1217 1221
72. Pollock J. M., Welsh M. D., The WC1 + T-cell population in cattle: a possible role in resistance to intracellular infection Veterinary Immunology and Immunopathology 2002 89 3-4 105 114
73. Smyth A. J., Welsh M. D., Girvin R. M., Pollock J. M., In vitro responsiveness of T cells from Mycobacterium bovis-infected cattle to mycobacterial antigens: predominant involvement of WC1 + cells Infection and Immunity 2001 69 1 89 96
74. Alvarez A. J., Endsley J. J., Werling D., Mark Estes D., WC1+ ; T cells indirectly regulate chemokine production during mycobacterium bovis Infection in SCID-bo mice Transboundary and Emerging Diseases 2009 56 6-7 275 284
75. Kaufmann S. H. E., Ladel C. H., Role of T cell subsets in immunity against intracellular bacteria: experimental infections of knock-out mice with Listeria monocytogenes and Mycobacterium bovis BCG Immunobiology 1994 191 4-5 509 519
76. Saunders B. M., Frank A. A., Cooper A. M., Orme I. M., Role of T cells in immunopathology of pulmonary Mycobacterium avium infection in mice Infection and Immunity 1998 66 11 5508 5514
77. Hoek A., Rutten V. P. M. G., Kool J., Arkesteijn G. J. A., Bouwstra R. J., Rhijn I. V., Koets A. P., Subpopulations of bovine WC1 + T cells rather than CD4 + CD25 high Foxp3 + T cells act as immune regulatory cells ex vivo Veterinary Research 2009 40 1
78. Cho S., Mehra V., Thoma-Uszynski S., Stenger S., Serbina N., Mazzaccaro R. J., Flynn J. L., Barnes P. F., Southwood S., Celis E., Bloom B. R., Modlin R. L., Sette A., Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis Proceedings of the National Academy of Sciences of the United States of America 2000 97 22 12210 12215
79. Dieli F., Troye-Blomberg M., Ivanyi J., Fourni J. J., Krensky A. M., Bonneville M., Peyrat M. A., Caccamo N., Sireci G., Salerno A., Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by V- 9/V 2 T lymphocytes Journal of Infectious Diseases 2001 184 8 1082 1085
80. Stenger S., Hanson D. A., Teitelbaum R., Dewan P., Niazi K. R., Froelich C. J., Ganz T., Thoma-Uszynski S., Melin A., Bogdan C., Porcelli S. A., Bloom B. R., Krensky A. M., Modlin R. L., An antimicrobial activity of cytolytic T cells mediated by granulysin Science 1998 282 5386 121 125
81. Stenger S., Mazzaccaro R. J., Uyemura K., Cho S., Barnes P. F., Rosat J.-P., Sette A., Brenner M. B., Porcelli S. A., Bloom B. R., Modlin R. L., Differential effects of cytolytic T cell subsets on intracellular infection Science 1997 276 5319 1684 1687
82. Capinos Scherer C. F., Endsley J. J., De Aguiar J. B., Jacobs W. R. Jr. , Larsen M. H., Palmer M. V., Nonnecke B. J., Ray Waters W., Mark Estes D., Evaluation of granulysin and perforin as candidate biomarkers for protection following vaccination with mycobacterium bovis BCG or M. bovis RD1 Transboundary and Emerging Diseases 2009 56 6-7 228 239
83. Kulberg S., Boysen P., Storset A. K., Reference values for relative numbers of natural killer cells in cattle blood Developmental and Comparative Immunology 2004 28 9 941 948
84. Storset A. K., Kulberg S., Berg I., Boysen P., Hope J. C., Dissen E., NKp46 defines a subset of bovine leukocytes with natural killer cell characteristics European Journal of Immunology 2004 34 3 669 676
85. Graham E. M., Thom M. L., Howard C. J., Boysen P., Storset A. K., Sopp P., Hope J. C., Natural killer cell number and phenotype in bovine peripheral blood is influenced by age Veterinary Immunology and Immunopathology 2009 132 24 101 108
86. Boysen P., Storset A. K., Bovine natural killer cells Veterinary Immunology and Immunopathology 2009 130 3-4 163 177
87. Denis M., Keen D. L., Parlane N. A., Storset A. K., Buddle B. M., Bovine natural killer cells restrict the replication of Mycobacterium bovis in bovine macrophages and enhance IL-12 release by infected macrophages Tuberculosis 2007 87 1 53 62
88. Hope J. C., Sopp P., Howard C. J., NK-like CD8+ cells in immunologically nave neonatal calves that respond to dendritic cells infected with Mycobacterium bovis BCG Journal of Leukocyte Biology 2002 71 2 184 194
89. Olsen I., Boysen P., Kulberg S., Hope J. C., Jungersen G., Storset A. K., Bovine NK cells can produce gamma interferon in response to the secreted mycobacterial proteins ESAT-6 and MPP14 but not in response to MPB70 Infection and Immunity 2005 73 9 5628 5635
90. Van Rhijn I., Koets A. P., Im J. S., Piebes D., Reddington F., Besra G. S., Porcelli S. A., Van Eden W., Rutten V. P. M. G., The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d Journal of Immunology 2006 176 8 4888 4893
91. Ly L. H., McMurray D. N., Tuberculosis: vaccines in the pipeline Expert Review of Vaccines 2008 7 5 635 650
92. Whelan A. O., Wright D. C., Chambers M. A., Singh M., Hewinson R. G., Vordermeier H. M., Evidence for enhanced central memory priming by live Mycobacterium bovis BCG vaccine in comparison with killed BCG formulations Vaccine 2008 26 2 166 173
93. Waters W. R., Palmer M. V., Nonnecke B. J., Thacker T. C., Scherer C. F. C., Estes D. M., Hewinson R. G., Vordermeier H. M., Barnes S. W., Federe G. C., Walker J. R., Glynne R. J., Hsu T., Weinrick B., Biermann K., Larsen M. H., Jacobs W. R. Jr. , Efficacy and immunogenicity of Mycobacterium bovis RD1 against aerosol M. bovis infection in neonatal calves Vaccine 2009 27 8 1201 1209
94. Vordermeier H. M., Villarreal-Ramos B., Cockle P. J., McAulay M., Rhodes S. G., Thacker T., Gilbert S. C., McShane H., Hill A. V. S., Xing Z., Hewinson R. G., Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis Infection and Immunity 2009 77 8 3364 3373
95. Dietrich J., Aagaard C., Leah R., Olsen A. W., Stryhn A., Doherty T. M., Andersen P., Exchanging ESAT6 with TB10.4 in an Ag85B fusion molecule-based tuberculosis subunit vaccine: efficient protection and ESAT6-based sensitive monitoring of vaccine efficacy Journal of Immunology 2005 174 10 6332 6339
96. Lyashchenko K., Whelan A. O., Greenwald R., Pollock J. M., Andersen P., Hewinson R. G., Vordermeier H. M., Association of tuberculin-boosted antibody responses with pathology and cell-mediated immunity in cattle vaccinated with Mycobacterium bovis BCG and infected with M. bovis Infection and Immunity 2004 72 5 2462 2467
97. Yao J., Production of high-quality normalized cDNA libraries representing bovine leukocytes and swine muscle Proceedings of the Plant and Animal Genome Conference 2000 San Diego, Calif, USA
98. Coussens P. M., Colvin C. J., Wiersma K., Abouzied A., Sipkovsky S., Gene expression profiling of peripheral blood mononuclear cells from cattle infected with Mycobacterium paratuberculosis Infection and Immunity 2002 70 10 5494 5502
99. Meade K. G., Gormley E., Park S. D. E., Fitzsimons T., Rosa G. J. M., Costello E., Keane J., Coussens P. M., MacHugh D. E., Gene expression profiling of peripheral blood mononuclear cells (PBMC) from Mycobacterium bovis infected cattle after in vitro antigenic stimulation with purified protein derivative of tuberculin (PPD) Veterinary Immunology and Immunopathology 2006 113 1-2 73 89
100. Murphy J. T., Sommer S., Kabara E. A., Verman N., Kuelbs M. A., Saama P., Halgren R., Coussens P. M., Gene expression profiling of monocyte-derived macrophages following infection with Mycobacterium avium subspecies avium and Mycobacterium avium subspecies paratuberculosis Physiological Genomics 2006 28 1 67 75
101. Wedlock D. N., Kawakami R. P., Koach J., Buddle B. M., Collins D. M., Differences of gene expression in bovine alveolar macrophages infected with virulent and attenuated isogenic strains of Mycobacterium bovis International Immunopharmacology 2006 6 6 957 961
102. Diez-Tascn C., Keane O. M., Wilson T., Zadissa A., Hyndman D. L., Baird D. B., McEwan J. C., Crawford A. M., Microarray analysis of selection lines from outbred populations to identify genes involved with nematode parasite resistance in sheep Physiological Genomics 2005 21 1 59 69
103. Widdison S., Watson M., Piercy J., Howard C., Coffey T. J., Granulocyte chemotactic properties of M. tuberculosis versus M. bovis -infected bovine alveolar macrophages Molecular Immunology 2008 45 3 740 749
104. Fietta A., Meloni F., Francioli C., Morosini M., Bulgheroni A., Casali L., Gialdroni Grassi G., Virulence of Mycobacterium tuberculosis affects interleukin-8, monocyte chemoattractant protein-1 and interleukin-10 production by human mononuclear phagocytes International Journal of Tissue Reactions 2001 23 4 113 125
105. Coussens P. M., Jeffers A., Colvin C., Rapid and transient activation of gene expression in peripheral blood mononuclear cells from Johne's disease positive cows exposed to Mycobacterium paratuberculosis in vitro Microbial Pathogenesis 2004 36 2 93 108
106. Coussens P. M., Verman N., Coussens M. A., Elftman M. D., McNulty A. M., Cytokine gene expression in peripheral blood mononuclear cells and tissues of cattle infected with Mycobacterium avium subsp. paratuberculosis: evidence for an inherent proinflammatory gene expression pattern Infection and Immunity 2004 72 3 1409 1422
107. Meade K. G., Gormley E., Doyle M. B., Fitzsimons T., O'Farrelly C., Costello E., Keane J., Zhao Y., MacHugh D. E., Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease BMC Genomics 2007 8, artile 400
108. Meade K. G., Gormley E., O'Farrelly C., Park S. D., Costello E., Keane J., Zhao Y., MacHugh D. E., Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program BMC Genomics 2008 9, article 447
109. Asselah T., Biche I., Sabbagh A., Bedossa P., Moreau R., Valla D., Vidaud M., Marcellin P., Gene expression and hepatitis C virus infection Gut 2009 58 6 846 858
110. Kagnoff M. F., Eckmann L., Analysis of host responses to microbial infection using gene expression profiling Current Opinion in Microbiology 2001 4 3 246 250
111. Manger I. D., Relman D. A., How the host 'sees' pathogens: global gene expression responses to infection Current Opinion in Immunology 2000 12 2 215 218
112. Skovgaard K., Grell S. N., Heegaard P. M. H., Jungersen G., Pudrith C. B., Coussens P. M., Differential expression of genes encoding CD30L and P-selectin in cattle with Johne's disease: progress toward a diagnostic gene expression signature Veterinary Immunology and Immunopathology 2006 112 3-4 210 224
113. Meade K. G., Gormley E., Doyle M. B., Fitzsimons T., O'Farrelly C., Costello E., Keane J., Zhao Y., MacHugh D. E., Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease BMC Genomics 2007 8, article 400
114. MacHugh D. E., Gormley E., Park S. D. E., Browne J. A., Taraktsoglou M., O'Farrelly C., Meade K. G., Gene expression profiling of the host response to mycobacterium bovis infection in cattle Transboundary and Emerging Diseases 2009 56 6-7 204 214
115. Doherty T. M., Arditi M., TB, or not TB: that is the questiondoes TLR signaling hold the answer? Journal of Clinical Investigation 2004 114 12 1699 1703
116. Van Rhijn I., Godfroid J., Michel A., Rutten V., Bovine tuberculosis as a model for human tuberculosis: advantages over small animal models Microbes and Infection 2008 10 7 711 715
117. Naranjo V., Gortazar C., Villar M., de la Fuente J., Comparative genomics and proteomics to study tissue-specific response and function in natural Mycobacterium bovis infections Animal Health Research Reviews 2007 8 1 81 88
118. Fernndez de Mera I. G., Pérez de la Lastra J. M., Ayoubi P., Naranjo V., Kocan K. M., Gortazar C., de la Fuente J., Differential expression of inflammatory and immune response genes in mesenteric lymph nodes of Iberian red deer (Cervus elaphus hispanicus) naturally infected with Mycobacterium bovis Developmental and Comparative Immunology 2008 32 2 85 91
119. Gallagher J., Clifton-Hadley R. S., Tuberculosis in badgers; a review of the disease and its significance for other animals Research in Veterinary Science 2000 69 3 203 217
120. Thacker T. C., Palmer M. V., Waters W. R., Associations between cytokine gene expression and pathology in Mycobacterium bovis infected cattle Veterinary Immunology and Immunopathology 2007 119 3-4 204 213
121. Seth M., Lamont E. A., Janagama H. K., Widdel A., Vulchanova L., Stabel J. R., Waters W. R., Palmer M. V., Sreevatsan S., Biomarker discovery in subclinical mycobacterial infections of cattle PLoS One 2009 4 5